Clinical trials: T2DM (Type 2 Diabetes Mellitus)
Diabetes Mellitus, Type 2
Long-term Efficacy and Safety of HMS5552 in T2DM Subjects
This study evaluates the efficacy and safety and population PK of HMS5552 as monotherapy in adult type 2 diabetic subjects, there will be 2 groups in the first 24 weeks, one group will receive HMS5552 , while the other group will…
- Trial name
- NCT03173391
- Testing
- HMS5552
- Where
- China
- Volunteers
- 463 people
- Sponsor
- Hua Medicine Limited
T2DM (Type 2 Diabetes Mellitus)
Single Escalating Dose Study Of HSK7653 In Healthy Subjects
To evaluate the safety, tolerability, pharmacokinetic (PK) and pharmacodynamic (PD) characteristics of single dose of HSK7653 tablets in healthy adult subjects, and to identify the metabolites of HSK7653 in healthy adult subjects
- Trial name
- NCT05983289
- Testing
- HSK7653
- Where
- China
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Type 2 Diabetes Mellitus, Obesity
RCT Examining Effects of Probiotics in T2DM Individuals
Background: The connection between gut health and diabetes status is increasingly recognized. Gut microbiota composition in diabetic differs from non-diabetic individuals.
- Conditions
- Type 2 Diabetes Mellitus, Obesity, Hypertension, Hyperlipidemia
- Trial name
- NCT01752803
- Testing
- Probiotic
- Where
- Malaysia
- Volunteers
- 100 people
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Type 2 Diabetes (T2DM)
Implementing WHO HEARTS-D Guidelines in Bangladesh for Diabetes Control and Prevention
Type-2 diabetes (T2D) is rising at an alarming rate in the low- and middle-income countries (LMIC). This rapid increase in the T2D burden has a particular impact on cities, where more than half the LMIC populations currently live…
- Trial name
- T2D IR (NCT07155902)
- Testing
- The community-to-facility integrated strategy
- Volunteers
- 5,000 people
- Sponsor
- Florida International University
Type 2 Diabetes Mellitus (T2DM)
A Study of BGM0504 in Poorly Controlled Type 2 Diabetes Patients Only Through Diet and Exercise
This is a multicenter, randomized, double-blind, placebo-controlled phase III clinical study to evaluate the efficacy and safety of BGM0504 in patients with type 2 diabetes (T2D) with poor glycemic control only through diet and…
- Trial name
- NCT06716203
- Testing
- Drug: 5 mg BGM0504 Administered SC, Drug: : 10 mg BGM0504 Administered SC
- Where
- China
- Volunteers
- 207 people
- Sponsor
- BrightGene Bio-Medical Technology Co., Ltd.
Type 2 Diabetes Mellitus
Efficacy and Safety of Ertugliflozin (MK-8835/PF-04971729) With Sitagliptin in the Treatment of Participants With Type 2 Diabetes Mellitus (T2DM) With Inadequate Glycemic Control on Diet and Exercise (MK-8835-017)
This is a study to evaluate the efficacy and safety of ertugliflozin (MK-8835/PF-04971729) in combination with sitagliptin in the treatment of participants with Type 2 diabetes mellitus (T2DM) with inadequate glycemic control on…
- Trial name
- NCT02226003
- Testing
- Ertugliflozin, Sitagliptin, Glimepiride
- Volunteers
- 291 people
- Sponsor
- Merck Sharp & Dohme LLC
DIABETES MELLITUS, NONINSULIN-DEPENDENT, 2 (Disorder)
Examining The Role of CGM in T2DM
Continuous glucose monitoring (CGM) technology has advanced the treatment of people with diabetes, however to date this technology had been primarily limited to use in patients treated with insulin.
- Trial name
- NCT01614262
- Testing
- Continuous Glucose Monitoring with treatment algorithm
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- University of North Carolina, Chapel Hill
Type 2 Diabetes Mellitus (T2DM), Cardiovascular Diseases
Bioequivalence Study to Compare Empagliflozin/Linagliptin/Metformin HCl 25 mg/5 mg/1000 mg Extended Release Tablet Versus Trijardy® XR 25 mg/5 mg/1000 mg Extended- Release Tablets
An open label, randomized, two-period, two treatment, two-sequence, crossover, balanced, single dose oral bioequivalence study to compare Empagliflozin/ Linagliptin/ Metformin HCl 25 mg/5 mg/1000 mg Extended Release Tablet versus…
- Trial name
- NCT07691203
- Testing
- Empagliflozin/Linagliptin/Metformin HCl Extended Release Tablet, Trijardy® XR Tablets
- Where
- India
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Humanis Saglık Anonim Sirketi
Type 2 Diabetes Mellitus (T2DM)
Bioequivalence Study to Compare Empagliflozin + Linagliptin 25 mg/5 mg Film-coated Tablets Versus Glyxambi 25 mg/ 5 mg Film-coated Tablets
An open label, balanced, randomized, single dose, two treatment, two sequence, two period, two way crossover oral bioequivalence study in healthy, adult, human subjects under fasting condition.
- Trial name
- NCT06932159
- Testing
- Empagliflozin + Linagliptin film-coated tablets, Glyxambi film-coated tablets
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Humanis Saglık Anonim Sirketi
Normoglycemia, T2DM (Type 2 Diabetes Mellitus)
To Study the Effects of Mango Ingestion in T2DM and Non-diabetic Subjects.
T2DM patient will be recruited from endocrine OPD 1. Clinical History and Examination: 1. General Physical Examination: Height (cm) weight (kg) BMI (kg/m2) Blood Pressure (mmHg) 2.
