Clinical trials: T2DM (Type 2 Diabetes Mellitus)
Type 2 Diabetes Mellitus
A Study on Safety, Pharmacokinetics and Pharmacodynamics of Lixisenatide in Pediatric Patients With Type 2 Diabetes Mellitus (T2DM)
Primary Objective: To demonstrate safety of 14-day repeated lixisenatide doses with 3 ascending doses as compared to placebo in pediatric patients with T2DM.
- Trial name
- NCT02803918
- Testing
- Lixisenatide (AVE0010), Basal Insulin, Metformin
- Where
- 11 sites in United States, Mauritius and 4 more
- Volunteers
- 23 people
- Sponsor
- Sanofi
Type 2 Diabetes Mellitus (T2DM)
Phase III Trial of SGLT2 Inhibitor and Thiazolidinedione Fixed-Dose Combination vs. Monotherapy in Type 2 Diabetes Patients on Metformin
This clinical trial is studying whether combining two commonly used diabetes medications into a single pill works better than taking them separately for people with type 2 diabetes who are already on metformin.
- Trial name
- CONTROL (NCT07057479)
- Testing
- Fixed-dose combination of SGLT2 inhibitor and thiazolidinedione, Control Group 1 Intervention - SGLT2 inhibitor monotherapy, Control Group 2 Intervention - Thiazolidinedione monotherapy
- Where
- Brazil
- Sponsor
- Eurofarma Laboratorios S.A.
Type 2 Diabetes (T2DM), Metabolic Dysfunction-Associated Steatotic Liver Disease
Cardiovascular Risk in T2DM With MAFLD: A Cohort Study
This study aims to address the following key scientific question by establishing a large-scale, high-standard clinical cohort: the independent contribution of MASLD and its progression to liver fibrosis on cardiovascular outcomes…
- Trial name
- NCT07706010
- Where
- China
- Volunteers
- 7,000 people
- Sponsor
- The Affiliated Hospital of Hangzhou Normal University
Type 2 Diabetes Mellitus
Safety, Tolerability and Efficacy of ISIS-GCGRRx in Type 2 Diabetes
The purpose of this study is to evaluate the efficacy, safety and tolerability of ISIS-GCGRRx in combination with metformin versus placebo + metformin
- Trial name
- NCT01885260
- Testing
- ISIS-GCGRRx - Dose Level 1, ISIS-GCGRRx - Dose Level 2
- Where
- 24 sites in United States, South Africa
- Volunteers
- 77 people
- Sponsor
- Ionis Pharmaceuticals, Inc.
T2DM
A Single-Center, Open-Label, Single Ascending Dose Study of Exenatide Circular RNA-Lipid Nanoparticle Injection (CR059) in Chinese Subjects With Type 2 Diabetes Mellitus
Primary Objectives: •To evaluate the safety and tolerability of a single dose of Exenatide Circular RNA-Lipid Nanoparticle Injection（CR059）in Chinese subjects with T2DM.
- Trial name
- CR059101 (NCT07347080)
- Testing
- Exenatide Circular RNA-Lipid Nanoparticle Injection（ CR059））
- Where
- China
- Volunteers
- 9 people
- Sponsor
- The First Affiliated Hospital of Henan University of Science and Technology
Cardiovascular Diseases, Obesity Prevention
Mediterranean Diet Education in Shift Nurses: Effects on Sleep, Activity, and Health Parameters
This study aimed to evaluate the effects of Mediterranean diet education on sleep quality, physical activity levels, blood parameters, and anthropometric measurements among shift-working nurses.
- Conditions
- Cardiovascular Diseases, Obesity Prevention, Atheroscleroses, Hypertension
- Trial name
- NCT07123610
- Testing
- Mediterranean Diet Education Program
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Diabetes Mellitus, Type 2
Efficacy and Safety Study of Chromium Picolinate + Biotin on Glucose and Cholesterol Control in T2DM
To evaluate the effect of the combination of chromium picolinate (600 μg Cr) + biotin (2 mg) versus placebo on glycosylated hemoglobin (HbA1c), lipid profiles (Total-C, HDL-C, LDL-C, TGs, TG/HDL ratio, etc), and pharmacoeconomic…
- Trial name
- NCT00289354
- Testing
- Chromium Picolinate (600 mcg Cr) + biotin (2 mg)
- Volunteers
- 600 people
- Sponsor
- Nutrition 21, Inc.
Type 2 Diabetes Mellitus
Peer-Supported Diabetes Self-Care Intervention to Improve Health Related Quality of Life (HRQoL) and Diabetes Management
Diabetes mellitus is the ninth leading cause of mortality worldwide. Diabetes is a chronic condition with a major impact on the life and well-being of individuals, families, and societies globally.
