Clinical trials: Systemic Reaction
COVID-19, Endothelial Function
Non-invasive Characterization of Systemic Microvascular Reactivity by Near-infrared Diffuse Optical Spectroscopy in COVID-19 Patients
The purpose of this study is to characterize microvascular reactivity on the forearm muscle using non-invasive near-infrared spectroscopy in critically ill COVID-19 patients, and to correlate its alterations with 28-day mortality…
- Trial name
- HEMOCOVID19 (NCT04689477)
- Testing
- Vascular occlusion test
- Where
- 8 sites in United States, Brazil and 2 more
- Volunteers
- 612 people, healthy volunteers welcome
- Sponsor
- Corporacion Parc Tauli
Coronavirus Infection, Endothelial Dysfunction
Microvascular Flow and Reactivity in Patients Presenting in the Acute Phase of COVID-19.
Considering that the intensity of systemic microvascular changes in patients in the acute phase of COVID-19 could be related to disease progression and prognosis, the present cross-sectional and observational study aims to…
- Conditions
- Coronavirus Infection, Endothelial Dysfunction, Microvascular Rarefaction
- Trial name
- NCT04406545
- Testing
- evaluation of skin microvascular flow and reactivity
- Where
- Brazil
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Sepsis Syndrome
Platelet REactivity in Sepsis Syndrome (PRESS)
Activation of blood platelets is a typical finding in patients with systemic inflammation and sepsis.They seem to mediate key pro-inflammatory mediator secretion, immune-cell activation while their adhesion to the endothelium…
- Trial name
- PRESS (NCT02562261)
- Where
- Greece
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Charalambos .A. Gogos
Drug Reaction to Analgesic Nos
Phase I Pharmacokinetic Study of RX0041-2
This Phase I study is to examine the systemic pharmacokinetics of RX0041-002 following acute, topical, intranasal administration to healthy male and female volunteers.
- Trial name
- NCT02667106
- Testing
- RX0041-2
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pharmaceutical Project Solutions, Inc.