Clinical trials: TKA
Total Knee Arthroplasty (TKA)
VRAS (Velys Robot-Assisted Solution) Operational Excellence Study
The aim of this study is to investigate the differences in process set-up, efficiency, OR team workload, instrument trays and OR financial performance when using the VRAS (Velys Robotic Assisted Solution) of DePuy Synthes…
- Trial name
- NCT06563843
- Testing
- Robotic-assisted TKA, Conventional TKA
- Where
- 10 sites in Austria, Belgium and 6 more
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- DEO NV
Arthroplasty, Arthroplasty Replacement, Knee
oneKNEE - Prospective, Non-interventional, Multicenter PMCF-Study
Safety and Clinical Performance in terms of clinical outcome of oneKNEE® (total knee arthroplasty TKA), evaluated 2 years after implantation.
- Conditions
- Arthroplasty, Arthroplasty Replacement, Knee, Prosthetic Joint Infections of Knee, TKA Outcomes
- Trial name
- oneKNEE (NCT07682909)
- Testing
- oneKNEE®
- Volunteers
- 1,020 people
- Sponsor
- Aesculap AG
Total Knee Arthroplasty (TKA), Total Knee Arthroplasty \(TKA\)
Suzetrigine in TKA
Total knee replacements are among the most common and painful orthopedic procedures performed worldwide, often requiring intensive analgesia to support early ambulation and recovery.
- Conditions
- Total Knee Arthroplasty (TKA), Total Knee Arthroplasty \(TKA\), Total Knee Replacement, Total Knee Replacement Surgery
- Trial name
- NCT07864896
- Testing
- Suzetrigine
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Total Knee Arthroplasty Recovery, Total Knee Arthroplasty Postoperative Pain
Effect of Foam Rolling After Total Knee Arthroplasty
The aim of this study is to investigate the effects of foam rolling in patients who have undergone total knee arthroplasty on pain, knee mobility, leg muscle strength, the ability to sense joint position, fear of movement…
- Conditions
- Total Knee Arthroplasty Recovery, Total Knee Arthroplasty Postoperative Pain, Total Knee ArthroplastyKnee Pain, Functionality, Total Knee Arthroplasty\(TKA\)
- Trial name
- NCT07848126
- Testing
- Foam rolling after total knee arthroplasty, Standard home exercise program after total knee arthroplasty
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Dokuz Eylul University
TKA, THA
Binaural Beats for Postoperative Pain and Anxiety Reduction
To deliver a 30-minute binaural beats audio intervention in PACU and collect pain and anxiety outcomes immediately following surgery, and 4 hours following surgery completion in adults undergoing ambulatory total knee…
- Conditions
- TKA, THA, Anxiety, Binaural Beats
- Trial name
- NCT07437469
- Testing
- Binaural Beats Audio Intervention, Music of Choice
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Miami
Total Knee Arthroplasty Recovery, Total Knee Replacement
Telerehabilitation Versus Clinic-Based Rehabilitation for Functional Recovery Following Primary Total Knee Arthroplasty
The goal of this clinical trial is to determine if rehabilitation delivered by telehealth works as well as rehabilitation delivered in person at a clinic, for people recovering from total knee replacement surgery.
- Conditions
- Total Knee Arthroplasty Recovery, Total Knee Replacement, Total Knee Arthroplasty\(TKA\), Knee Arthritis Osteoarthritis
- Trial name
- NCT07834229
- Testing
- Rehabilitation treatment sessions focussing on education and exercise prescription.
- Where
- Australia
- Volunteers
- 108 people
- Sponsor
- The University of Western Australia
Total Hip Arthroplasty (THA) or Total Knee Arthroplasty (TKA), Preoperative Adductor Canal Block (ACB)
The Impact of Regional Motor-sparing Blocks on Early Rehabilitation Following Primary Hip or Knee Arthroplasty
The purpose of this study is to determine whether a single nerve block given before surgery can help patients regain independence and mobility more quickly after planned hip or knee replacement surgery for osteoarthritis.
