Clinical trials: THC
Cannabis Intoxication
Pregnenolone as a Treatment for Cannabis Intoxication
The present study will characterize the ability of pregnenolone to reverse the acute intoxication and associated symptoms of cannabis.
- Trial name
- NCT07216690
- Testing
- Cannabis, Pregnenolone 250 mg, Pregnenolone 500 mg
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Psychosis, Cannabis Use
Probing the Cannabinoid System in Individuals With a Family History of Psychosis
The overall purpose of this study is to determine whether a family history of psychosis is associated with an altered cannabinoid system.
- Conditions
- Psychosis, Cannabis Use, THC, Marijuana
- Trial name
- NCT02102113
- Testing
- Very Low Dose THC, Low Dose THC
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Yale University
Drug Safety
Safety and Tolerability of Namisol in the Elderly
The results of phase I Namisol® study (Klumpers et al. Br J Clin Pharmacol, 2012), implicate that Namisol® may have a favorable PK and PD characteristics and is safe to use in people.
- Trial name
- THC (NCT01740960)
- Testing
- delta-9-tetrahydrocannabinol
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Pain, Abuse, Drug
Analgesic and Subjective Effects of Terpenes
The purpose of this research is to assess the analgesic and subjective effects of terpenes administered alone and in combination of THC.
- Trial name
- NCT04451863
- Testing
- Low THC, High THC, Low Myrcene
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Marijuana Abuse
Dronabinol Treatment for Marijuana Addiction
The purpose of this study is to determine if dronabinol decreases the symptoms of marijuana addiction and withdrawal.
- Trial name
- MARINOL (NCT00217971)
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Pain
Cannabinoid Modulation of Pain
The purpose of this study is to test the effects of cannabinoids on pain response using a variety of human experimental pain models.
- Trial name
- NCT01595620
- Testing
- Thermal, Electrical, Capsaicin
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Yale University
THC, Cannabis
Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration
This is a crossover, randomized, double-blinded clinical pharmacology study enrolling dual cannabis-tobacco smokers to better understand the combined effects of co-administering cannabis and tobacco.
- Conditions
- THC, Cannabis, Cannabis Use, Cannabis Smoking
- Trial name
- CANNIC (NCT05999383)
- Testing
- Cannabis, Nicotine, Pax Loose Leaf Vaporizer
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Bipolar Disorder
Effects of Cannabis on Cognition and Endocannabinoid Levels in Bipolar Disorder Patients and Healthy Volunteers
Cannabis use is associated with younger age at onset of bipolar disorder, poor outcome, and more frequent manic episodes, but the effects of cannabis on cognition are less clear.
- Trial name
- NCT04231643
- Testing
- Dronabinol, Epidiolex
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Pregnancy Related, Cannabis Use
Effects of Pregnancy-associated Hormones on THC Metabolism in Women
Cannabis use is prevalent among pregnant women, but the effects of use on both the developing fetus and pregnant woman are unknown.
- Trial name
- PrECEPT (NCT04374773)
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Washington
Biological Availability, Skin Absorption
A Study to Investigate the Bioavailability and Skin Absorption of CBD and THC From GT4 Technology in Healthy Adults
The bioavailability of cannabinoids differs greatly for different routes of administration. When applied topically to the skin, they are absorbed through the skin or hair follicles while interacting with receptors to provide…
- Conditions
- Biological Availability, Skin Absorption, CBD, THC
- Trial name
- NCT05121506
- Testing
- CBD and THC with GT4 technology
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Gefion Canada Inc.
Cannabis
Comparative PK Study Of THC/CBD Formulations
A phase I, single center crossover study. The goal of this clinical trial is to learn about self-emulsified THC/CBD powder compared with equivalent dose of THC/CBD oil, orally administerd in healthy volunteers.
- Trial name
- NCT06149988
- Testing
- THC/CBD S.E powder, THC/CBD oil
- Where
- Israel
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- CapSoil
Bioavailability
Comparative Bioavailability of Dronabinol Oral Solution Versus Branded Capsule 5 mg Under Fasting Conditions
This is a comparative study to assess bioavailability of a proposed alternate dosage form against the current FDA-approved branded product.