- Trial name
- NCT05637437
- Testing
- Peer supported diabetes self-care intervention, Usual care
- Where
- Malaysia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Type 2 Diabetes Mellitus (T2DM)
Quinoa Improves Glycolipid Metabolism and Glucose Fluctuation Based on β-Cell Function in Early-stage Type 2 Diabetes
The goal of this clinical trial is to explore whether quinoa diet can improve glycolipid metabolism and glucose fluctuations in patients with early-stage type 2 diabetes mellitus (T2DM) and observe its impact on islet β-cell…
- Trial name
- QIGMAGFBOβFIET (NCT07329231)
- Testing
- Quinoa-based foods
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Qilu Hospital of Shandong University
Type 2 Diabetes Mellitus (T2DM)
Effect of Tai Chi Versus Moderate-intensity Combined Exercise Training on Cardiovascular Health and Physical Functional Performance in Older Men and Women With T2DM: the Tai Chi Intervention for Diabetes Management During Aging (TIDA) Study
This randomized, single-blind, controlled clinical trial compares the effects of a 12-week Tai Chi program versus moderate-intensity combined exercise (MICE) training on cardiovascular health, glycemic control, and physical…
- Trial name
- TIDA (NCT07131761)
- Testing
- Tai chi, Moderate-Intensity Combined Exercise (MICE), Control ( No Exercise )
- Volunteers
- 66 people
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Type 2 Diabetes Mellitus, Mild Cognitive Impairment
Effects of Olfactory Training on the Brain Function in T2DM Patients With Mild Cognitive Impairment
This is a prospective, randomized, open label, parallel, 4-month study to explore and evaluate the therapeutic effects of olfactory training on the cognitive function, olfactory function, and odor-induced brain activation in T2DM…
- Trial name
- NCT06327633
- Testing
- Olfactory Training
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Diabetes Mellitus, Type 2, Cardiovascular Diseases
Educational Intervention to Increase Select Guideline-recommended Cardioprotective Medications in Patients With Diabetes
This is an educational outreach to patients with type 2 diabetes mellitus (T2DM) and atherosclerotic cardiovascular disease (ASCVD) and their primary care and specialist providers to improve use of guideline-recommended…
- Trial name
- NCT04862858
- Testing
- Educational Intervention
- Where
- United States
- Volunteers
- 4,197 people
- Sponsor
- Humana Inc.
Type 2 Diabetes Mellitus (T2DM), Neuropathic Pain
The Effect of Aromatherapy Foot Massage on Neuropathic Pain in Patients With Type2 Diabetes
The aim of this clinical trial is to learn about the effect of aromatherapy foot massage on neuropathic pain in patients with Type 2 diabetes.
- Trial name
- NCT07271160
- Testing
- intervention I group, Intervention II group
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- TC Erciyes University
Type 2 Diabetes Mellitus (T2DM)
Study of AI-based Prediction Models for Exercise-Induced Gut Microbiota Alterations in Patients With Type 2 Diabetes
This study is a randomized controlled clinical trial. The participants will be randomized into two groups in a 1:1 ratio: exercise intervention and sedentary control group.
- Trial name
- NCT06931210
- Testing
- Sedentary behavior, Exercise intervention
- Where
- China
- Volunteers
- 79 people
- Sponsor
- Shanghai 6th People's Hospital
Nonalcoholic Steatohepatitis (NASH), Type 2 Diabetes
HTD1801 in Adults With Nonalcoholic Steatohepatitis and Liver Fibrosis Who Have Type 2 Diabetes or Pre-Diabetes
A phase 2b, multicenter, randomized, double-blind, placebo-controlled study of HTD1801 in adult subjects with non-alcoholic steatohepatitis and liver fibrosis who have type 2 diabetes mellitus or pre-diabetes.
- Trial name
- CENTRICITY (NCT05623189)
- Testing
- HTD1801
- Where
- 45 sites in United States, Hong Kong and 1 more
- Volunteers
- 218 people
- Sponsor
- HighTide Therapeutics (Hong Kong) Limited
Type 2 Diabetes Mellitus (T2DM), Diabetic Foot Disease
NAFF Arabic Validation Study
This study aims to evaluate a new Arabic version of the NAFF questionnaire, which measures foot care behaviors in adults with type 2 diabetes.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Diabetic Foot Disease, Behavior, Self Care
- Trial name
- NCT07271550
- Where
- Tunisia
- Volunteers
- 255 people
- Sponsor
- Faculty of Medicine, Sousse
Type 2 Diabetes Mellitus
The Role of Vitamin D3 and Calcium Supplementation in Attenuating T2DM Severity
The purpose of this study is to investigate the effect of vitamin D3 and calcium supplementation in attenuating type 2 diabetes mellitus outcomes in ethnic diverse, diabetic patiens.
- Trial name
- NCT02464462
- Testing
- vitamin D3 and calcium
- Volunteers
- 11 people
- Sponsor
- York University
Type 2 Diabetes
Effect of Gastric Bypass on Patients With Type 2 Diabetes and/or Dyslipidemia
This is a retrospective review of patients who have undergone bariatric surgery at VUMC and who have type 2 Diabetes and/or dyslipidemia.
- Trial name
- NCT00879125
- Where
- United States
- Volunteers
- 219 people
- Sponsor
- Vanderbilt University
Diabetes Mellitus, Diabetes Mellitus, Type 2
Multiple Dose Study of PF-04991532 in Patients With Type 2 Diabetes
The purpose of this study is to characterize the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of PF-04991532 following multiple (14 days) escalating oral doses in patient wtih type 2 diabetes.
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 2, Glucose Metabolism Disorders
- Trial name
- NCT01129258
- Testing
- PF-04991532
- Where
- 4 sites in United States
- Volunteers
- 110 people
- Sponsor
- Pfizer
Type 2 Diabetes
A Study of HS-20094 in T2DM Participants
This is a randomized, placebo and active-control, multiple-dose, phase IIa trial. Patients were randomly assigned to receive HS-20094 (12 patients), placebo (3 patients), or active control drug Semaglutide injection (3 patients)…
- Trial name
- NCT06118008
- Testing
- HS-20094 5mg, HS-20094 10mg, HS-20094 15mg
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Jiangsu Hansoh Pharmaceutical Co., Ltd.