Clinical trials: T Cells
Diffuse Large B Cell Lymphoma, Peripheral T Cell Lymphoma
Effectiveness of Circulating DNA for Predicting the Relapse and Overall Survival in NHL Patients
The purpose of this study is to evaluate the effectiveness of circulating DNA from peripheral blood for predicting the prognosis and relapse in DLBCL and PTCL patients.
- Trial name
- NCT03079947
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
T-Cell and NK-Cell Neoplasm
A Global Study of the PETAL Consortium
The goal of this observational study is to correlate molecular alterations with outcomes including overall survival (OS), progression-free survival (PFS), response rates for patients with a new diagnosis, primary refractory or…
- Trial name
- PETAL (NCT06067347)
- Where
- 14 sites in United States, Australia and 2 more
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Inflammation, Aging
Impact of Ageing on Adipose, Muscle and Systemic Inflammation
The accumulation and dysfunction of excess adipose (fat) tissue that occurs with ageing is associated with a number of chronic inflammatory disorders such as type 2 diabetes and cardiovascular disease but the underlying…
- Trial name
- NCT02777138
- Testing
- Maintaining a normal daily living lifestyle
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Bath
Cutaneous T Cell Lymphoma, Mycosis Fungoides
A Phase 1, Open-label Study of the Absorption, Metabolism, Excretion of [14C]-Resminostat
Resminostat is a potent, orally available inhibitor of Class I, IIb and IV histone deacetylases (HDACs), including a pronounced activity against HDAC6.
- Conditions
- Cutaneous T Cell Lymphoma, Mycosis Fungoides, Sezary Syndrome
- Trial name
- NCT04955340
- Testing
- [14C]-resminostat
- Where
- United Kingdom
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- 4SC AG
Graft-versus-host Disease, Poor Graft Function
Mesenchymal Stem Cell Infusion as Treatment for Steroid-Resistant Acute Graft Versus Host Disease (GVHD) or Poor Graft Function
The present project aims at investigating the role of MSC for the treatment of patients with Part 1: Steroid-refractory grade II-IV acute GVHD.
- Conditions
- Graft-versus-host Disease, Poor Graft Function, Low Donor T-cell Chimerism
- Trial name
- NCT00603330
- Testing
- Mesenchymal stem cells
- Where
- 12 sites in Belgium, Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Liege
Kidney Transplantation, Rejection
Monitoring Concentration and Pharmacodynamic Effects of Tacrolimus in Peripheral Blood Lymphocytes of Kidney Transplant Recipients
Therapeutic drug monitoring (TDM) of immunosuppressive drugs is used to improve the immunosuppressive effect while minimizing the toxicity related to exposition to high serum levels.
- Trial name
- NCT03425071
- Where
- Brazil
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Bronchiolitis Acute, Wheezing
The Role of Vitamin D and Vitamin D Receptor in Recurrent Wheezing in Children With Bronchiolitis: Immunological Association With T-lymphocyte Mitochondrial Mass
A prospective study will be conducted involving children under 2 years of age hospitalized for bronchiolitis during the period 2025-2026.
- Conditions
- Bronchiolitis Acute, Wheezing, RSV
- Trial name
- NCT07700134
- Testing
- No Intervention: Observational Cohort
- Where
- Greece
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Primary T-cell Immunodeficiency Disorders, Common Variable Immunodeficiency
Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary Immunodeficiencies
Background: Allogeneic blood or marrow transplant is when stem cells are taken from one person s blood or bone marrow and given to another person. Researchers think this may help people with immune system problems.
- Conditions
- Primary T-cell Immunodeficiency Disorders, Common Variable Immunodeficiency, Immune System Diseases, Autoimmune Lymphoproliferative
- Trial name
- NCT02579967
- Testing
- Immunosuppression Only Conditioning -Closed with amendment L, Reduced Intensity Conditioning, Myeloablative Conditioning-Closed with amendment L
- Where
- 2 sites in United States
- Volunteers
- 354 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Influenza
Comparison of Three Licensed Influenza Vaccines
This study will evaluate in detail the way that the immune system responds to three different kinds of flu shots that are licensed in the United States.
