Clinical trials: Tachyphylaxis
Psoriasis
Assessment for Tachyphylaxis to Topical Corticosteroids in the Treatment of Psoriasis
Tachyphylaxis occurs when a medication is applied multiple times and a decreased response takes place. Many dermatologists believe that tachyphylaxis to topical steroids commonly occur.
- Trial name
- Tachyphylaxis (NCT01404338)
- Testing
- Halobetasol 0.05% ointment
- Volunteers
- 10 people
- Sponsor
- Patel, Rita Vikram, M.D.
Bipolar Disorder, Schizophrenia
Tachyphylaxis, Tolerance, & Withdrawal Post Treatment With Igalmi for Agitation in Schizophrenia or Bipolar Disorder
This is an in-clinic, single arm, open-label study assessing tachyphylaxis, tolerance, and withdrawal following repeated doses of Igalmi in adult males and females with agitation associated with schizophrenia or bipolar disorder.
- Conditions
- Bipolar Disorder, Schizophrenia, Agitation,Psychomotor, Schizo Affective Disorder
- Trial name
- NCT06041646
- Testing
- Sublingual film containing Igalmi
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- BioXcel Therapeutics Inc
Hyperhidrosis
Long Term Results of the Use of Oxybutynin for the Treatment of Hyperhidrosis
Evaluate the long term efficacy and side effects of oxybutynin in the treatment of hyperhidrosis.
- Trial name
- NCT01956591
- Testing
- Oxybutynin
- Where
- Brazil
- Volunteers
- 1,100 people
- Sponsor
- Hospital Israelita Albert Einstein
Type 2 Diabetes
The Reduced Insulinotropic Effect of a Continuous Infusion Relative to a Bolus Injection of GIP
In patients with type 2 diabetes, the incretin hormone glucose-dependent insulinotropic polypeptide (GIP) has lost its insulinotropic activity, but more so after continuous versus bolus administration.
- Trial name
- NCT02673554
- Testing
- GIP Bolus, GIP Clamp, Oral glucose tolerance test (OGTT)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Diabeteszentrum Bad Lauterberg im Harz
Orthostatic Hypotension
Water and the Gastropressor Response - Tachyphylaxis
We are studying the effects of oral water ingestion in patients with orthostatic hypotension. In this study, we are testing the null hypothesis that the blood pressure increase with oral water ingestion will not be diminished if…
- Trial name
- NCT00580996
- Testing
- water high dose, water tiny dose
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Satish R. Raj
Allergic Rhinitis, Tachyphylaxis
Differential Adrenoreceptor Mediated Tachyphylaxis and Upregulation
The investigators wish to evaluate the onset of tolerance to nasal decongestants like oxymetazoline (available over the counter) and the mechanism of tolerance particularly with differential effects on alpha 1 and alpha 2…
- Conditions
- Allergic Rhinitis, Tachyphylaxis, Rhinitis Medicamentosa
- Trial name
- NCT00487032
- Testing
- Oxymetazoline 0.05% w/v, Fluticasone propionate 50 micrograms per actuation, Prazosin hydrochloride
- Where
- 2 sites in United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Brian J Lipworth
Allergic Rhinitis, Tachyphylaxis
Preventing Tolerance to Oxymetazoline in Allergic Rhinitis
The investigators wish to evaluate the effects of decongestants like oxymetazoline and the lessening of this effect with time called 'tolerance'.
- Conditions
- Allergic Rhinitis, Tachyphylaxis, Rhinitis Medicamentosa
- Trial name
- NCT00846326
- Testing
- oxymetazoline-fluticasone propionate, Oxymetazoline
- Where
- 2 sites in United Kingdom
- Sponsor
- Brian J Lipworth