Clinical trials: TQT Study
Cardiac Conduction and Repolarization
Thorough QT/QTc (Corrected QT Interval) Study to Evaluate the Effect of Custirsen on Cardiac Repolarization
This is a 3-arm, parallel-group, active- and placebo-controlled, double-blind, randomized study, to compare treatment with intravenous custirsen at 640 mg (highest intended therapeutic dose) with placebo.
- Trial name
- NCT01874561
- Testing
- Custirsen, Moxifloxacin
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Achieve Life Sciences
Healthy
A Phase 1 Study to Investigate the Effects of Talampanel on the Heart Rhythm
The purpose of this study is to assess whether multiple doses of Talampanel increase the QT interval when compared to placebo
- Trial name
- NCT00964730
- Testing
- Talampanel, Moxifloxacin
- Where
- United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
RSV Infection, QTc Interval
A Study to Investigate the Effects of Zelicapavir (EDP-938) on QTc Interval in Healthy Adults
The purpose of the study is to assess the effect of a therapeutic and supratherapeutic dose of zelicapavir on the corrected cardiac QT interval relative to a placebo and positive control in healthy participants.
- Trial name
- NCT06601192
- Testing
- zelicapavir (therapeutic dose), zelicapavir (supratherapeutic dose), moxifloxacin
- Where
- 2 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Enanta Pharmaceuticals, Inc
Healthy Subject
Evaluate the Effect of Orelabrutinib on Cardiac Repolarization in Healthy Subjects
This is A Randomized, Blinded, Placebo- and Positive-Controlled, Four-Period, Crossover-Design Thorough QT/QTc (TQT) Study to Evaluate the Effect of Orelabrutinib on Cardiac Repolarization in Healthy Subjects
- Trial name
- NCT05660720
- Testing
- Orelabrutinib, Moxifloxacin hydrochloride
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Beijing InnoCare Pharma Tech Co., Ltd.
Healthy Subjects, Cardiac Repolarization
Phase 1 Study to Assess the Effects of EVP-6124 on the QT/QTc Interval in Healthy Subjects
The purpose of this study is to evaluate the effect of EVP-6124 at therapeutic and supratherapeutic concentrations on cardiac repolarization in healthy subjects.
- Trial name
- TQT (NCT01487135)
- Testing
- EVP-6124, Moxifloxacin
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- FORUM Pharmaceuticals Inc
Healthy
Investigate the Effect on the QT/QTc Interval of Repeated and Escalating Doses of AZD3480 During 6 Days
The purpose of this study is to evaluate the effects on cardiac repolarisation of supratherapeutic doses of AZD3480 compared to placebo in healthy male volunteers, subgrouped as extensive metabolisers and poor metabolisers…
- Trial name
- TQT (NCT00686179)
- Testing
- AZD3480, Moxifloxacin
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Cardiac Repolarization in Healthy Subjects
A TQT Study to Evaluate the Electrocardiographic Effects of Carbidopa in Healthy Subjects
The purpose of this trial is to assess the effects of a single supratherapeutic dose of carbidopa on cardiac repolarization relative to placebo in healthy adult subjects.
- Trial name
- NCT06161220
- Testing
- Carbidopa capsule, Moxifloxacin Tablets, USP
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Impax Laboratories, LLC
Qt Interval, Variation in
Study to Evaluate the Effect Of WCK 2349 on the QT/QTc Interval in Health Volunteers
The study designed to determine the effect induced by WCK 2349 on the QT interval. The study will be conducted in two parts: 1) to determine the supratherapeutic dose; and 2) to assess the safety of high doses of single-dose…
- Trial name
- NCT02217930
- Testing
- WCK 2349, Moxifloxacin
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Wockhardt
Acinetobacter Baumannii-calcoaceticus Complex Infections
Study Evaluating the Effect of ETX2514 on Cardiac Repolarization in Healthy Male or Female Volunteers
This study is being conducted to evaluate the effects of supratherapeutic ETX2514 plasma concentrations on the heart rate-corrected QT interval (QTc).
- Trial name
- NCT03985410
- Testing
- ETX2514, moxifloxacin
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Entasis Therapeutics
Healthy Volunteers
Phase I Study to Evaluate the Effect of GFT505 on QT/QTc Interval in Healthy Volunteers
In accordance with International Conference on Harmonisation (ICH) E14 guidelines, this Phase I thorough QT (TQT) study will assess the arrhythmogenic potential of GFT505, by evaluating its effect on QT/QTc prolongation in…
- Trial name
- NCT02091310
- Testing
- GFT505, Moxifloxacin 400 mg
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Genfit
Healthy
Thorough QT Study to Evaluate the Effects of BI 207127 (Deleobuvir) Combined With Faldaprevir on Cardiac Safety Parameters in Healthy Subjects.