- Trial name
- NCT03068949
- Testing
- FluBlok, Fluzone, FluCelVax
- Where
- United States
- Volunteers
- 413 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Multiple Sclerosis
Mechanistic Study of Ocrevus
The purpose of this study is to investigate the immune cell and other factor changes with Ocrevus in Multiple Sclerosis (MS) patients. Researchers will recruit 35 participants for this study.
- Trial name
- NCT04459988
- Testing
- Ocrelizumab
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Michigan
COVID-19 Vaccine, Safety Issues
ChulaCov19 Vaccine in Healthy Adults
This study will be conducted in 2 phases. Phase 1 of this study will be a single-centre, open label, dose escalation first in human (FIH) study conducted in 2 groups of healthy participants.
- Trial name
- NCT04566276
- Testing
- ChulaCov19 vaccine
- Where
- 2 sites in Thailand
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Polymorphic Light Eruption, Psoriasis
Regulatory T Cells (Tregs) in Polymorphic Light Eruption
Polymorphic light eruption (PLE) is a photodermatosis with an extremely high prevalence, particularly among young women (up to 20%).
- Conditions
- Polymorphic Light Eruption, Psoriasis, Atopic Eczema
- Trial name
- NCT00555178
- Where
- 2 sites in Austria
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Cytomegalovirus Infections
Trial of Donor T Cells Sensitized With Pentadecapeptides of the CMV-PP65 Protein for the Treatment of Cytomegalovirus (CMV) Infections Following Allogeneic Hematopoietic Stem Cell Transplants
The purpose of this study is to test the safety of a transfusion of specialized white cells from your transplant donor's blood, called T-cells, that have been grown and immunized against the CMV virus in the test tube.
- Trial name
- NCT00674648
- Testing
- CMV-Peptide-Specific T cells
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Alopecia Areata
Characteristics of T Cells From Alopecia Areata Scalp Skin Before and After Treatment With Aldara 5%
It is thought that alopecia areata occurs as the result of an inappropriate response of the body's own immune system to certain substances in or around the hair follicle.
- Trial name
- NCT00176943
- Testing
- Aldara Cream 5%
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hordinsky, Maria K., MD
Pregnant Women, Cytomegalovirus Infections
The Maternal Cellular Immune System and Cytomegalovirus Intrauterine Infection
The purpose of this study is to find a correlation between function of cytomegalovirus -specific T cells and the probability for intrauterine transmission.
- Trial name
- NCT01081379
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Parkinson Disease
Parkinson's Disease Inflammatory Biomarker Profiling
This study compares a comprehensive panel of immunological biomarkers between Parkinson's disease patients and healthy, environmentally matched participants.
- Trial name
- NCT03633513
- Testing
- LBT-3627, Immunological profiling
- Where
- 2 sites in United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Longevity Biotech
Immune System Diseases
Zoster Vaccine Response in the Frail Elderly
This study is being done to evaluate the zoster vaccine response in the nursing home elderly (80 years or older). As the immune system ages, the response to vaccines is not always as strong as in younger people.
- Trial name
- NCT01328548
- Testing
- Zostavax
- Where
- Canada
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- McMaster University
Rheumatoid Arthritis
Alterations in CD8αβ and CD8αα T Cell Levels in Patients With Rheumatoid Arthritis
To evaluate the changes in the frequencies of circulating CD4+ and CD4- T cells expressing CD8αα and CD8αβ in peripheral blood of RA patients in comparison with healthy controls.
- Trial name
- NCT05827562
- Testing
- flow cytometry
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Graft Versus Host Disease
Ex-vivo Expanded Donor Regulatory T Cells for Prevention of Acute Graft-Versus-Host Disease
Clinical trial of allospecific regulatory t cells (Tregs) for prevention of acute graft-versus-host disease (GVHD) in human leukocyte antigen (HLA) identical sibling transplants.
- Trial name
- NCT01795573
- Testing
- Cultured Treg cells
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
HIV
Assess the Downregulation of HIV-1 When Raltegravir is Added to a Virologically Suppressed HAART Regimen
The purpose of this study is to determine whether or not adding Raltegravir to a fully suppressive antiretroviral regimen will assist in reducing HIV-1 associated chronic inflammation and increase the t-lymphocyte memory cell…
- Trial name
- NCT00738569
- Testing
- Raltegravir
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Jewish Health