Clinical trials: THC
Marijuana Dependence
Ph1 Marinol Interaction Study - Part 2 - 1
This study will examine the effects of oral dronabinol tetrahydrocannabinol (THC) on withdrawal symptoms in marijuana dependent volunteers, and evaluate the safety, pharmacokinetics (PK), and cardiovascular effects of the…
- Trial name
- NCT00490269
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Healthy Participants
Cannabinoid Control of Fear Extinction Neural Circuits in Humans
The goal of the current proposal is to investigate the effects of a cannabinoid drug on the memory of extinguished fear in humans and the brain circuitry important for the recall of extinction learning.
- Trial name
- NCT02472847
- Testing
- Dronabinol
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Intoxication Alcohol, Intoxication THC
Using Imaging to Assess Effects of THC on Brain Activity
This study will assess effects of tetrahydrocannabinol (THC) and THC + alcohol in marijuana users on prefrontal brain activity, using functional near-infrared spectroscopy (fNIRS) during resting state and during memory task…
- Conditions
- Intoxication Alcohol, Intoxication THC, Intoxication Combined Alcohol THC
- Trial name
- fNIRS (NCT03655717)
- Testing
- Dronabinol, Ethanol
- Where
- United States
- Volunteers
- 316 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Marijuana Abuse
Dronabinol Treatment for Marijuana Addiction
The purpose of this study is to determine if dronabinol decreases the symptoms of marijuana addiction and withdrawal.
- Trial name
- MARINOL (NCT00217971)
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Pregnancy Related, Cannabis Use
Effects of Pregnancy-associated Hormones on THC Metabolism in Women
Cannabis use is prevalent among pregnant women, but the effects of use on both the developing fetus and pregnant woman are unknown.
- Trial name
- PrECEPT (NCT04374773)
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Washington
Tolerance, Adolescent Behavior
Age-Related Effects of THC
Increased accessibility to cannabis and its primary psychoactive constituent THC has raised public health concerns. One major concern surrounds the potential risks associated with acute THC intoxication and who might be most at…
- Conditions
- Tolerance, Adolescent Behavior, THC
- Trial name
- ART (NCT04294966)
- Testing
- Dextrose, Dronabinol
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Post-Traumatic Stress Disorder
Cannabinoid Control of Fear Extinction Neural Circuits in Post-traumatic Stress Disorder
The goal of this study is to look at how a type of drug called cannabinoids are related to the processing of fear signals, the experience of emotions and fear, and the pattern of activity in the brain that is involved in these…
- Trial name
- NCT02069366
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Healthy
Individual Differences in the Response to Drugs
The purpose of this study is to examine whether individual differences in acute responses to drugs co-vary across three drugs from different drug classes: alcohol, amphetamine and delta-9-tetrahydrocannabinol (THC).
- Trial name
- TDS (NCT02485158)
- Testing
- THC, AMP, ALC
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Measuring THC-induced Cognitive Impairment Using a Mobile Application
Developing a Mobile Method to Measure THC-induced Impairment
Marijuana use, for both recreational and therapeutic purposes, is becoming increasingly common as states remove restrictions on use.
- Trial name
- AIS (NCT03804840)
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Chicago
D-limonene and THC Pharmacodynamics
Behavioral Pharmacology of THC and D-limonene
This study will evaluate the pharmacokinetics and pharmacodynamics of vaporized d-limonene and THC administered via inhalation.
