Clinical trials: T1D
Type 1 Diabetes (T1D)
Lactobacillus Johnsonii Supplementation in Adults With T1D
While genetics demonstrated a major risk factor for the development of type 1 diabetes (T1D), microbiota dysbiosis has been suggested as an elicitor in immunological tolerance and of beta cell autoimmunity.
- Trial name
- NCT03961347
- Testing
- L. johnsonii Probiotic
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Florida
Type 1 Diabetes
Hypoglycemia Associated Autonomic Failure in Type 1 DM, Q5
When a patient with Type 1 diabetes exercises, he or she is more prone to low blood sugar, or hypoglycemia. It is known that antecedent exercise can blunt defense responses, called counterregulatory responses to subsequent…
- Trial name
- NCT00605774
- Testing
- epinephrine
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University
Diabetic Foot Ulcer t, Type 1 Diabetes Mellitus
"Ultrasound-Enhanced Propolis Therapy for Healing Diabetic Foot Wounds"
This study aims to evaluate whether using ultrasound (phonophoresis) can help deliver propolis-a natural compound made by bees-more effectively into the skin to speed up wound healing in people with diabetic foot ulcers.
- Conditions
- Diabetic Foot Ulcer t, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Wound Management
- Trial name
- PEARL (NCT07099482)
- Testing
- Propolis gel (10%)
- Volunteers
- 80 people
- Sponsor
- Sinai University
Type1diabetes, Fear of Hypoglycemia
Intervention to Reduce Fear of Hypoglycemia and Optimize Type 1 Diabetes Outcomes
The overall objective and Primary Aim of this Limited Competition: Small Grant Program (R03) is to address the critical need of identifying and decreasing fear of hypoglycemia, which will be accomplished by conducting a pilot…
- Trial name
- NCT03039933
- Testing
- Fear of Hypoglycemia, Treatment As Usual
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Colorado, Denver
Diabetes Type 1
National Epidemiological Study of the Possible Impact of Stress on Glycaemic Control in Patients With Type 1 Diabetes
The EPISTRESS2 study is a one-off cross-sectional epidemiological survey, carried out via an online form in patients with type 1 diabetes followed up by participating investigating centres.
- Trial name
- EPISTRESS2 (NCT06365255)
- Testing
- questionnaires
- Where
- 11 sites in France
- Volunteers
- 1,344 people
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Non-Small Cell Lung Cancer, Colorectal Cancer
A Study of a Personalized Cancer Vaccine Targeting Shared Neoantigens
The purpose of this study is to evaluate the dose, safety, immunogenicity and early clinical activity of GRT-C903 and GRT-R904, a neoantigen-based therapeutic cancer vaccine, in combination with immune checkpoint blockade, in…
- Conditions
- Non-Small Cell Lung Cancer, Colorectal Cancer, Pancreatic Cancer, Solid Tumor
- Trial name
- NCT03953235
- Testing
- GRT-C903, GRT-R904, nivolumab
- Where
- 12 sites in United States
- Volunteers
- 39 people
- Sponsor
- Gritstone bio, Inc.
Type 1 Diabetes Mellitus
Anti-CD3 mAb Treatment of Recent Onset Type 1 Diabetes
This is a randomized placebo controlled study to test whether a single 14 course of treatment with the anti-CD3 monoclonal antibody, hOKT3gamma1(Ala-Ala),Teplizumab will prevent the loss of insulin secretory capacity in…
- Trial name
- NCT00378508
- Testing
- mAb hOKT3gamma1(Ala-Ala), Teplizumab
- Where
- 4 sites in United States
- Volunteers
- 63 people
- Sponsor
- Yale University
Diabetes Mellitus, Type 1
Non-compliance on Treatment Among Diabetic Students at Sohag University
A cross-sectional study on diabetic students in Sohag University will be conducted to collect data about factors affecting compliance and adherence to diabetes treatment and its impact on development of complications.
- Trial name
- NCT05286450
- Where
- Egypt
- Volunteers
- 153 people
- Sponsor
- Sohag University
Diabetes Type 1
Transition of T1DM Patients Aged Over 65 Years Into AHCL (780G) Insulin Pump
Older people with diabetes have a higher risk for cognitive impairment and for physical disability whether this may be effected by an improvement in glucose indices is unknown.
- Trial name
- 780G65+ (NCT06207838)
- Testing
- MiniMed 780G system
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Jagiellonian University
Diabetes Mellitus, Type 1
APIDRA Registration Study
To collect effectiveness and safety data during the treatment with Apidra glulisine (HMR1964) by means of subcutaneous injections to patients with Diabetes Mellitus 1st type during 12 weeks-active phase.