- Trial name
- NCT01448772
- Testing
- Dronabinol Capsules, 5 mg, Dronabinol Oral Solution
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- INSYS Therapeutics Inc
Alzheimer Disease
Use of a Cannabinoids as a Treatment Strategy for Alzheimer's Disease
Brief Summary: The objective of the study is to evaluate the effect of cannabinoids on Alzheimer's Disease. This is a double-blind, randomized, placebo-controlled clinical trial.
- Trial name
- DAZACANN (NCT06570928)
- Testing
- Cannabis
- Where
- Brazil
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Federal University of Latin American Integration
Tolerance, Adolescent Behavior
Age-Related Effects of THC
Increased accessibility to cannabis and its primary psychoactive constituent THC has raised public health concerns. One major concern surrounds the potential risks associated with acute THC intoxication and who might be most at…
- Conditions
- Tolerance, Adolescent Behavior, THC
- Trial name
- ART (NCT04294966)
- Testing
- Dextrose, Dronabinol
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Cannabis, THC
Modulation of THC Effects by CBD: a Dose-ranging Study
The purposes of this study are 1) to determine if CBD modulates THC-induced acute psychoactive effects at different CBD:THC ratios, compared with the control product (0:20, 20:20, 40:20, 80:20, 120:20) and 2) to determine if…
- Trial name
- SPECTRE (NCT06099379)
- Testing
- ∆9-tetrahydrocannabinol
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Cannabis, Drug Effects, Driving Performance
Clinical Study to Evaluate the Effects of Oral Delta-9-tetrahydrocannabinol (Δ9-THC) With and Without Alcohol on Perception and Driving Performance in Healthy Adults
With the increasing prevalence and use of cannabis products by the public, there exists a need to better understand the safety impact of cannabis use, particularly when it comes to subjective perceptions of drug effect and…
- Trial name
- NCT07176208
- Testing
- 5 mg Dronabinol (Marinol®) + Alcohol Beverage, 10 mg Dronabinol (Marinol®) + Alcohol Beverage
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Food and Drug Administration (FDA)
Cannabis Use, Tobacco Use
Effect of Cannabis on E-Cigarette Use Behavior
The purpose of this study is to determine the impact of tetrahydrocannabinol (THC) administration on motivational, subjective, and physiological effects of electronic cigarettes.
- Conditions
- Cannabis Use, Tobacco Use, Electronic Cigarette Use
- Trial name
- NCT06609109
- Testing
- THC High Dose, THC Low Dose, THC 0mg
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Behavioral Pharmacology of Cannabis
Comparative Pharmacokinetic and Pharmacodynamic Effects of Delta-8 and Delta-9 THC
The current study will investigate the subjective, physiological, and cognitive performance effects of inhaled and orally ingested Delta-8 tetrahydrocannabinol (THC) in comparison to both placebo and Delta-9 THC.
- Trial name
- NCT05287256
- Testing
- Oral Delta-8-THC Cannabis, Oral Delta-9-THC Cannabis, Vaporized Delta-8-THC Cannabis
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cannabis Use, Tobacco Use
Effect of Cannabis on Cigarette Use Behavior
The purpose of this study is to determine the impact of tetrahydrocannabinol (THC) administration on motivational, subjective, and physiological effects of cigarettes.
- Conditions
- Cannabis Use, Tobacco Use, Cigarette Smoking
- Trial name
- NCT06609083
- Testing
- THC 30mg, THC 5mg, THC 0mg
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Hypotension, Tachycardia
Processing and Effects of Cannabis
The purpose of this study is to investigate the processing of cannabis, and to investigate the occurrence of effects of cannabis on the cardiovascular system and the central nervous system; at higher levels of exposure.
- Trial name
- NCT00225407
- Testing
- Smoking of cannabis cigarettes (different strength)
- Where
- Netherlands
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht