Clinical trials: TNM Staging
Gastric Cancer (Diagnosis), TNM Staging
Multicenter Study of Clinical-Pathological Correlation in cT2N0 Gastric Cancer and Its Prognostic Implications
In gastric cancer, accurate preoperative staging of patients with T2N0 disease remains challenging. Correct assessment of tumor depth and lymph node involvement is particularly important in this subgroup, as treatment strategies…
- Conditions
- Gastric Cancer (Diagnosis), TNM Staging, Perioperative Treatment in Subjects With Locally Advanced Resectable Gastric Cancer or Gastroesophageal Junction Cancer, Gastric Surgery
- Trial name
- NCT07842549
- Where
- Spain
- Volunteers
- 1,024 people, healthy volunteers welcome
- Sponsor
- Hospital of Navarra
Bladder Cancer, Bladder Cancer TNM Staging Primary Tumor (T) T1
REtrieval of Transurethrally Resected Intact En-bloc Vesical Tumors Using a Retrieval Device for Bladder Tumors
Bladder cancer is the most common malignancy of the urinary tract, and approximately 75% of cases are non-muscle invasive (NMIBC) at diagnosis. The standard treatment is transurethral resection of the bladder tumor (TURBT).
- Trial name
- RETRIEVE-BT (NCT07762820)
- Testing
- CURTIS retrieval device
- Where
- 9 sites in Denmark, Germany and 1 more
- Volunteers
- 75 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Colon Cancer, Tumor Deposits
A New Classification System for Lymph Nodes in Colon Cancer: The Prognostic Significance of the Anatomical Distribution of Metastatic Lymph Nodes and the Number of Tumor Deposits
This study aims to investigate the prognostic significance of LNM distribution and establish a new classification system integrating both nodal quantity and anatomical location.The main question it aims to answer is: Does the new…
- Conditions
- Colon Cancer, Tumor Deposits, Lymph Node Metastases, TNM Staging
- Trial name
- NCT07380464
- Volunteers
- 1,500 people
- Sponsor
- Cai Zerong
Esophageal Cancer TNM Staging Primary Tumor (T) T4
Establishing Best Treatment Strategy for T4 Esophageal Cancer
The goal of this clinical trial is to investigate the safety and efficacy of a new treatment approach for T4-stage esophageal cancer, which involves chemoradiotherapy after induction chemotherapy.
- Trial name
- NCT06531434
- Testing
- "Docetaxel", "Cisplatin", "fluorouracil", "Radiation"
- Where
- Taiwan
- Volunteers
- 22 people
- Sponsor
- National Cheng-Kung University Hospital
Tongue Cancer, Tongue Cancer TNM Staging Primary Tumor (T) T1
Clinical Study Evaluating the Proper Surgical Safety Margin for Early Stage Oral Tongue Cancers
A prospective multicenter randomized non-inferiority clinical trial, to evaluate the efficacy and safety of 1.0 cm-safety margin surgery, compared with 1.5 cm safety margin surgery for cT1-2N0 oral tongue cancer Summary: A…
- Conditions
- Tongue Cancer, Tongue Cancer TNM Staging Primary Tumor (T) T1, Tongue Cancer TNM Staging Primary Tumor (T) T2, Surgery
- Trial name
- NCT04738786
- Testing
- 1.5 cm surgical safety margin for cT1-2N0 oral tongue cancers, 1.0 cm surgical safety margin for cT1-2N0 oral tongue cancers
- Where
- 4 sites in South Korea
- Volunteers
- 125 people
- Sponsor
- Samsung Medical Center
68Ga-PSMA PET/CT Guided Prostate Biopsy, Mp-3TMRI Guided Prostate Biopsy
Mp-3TMRI and 68Ga-PSMA PET/CT Guided Prostate Biopsy and Tumor Node Metastasis (TNM) Staging.
BIOPSTAGE is a prospective, non-randomized, diagnostic, multi-cohort investigational study to evaluate the impact of pelvic Multi-parametric 3-Tesla magnetic resonance imaging (mp-3TMRI) and whole-body 68Ga-PSMA PET/CT for…
- Conditions
- 68Ga-PSMA PET/CT Guided Prostate Biopsy, Mp-3TMRI Guided Prostate Biopsy, Prostate Cancer, TNM Staging
- Trial name
- BIOPSTAGE (NCT03465579)
- Testing
- pelvic MRI, 68Ga-PSMA PET/CT
- Where
- 2 sites in Italy
- Volunteers
- 261 people
- Sponsor
- Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
Bladder Cancer TNM Staging Primary Tumor (T) T2, Bladder Cancer TNM Staging Primary Tumor (T) T2A
Safety and Tolerability of TAR-200 and Nivolumab in Subjects With Muscle-Invasive Bladder Cancer
The purpose of this study is to determine if TAR-200, an investigational drug delivery system, in combination with nivolumab is safe and tolerable in patients with muscle-invasive bladder cancer (MIBC) who are scheduled for…
- Conditions
- Bladder Cancer TNM Staging Primary Tumor (T) T2, Bladder Cancer TNM Staging Primary Tumor (T) T2A, Bladder Cancer TNM Staging Primary Tumor (T) T2B, Bladder Cancer TNM Staging Primary Tumor (T) T3
- Trial name
- NCT03518320
- Testing
- Gemcitabine-Releasing Intravesical System (GemRIS)/TAR-200, Nivolumab Injection [Opdivo]
- Where
- 6 sites in United States
- Volunteers
- 13 people
- Sponsor
- Taris Biomedical LLC
Gastric Cancer, Gastric Adenocarcinoma
Stomach Cancer Exosome-based Detection
Gastric cancer continues to have a poor prognosis primarily due to the inability to detect it in its early stages. This study will develop and validate a blood assay to facilitate the non-invasive detection of gastric cancer.
- Conditions
- Gastric Cancer, Gastric Adenocarcinoma, Gastric Cancer Stage, Gastric Neoplasm
- Trial name
- DESTINEX (NCT06342427)
- Testing
- DESTINEX
- Where
- 3 sites in United States, Japan
- Volunteers
- 809 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Muscle-Invasive Bladder Carcinoma, Muscle Invasive Bladder Urothelial Carcinoma
Study on the Quality of Life and Pathological State in Patients Who Underwent Radical Cystectomy
Observational study on the quality of life and pathological state of patients underwent radical cystectomy.
- Conditions
- Muscle-Invasive Bladder Carcinoma, Muscle Invasive Bladder Urothelial Carcinoma, Bladder Cancer TNM Staging, Bladder Cancer Stage IIa
- Trial name
- NCT06170177
- Testing
- Radical Cystectomy
- Where
- Italy
- Volunteers
- 4,000 people
- Sponsor
- IRCCS San Raffaele
Malignant Neoplasm of Nasopharynx TNM Staging Distant Metastasis (M), Breast Cancer Recurrent
EpCAM CAR-T for Treatment of Advanced Solid Tumors
This study is for patients that have nasopharyngeal carcinoma, breast cancer, gastric cancer and other solid tumors. As epithelial cell adhesion molecule (EpCAM) is a well characterized molecule that is closely with poor…
- Conditions
- Malignant Neoplasm of Nasopharynx TNM Staging Distant Metastasis (M), Breast Cancer Recurrent, Gastric Cancer With Metastasis
- Trial name
- NCT02915445
- Testing
- EpCAM CAR-T cells
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Sichuan University
Cervical Cancer TNM Staging Regional Lymph Nodes (N)
Induction Chemotherapy Followed by Standard Therapy in Cervical Cancer With Aortic Lymph Node Spread
The main objective of this study is to determine whether neoadjuvant chemotherapy with Carboplatin and paclitaxel plus standard cisplatin-based chemoradiation with extended fields improves overall survival rates compared to…
- Trial name
- ONCOCOL01 (NCT03534713)
- Testing
- Carboplatin, Paclitaxel, Cisplatin
- Where
- 11 sites in France
- Volunteers
- 310 people
- Sponsor
- University Hospital, Toulouse
Malignant Neoplasm of Large Intestine TNM Staging Primary Tumor (T) T4, Peritoneal Carcinomatosis
Surgery With HIPEC in Treating Patients With a High Risk of Developing Colorectal Peritoneal Carcinomatosis
Multicentric randomised trial. The goal of this clinical research study is to learn if hyperthermic intraperitoneal chemotherapy (HIPEC) will help to decrease the rate of peritoneal carcinomatosis(PC) in patients with high risk…
- Trial name
- NCT02179489
- Testing
- Surgery and Hyperthermic Intraperitoneal Chemotherapy with MMC
- Where
- 9 sites in China
- Volunteers
- 271 people
- Sponsor
- Zhejiang University
Selenium Deficiency, Thyroid Cancer TNM Staging
Clinical Study on the Effect of Selenium Yeast Capsule on Prognosis of Differentiated Thyroid Carcinoma
Oxidative stress is involved in the pathogenesis of thyroid cancer, but the mechanism is not clear. The thyroid is the organ with the most abundant selenium content, and selenium may be involved in protecting the gland from the…
- Conditions
- Selenium Deficiency, Thyroid Cancer TNM Staging, Recurrence, Metastasis
- Trial name
- NCT04683575
- Testing
- Selenium Yeast
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Qianfoshan Hospital
Malignant Neoplasm of Large Intestine TNM Staging Primary Tumor (T) T4
Surgery for Locally Advanced Colon Cancer: is it Worth it? A Multicenter Retrospective Analysis.
The aim of the present study is to assess the post-operative outcomes (morbidity and mortality) in relation to preoperative data and the oncological outcomes (overall and disease-free survival) in patients with a locally advanced…
- Trial name
- LACC (NCT04646772)
- Testing
- Multivisceral resection
- Volunteers
- 100 people
- Sponsor
- Santo Spirito Hospital, Italy
Malignant Neoplasm of Breast TNM Staging Distant Metastasis (M), Untreated Bone Metastases
NaF PET/MRI Evaluation for Bone Metastases in Breast Cancer
This study will look at two new technologies being developed for measuring cancer in bones. One of these technologies is a substance called Sodium Fluoride (NaF). Fluoride is a normal body substance.
- Trial name
- NCT02103634
- Testing
- NaF PET/MRI, NaF PET/CT, FDG PET/CT
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Case Comprehensive Cancer Center
Esophageal Cancer TNM Staging, Magnetic Resonance Imaging
The Application of 3T MRI in Esophageal Cancer
It is very significant that assessing TN staging in esophageal cancer patients before surgery, furthermore, determining the optimize surgical strategy, predict the the efficacy of radiotherapy for patients who were not chosen to…
- Conditions
- Esophageal Cancer TNM Staging, Magnetic Resonance Imaging, Prognosis
- Trial name
- NCT03635619
- Testing
- No intervention
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Henan Cancer Hospital
Esophageal Neoplasm, Esophageal Cancer TNM Staging Primary Tumor (T) T2
Efficacy of Intensity Modulated Radiation Therapy After Surgery in Early Stage of Esophageal Carcinoma;
The purpose of this study is to determine the efficacy of preventive intensity modulated radiation therapy after surgery in stage T2-3N0M0 disease of thoracic esophageal squamous cell carcinoma(UICC 7th edition) and to identify…
- Conditions
- Esophageal Neoplasm, Esophageal Cancer TNM Staging Primary Tumor (T) T2, Esophageal Cancer TNM Staging Primary Tumor (T) T3, Esophageal Cancer TNM Staging Regional Lymph Nodes (N) N0
- Trial name
- IMRT (NCT01745107)
- Testing
- Prophylactic postoperative radiation therapy
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Chinese Academy of Medical Sciences
Esophageal Cancer TNM Staging Primary Tumor (T) T3
Detection of Circulating Tumor Tells as The Guidance of the Neoadjuvant Chemotherapy of Esophageal Cancer
Esophageal carcinoma is a common digestive system tumor, with number of deaths ranking No. 4 in malignant tumors. Esophageal squamous cell carcinoma in stage Ⅱ, III is the most common in China.
- Trial name
- NCT03005314
- Testing
- chemotherapy, Surgery
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The Second Hospital of Shandong University
Bladder Cancer TNM Staging Primary Tumor (T) Ta, Bladder Cancer TNM Staging Primary Tumor (T) T1
Intravesical Adjuvant Electromotive Mitomycin-C
In laboratory and clinical studies, intravesical electromotive drug administration increased mitomycin bladder uptake, improving clinical efficacy in high-risk non-muscle invasive urothelial bladder cancer.
- Conditions
- Bladder Cancer TNM Staging Primary Tumor (T) Ta, Bladder Cancer TNM Staging Primary Tumor (T) T1, Bladder Cancer Transitional Cell Grade
- Trial name
- EMDA/MMC (NCT01920269)
- Testing
- Trans-urethral resection, intravesical passive diffusion mitomycin, intravesical electromotive mitomycin
- Where
- Italy
- Volunteers
- 331 people
- Sponsor
- University of Rome Tor Vergata