Clinical trials: T2DM, open to volunteers
Type 2 Diabetes Mellitus (T2DM), Diabetes Distress
Achieving Routine Intervention and Screening for Emotional Health
The purpose of this project is to evaluate the effectiveness of diabetes distress screening and intervention on patients with type 2 diabetes mellitus (T2DM).
- Trial name
- ARISE (NCT06887049)
- Testing
- ARISE Learning Community Diabetes Distress Screening and Intervention, ARISE Enhanced Care brief training
- Where
- United States
- Volunteers
- 880 people
- Sponsor
- University of Chicago
Prediabetes, Type 2 Diabetes (T2DM)
Vitamin D and Type 2 Diabetes - Treat-To-Target
This study tests whether taking a weekly dose of vitamin D, with the dose adjusted to reach a target blood vitamin D level, can help control blood sugar levels in adults at high risk of developing type 2 diabetes (prediabetes).
- Trial name
- D2d-TTT (NCT07448974)
- Testing
- Vitamin D (Cholecalciferol )
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Tufts Medical Center
Diabetes Mellitus, Microbiome
Supplementation of Inulin + L. Acidophilus in Elders With T2DM
This study investigates the effects of a symbotic supplement (Inulin + Lactobacillus acidophilus) on cognitive impairment in older adults with type 2 diabetes mellitus (T2DM).
- Conditions
- Diabetes Mellitus, Microbiome, Cognition Disorders
- Trial name
- NCT06830824
- Testing
- Lactobacillus acidophilus
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Anahuac University
Type 2 Diabetes Mellitus (T2DM), Atherosclerosis
Colchicine for Primary Prevention of Cardiovascular Disease in Adults With Type 2 Diabetes
This study will test whether a low-cost anti-inflammatory medicine called colchicine can help protect the blood vessels of people with type 2 diabetes.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Atherosclerosis, Cardiovascular Diseases
- Trial name
- Col-DM (NCT07837934)
- Testing
- Colchicine 0.5 MG Oral Tablet Once Daily
- Where
- Singapore
- Volunteers
- 300 people
- Sponsor
- Tan Tock Seng Hospital
Metabolic Dysfunction-associated Steatotic Liver Disease, Type 2 Diabetes Mellitus
Henagliflozin on Liver Fibrosis in Patients with MASLD and T2DM
The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) is increasing due to changes in economic conditions and lifestyle, and it is anticipated to become a significant liver disease burden in the…
- Trial name
- NCT06762223
- Testing
- Henagliflozin 10 mg daily, Metformin 1700 mg daily
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Xiqiao Zhou
Fatty Liver, Overweight/Obesity
Effects of Testosterone Undecanoate vs Placebo on Intrahepatic Fat Content in Overweight/Obese Men With T2DM or Prediabetes and Hypogonadism
The epidemics of obesity, MeTSy, T2DM and CVD are increasing worldwide. Non-alcoholic fatty liver disease (NAFLD) is becoming recognized as a condition possibly involved in the pathogenesis of these diseases.
- Conditions
- Fatty Liver, Overweight/Obesity, Prediabetes/Type2 Diabetes Mellitus, Hypogonadism, Male
- Trial name
- Test2Func (NCT03851627)
- Testing
- Testosterone Undecanoate
- Where
- Austria
- Volunteers
- 32 people
- Sponsor
- Alexandra Kautzky-Willer
Type 2 Diabetes Mellitus (T2DM) and Chronic Kidney Disease (CKD)
A Study of REGEND003 on Patients With Type 2 Diabetes Mellitus (T2DM) and Chronic Kidney Disease (CKD)
REGEND003, which consists of human kidney progenitor cells, demonstrates promising potential in repairing kidney injury. The purpose of this study is to assess the saftey and tolerability of REGEND003 on patients with Type 2…
- Trial name
- NCT07275788
- Testing
- REGEND003
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Regend Therapeutics
Type 2 Diabetes Mellitus (T2DM)
Long-Term Benefits of Eccentric Cycling Exercise in Patients With Type 2 Diabetes Mellitus
The goal of this interventional study is to evaluate the long-term benefits of eccentric (ECC) cycling exercise on physiological responses, exercise capacity, and quality of life (QoL) in patients with type 2 diabetes mellitus…
- Trial name
- NCT07109102
- Testing
- Moderate-intensity eccentric cycling, High-intensity eccentric cycling, Moderate-intensity concentric cycling
- Where
- Malaysia
- Volunteers
- 30 people
- Sponsor
- Universiti Sains Malaysia
Self-management, Type 2 Diabetes Mellitus (T2DM)
Development and Evaluation of a Culturally Sensitive Structured Diabetes Self-Management Program for People With Type 2 Diabetes Residing in Qatar
This study is about helping people in Qatar who have Type 2 Diabetes take better care of their health. Diabetes is a common and growing problem in Qatar, and many people need more support and information to manage it well in…
- Conditions
- Self-management, Type 2 Diabetes Mellitus (T2DM), Diabetes Self-management
- Trial name
- PARADIGM-Q (NCT06948370)
- Testing
- Intervention Name: PARADIGM-Q Diabetes Self-Management Education Program, Control Arm (DESMOND): DESMOND Diabetes Self-Management Education Program
- Volunteers
- 200 people
- Sponsor
- Ragae Dughmosh
T2DM (Type 2 Diabetes Mellitus)
Food Effect and Multiple-Dose Study of Chiglitazar/Metformin Extended-Release Tablets
This trial includes two parts: a food effect (FE) study and a multiple-dose pharmacokinetic (PK) study. The FE study is a randomized, open-label, two-period, two-sequence crossover study designed to evaluate the effect of a…
- Trial name
- NCT07511010
- Testing
- Chiglitazar/Metformin extended-release tablets under fasting conditions, Chiglitazar/Metformin extended-release tablets after a high-fat meal, multiple-dose of Chiglitazar/Metformin extended-release tablets
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Chipscreen Biosciences, Ltd.
