Clinical trials: T2DM (Type 2 Diabetes Mellitus)
Nonalcoholic Fatty Liver Disease, Type 2 Diabetes Mellitus
Non-Alcoholic Fatty Liver Disease in a Saudi Cohort With Type 2 Diabetes Mellitus
The global rise in the prevalence of obesity paved the way for the increased prevalence of yet another obesity-related complication significant enough to be considered within the roster of major public health threats…
- Trial name
- CORDIAL (NCT05697991)
- Where
- Saudi Arabia
- Volunteers
- 1,000 people
- Sponsor
- King Saud University
Type 2 Diabetes
To Evaluate the Response to Glucagon During Hypoglycemia
The purpose of this study is to evaluate the response to Glucagon versus the spontaneous hormonal response to low blood sugar levels in T2DM Patients treated with AZD1656 and Metformin
- Trial name
- NCT00817271
- Testing
- AZD1656, Glucagon
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- AstraZeneca
Type 2 Diabetes
A Phase 3 Study of HS-20094 in Patients With T2DM Inadequately Controlled With Diet and Exercise Alone
This is a multicenter, randomized, double-blind, placebo-controlled Phase III clinical study to evaluate the efficacy and safety of HS-20094 injection in subjects with type 2 diabetes who have inadequate glycemic control with…
- Trial name
- NCT07156500
- Testing
- HS-20094 Injection
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Jiangsu Hansoh Pharmaceutical Co., Ltd.
Diabetes Mellitus, Type 2
Dulce Digital-Me: An Adaptive mHealth Intervention for Underserved Hispanics With Diabetes
This study will compare Dulce Digital (i.e., the investigators' proven-effective combination of "one-size-fits-all" educational text messages and nurse monitoring of patient-transmitted blood glucose values) and Dulce Digital-Me…
- Trial name
- DD-Me (NCT03130699)
- Testing
- Dulce Digital, Dulce Digital-Me (Automated Delivery), Dulce Digital-Me (Medical Assistant)
- Where
- 2 sites in United States
- Volunteers
- 310 people
- Sponsor
- Scripps Whittier Diabetes Institute
T2DM (Type 2 Diabetes Mellitus)
The Efficacy Nad Safety of DWP16001 Compared to Active Drug in the Treatment of Type 2 Diabetes Mellitus
The purpose of this study is to determine the efficacy and safety of DWP16001 compared to active drug in the treatment of type 2 diabetes mellitus.
- Trial name
- NCT04654390
- Testing
- DWP16001 Amg
- Where
- South Korea
- Volunteers
- 270 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Diabetes Mellitus, Type 2, Arthroplasty, Replacement, Hip
CGM Monitoring in T2DM Patients Undergoing Orthopaedic Replacement Surgery
The purpose of this study is to analyze the efficacy and accuracy of real-time continuous glucose monitoring devices (rtCGM) in patients with Type 2 diabetes undergoing inpatient elective hip or knee surgery in the pre-, peri…
- Conditions
- Diabetes Mellitus, Type 2, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee
- Trial name
- NCT05666479
- Testing
- Dexcom G6 Pro Continuous Glucose Monitor (CGM)
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Stony Brook University
Diabetes Mellitus, Type 2
Long-term Efficacy and Safety of HMS5552 add-on to Metformin in T2DM Subjects
This study evaluates the efficacy and safety and population PK of HMS5552 add-on to Metformin in adult type 2 diabetic subjects.
- Trial name
- NCT03141073
- Testing
- HMS5552
- Where
- China
- Volunteers
- 767 people
- Sponsor
- Hua Medicine Limited
Type 2 Diabetes
Impact on Glycemic Variability in Newly Onset T2DM Patients Initiating Dapagliflozin Plus Metformin Versus Metformin Alone
This study will compare the effect of Dapagliflozin added to Metformin vs Metformin alone on blood sugar fluctuations of adults with a recent diagnosis of Type 2 Diabetes (T2D). The duration of the protocol will be 12 weeks.
- Trial name
- MAGNNIFY (NCT04090580)
- Testing
- Continuous glucose monitoring
- Where
- Mexico
- Volunteers
- 88 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Diabetes Mellitus, Type II, Overweight or Obesity
Differences in Postprandial Glucose Changes
Following a meal, in nondiabetic individuals, blood glucose rises to peak at 1hr and returns to baseline in 2 - 3 hours. In T2DM, this peak is higher and prolonged.
