Clinical trials: T1D, open to volunteers
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Prospective Study on Diabetes Mellitus and Its Complications in Newly Diagnosed Adult Patients
The aim of the prospective observational GDC-Study in patients with newly diagnosed diabetes mellitus aged 18-69 years at inclusion into the study is to characterize in detail the clinical, metabolical and immunological phenotype…
- Trial name
- GDC (NCT01055093)
- Where
- Germany
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- German Diabetes Center
Healthy Adult, Type 1 Diabetes (T1D)
Finding Immune Nascent Type 1 Diabetes
The goal of this clinical trial is to understand how many individuals who previously participated in the Indiana Biobank will return a type 1 diabetes home screening kit based upon different methods of recruitment communication.
- Trial name
- FIND T1D (NCT07663136)
- Testing
- phone call, email/mail
- Where
- United States
- Volunteers
- 3,800 people, healthy volunteers welcome
- Sponsor
- Indiana University
Type 1 Diabetes Mellitus (T1DM), Healthy Control
Environmental Determinants of Type 1 Diabetes Risk
To analyze the environmental risk factors for type 1 diabetes in China.
- Conditions
- Type 1 Diabetes Mellitus (T1DM), Healthy Control, Relatives to/Carers of Patients
- Trial name
- NCT07835724
- Where
- China
- Volunteers
- 11,240 people, healthy volunteers welcome
- Sponsor
- Second Xiangya Hospital of Central South University
Diabetes, Mellitus, Type 1
A Study About Patient Decision Aids Designed to Help Parents and Guardians in Canada Make Evidence-informed, Values-congruent Decisions About Screening Children for Type 1 Diabetes and Follow-up Decisions.
This study will design and test patient decision aids to help parents and guardians in Canada make decisions about screening their children for type 1 diabetes.
- Trial name
- NCT07317973
- Testing
- Web-based patient decision aid, Standard materials
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Laval University
Type 1 Diabetes Mellitus, Exercise Physiology
Using a Personalized Decision Support Tool to Help People With Type 1 Diabetes Manage Exercise
This study evaluates a clinician-facing decision-support toolkit designed to assist adults with type 1 diabetes in preparing for moderate-intensity exercise.
- Trial name
- NEXT (NCT07226583)
- Testing
- Standard-of-Care Guidance (SoC), Usual Care (UC), netIOB & Exercise Toolkit (NEXT)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Stanford University
Diabetes
Body Composition, Fitness, and Thermoregulation in Young Boys With Type I Diabetes vs. Healthy Soccer Players
The study aims to assess differences in body composition, exercise capacity, and thermoregulation between young soccer players with type 1 diabetes and their healthy peers.
- Trial name
- BCFTYR (NCT06676878)
- Testing
- Incremental exercise
- Where
- Poland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Paweł Korman
Cancer, Immune System Disorder
Montreal Immune-Related Adverse Events (MIRAE) Study
Immune checkpoint inhibitors (ICI) are among the most promising approaches to fighting cancer. However, a substantial percentage of patients experience off-target adverse effects in the form of mild to severe inflammation in…
- Conditions
- Cancer, Immune System Disorder, Inflammatory Reaction, Autoimmune Diseases
- Trial name
- MIRAE (NCT05139706)
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Exercise, Healthy Participants
Inter- and Intraindividual Variability of the Acute Glucose Response to Exercise in Healthy Adults and People Living With Type 1 Diabetes: A Cross-over Replicate Trial
The goal of this clinical trial is to investigate if blood glucose responses are similar between and within individuals in response to standardized exercise in adults with and without Type 1 diabetes.
- Conditions
- Exercise, Healthy Participants, Glucose Variability, Type 1 Diabetes (T1D)
- Trial name
- NCT07209930
- Testing
- Exercise, Rest
- Where
- Ireland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Type 1 Diabetes Mellitus
Establishment of Screening Pathway for High-Risk Population of Type 1 Diabetes
This study aims to establish a system for identifying and screening high-risk individuals for type 1 diabetes (T1D) and a standardized management pathway for high-risk individuals. It is a prospective cohort study.
