Clinical trials: TBI Traumatic Brain Injury
Brain Concussion, Traumatic Brain Injury
Balance and Mild Traumatic Brain Injury (TBI)
The purpose of this pilot project is to determine whether using one inertial sensor on the waist during routine clinical balance testing (i.e.
- Trial name
- NCT01377454
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Concussion, Brain
A Pragmatic Rehabilitation Intervention: The Active Rehab Study
The strategic objective of this research line is to examine improving short- and long-term outcomes for soldiers following mild traumatic brain injury (mTBI).
- Trial name
- ARM (NCT05320822)
- Testing
- Active Rehab (Group 2), Progressive Return to Activity (Group 1)
- Where
- 2 sites in United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Brain Injuries
Youth Soccer Header Study
This study aims to establish and validate age-based head kinematics, force-strain models and brain injury probability maps from sensor worn data during soccer heading tasks.
- Trial name
- NCT04919707
- Testing
- Header Session, MRI Session
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Trauma, Brain
The Role of Hypoxia on Subconcussive Head Impacts
The purpose of this study is to examine the combined effects of hypoxia and a short bout of subconcussive head impacts on neurocognitive and ocular-motor function and plasma expression of brain-derived blood biomarkers.
- Trial name
- NCT04624152
- Testing
- Soccer heading
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Indiana University
Eye-tracking
EYE-TRAC Advance: Technology Verification (ETA-TV) Cohort 1
This study will assess the effects of exercise and non-concussive bodily contact on eye-tracking scores collected by the EYE-SYNC eye-tracking device.
- Trial name
- ETA-TV (NCT02844543)
- Testing
- EYE-SYNC eye-tracking device, SCAT-3, Desktop Eye-Tracker
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Stanford University
Traumatic Brain Injury, Injury of Body Region
Neuroimaging & Plasma Markers for Predicting Outcomes After Mild Traumatic Brain Injury
This exploratory study aims to identify the most promising biomarkers that alone or in combination might predict development of mood disorders [i.e., major depression (MD], cognitive disorders [i.e., executive function deficits…
- Trial name
- NCT02891941
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Traumatic Brain Injury, Mild Traumatic Brain Injury
Brain Research Assessing Impacts of Neurophysiological Processing Speed Training in Veterans
Older veterans with a history of mild brain trauma exhibit early cognitive challenges, especially in driving-related tasks. This is attributed to alterations in the brain's excitatory/inhibitory (E/I) balance.
- Conditions
- Traumatic Brain Injury, Mild Traumatic Brain Injury, Aging, Cognitive Decline
- Trial name
- BRAIN-SPEED (NCT06217575)
- Testing
- Alpha neurofeedback training, Visual Attention Training
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Brain Concussion
Effects of Neuromuscular Training on EEG Adaptations in Young Athletes
The purpose of the current project is to determine the effects of augmented neuromuscular training on brain neuroplasticity. Specifically we aim to evaluate the potential of augmented NMT (aNMT) to alter brain neural performance…
- Trial name
- NCT03913975
- Testing
- Neuromuscular training
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
TBI (Traumatic Brain Injury)
Evaluation of Military Service and Family Members for Post Concussive and Posttraumatic Stress Symptoms
This protocol is designed to facilitate the recruitment, screening and registry of Military Service Members (SMs) and individuals eligible for care in the Department of Defense (DoD) healthcare system.
- Trial name
- MRP (NCT03191357)
- Testing
- n/a observational
- Where
- United States
- Volunteers
- 424 people, healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
Severe Traumatic Brain Injury, Trauma
Impact of Severe Brain Injury on Neuro-vascular and Endothelial Regulation of Peripheral Microcirculation.
Severe brain injury (SBI) is one of the world's leading causes of death and disability in young adults, but its peripheral vascular consequences in humans are poorly understood.
- Trial name
- MicroTC (NCT04597879)
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Weaning Failure
Predictive Value of Airway Occlusion Pressure, Maximal Inspiratory Pressure and Their Ratio for Successful Extubation in Patients With Traumatic Brain Injury
The aim of this study will be to measure the predictive power of the respiratory muscle determinants including The maximal inspiratory pressure, and central drive determinant including Airway occlusion pressure and ratio between…
- Trial name
- NCT06627686
- Testing
- Air way occlusion pressure
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Benha University
Mild Traumatic Brain Injury
Behavioral Profile Matching: A Precision Medicine Approach to Concussion Rehabilitation
At least 1 in 5 people who sustain a concussion will have persistent symptoms and difficulties with daily activities. The researchers have identified two unhelpful coping styles following a concussion - avoidance and endurance.
- Trial name
- NCT03972579
- Testing
- Graded exposure therapy, Pacing + mindfulness
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Convergence Insufficiency
Home-based Vision Therapy
Post-concussive vision symptoms affect many Veterans who have experienced traumatic brain injury (TBI). One common issue is trouble with near vision, a problem that may persist long after the acute injury.
- Trial name
- NCT06886737
- Testing
- Virtual-reality convergence training game
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Mild Traumatic Brain Injury, Internet-Delivered Cognitive Behavioural Therapy
Internet Delivered Cognitive Behavioural Therapy for Persons With Mild Traumatic Brain Injury
Background: Individuals with neurological conditions (stemming from brain injury or stroke) can experience high levels of emotional distress leading to decreased quality of life and increased health care costs.
- Conditions
- Mild Traumatic Brain Injury, Internet-Delivered Cognitive Behavioural Therapy, Depression, Anxiety
- Trial name
- NCT04561011
- Testing
- Internet-delivered Cognitive Behavioural Therapy(ICBT)
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Injury of Unknown Intent Due to Fall From Height, Traumatic Brain Injury
Addressing Attitudes to Improve Use of Protective Headwear in Older Adults
The goal of this phase of the project is to identify the elements of the Theory of Planned Behavior (TPB) that should be targeted to provide the most influence on older adults' behavior (or other stakeholders) to purchase and…
- Trial name
- AAIU-PHOA (NCT01582464)
- Testing
- Social Marketing for protective headgear
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Traumatic Brain Injury, Multiple Trauma
Evolution of Oropharyngeal and Rectal Microbiota After Severe Traumatic Brain Injury
Modifications of the human gut microbiota have been associated with different pathological conditions such as obesity, inflammatory bowel diseases and neurodegenerative diseases.
- Trial name
- BBAX (NCT03965611)
- Testing
- Oropharyngeal swab, Rectal swab, Disability rating scale (DRS-F)
- Where
- France
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Traumatic Brain Injury, Coping Skills
Brain Injury Coping Skills - Telemedicine: Phase II
For phase II, the objective is to compare the effectiveness of BICS-T with the well-established BICS in-person group. Information gained from phase I (the feasibility study) was used to make necessary changes to the BICS-T…
- Conditions
- Traumatic Brain Injury, Coping Skills, Caregivers
- Trial name
- BICS-T-2 (NCT04386655)
- Testing
- Brain Injur Coping Skills - Telemedicine
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Devan Parrott
Brain Injuries, Traumatic
Glutamine and Traumatic Brain Injury
Glutamate is an important neurotransmitter present in over 90% of all brain synapses and is a naturally occurring molecule that nerve cells use to send signals to other cells in the central nervous system.
- Trial name
- NCT05569993
- Testing
- Glutamine, Placcebo
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Traumatic Brain Injury
Emotional Processing Intervention for Children With TBI
Investigating an emotional processing program, that is modified for use with children, is effective for children with a traumatic brain injury (TBI).
- Trial name
- NCT04826068
- Testing
- Emotional Processing
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Concussion, Brain, Dynamic Vision Tests
A Comparison of Dynamic Vision Between College Athletes & Controls
The purpose of this study is to establish baseline reference values for tests of static and dynamic visual acuity and gaze stabilization in collegiate athletes and non-athletes, and to determine if there are differences in vision…
- Trial name
- NCT05819489
- Testing
- Dynamic Vision Testing
- Where
- United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- California State University, Northridge