- Trial name
- NCT06055582
- Testing
- Bread, Mango
- Where
- India
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Diabetes Foundation, India
Diabetes Mellitus, Type 2
Study of Efficacy and Safety LMF237 in Patients With Type 2 Diabetes Mellitus (T2DM) Inadequately Controlled With Vildagliptin Monotherapy
The purpose of the study was to evaluate the efficacy and safety of LMF237 50/250 mg and 50/500 mg bid in Japanese patients with T2DM inadequately controlled with vildagliptin monotherapy.
- Trial name
- CLMF237A1303 (NCT01811485)
- Testing
- LMF237 50/250 mg, LMF237 50/500 mg
- Where
- 30 sites in Japan
- Volunteers
- 171 people
- Sponsor
- Novartis Pharmaceuticals
Coronary Artery Disease, Type 2 Diabetes
Empagliflozin Versus Vildagliptin in CAD Patients With T2DM
We compared the cardioprotective effects of empagliflozin, an SGLT2 inhibitor, with those of vildagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, focusing on various inflammatory biomarkers lipid profile, and cardiac…
- Trial name
- NCT06313008
- Testing
- Empagliflozin 10 MG, Vildagliptin 50 MG
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Damanhour University
Food Insecurity, Type 2 Diabetes Mellitus (T2DM)
Food Insecurity, Social Determinants of Health
Food is Medicine for the whole will test an intervention which provides medically tailored meals, or grocery voucher cards, or a combination of these food and nutrition resources to a caregiver and children living in the…
- Conditions
- Food Insecurity, Type 2 Diabetes Mellitus (T2DM), Hypertension
- Trial name
- NCT06784310
- Testing
- Medically Tailored Meals, Grocery Prescription, Medically Tailored Meals and Grocery Prescription
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Alison Gustafson
Type 2 Diabetes (T2DM)
Impact of a Nutritional Intervention Based on Moroccan Dietary Habits on the Glycemic Control of Type 2 Diabetics
The goal of this study is to learn if a nutritional intervention adapted to Moroccan dietary habits can improve blood sugar control in adults with Type 2 Diabetes.
- Trial name
- NCT07404280
- Testing
- Moroccan-Adapted Nutritional Plan
- Where
- Morocco
- Volunteers
- 50 people
- Sponsor
- Avicenna Military Hospital
Diabetes Mellitus, Type 2
A 2-Part Trial in Subjects With Type 2 Diabetes and in Healthy Subjects to Evaluate GSK1614235, a New Glucose Lowering Drug to Treat Type 2 Diabetes
The purpose of Part A of this study is to test whether repeated doses of the study drug (GSK1614235) are safe and well tolerated (i.e.
- Trial name
- SGA112534 (NCT00976261)
- Testing
- GSK1614235, Sitagliptin
- Where
- 9 sites in United States, France and 2 more
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Type 2 Diabetes Mellitus, Iron Deficiency
Ferric Carboxymaltose in Type 2 Diabetes Mellitus (T2DM) Patients With Iron Deficiency
The purpose of this study is to investigate the correlation between HbA1c and iron status in Type 2 Diabetes mellitus patients with iron deficiency by intravenous substitution of iron.
- Trial name
- CLEVER (NCT01513369)
- Testing
- ferric carboxymaltose, NaCl (0,9%)
- Where
- 6 sites in Germany
- Volunteers
- 152 people
- Sponsor
- GWT-TUD GmbH
Malnourished Elderly, Malnourishment
Retrospective, Multicenter, Single-arm, Observational Study, With Data From Patients With T2DM With Malnutrition or at Risk, Who Were Prescribed Resource® Diabet Plus as a Hypercaloric and Hyperproteic Specific Formula for Patients With T2DM
This retrospective multicentre study aims to provide real-world evidence of the effectiveness of Resource® Diabet Plus as supplementation tool for T2DM patients with malnutrition or at risk of malnutrition, under conditions of…
- Conditions
- Malnourished Elderly, Malnourishment, Diabetes Mellitus Type 2
- Trial name
- ReDiPLUS (NCT06866366)
- Where
- 4 sites in Spain
- Volunteers
- 59 people
- Sponsor
- Outcomes'10
Type 2 Diabetes
A Study of GZR18 Injection in Chinese Adult Patients With Type 2 Diabetes Mellitus (T2DM)
This is a randomized, double-blind, placebo-controlled Phase Ib/IIa clinical study in Chinese patients with type 2 diabetes mellitus (T2DM) inadequately controlled with diet and exercise and/or treated with irregular use of…
- Trial name
- NCT06256523
- Testing
- GZR18
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Gan and Lee Pharmaceuticals, USA
Type 2 Diabetes Mellitus (T2DM), Hypertension
Eating Window and Sleep Disorders on Glycemic Control, Cardiovascular Risk, and Weight Loss
This project aims to offer a quantitative and qualitative nutritional approach, along with educational nutritional guidelines for participants with Non-Communicable Chronic Diseases.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Hypertension, Obesity and Type 2 Diabetes, Cardiovascular Diseases
- Trial name
- NCT06735859
- Testing
- Comparison of eating windows intervention
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of São Paulo
Type 2 Diabetes Mellitus
Efficacy Of Autologous Bone Marrow Derived Stem Cell Transplantation In Patients With Type 2 Diabetes Mellitus
India is the "Diabetes Capital of the World" with 41 million Indians having diabetes i.e. every fifth diabetic in the world is an Indian1.
- Trial name
- SCT (NCT00644241)
- Testing
- stem cell harvest, angiographic transplantation of stem cells
- Where
- India
- Volunteers
- 10 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh