Clinical trials: TKA, open to volunteers
Total Knee Arthroplasty
IO Vancomycin Administration in TKA
This is a prospective, single-center, open-label study evaluating systemic vancomycin levels following preoperative intraosseous administration in patients undergoing primary unilateral total knee arthroplasty.
- Trial name
- IO Vanco (NCT07633418)
- Testing
- Intraosseous Vamcomycin Administration
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Diego
Total Knee Anthroplasty
Smart Knee Evaluation of Exparel and Zynrelef in TKA Recovery
This study looks at how three different numbing injections affect how quickly patients recover after knee replacement surgery (total knee arthroplasty, or TKA).
- Trial name
- NCT07878507
- Testing
- Intra-articular injection of bupivacaine in the knee joint, intra-articular injection of Exparel in the knee joint, Zynrelef
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Foundation for Orthopaedic Research and Education
Knee Osteoarthritis (Knee OA), Knee Pain Chronic
Advanced Brain Imaging-TKA (fMRI-TKA)
Knee replacement surgery is a common and effective treatment for pain and mobility loss, yet up to 1 in 5 patients remain dissatisfied after surgery due to ongoing pain or difficulty with daily activities.
- Conditions
- Knee Osteoarthritis (Knee OA), Knee Pain Chronic, Brain Network Connectivity, Patient Satisfaction
- Trial name
- fMRI-TKA (NCT07464080)
- Testing
- fMRI Brain Scan
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Ottawa Hospital Research Institute
Osteoarthritis, Unicompartmental Knee Arthroplasty
Post-op Prednisone and Glucose Monitoring in TKA
This study compares the efficacy of a 5-day post-operative oral prednisone regimen (40 mg daily) with the standard intraoperative steroid regimen, focusing on pain, swelling, range of motion, opioid use, and glucose levels…
- Conditions
- Osteoarthritis, Unicompartmental Knee Arthroplasty, Total Hip Arthroplasty (THA)
- Trial name
- NCT07630896
- Testing
- Prednisone, Continuous Glucose Monitor, InkWell Health Tattoos
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Columbia University
Pain, Postoperative, Osteoarthritis, Knee / Osteoarthritis, Hip
iPACK Block vs. Periarticular Infiltration for TKA Pain Control
This study aims to retrospectively compare two different multimodal analgesic techniques for pain management after total knee arthroplasty (TKA).
- Trial name
- NCT07267650
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Turgutlu State Hospital
Arthroplasty, Replacement
sACB vs cACB in TKA
This study compares the analgesic efficacy of single-dose adductor canal block (sACB) versus continuous-dose adductor canal block (cACB) for postoperative pain management in total knee replacement patients.
- Conditions
- Arthroplasty, Replacement, Knee
- Trial name
- NCT07581886
- Testing
- Continuous ACB, Single-shot ACB
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Total Knee Arthroplasty, Total Hip Arthroplasty (THA)
AI-based Rehabilitation for Hip and Knee Surgery Patients
This study aims to evaluate the efficacy and safety of an AI-based home rehabilitation application ("Exersite Rehab") for patients who have undergone hip or knee arthroplasty(Total Knee Arthroplasty (TKA), Total Hip Arthroplasty…
- Conditions
- Total Knee Arthroplasty, Total Hip Arthroplasty (THA), Hip Fracture Surgery
- Trial name
- NCT07505628
- Testing
- Exersite Rehab (AI-based Mobile Application), Printed Educational Brochure (Traditional Rehabilitation)
- Where
- 2 sites in South Korea
- Volunteers
- 106 people
- Sponsor
- Gangnam Severance Hospital
Total Knee Arthroplasty
Methadone in the Management of Post-Operative Pain in Total Knee Replacement
The goal of this study is to determine whether one dose of IV methadone given right before surgery will help patients' pain management after a total knee replacement and reduce the amount of pain medications taken in the weeks…
- Trial name
- NCT07485803
- Testing
- Methadone
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- AdventHealth
Knee Arthroscopy
Outpatient Total Knee Arthroscopy (TKA): Comparison of Postoperative Recovery Versus a Conventional Hospitalization
Outpatient TKA is a controversial topic due to concerns about its safety as an outpatient procedure, and remains a marginal procedure.