Type 2 Diabetes Mellitus (T2DM), Cardiovascular Diseases
Cardioprotective Effects of SGLT2 Inhibitors and GLP-1 Receptor Agonists in Korean Patients With Type 2 Diabetes
This observational study will evaluate the cardiovascular effects of sodium-glucose cotransporter-2 inhibitors (SGLT2 inhibitors) and glucagon-like peptide-1 receptor agonists (GLP-1 receptor agonists) in Korean adults with type…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Cardiovascular Diseases, Stage B Heart Failure
- Trial name
- NCT07770737
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Dongtan Sacred Heart Hospital
Cardiometabolic Conditions, Hypertension (HTN)
To Test the Effectiveness and Implementation Approach of a 3-month PILI Pasifika Program Lifestyle Program With Components of Social Determinants of Health Activities in Real-world Settings (Clinical and Non-clinical Settings) Across 3 Years
In this study, the investigators are conducting a Type 3 hybrid effectiveness-implementation trial to evaluate the implementation of the Community Health Workers (CHW)-delivered PILI Pasifika Program (PPP) across 3 regions, the…
- Conditions
- Cardiometabolic Conditions, Hypertension (HTN), Dyslipidemia, Pre-diabetes
- Trial name
- NCT07387393
- Testing
- PILI (Partnership for Improving Lifestyle Intervention) Pasifika Program
- Where
- 2 sites in United States
- Volunteers
- 400 people
- Sponsor
- University of Hawaii
Type 2 Diabetes Mellitus (T2DM), Neuropathic Pain
The Effect of Aromatherapy Foot Massage on Neuropathic Pain in Patients With Type2 Diabetes
The aim of this clinical trial is to learn about the effect of aromatherapy foot massage on neuropathic pain in patients with Type 2 diabetes.
- Trial name
- NCT07271160
- Testing
- intervention I group, Intervention II group
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- TC Erciyes University
Type 2 Diabetes Mellitus (T2DM)
BALANCE-DM2 Study of Bofanglutide in Adults With Type 2 Diabetes
The goal of this clinical trial is to evaluate the efficacy and safety of Bofanglutide (GZR18) compared with Semaglutide in Latin American adults with type 2 diabetes mellitus who have inadequate glycemic control while receiving…
- Trial name
- NCT07628985
- Testing
- Bofanglutide, Semaglutide
- Where
- 7 sites in Mexico
- Volunteers
- 374 people
- Sponsor
- Carnot Laboratories
Type 2 Diabetes
A Phase 3 Study of HS-20094 in Patients With T2DM Inadequately Controlled With Diet and Exercise Alone
This is a multicenter, randomized, double-blind, placebo-controlled Phase III clinical study to evaluate the efficacy and safety of HS-20094 injection in subjects with type 2 diabetes who have inadequate glycemic control with…
- Trial name
- NCT07156500
- Testing
- HS-20094 Injection
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Jiangsu Hansoh Pharmaceutical Co., Ltd.
Diabetes Mellitus, Type 2, Prediabetic State
PREDICT-DM: Community Pharmacy-Based Point-of-Care Testing for Undiagnosed T2DM
The goal of this observational study is to learn whether community pharmacy-based risk assessment and point-of-care HbA1c testing can help detect undiagnosed type 2 diabetes and prediabetes among adults in Irbid Governorate…
- Conditions
- Diabetes Mellitus, Type 2, Prediabetic State, Prediabetes / Type 2 Diabetes, T2DM
- Trial name
- PREDICT-DM (NCT07795918)
- Where
- Jordan
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Diabetes Mellitus, Type 2
Reversibility of Brain Glucose Transport in Type 2 Diabetes Mellitus (T2DM)
The goal of this clinical trial is to learn about the effects of high blood glucose levels in the brain and assess if the changes seen in individuals with poorly control T2DM can be reversed with good glucose control.
- Trial name
- NCT05776563
- Testing
- Nutrition visits, Intensification of diabetes regimen, Continuous glucose monitor (CGM)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Yale University
Type 2 Diabetes Mellitus (T2DM)
Continuous Glucose Monitoring for Self-Management of Type 2 Diabetes in Young Adults
Type 2 diabetes in increasing common in young adults. Utilizing a mixed-methods, community-based approach, this study offers continuous glucose monitors (CGMs) to young adults with type 2 diabetes for 30 days, and collects both…
- Trial name
- CAPAZ-2D (NCT07065721)
- Testing
- Continuous glucose monitor
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- San Diego State University
Food Insecurities, Cardiometabolic Comorbidities
Human Immunodeficiency Virus (HIV) Food Insecurities
The objectives of this study are to better understand how FI (food insecurities) contributes to the development of cardiometabolic comorbidities among PWH (People with HIV) and to test a novel bilingual FI intervention designed…
- Conditions
- Food Insecurities, Cardiometabolic Comorbidities, HIV, PreDiabetes
- Trial name
- NCT04943861
- Testing
- weCare/Secure, Usual Care
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Wake Forest University Health Sciences
Type 2 Diabetes Mellitus (T2DM), Time Restricted Eating
Time Restricted Eating in Patients With Microalbuminuria
This is a clinical trial to assess how time-restricted eating (TRE) may improve kidney health and filtration patients with type 2 diabetes and increased protein content in their urine.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Time Restricted Eating, Microalbuminuria
- Trial name
- TREK (NCT06884059)
- Testing
- Time Restricted Eating
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of California, San Diego