- Trial name
- NCT05957224
- Testing
- Shake 1 then Shake 2, Shake 2 then Shake 1
- Volunteers
- 25 people
- Sponsor
- The University of The West Indies
Food Insecurities, Cardiometabolic Comorbidities
Human Immunodeficiency Virus (HIV) Food Insecurities
The objectives of this study are to better understand how FI (food insecurities) contributes to the development of cardiometabolic comorbidities among PWH (People with HIV) and to test a novel bilingual FI intervention designed…
- Conditions
- Food Insecurities, Cardiometabolic Comorbidities, HIV, PreDiabetes
- Trial name
- NCT04943861
- Testing
- weCare/Secure, Usual Care
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Wake Forest University Health Sciences
Type 2 Diabetes Mellitus (T2DM), Pain
Effects of Self-Selected Music on Self-Injection Fear, Blood Glucose Testing Fear, and Pain
Fear and pain associated with self-insulin injection and blood glucose self-testing may negatively affect diabetes self-management.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Pain, Fear of Injections
- Trial name
- NCT06790550
- Testing
- Self-Selected Music Listening
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Dicle University
Type 2 Diabetes Mellitus (T2DM), Hyperglycemia
Combined Bitter Melon Extract and Snakehead Fish Powder Supplementation for Glycemic Control in Type 2 Diabetes
Type 2 diabetes mellitus (T2DM) remains a major global health problem due to its high prevalence, long-term complications, and substantial economic burden.
- Trial name
- BM-SF Glycemia (NCT07302178)
- Testing
- Snakehead Fish Powder + Bitter Melon Extract
- Volunteers
- 80 people
- Sponsor
- Universitas Muhammadiyah Surakarta
Type 2 Diabetes Mellitus
Safety and Efficacy Study of Tesofensine/Metoprolol Treatment in Subjects With Type 2 Diabetes Mellitus
Safety and Efficacy Study of Tesofensine/Metoprolol Treatment in Subjects With Type 2 Diabetes Mellitus
- Trial name
- NCT02737891
- Testing
- Tesofensine/Metoprolol
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Saniona
Type 2 Diabetes Mellitus (T2DM), Necrotic Pulp
Photodynamic Therapy in Root Canal Treatment of T2DM Patients: Microbiome Analysis Via Next-Gen Sequencing
This clinical study investigates the effectiveness of antimicrobial photodynamic therapy (aPDT) as an additional disinfection method in root canal treatment of patients with Type 2 Diabetes Mellitus (T2DM) who have apical…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Necrotic Pulp, Apical Periodontitis
- Trial name
- NCT06931678
- Testing
- aPDT
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Type 2 Diabetes Mellitus, Overweight
Impact of Liraglutide on Sensory Perception, Sensory Specific Satiety, Liking and Wanting in Type 2 Diabetic Patients
Besides their potential action in the treatment of type 2 diabetes mellitus (T2DM), GLP-1 analogues decrease satiety and food intake leading to a significant weight loss in patients.
- Trial name
- NCT01599338
- Testing
- Liraglutide
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
T2DM (Type 2 Diabetes Mellitus)
Pilot Bioequivalence Study of Chiglitazar/Metformin Extended-Release Tablets
This is a pilot bioequivalence study. It is a randomized, open-label, single-dose, crossover study. The primary objective of this study is to preliminarily evaluate the pharmacokinetic parameters and their variability of the test…
- Trial name
- NCT07412015
- Testing
- treatment T (dose 1), treatment T (dose 2), treatment R (dose 1)
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Chipscreen Biosciences, Ltd.
Type 2 Diabetes Mellitus With Complication
To Compare People With T2DM Who Have Double Hump Versus Who do Not Have Double Hump
Hypothesis: Double Hump in people with T2D is associated with higher magnitude of complication than people with single hump or no hump Objectives: To correlate single and double hump with diabetes complication T2DM patient will…
- Trial name
- NCT06386952
- Where
- India
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Diabetes Foundation, India
Type 2 Diabetes Mellitus
PK Study of Dapagliflozin in Pediatric Subjects With T2DM
The primary purpose of this study is to evaluate the pharmacokinetics (PK) of Dapagliflozin in pediatric subjects with type 2 diabetes mellitus (T2DM)
- Trial name
- NCT01525238
- Testing
- Dapagliflozin
- Where
- 17 sites in United States, Mexico
- Volunteers
- 53 people
- Sponsor
- AstraZeneca
Type 2 Diabetes Mellitus (T2DM), Thoracic Surgery
Effect of Inhalational Anesthesia Versus Total Intravenous Anesthesia on Blood Glucose in Type 2 Diabetes Patients
The aim of this study is to compare the effect of total intravenous anesthesia (TIVA) and inhalational anesthesia (IHA) as maintenance anesthesia on blood glucose level and complications in type 2 diabetic patients undergoing…
- Trial name
- NCT06613893
- Testing
- TIVA, Inhalational anesthesia
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Ain Shams University
Healthy Participants
A Study to Investigate the Relative Bioavailability and Safety of Different Oral Formulations of Elecoglipron in Healthy Participants
The purpose of this study is to measure the pharmacokinetics (PK-how the body processes the study drug) of elecoglipron in healthy participants when taken by mouth as different formulations.
- Trial name
- NCT07723833
- Testing
- Elecoglipron Reference Formulation Dose A, Elecoglipron Test formulation 1 Dose A, Elecoglipron Reference Formulation Dose B
- Where
- 2 sites in United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- AstraZeneca