- Trial name
- PTG (NCT07276061)
- Where
- France
- Volunteers
- 440 people
- Sponsor
- University Hospital, Strasbourg, France
Postoperative Wound Care After TKA
Evaluation of Ioband Coverage Waterproof Dressing Versus Isolated Waterproof Dressing After Primary Total Knee Arthroplasty
Title: Evaluation of Ioband® Coverage Waterproof Dressing in Post-Operative Total Knee Arthroplasty (TKA) Goal: To evaluate the effectiveness of Ioband® coverage waterproof dressing compared to standard waterproof dressing in…
- Trial name
- Wound coverage (NCT06943053)
- Testing
- Isolate waterproof dressing (Opsite), Ioban coverage group
- Where
- 2 sites in Thailand
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Thammasat University Hospital
Total Knee Arthroplasty (TKA)
Total Intravenous Anesthesia vs Spinal Anesthesia in Patients Undergoing Unilateral Primary Total Knee Arthroplasty
The purpose of this study is to compare same-day discharge rates and recovery outcomes across an adult patient population undergoing elective Total Knee Arthroplasty (TKA), and randomized to receive either spinal block anesthesia…
- Trial name
- NCT07672301
- Testing
- Total IntraVenous Anesthesia (TIVA), Spinal-Block, Electroencephalogram (EEG)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Chicago
Knee Osteoarthritis
Dexamethasone vs Dexmedetomidine for iPACK + ACB in TKA
This randomized, double-blind, controlled trial is designed to compare the analgesic efficacy and safety of perineural dexamethasone versus perineural dexmedetomidine as adjuvants to ropivacaine for ultrasound-guided interspace…
- Trial name
- NCT07386600
- Testing
- Ropivacaine 0.2% Injectable Solution, Dexamethasone 4mg, Dexmedetomidine
- Where
- Poland
- Volunteers
- 96 people
- Sponsor
- Poznan University of Medical Sciences
ERAS, TKA
ERAS in Total Knee Arthroplasty: a Randomized Controlled Trial
Total knee arthroplasty(TKA) is the most commonly performed procedure for advanced knee osteoarthritis. Enhanced recovery after surgery (ERAS) protocols are primarily implemented to reduce perioperative stress and improve…
- Trial name
- ERAS (NCT07655921)
- Testing
- ERAS PROTOCOL
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- Liaquat National Hospital & Medical College
Wound Surgical, Diabetes
Negative Pressure Wound Therapy Devices in Total Knee Arthroplasty
This study is a single-center, prospective, randomized, open-label clinical trial evaluating three commercially available closed-incision negative pressure wound therapy (ciNPWT) devices: NPseal, PICO, and Prevena, in adult…
- Conditions
- Wound Surgical, Diabetes, Obesity, Chronic Kidney Diseases
- Trial name
- NCT07770633
- Testing
- NP Seal, PICO, Prevena
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
TKA, THA
Binaural Beats for Postoperative Pain and Anxiety Reduction
To deliver a 30-minute binaural beats audio intervention in PACU and collect pain and anxiety outcomes immediately following surgery, and 4 hours following surgery completion in adults undergoing ambulatory total knee…
- Conditions
- TKA, THA, Anxiety, Binaural Beats
- Trial name
- NCT07437469
- Testing
- Binaural Beats Audio Intervention, Music of Choice
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Miami
Prosthetic-joint Infection
Evaluation of PLG0206 in Prevention of Recurrent Infection in Patients Undergoing Debridement, Antibiotics, and Implant Retention (DAIR) for Treatment of a Periprosthetic Joint Infection (PJI) Following Knee Arthroplasty
The goal of this clinical trial is to evaluate whether the investigational drug PLG0206 can help reduce recurrence of infection in adults who have undergone total knee replacement and are receiving a DAIR (Debridement…
- Trial name
- RETAIN (NCT07214311)
- Testing
- PLG0206
- Where
- 21 sites in United States, United Kingdom
- Volunteers
- 240 people
- Sponsor
- Peptilogics
Venous Thromboembolism (VTE)
REGN7508 Versus Apixaban and Enoxaparin for Thromboprophylaxis After Total Knee Arthroplasty in Adults
This study is researching an experimental drug called REGN7508 (called "study drug"). The study is focused on adults undergoing elective, unilateral (one side) total knee replacement surgery.
- Trial name
- ROXI-APEX (NCT07015905)
- Testing
- REGN7508, Apixaban, Enoxaparin
- Where
- 47 sites in United States, Bulgaria and 6 more
- Volunteers
- 2,000 people
- Sponsor
- Regeneron Pharmaceuticals
Osteoarthritis, Knee, Osteoarthritis, Hip
Surgical Joint Registry MBJRF
The purpose of this study is to follow the patient's short term and long term clinical outcome after undergoing joint replacement surgery.
- Trial name
- MBJRFREG (NCT03484325)
- Where
- United States
- Volunteers
- 990 people, healthy volunteers welcome
- Sponsor
- Memorial Bone and Joint Research Foundation
Inflammatory Arthritis, Primary Total Knee Arthroplasty Due to Degenerative Joint Disease (Primary Diagnosis of Osteoarthritis)
A Multi-Center Study Assessing the Safety and Efficacy of the LEGION Medial Stabilized (MS) Insert in Patients Undergoing a Total Knee Arthroplasty (TKA)
The purpose of this study is to assess the long-term safety and performance of the LEGION Medial Stabilized insert and to generate clinical evidence to support and maintain product registration in global markets.
- Conditions
- Inflammatory Arthritis, Primary Total Knee Arthroplasty Due to Degenerative Joint Disease (Primary Diagnosis of Osteoarthritis), Post-traumatic Arthritis
- Trial name
- NCT07199738
- Testing
- Cemented CoCr, Cemented Oxinium, Cementless
- Where
- 4 sites in United States
- Volunteers
- 144 people
- Sponsor
- Smith & Nephew, Inc.
Knee Osteoarthristis, Knee Replacement Arthroplasty
Comparing Articular Noise and Its Perception Between Two Different Types of Total Knee Arthroplasty
Some patients complain of articular noise (such as clicking, snapping, cracking or popping) after a total knee replacement. Controversy remains about whether there is a correlation between articular noise and worse outcomes…
- Conditions
- Knee Osteoarthristis, Knee Replacement Arthroplasty, Knee Replacement, Total
- Trial name
- NATKA (NCT06880497)
- Testing
- total knee arthroplasty
- Where
- France
- Volunteers
- 170 people
- Sponsor
- Elsan