Clinical trials: Systemic Reaction
SARS-CoV Infection, COVID-19
COVID19 SARS Vaccinations: Systemic Allergic Reactions to SARS-CoV-2 Vaccinations
Background: Allergic reactions have been reported to occur after vaccination with both the Pfizer-BioNTech COVID-19 Vaccine and Moderna COVID-19 Vaccine.
- Conditions
- SARS-CoV Infection, COVID-19, Allergic Reaction, Mast Cell Disorder
- Trial name
- SARS (NCT04761822)
- Testing
- Moderna COVID-19 Vaccine, Pfizer-BioNTech COVID-19 Vaccine
- Where
- 29 sites in United States
- Volunteers
- 746 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
Markers of T Cell Suppression: Antimalarial Treatment and Vaccine Responses in Healthy Malian Adults
Background: People with malaria often show altered immune responses to many illnesses and vaccines. This means that the malaria might cause immune suppression. It is not clear how or which vaccines are impacted by malaria.
- Trial name
- NCT02544048
- Where
- Mali
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Trauma, Sepsis
System-level Monitoring of Immune Activation Concerning Susceptibility to Sepsis in Trauma Patients
Sepsis remains a common entity in critical care patients with remarkable mortality. Despite extended research activities, no reliable bio-markers or scoring systems attributing the individual risk of developing sepsis have been…
- Trial name
- NCT01472952
- Volunteers
- healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim
Septic Shock, Refractory Shock
Terlipressin for Refractory Septic Shock
Norepinephrine was recommended as the first vasopressor for septic shock resuscitation. For the patient who did not response to high dose norepinephrine, epinephrine was recommended.
- Conditions
- Septic Shock, Refractory Shock, Norepinephrine Adverse Reaction
- Trial name
- TERESEP (NCT04339868)
- Testing
- Terlipressin
- Where
- Thailand
- Volunteers
- 130 people
- Sponsor
- Mahidol University
Healthy Volunteers
Effect of Systemic Ropivacaine on Hyperalgesia, Flare Reaction and Peripheral Nerve Excitability
The purpose of this study is to compare the effect of intravenous ropivacaine and lidocaine on the receptive field of primary sensory afferents and their influence on the vascular bed. *Trial with medicinal product
- Trial name
- NCT00900913
- Testing
- ropivacaine (Naropin)
- Where
- Switzerland
- Volunteers
- 34 people
- Sponsor
- University of Zurich
Oxidative Stress, Endothelial Dysfunction
Genes, Fibrinolysis and Endothelial Dysfunction- Dialysis Aim 3
The purpose of the study is to see how two classes of blood pressure medications,angiotensin-converting enzyme inhibitors (Ace inhibitors) and angiotensin receptor blockers (ARBs), differ in their long term effects on certain…
- Trial name
- NCT00878969
- Testing
- valsartan (ARB), ramipril (ACE inhibitor)
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Drug Hypersensitivity
Treatment of Hypersensitivity Syndrome (DRESS) With Tegeline® (Human Immunoglobulin)
Efficacy and tolerance of Tegeline® treatment in hypersensitivity syndrome. Immunological study of the T cell index phenotype and functionality in hypersensitivity syndrome.
- Trial name
- DRESS2 (NCT00505648)
- Testing
- Tegeline®
- Where
- 2 sites in France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Rouen
Major Abdominal Surgery
Albumin Kinetics in Generalized Inflammation
The purpose of this study is to determine whether the kinetics of endogenous albumin is altered by the generalized inflammation caused by major abdominal surgery.
- Trial name
- NCT01194492
- Testing
- Albumin transcapillary escape rate (125I-albumin)
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Karolinska Institutet
Hepatic Encephalopathy
Cerebrovascular Reactivity in Hepatic Encephalopathy
It has been observed that patients with cirrhosis present a generalized state of vasoconstriction as an homeostatic response to splanchnic arteriolar vasodilatation.
- Trial name
- NCT01099293
- Where
- Mexico
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Adverse Reaction to Systemic Agents
Clinical Variations and Pain Assessment in Newborns Submitted to Intratracheal Aspiration With Open and Closed System
To compare clinical effects identified in infants undergoing intratracheal aspiration with open and closed systems and verify the presence and intensity of pain in newborns during intratracheal suction, according to the system…
- Trial name
- NCT01276873
- Testing
- Tracheal aspiration close system
- Where
- 2 sites in Brazil
- Volunteers
- 13 people
- Sponsor
- Federal University of São Paulo
Food Allergy
Role of Recombinants in Peach Allergy
This study is aimed at verifying the role and the efficacy of the recombinants allergens Pru p 1, Pru p 3 and Pru p 4, Bet v 1, Bet v 2 and Bet v 4 in the diagnosis of peach allergy
- Trial name
- NCT00715156
- Where
- Italy
- Volunteers
- 148 people
- Sponsor
- Niguarda Hospital
Discrimination, Racial, Stress Physiology
Oklahoma Study of Native American Pain Risk III: Stress and Resilience
The goal of this observational study is to learn about the relationship between environmental structural racism and discrimination and chronic pain risk in Native American adults. The main questions it aims to answer are: 1.