- Trial name
- NCT03609853
- Testing
- Vaporized THC, limonene, or THC and limonene
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Differential Female Response to Δ9-tetrahydrocannabinol (THC)
Individual Differences in Drug Response
Females are increasingly using cannabis, yet remain underrepresented in preclinical and clinical cannabinoid research. This female-specific research plan will test the effects of two recreationally relevant doses of oral THC and…
- Trial name
- IDT (NCT03809546)
- Testing
- Dronabinol, dextrose
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Pain, Cannabis
Enhancing Medication-based Analgesia in Humans
This is a single-group, within-subject, double-blind, double-dummy, placebo and active-controlled study evaluated whether the FDA-approved cannabinoid dronabinol (Marinol) would enhance analgesia, subjective reports, and…
- Conditions
- Pain, Cannabis, Opioid Use, Unspecified
- Trial name
- NCT02901275
- Testing
- Within-subject test of blinded study medications
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Pain Threshold, Mood
Comparison of the Analgesic Effects of Dronabinol and Smoked Marijuana in Daily Marijuana Smokers
The following study is designed to determine the analgesic efficacy of smoked marijuana (0, 1.98, and 3.56% THC) and oral THC (0, 10, and 20 mg) in the Cold-Pressor Test (CPT), a laboratory model of pain which has predictive…
- Trial name
- NCT00743119
- Testing
- Inactive marijuana (0% THC), Low dose Dronabinol, High dose Dronabinol
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Marijuana Dependence
Vaping THC From Electronic Cigarettes
This study aims to understand THC pharmacology and the safety of cannabis vaping, including the pharmacology and safety of co-administration of nicotine and THC.
- Trial name
- V-PAX (NCT02955329)
- Testing
- Nicotine, Cannabis, PAX Loose Leaf Vaporizer
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cannabis Use
Cannabis Edibles Packaging Imagery Experiment
The purpose of this study is to assess differences in perceptions of product appeal, harm, and subsequent willingness to try cannabis edibles products with/without packaging imagery.
- Trial name
- NCT06358144
- Testing
- Packaging imagery, No Imagery (Control)
- Where
- United States
- Volunteers
- 1,260 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Alcohol Drinking, Marijuana Smoking
Motivation and Skills for Delta-9-tetrahydrocannabinol/Ethanol (THC/ETOH+) Teens in Jail
This study will focus on treating substance abusing incarcerated teens using individually administered Motivational Interviewing (MI) followed by group Cognitive Behavior Therapy (CBT).
- Trial name
- SMART (NCT00506753)
- Testing
- MI/CBT, RT/SU
- Where
- United States
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- University of Rhode Island
Delta-9-tetrahydrocannabinol (THC), Stress
Effects of Drugs on Stress Memories
There is evidence that cannabinoids, including delta-9-tetrahydrocannabinol (THC), reduce responses to acute stress and fear-related stimuli, but few studies have examined the effects of THC on memories of stressful experiences.
- Trial name
- ETS (NCT06471647)
- Testing
- delta-9-tetrahydrocannabinol (THC) (5), delta-9-tetrahydrocannabinol (THC) (10)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Marijuana Smoking
Effects of Dronabinol (Oral THC) on Cannabis Use
Study participants received dronabinol (0, 120mg/day and 240mg/day) for 12 consecutive days in a randomized order. During each dronabinol maintenance period they were able to self-administer active or placebo cannabis using…
- Trial name
- NCT01394185
- Testing
- Dronabinol 120mg/day, Dronabinol 240mg/day
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Schizophrenia, Dual Diagnosis
Cannabis and Schizophrenia: Self-Medication and Agonist Treatment
The first aim of this study is to determine whether a brain reward center (BRC) deficiency in patients with schizophrenia (SCZ) and cannabis use disorder (CUD) will be normalized when patients are given cannabis or dronabinol.
- Conditions
- Schizophrenia, Dual Diagnosis, Schizoaffective Disorder, Psychotic Disorder
- Trial name
- NCT00946348
- Testing
- Dronabinol, Cannabis
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Wiskott-Aldrich Syndrome, Thrombocytopenia
Thrombocytopenia and Bleeding in Wiskott-Aldrich Syndrome (WAS) Patients
The purpose of this project is to describe the pathophysiology of thrombocytopenia and bleeding in patients with Wiskott-Aldrich Syndrome (WAS) and determine the response to thrombopoietic agents in vitro and in vivo.
- Conditions
- Wiskott-Aldrich Syndrome, Thrombocytopenia, Bleeding
- Trial name
- WAS (NCT00909363)
- Testing
- Promacta, blood drawing in patients with WAS, blood drawing in healthy controls
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University