Clinical trials: Systemic Inflammatory Response Syndrome (SIRS)
Infections, Critical Illness
Ventilator-Associated Pneumonia in Critically Ill COVID-19 vs. Non-COVID-19 Patients
The COVID-19 pandemic has led to an increased incidence of ventilator-associated pneumonia (VAP) among critically ill patients. However, in a context of high prevalence of multidrug-resistant organisms (MDROs) there is a lack of…
- Conditions
- Infections, Critical Illness, Superinfection, Organ Failure, Multiple
- Trial name
- NCT05972980
- Testing
- COVID-19
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Turin, Italy
Sepsis
A Study of HY209 in Healthy Male Volunteers for Sepsis
A randomized, double-blind, placebo-controlled single dosing, dose escalation phase I clinical trial to investigate the safety/tolerability and pharmacokinetics of HY209 after intravenous administration in healthy male volunteers
- Trial name
- NCT04255979
- Testing
- HY209
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shaperon
Septic Shock
Capillary Refill Time Response to a Rapid Fluid Challenge in Septic Shock Patients
In septic shock patients, the hemodynamic coherence between systemic, regional and microcirculatory blood flow can be tracked by "capillary refill time (CRT) response to an increase in stroke volume induced by a rapid fluid…
- Trial name
- AUSTRALIS (NCT04693923)
- Testing
- Fluid challenge
- Where
- Chile
- Volunteers
- 42 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Community-acquired Pneumonia, Hospital-acquired Pneumonia
Use of Presepsin as a Marker for Immunotherapy Administration in Pneumonia
The current study is an exploratory, phase IIa randomized clinical trial (RCT) aiming to evaluate if early presepsin increase coupled with early initiation of anakinra as an adjunct therapy to the standard-of-care treatment may…
- Trial name
- INSPIRE (NCT05785442)
- Testing
- Anakinra Prefilled Syringe
- Where
- 5 sites in Greece
- Volunteers
- 60 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Sepsis, Septic Shock
Ulinastatin Treatment in Adult Patients With Sepsis and Septic Shock in China
A Prospective, Multi-Centre, Double-Blind, Randomized, Placebo-Controlled, Trial of Ulinastatin Treatment in Adult Patients with Sepsis and Septic Shock in China
- Trial name
- NCT02647554
- Testing
- ulinastatin
- Where
- China
- Volunteers
- 347 people
- Sponsor
- Peking Union Medical College Hospital
Severe Sepsis
Targeted Exercise Intervention to Reduce Morbidity and Mortality in Sepsis
This is a single arm, pilot study. Patients in the LHSC adult ICU (Critical Care Trauma Centre) (1200 patients/annum) are screened daily for severe sepsis by the Clinical Research Assistants.
- Trial name
- TERMS (NCT04938531)
- Testing
- Exercise
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Critical Illness, Sepsis
Peer Support for Post Intensive Care Syndrome Self-Management
A prospective, 2-arm, single-blind, randomized controlled clinical feasibility trial design is planned. Forty CCI survivors will be randomized (1:1) to either the PS-PICS (peer support) intervention or usual care (control) group.
- Conditions
- Critical Illness, Sepsis, Shock, Septic, Shock
- Trial name
- PS-PICS (NCT03788096)
- Testing
- Peer Support with Motivational Interviewing, Usual Care Group
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Texas at Austin
CLABSI - Central Line Associated Bloodstream Infection, CRBSI - Catheter Related Bloodstream Infection
Neonatal Catheter Lock for Infection Prevention
For newborns admitted to Neonatal Intensive Care Units (NICUs), one of the main risk factors for late-onset sepsis is the presence of a central venous catheter (CVC), which is often essential for the administration of medications…
- Conditions
- CLABSI - Central Line Associated Bloodstream Infection, CRBSI - Catheter Related Bloodstream Infection, Neonatal Sepsis, Late-Onset
- Trial name
- Neo-CLIP (NCT07585188)
- Testing
- Taurolidine 2% lock, Normal saline lock
- Where
- Italy
- Volunteers
- 576 people
- Sponsor
- University of Turin, Italy
Sepsis, Lung Injury
Inhalational Versus Intravenous Anesthesia on Postoperative Lung Injury in Septic Patients Undergoing Surgery
This randomized controlled trial will compare the effects of intraoperative inhalational anesthesia versus intravenous anesthesia on postoperative lung injury in septic patients undergoing surgery.
- Trial name
- NCT07601256
- Testing
- Inhalation Anesthesia, intravenous anesthesia
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Initial Phase of Severe Sepsis and Septic Shock
Population Pharmacokinetics and Monte Carlo Dosing Simulations of Meropenem During the Early Phase of Severe Sepsis and Septic Shock in Critically Ill Patients in Intensive Care Units
This is a prospective, noncomparative study to assess the pharmacodynamics of meropenem during early phase of severe sepsis and septic shock in critically ill patients in an intensive care unit.
- Trial name
- NCT02213796
- Testing
- Meropenem
- Where
- Thailand
- Volunteers
- 9 people
- Sponsor
- Sutep Jaruratanasirikul
Shock, Septic
Protocolized Reduction of Non-resuscitation Fluids vs Usual Care in Septic Shock Feasibility Trial
The objectives of this feasibility trial are to assess the efficacy and feasibility of methods and procedures of a protocol purposed to compare a reduction of administration of non-resuscitation fluids to usual care in patients…
- Trial name
- NCT05249088
- Testing
- Protocolised reduction of non-resuscitation fluids, Usual care
- Where
- 8 sites in Sweden
- Volunteers
- 98 people
- Sponsor
- Region Skane
Bacteremia
Cefepime vs. Carbapenems for Treating AmpC β-lactamase-producing Enterobacteriaceae Bloodstream Infections
Recent international recommendations suggest the use of carbapenem rather than cefepime in this situation, but with a low level of evidence, given the few existing studies.
- Trial name
- CARBAPENEM (NCT05535751)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Strasbourg, France
Critical Illness, Severe Sepsis
Near Infrared Spectroscopy (NIRS) in Severe Sepsis
The purpose of this study is to evaluate the usefulness of an optimization of muscle perfusion and oxygenation, as assessed by the NIRS technique, in critically ill patients with sepsis.
- Trial name
- OTO-STS (NCT00167596)
- Testing
- Near Infrared Spectroscopy, conventional
- Where
- 7 sites in France, Germany and 2 more
- Volunteers
- 103 people
- Sponsor
- University of Versailles
Sepsis
Adaptive Platform Trial for Personnalisation of Sepsis Treatment in Children and Adults: a Multi-national, Treatable Traits-guided, Adaptive, Exploratory, Bayesian Basket Trial
PALETTE is a perpetual adaptive platform to efficiently study sepsis interventions within 'treatable traits' in all-ages patients enabling prompt evaluation of pandemic treatments.
- Trial name
- PALETTE (NCT06381661)
- Testing
- Tocilizumab, Baricitinib, Anakinra
- Where
- 19 sites in France
- Volunteers
- 2,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Septic Shock, Sepsis
Vitamin C and Septic Shock
This is a randomized, double-blind, placebo-controlled clinical trial to compare Vitamin C versus placebo for patients presenting to the ICU with a diagnosis of septic shock.
- Trial name
- NCT03338569
- Testing
- Vitamin C
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of Minnesota
Acinetobacter Baumannii-calcoaceticus Complex, Hospital-acquired Bacterial Pneumonia
Study to Evaluate the Efficacy and Safety of Intravenous Sulbactam-ETX2514 in the Treatment of Patients With Infections Caused by Acinetobacter Baumannii-calcoaceticus Complex
This is a 2-part study, with Part A being the randomized, controlled portion of the study in patients with ABC hospital-acquired bacterial pneumonia (HABP), ventilator-associated bacterial pneumonia (VABP), or bacteremia.
- Conditions
- Acinetobacter Baumannii-calcoaceticus Complex, Hospital-acquired Bacterial Pneumonia, Ventilator-associated Bacterial Pneumonia, Bacteremia
- Trial name
- ATTACK (NCT03894046)
- Testing
- Sulbactam, Durlobactam, Colistin
- Where
- 90 sites in United States, Belarus and 15 more
- Volunteers
- 207 people
- Sponsor
- Entasis Therapeutics
Shock Hypovolemic, Shock, Septic
Management of Shock in Children With SAM or Severe Underweight and Diarrhea
Diarrhea is one of the leading causes of under-five childhood mortality and accounts for 8% of 5.4 million global under-5 deaths.
- Conditions
- Shock Hypovolemic, Shock, Septic, Blood Transfusion, Adrenaline
- Trial name
- NCT04750070
- Testing
- Blood and Dopamine, Blood and adrenaline
- Where
- Bangladesh
- Volunteers
- 135 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Septic Shock, Adult Respiratory Distress Syndrome
Hyperoxia and Hypertonic Saline in Septic Shock
Assessment of the effect of hyperoxia and hypertonic saline on survival in patients with septic shock Hyperoxia and hypertonic saline may have beneficial effects on organ perfusion and oxygenation and may reduce the organ failure…
- Trial name
- Hyper2S (NCT01722422)
- Testing
- oxygen and saline
- Where
- France
- Volunteers
- 441 people
- Sponsor
- University Hospital, Angers
Septic Shock, Vasodilatory Shock
Heparin Anticoagulation in Septic Shock
This study is a pragmatic open-label international randomized trial comparing therapeutic dose intravenous unfractionated heparin (UFH) to standard care venous thromboprophylaxis in patients diagnosed with septic shock.
- Trial name
- HALO (NCT03378466)
- Testing
- Unfractionated heparin, Venous thromboprophylaxis (VTE)
- Where
- 51 sites in United States, Brazil and 5 more
- Volunteers
- 178 people
- Sponsor
- University of Manitoba
Bacteremia, Streptococcus Infection
Beta-lactam Plus Levofloxacin to Enhance Therapy in Streptococcal Septicemia
A double-blind randomized controlled trial comparing beta-lactam plus levofloxacin versus beta-lactam monotherapy for the treatment of Streptococcal bacteremia
- Trial name
- BLESS (NCT07240077)
- Testing
- Beta-lactam monotherapy, Beta-lactam plus levofloxacin combination therapy
- Where
- 4 sites in Thailand
- Volunteers
- 165 people
- Sponsor
- Mahidol University