- Trial name
- NCT07468474
- Testing
- Gene polymorphic detection
- Where
- China
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Type 1 Diabetes, Overweight
Impact of Obesity on Microvascular Insulin Action and Cardiorespiratory Fitness in Type 1 Diabetes
The purpose of this study is: To see if insulin resistance (how sensitive your muscle tissue is to insulin) is associated with lower cardio fitness in people with Type 1 diabetes compared to healthy controls, before and after a…
- Trial name
- ZQL010 (NCT07573228)
- Testing
- Exercise training
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Diabetes Mellitus, Type 1
Healthy Outcomes for Muscle with Exercise in T1D
Over 300,000 people in Canada suffer from Type 1 Diabetes (T1D), a chronic condition whose incidence rate has been increasing in Canada every year by 5.1% (higher than the global average).
- Trial name
- HOME T1D (NCT05740514)
- Testing
- Exercise, De-training
- Where
- Canada
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- McMaster University
Healthy Volunteers and Diabetes Participants
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PAL-119 in Healthy Volunteers and Adult Participants With Type 1 or Type 2 Diabetes
This is a Phase 1/2 randomized study of oral doses of PAL-119 in healthy volunteers and participants with diabetes.
- Trial name
- NCT07901595
- Testing
- PAL-119
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Paulex Bio Inc.
Diabetes
Genetically Informed Screening for Early-Stage Type 1 Diabetes
This study is a test to find out if genetic information can be used to help healthcare providers identify diseases. Specifically, the investigators want to find out how genetic information can help healthcare providers identify…
- Trial name
- PATHS-T1D (NCT07802496)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Type 1 Diabetes, T1D
DASH-Obesity: Explainable AI for Family-Centric Personalized Weight Control in Adolescents and Young Adults With Obesity and Chronic Conditions
This prospective single-arm feasibility study evaluates the Adhera Caring Digital Program for Obesity (ACDP-O), a family-centered digital health intervention designed to support adolescents and young adults with…
- Conditions
- Type 1 Diabetes, T1D, Obesity & Overweight, Obesity Type 2 Diabetes Mellitus
- Trial name
- DASH-Obesity (NCT07638345)
- Testing
- Adhera Caring Digital Program-Obesity (ACDP-O)
- Where
- Spain
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Adhera Health, Inc.
Insulin Response, Type 1 Diabetes
Advancing Precision Nutrition: Wearable Technology for Noninvasive Insulin Monitoring
Noninvasively monitoring insulin is crucial for advancing precision nutrition and promoting healthy living by enabling a deeper understanding of individual metabolic responses to dietary intake.
- Trial name
- NCT07254364
- Testing
- Standardized meal 1
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Neurocognitive Disorders
CONCEPTT Kids International Neurodevelopmental Outcomes Among Offspring of Women With Type 1 Diabetes
Neurodevelopmental Outcomes among Offspring of women with Type 1 Diabetes: A Follow up Study of the CONCEPTT Randomized Control Trial (CONCEPTT Kids International).
- Trial name
- CONCEPTTKids (NCT05754567)
- Where
- 10 sites in Canada, Spain and 1 more
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Diabetes Type 2, Diabetes Type 1
Disentangling the Effect of Brain Insulin Resistance on Brain Health
People with diabetes are at increased risk of developing dementia, including Alzheimer's disease and vascular dementia. In addition, persons with diabetes have more pronounced age-related brain atrophy and cognitive difficulties…
- Trial name
- BIR 1 (NCT07374705)
- Where
- 3 sites in Denmark, Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Henrik Bo Wiberg Larsson
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Gastric Pathophysiology in Diabetes
This is a comprehensive pathophysiological study assessing various gastric functions in patients with diabetes mellitus. The investigators aim to examine the stomach with various measurement devices to gain information about its…
- Conditions
- Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Functional Dyspepsia, Gastroparesis
- Trial name
- DiaFLIP (NCT06068114)
- Where
- 5 sites in Czechia, Slovakia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Institute for Clinical and Experimental Medicine
Pregnancy in Diabetic, Diabetes Mellitus, Type 1
Noninvasive Evaluation of Fetal Hyperinsulinemia With Ultrasound Radiomics
The goal of this observational study is to compare fetal liver ultrasound radiomics between pregnancies complicated by type 1 diabetes and healthy controls.
- Trial name
- NCT06343974
- Where
- 2 sites in Finland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Type 1 Diabetes
BeAT1D: Benign Autoimmunity and Type 1 Diabetes
National multi-center non-interventional case-control cohort study with collection of biological samples to characterize the autoimmune T and B lymphocytes involved in the development of type 1 diabetes.
- Trial name
- BeAT1D (NCT05139784)
- Testing
- Biosampling
- Where
- 17 sites in France
- Volunteers
- 1,160 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France