The objective of this study is to evaluate the effect of multiple doses of BI 207127 combined with faldaprevir on cardiac safety parameters in healthy subjects
- Trial name
- NCT01965431
- Testing
- BI 207127, Faldaprevir, Moxifloxacin (Avalox®)
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Healthy Volunteers
A Study of TAK-279 in Healthy Adults on the Effect on ECG Measurements
The main aim of this study is to find out how more than one dose of TAK-279 changes the heart-rate corrected QT (QTc) interval of healthy adults.
- Trial name
- NCT06258265
- Testing
- TAK-279, Moxifloxacin
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Takeda
Healthy
Study to Investigate the Effects of Single Intravenous Doses of Difelikefalin (CR845) on the QTc Interval in Healthy Subjects
This is a Phase 1, randomized, double-blind (except for moxifloxacin), placebo- and positive-controlled, single-site, 4-way crossover study to investigate the effects of single therapeutic and supratherapeutic IV doses of…
- Trial name
- NCT04019574
- Testing
- CR845 0.5 mcg/kg IV, CR845 3 mcg/kg IV, Moxifloxacin 400 mg Oral Tablet
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Cara Therapeutics, Inc.
Torsades de Pointes
A Study to Evaluate How VI-0521 Affect Cardiac Repolarization in Healthy Male and Female Volunteers
Determine whether VI-0521 has an effect on the electrical activity of the heart in healthy subjects. Find out how much VI-0521 is in the blood and any potential side effects on ECG's of healthy subjects after taking the study…
- Trial name
- TQT (NCT00839891)
- Testing
- VI-0521
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- VIVUS LLC
Fibromyalgia
Phase 1 Thorough QT (TQT) Study in Young Healthy Volunteers
This Phase 1 study will assess the effects of esreboxetine on the heart. In particular the effects on a specific electrocardiogram (ECG) measurement called QTc will be measured.
- Trial name
- TQT (NCT00809289)
- Testing
- esreboxetine, moxifloxacin
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pfizer
Asthma, Chronic Obstructive Pulmonary Disease (COPD)
A Thorough QT (TQT) Study of CHF5993 pMDI in Healthy Volunteers (HV)
The purpose of this study is to evaluate the potential for cardiac repolarization, according to electrocardiographic monitoring (including QT and QTc intervals), of two dose levels of CHF5993 pMDI (beclomethasone…
- Trial name
- NCT05830071
- Testing
- CHF5993, CHF5259, Moxifloxacin 400mg
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
Healthy Volunteer
A Cardiac Liability Study of Varegacestat in Healthy Participants
This clinical study is designed to study the effect of a single dose of varegacestat on cardiac repolarization in healthy adult participants.
- Trial name
- NCT06855264
- Testing
- varegacestat, Moxifloxacin 400 mg
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Immunome, Inc.
Myelofibrosis
QT Interval/Corrected QT Interval （QT/QTc） Clinical Study to Evaluate the Cardiac Safety of TQ05105 Tablets in Healthy Participants
Primary Objective: To evaluate the effect of single-dose TQ05105 on QTcF interval in healthy Chinese participants. Secondary Objectives: To evaluate the effects of single-dose TQ05105 on other cardiac parameters (heart rate, QT…
- Trial name
- NCT07708272
- Testing
- TQ05105 tablets, Moxifloxacin Hydrochloride Tablets
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Healthy
Thorough QT Study of Intravenous Amisulpride
Randomised, single-dose, crossover, placebo-controlled study to see if intravenous amisulpride has any effect on the heart rhythm, in particular the QT interval, in healthy adult volunteers.
- Trial name
- NCT02661594
- Testing
- APD421 5 mg, APD421 40 mg, Moxifloxacin
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Acacia Pharma Ltd
Effects of Sativex on ECG
Sativex Thorough QT/QTc Study
This study was to evaluate effects of Sativex on electrocardiogram (ECG) traces when administered at its therapeutic dose of 8 sprays per day and at multiples of the therapeutic dose (24 or 36 sprays per day), and to evaluate its…
- Trial name
- NCT01322139
- Where
- Canada
- Volunteers
- 258 people, healthy volunteers welcome
- Sponsor
- Jazz Pharmaceuticals