- Conditions
- Discrimination, Racial, Stress Physiology, Pain
- Trial name
- OK-SNAPIII (NCT05723081)
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Dapagliflozin Adverse Reaction, Efficacy
Dapagliflozin in Systemic Right Ventricle (DAPA-SERVE)
The purpose of this study is to describe safety and efficacy of Dapaglifozin in adults patients with a systemic right ventricle (congenitally corrected transposition of the great arteries or transposition of the great arteries…
- Conditions
- Dapagliflozin Adverse Reaction, Efficacy, Systemic Right Ventricle
- Trial name
- DAPA-SERVE (NCT05717257)
- Testing
- Dapagliflozin 10mg Tab
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Monaldi Hospital
Hematologic Diseases, Neutropenia
Value of the LightCycler® SeptiFast Test MGRADE for the Pathogen Detection in Neutropenic Hematological Patients
The overall objective of this study is to assess the clinical value of the SeptiFast Test as an adjunct to traditional microbiological, clinical, and other laboratory assessments in early detection and identification of a…
- Conditions
- Hematologic Diseases, Neutropenia, Febrile Neutropenia, Sepsis
- Trial name
- NCT01114165
- Testing
- Detection of microbial DNA in blood by SeptiFast Test, Pathogen detection by blood culture
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- University Hospital Muenster
Quality of Life, Injection Site Reaction
Simultaneous mRNA COVID-19 and IIV4 Vaccination Study
This study is a prospective, randomized clinical trial. During this study, participants will be randomly assigned to receive quadrivalent inactivated influenza vaccine (IIV4) and mRNA COVID-19 vaccine either simultaneously or…
- Conditions
- Quality of Life, Injection Site Reaction, Adverse Drug Event, Systemic Reaction
- Trial name
- NCT05028361
- Testing
- mRNA COVID-19, IIV4
- Where
- 3 sites in United States
- Volunteers
- 348 people, healthy volunteers welcome
- Sponsor
- Duke University
Morbid Obesity, Opioid Use
Inflammatory Response to Opioid Versus Opioid Free Anesthesia
Anesthetic agents, including opioids can modulate the altered immune function in patients with obesity through mechanisms that involve the expression and release of cytokines.
- Conditions
- Morbid Obesity, Opioid Use, Fentanyl Adverse Reaction, Cytokine Storm
- Trial name
- NCT04854252
- Testing
- Fentanyl
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- University of Guadalajara
Child, Only, Essential Hypertension
Juvenile Essential Arterial Hypertension and Vascular Function
The main goal of this study is to investigate the association of the juvenile essential arterial hypertension with systemic micro- and macrovascular reactivity and cerebral vascular function, and to examine the potential impact…
- Trial name
- NCT05109013
- Where
- Croatia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Stevens-Johnson Syndrome, Drug Reaction With Eosinophilia and Systemic Symptom
Vitamin D Levels in Non-immediate Drug Hypersensitivity Case-control Study
Serum vitamin D levels in drug-induced non-immediate reactions
- Conditions
- Stevens-Johnson Syndrome, Drug Reaction With Eosinophilia and Systemic Symptom, Maculopapular Exanthem, Vitamin D Deficiency
- Trial name
- NCT06263140
- Where
- Thailand
- Volunteers
- 120 people
- Sponsor
- Chulalongkorn University
Systemic Allergic Reaction
The Safety of Administering a Second Dose of a COVID-19 mRNA Vaccine in Individuals Who Experienced a Systemic Allergic Reaction to an Initial Dose
Background: Some people have allergic reactions to COVID-19 mRNA vaccines. Researchers want to learn more about these reactions to provide guidance on who can safely receive the vaccines, including a second dose in people who had…
- Trial name
- NCT04977479
- Testing
- Pfizer-BioNTech COVID-19 Vaccine (Comirnaty), Pfizer-BioNTech COVID-19 Vaccine, Bivalent
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Neuroinflammation
The White Blood Cell Reactivity Following Surgical Trauma and Associated Regulatory Mechanisms.
The purpose of this study is to describe numerical and functional changes in the white blood cell efter surgical trauma. Further, observed immune cell changes correlate to heart rate variability and cognitive function will be…
- Trial name
- NCT03058328
- Testing
- Cognitive testing, testing of heart rate variability and blood samples
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska University Hospital