- Trial name
- NCT00489190
- Testing
- Insulin Glulisine
- Where
- Kazakhstan
- Volunteers
- 45 people
- Sponsor
- Sanofi
Type 1 Diabetes
Effectiveness of Carbohydrate Counting Method With Mixed Meals
In a randomized, cross-over designed study, the investigators examined the effectiveness of the carbohydrate counting method after consumption of mixed meals typical of the Greek cuisine with various protein and fat contents in a…
- Trial name
- NCT02928016
- Testing
- Mixed meal 1, Mixed meal 2, Mixed meal 3
- Volunteers
- 120 people
- Sponsor
- Agricultural University of Athens
Type1 Diabetes
The Role of the Thymus in Type I Diabetes.
Regulatory T lymphocytes play a major role in the protection from autoimmune pathology. Defects in immunosuppression mediated by these cells is therefore suspected to contribute to these diseases.
- Trial name
- TregDiab (NCT03236558)
- Testing
- Blood collection
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Type 1 Diabetes
Carbohydrate Counting in Children and Adolescents With Type 1 Diabetes
The total amount of carbohydrates (CHO) at meal consumed strongly predicts the glycemic response in children and adolescents with type 1 diabetes.
- Trial name
- NCT02350374
- Testing
- carbohydrate counting
- Where
- France
- Volunteers
- 82 people
- Sponsor
- Fondation Lenval
Diabetes Mellitus Type 1, Healthy Ageing
FinnDiane LifeOne Study - Impact of Ageing on People With Type 1 Diabetes
Healthy aging refers to functional ability that enables well-being in older individuals. The focus thus shifts from chronological age to functional capacity and the individual's own experience of well-being.
- Trial name
- LifeOne (NCT07289204)
- Where
- Finland
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Type 2 Diabetes, Nephropathy
A Research Study to Evaluate the Renal (Kidney) Protective Effects of Losartan in Patients With Non-insulin Dependent Diabetes (0954-147)(COMPLETED)
Evaluate the effect of Losartan in reducing kidney disease in patients with Non-insulin Dependent Diabetes and Nephropathy (kidney damage that usually accompanies late stage Diabetes Mellitus).
- Trial name
- NCT00308347
- Testing
- MK0954, losartan / Duration of Treatment: mean 3.4 years
- Volunteers
- 1,513 people
- Sponsor
- Organon and Co
Diabetes Mellitus - Type 1, Diabetes Mellitus - Type 2
Diabetes Visual Function Supplement Study
This study will evaluate the effects of a novel multi-component dietary supplement on the visual function and retinal structure of patients with diabetes with both no diabetic retinopathy and mild to moderate diabetic…
- Conditions
- Diabetes Mellitus - Type 1, Diabetes Mellitus - Type 2, Non-proliferative Diabetic Retinopathy
- Trial name
- DiVFuSS (NCT01646047)
- Testing
- multi-component nutritional supplement capsules, multi-component dietary supplement
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- ZeaVision, LLC
Diabetes Mellitus, Type 1
Type 1 Diabetes Impacts of Semaglutide on Cardiovascular Outcomes
This trial plans to learn more about the effects of a medication, semaglutide, on cardiovascular function, kidney function, and insulin sensitivity in adults with type 1 diabetes.
- Trial name
- T1-DISCO (NCT05819138)
- Testing
- Semaglutide Pen Injector
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Colorado, Denver
Diabetes, Diabetes Mellitus, Type 1
Pharmacokinetics of Insulin Detemir in Subjects With Type 1 Diabetes
This trial is conducted in Japan. The aim for this trial is to investigate the pharmacodynamics and pharmacokinetics of insulin detemir and insulin NPH in Japanese subjects with type 1 diabetes mellitus.
- Trial name
- NCT01542450
- Testing
- insulin detemir, insulin NPH
- Where
- Japan
- Volunteers
- 23 people
- Sponsor
- Novo Nordisk A/S
Nonalcoholic Fatty Liver, Nonalcoholic Steatohepatitis
Prevalence of NAFLD and Advanced Fibrosis in Patients With Type 1 Diabetes
The aim of this study is to assess the prevalence of nonalcoholic fatty liver disease (NAFLD) in patients with type 1 diabetes receiving care at Joslin clinic using noninvasive imaging and serum-based methods with the goal of…
- Conditions
- Nonalcoholic Fatty Liver, Nonalcoholic Steatohepatitis, Fibrosis, Liver, Type 1 Diabetes
- Trial name
- NCT04595474
- Testing
- Transient Elastography
- Where
- United States
- Volunteers
- 533 people
- Sponsor
- Joslin Diabetes Center
Type 1 Diabetes (Juvenile Onset), Continuous Glucose Monitoring System
Mediterranean Diet and Oxidative Stress in Type 1 Diabetes (MEDOX-T1D)
Achieving optimal glycemic control in type 1 diabetes requires a holistic approach that includes individualized medical nutrition therapy in addition to appropriate insulin therapy.
- Conditions
- Type 1 Diabetes (Juvenile Onset), Continuous Glucose Monitoring System, Oxidative Stress
- Trial name
- MEDOX-T1D (NCT07544368)
- Testing
- Mediterranean Diet Intervention
- Volunteers
- 54 people
- Sponsor
- Istanbul University
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