- Conditions
- Total Hip Arthroplasty (THA) or Total Knee Arthroplasty (TKA), Preoperative Adductor Canal Block (ACB), Preoperative Pericapsular Nerve Group (PENG)
- Trial name
- NCT07834619
- Testing
- PENG Block with Ropivacaine, Adductor Canal Block with Ropivacaine, Subarachnoid anesthesia
- Where
- Poland
- Volunteers
- 220 people
- Sponsor
- Poznan University of Physical Education
Femoral Nerve Block (FNB), Interspace Between the Popliteal Artery and the Capsule of the Knee (IPACK)
A Multicentre, Randomised, Double-blind, Positive-drug-controlled Phase III Clinical Trial on the Efficacy and Safety of CZ1S Peroneal Nerve Block Combined With Popliteal Artery and Posterior Capsule Gap Block for Postoperative Analgesia in Total Knee Arthroplasty.
This is a multicentre, randomised, double-blind, positive-drug-controlled confirmatory clinical trial designed to evaluate the efficacy and safety of CZ1S injection for femoral nerve block (FNB) combined with the interspace…
- Conditions
- Femoral Nerve Block (FNB), Interspace Between the Popliteal Artery and the Capsule of the Knee (IPACK), Total Knee Arthroplasty (TKA)
- Trial name
- NCT07812558
- Testing
- ropivacaine (local infiltration), CZ1S for Injection
- Where
- China
- Volunteers
- 166 people
- Sponsor
- Zhejiang Cuize Pharmaceutical Technology Co., Ltd.
TKA, Knee Osteoarthritis
Wearable Electrogoniometry-Based Telerehabilitation After Total Knee Arthroplasty
This study evaluated a wearable electrogoniometry-based telerehabilitation system designed to support recovery after total knee arthroplasty.
- Trial name
- NCT07779122
- Testing
- Wearable Electrogoniometry-Based Telerehabilitation System, Standard Home-Based Rehabilitation Program
- Where
- Chile
- Volunteers
- 82 people
- Sponsor
- University of Chile
Osteoarthritis (OA) of the Knee, Knee Pain Arthritis
Imageless Navigation Versus Image-Based Navigation in Robotic-Assisted Total Knee Arthroplasty for Knee Osteoarthritis
The goal of this clinical trial is to learn if imageless navigation is not inferior to image-based navigation in robotic-assisted total knee arthroplasty (RA-TKA) for treating patients with knee osteoarthritis.
- Conditions
- Osteoarthritis (OA) of the Knee, Knee Pain Arthritis, Total Knee Arthroplasty (TKA), Robotic Assisted Arthroplasty
- Trial name
- NCT07522489
- Testing
- Imageless Robotic-Assisted Total Knee Arthroplasty, Image-based Robotic-Assisted Total Knee Arthroplasty
- Where
- Poland
- Volunteers
- 146 people
- Sponsor
- Medical University of Warsaw
Pain Management, TKA
Photobiomodulation Therapy for Pain Control in Post-Operative Total Knee Arthroplasty Patients: A Pilot Study
A pilot study to assess the efficacy and feasibility of PBMT for pain control in patients undergoing a TKA and are discharged the same day from an ambulatory surgery center.
- Conditions
- Pain Management, TKA, Post Operative Analgesia, Low Level Laser Therapy
- Trial name
- NCT07750912
- Testing
- LightForce XLI
- Volunteers
- 15 people
- Sponsor
- Mohammad Burney, MD
Knee Osteoarthritis (OA), Total Knee Arthroplasty (TKA)
Manual Traction and Rehabilitation After Knee Replacement Surgery
The goal of this clinical trial is to determine whether the addition of manual traction to a standard rehabilitation protocol improves early recovery after primary total knee arthroplasty (TKA) in women aged 50-75 years with knee…
- Trial name
- SMART-TKA (NCT07722559)
- Testing
- Manual Tibiofemoral Traction
- Where
- Kosovo
- Volunteers
- 48 people
- Sponsor
- Alma Mater Europaea - Slovenia
Total Knee Arthroplasty Postoperative Pain, Opioid Reduction After TKA
NEUROCUPLE™ as an Opioid Alternative Following Total Knee Arthroplasty
The goal of this clinical trial is to learn if the NEUROCUPLE device can reduce pain and opioid use after primary unilateral total knee arthroplasty (TKA) in adults.
- Trial name
- NCT07439666
- Testing
- NEUROCUPLE™ Patch, Enhanced Recovery After Surgery (ERAS) Standard of Care
- Where
- 3 sites in United States
- Volunteers
- 274 people
- Sponsor
- Jacques E. Chelly
Total Knee Arthroplasty (TKA)
Total Intravenous Anesthesia vs Spinal Anesthesia in Patients Undergoing Unilateral Primary Total Knee Arthroplasty
The purpose of this study is to compare same-day discharge rates and recovery outcomes across an adult patient population undergoing elective Total Knee Arthroplasty (TKA), and randomized to receive either spinal block anesthesia…
- Trial name
- NCT07672301
- Testing
- Total IntraVenous Anesthesia (TIVA), Spinal-Block, Electroencephalogram (EEG)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Chicago
ERAS, TKA
ERAS in Total Knee Arthroplasty: a Randomized Controlled Trial
Total knee arthroplasty(TKA) is the most commonly performed procedure for advanced knee osteoarthritis. Enhanced recovery after surgery (ERAS) protocols are primarily implemented to reduce perioperative stress and improve…
- Trial name
- ERAS (NCT07655921)
- Testing
- ERAS PROTOCOL
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- Liaquat National Hospital & Medical College
Postoperative Swelling After TKA, Postoperative Pain After Tka
Postoperative Cryocuff vs. Conventional Icepack in TKA - What is More Effective in Reducing Pain and Swelling?
Topic/Disease Pattern Postoperative pain and swelling management after knee prosthesis implantation using cryotherapy Objective To determine possible differences in postoperative swelling and pain following primary total knee…
- Trial name
- NCT07627854
- Testing
- cryo cuff treatment, postoperative cooling with conventional ice pack
- Where
- Germany
- Volunteers
- 102 people
- Sponsor
- Prof. Dr. med. Andreas Halder
Knee Flexion Contracture, Total Knee Arthroplasty (TKA)
Anterior Heel Wedge to Treat Flexion Contracture After Total Knee Arthroplasty
Total knee arthroplasty (TKA) remains the only treatment for end-stage knee osteoarthritis, whereby the diseased ends of the bones comprising the knee joint are removed and replaced with prosthetic joint components.
- Trial name
- NCT07620145
- Testing
- Anterior heel wedge
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of North Carolina, Charlotte
TKA, Muscle Strength
Effect of Bupivacaine Liposome Injection on Muscle Strength After Total Knee Arthroplasty
This study employs a randomized controlled trial to investigate whether bupivacaine liposome injection for adductor canal block can effectively improve lower limb muscle strength after total knee arthroplasty.
- Trial name
- TKA (NCT07616102)
- Testing
- a single-injection adductor canal block, continuous femoral nerve block
- Where
- China
- Volunteers
- 80 people
- Sponsor
- General Hospital of Ningxia Medical University
Sleep Quality Post-TKA, Postoperative Knee Function
Doxepin Alone or Combined With Ramelteon Versus Placebo for Improving Sleep Quality After Primary Total Knee Arthroplasty
Many patients experience poor sleep during recovery after total knee arthroplasty (TKA). Disturbed sleep can last weeks to months and may worsen pain, slow healing, and reduce overall quality of life.
- Conditions
- Sleep Quality Post-TKA, Postoperative Knee Function, Quality of Life After Primary TKA
- Trial name
- NCT07598734
- Testing
- Doxepin 6 mg, Ramelteon 8 mg
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- University of Washington
Total Knee Arthroplasty\(TKA\), Osteoartrosi
Use of Cryopressotherapy in Patiens Undergoing Total Knee Replacement to Improve Clinical Outcome
The purpose of this study is to evaluate the effectiveness of cryopressotherapy in patients undergoing total knee arthroplasty by assessing clinical improvement using the KOOS at 14 days after surgery.
- Trial name
- CRYO-KNEE (NCT07456787)
- Testing
- Cryopressotherapy, Ice pack
- Where
- Italy
- Volunteers
- 78 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio