Clinical trials: Tailored Condition
Multiple Myeloma, Frailty
Individualized Dynamic Frailty-tailored Therapy (DynaFiT) in Elderly Patients With NDMM
Frailty is dynamic and confers poor outcomes in elderly patients with newly diagnosed multiple myeloma (NDMM), mainly because of the high prevalence of treatment discontinuation due to intolerability.
- Trial name
- DynaFiT (NCT06099912)
- Where
- China
- Volunteers
- 131 people
- Sponsor
- FengYan Jin
Sedentary Lifestyle, Breast Neoplasms
Step by Step: A Tailored Walking Intervention for Breast Cancer Survivors
This study aims to recruit post-treatment breast cancer survivors for a 12-week 2-arm randomized walking intervention. All intervention materials will be delivered electronically.
- Conditions
- Sedentary Lifestyle, Breast Neoplasms, Survival Rate (Survivorship)
- Trial name
- NCT01845519
- Testing
- Tailored Email, Targeted Email
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Leanne Kaye
Stroke
Improving Motor Stroke Recovery Using Patient-tailored Non-invasive Brain Stimulation
Many individuals are often left with problems moving their arm and hand, months to even years after a stroke. Recent progress in research suggests the application of non-invasive brain stimulation, such as transcranial direct…
- Trial name
- NCT02473549
- Testing
- Anodal TDCS, Cathodal TDCS, Magnetic Resonance Imaging (MRI)
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Sunnybrook Health Sciences Centre
Diabetes, Surgery
Tailored Bilio-Pancreatic Limb and HbA1c 10 Years Post Mini-Gastric Bypass
Diabetes is now or soon will be a worldwide epidemic. Diabetes has impact on both healthcare costs in addition to the costs in human lives, suffering and disability. Treatment that lowers Hemoglobin A1c (HbA1c) improved outcomes.
- Trial name
- BPLLvHbA1c (NCT04442698)
- Testing
- Mini-Gastric Bypass Original Technique
- Where
- India
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Kular Hospital
Fibromyalgia
Subgroups of Fibromyalgia Syndrome (FMS): Symptoms, Beliefs, and Tailored Treatment
Fibromyalgia syndrome (FMS) refers to a set of symptoms that include exhaustion, muscle pain, and tender points, where slight pressure can cause pain.
- Trial name
- NCT00762125
- Testing
- CR+ST, ET, AC treatment
- Where
- United States
- Volunteers
- 266 people
- Sponsor
- University of Washington
Congestive Heart Failure
Peripheral Venous Oxygen Saturation and Biomarkers to Estimate Cardiac Output and Filling Pressures in Heart Failure
The relationship between peripheral venous saturation and central hemodynamics (including right and left heart filling pressures and cardiac output), mixed venous oxygen saturation, and contemporary biomarkers of heart failure is…
- Trial name
- NCT00595738
- Testing
- Standard of care therapy for severe decompensated heart failure
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Obese
Dynamo: a Tailored Lifestyle Promotion Intervention Among Pediatric Patients With Cardiometabolic Risk Factors
The Dyn@mo lifestyle intervention (CHU Sainte-Justine, Quebec, Canada) targets children and adolescents aged 6 to 17 years old with cardiometabolic risk factors, such as obesity, hypertension, disorders in glucose regulation or…
- Trial name
- CIRCUIT (NCT01736748)
- Testing
- Sensor based PA intervention, Traditional PA counseling
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- St. Justine's Hospital
Coronary Arterial Disease (CAD), Percutaneous Coronary Intervention (PCI)
Dual Antiplatelet Therapy Escalation From Standard-dose Clopidogrel to Low-Dose Prasugrel in Patients With High Bleeding and Ischemic Risk Undergoing PCI: A Prospective, Randomized Pharmacodynamic Study (TAILOR-BLEED-2)
The primary aim of this study is to investigate the PD effects of switching from standard-dose clopidogrel dose to low-dose prasugrel versus continuing standard-dose clopidogrel in patients at dual-risk (HBR defined as the…
- Trial name
- NCT07025148
- Testing
- Prasugrel, Clopidogrel
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Florida
Heart Failure
Randomized Controlled Trial to Test the Efficacy of Motivational Interviewing on Self-care
Introduction: Heart failure (HF) is characterized by an increasing prevalence and burden, representing a public health problem and a major cause of morbidity and mortality.
- Trial name
- NCT05595655
- Testing
- Motivational Interviewing
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- Azienda Socio Sanitaria Territoriale di Lodi
HIV Infections, Tobacco Use Cessation
Tobacco Cessation Tailored to Patients Living With HIV (PLWH) in Brazil
The overall goal of this feasibility study is to make adaptations to these evidence-based approaches in collaboration with PLWH and health care providers working with this population, and develop, implement, and evaluate the…
- Trial name
- NCT05560243
- Testing
- Tobacco cessation
- Where
- Brazil
- Volunteers
- 56 people
- Sponsor
- University of Alabama at Birmingham
Endometrial Cancer
Adjuvant Therapy in POLE-Mutated and p53-Wildtype/NSMP Early Stage Endometrial Cancer RAINBO BLUE & TAPER
This protocol tests de-escalated adjuvant treatment in patients with POLE-mutated or p53wt/NSMP (p53 wildtype/no specific molecular profile) early-stage endometrial cancer (EC).
- Trial name
- NCT05640999
- Testing
- Vaginal brachytherapy, Adjuvant radiotherapy (EBRT +/- brachytherapy), Observation
- Where
- 123 sites in United States, Australia and 7 more
- Volunteers
- 393 people
- Sponsor
- Canadian Cancer Trials Group
Chronic Obstructive Pulmonary Disease, Health Status
Secondary Prevention of Problems in Health Status in Patients With Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this study is to determine the effectiveness of an intervention conducted by a pulmonary nurse in patients with COPD.
- Trial name
- NCT00940355
- Testing
- Intervention pulmonary nurse
- Where
- Netherlands
- Volunteers
- 303 people
- Sponsor
- Radboud University Medical Center
Obesity
Changing Dietary Patterns: an Individually Tailored Nutrition Intervention (OKE-study)
The main objective of this study is to investigate the effect of a personalized nutrition intervention on the dietary pattern of apparently healthy adults with one or more children aged 4 to 12 years.
- Trial name
- NCT01509222
- Testing
- Personalized nutrition counseling
- Where
- Netherlands
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Cardiovascular Kidney Metabolic Syndrome, Type 2 Diabetes
Food and Fitness With Medicine (FFWM)
Food and Fitness with Medicine (FFWM) is a 24-week randomized controlled trial (RCT) enrolling 200 post-menopausal women (PMW) with stage 2 cardio-kidney metabolic (CKM) syndrome and type-2 diabetes (T2D) within 6 weeks of…
- Trial name
- FFWM (NCT07027995)
- Testing
- Exercise is Medicine (EIM), Culinary Education, Food is Medicine
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- Ohio State University
Anxiety, Depression
Internet-delivered Cognitive Behaviour Therapy for Older Adults With Anxiety
The purpose of this study is to determine whether tailored internet-administrated cognitive behaviour therapy (ICBT) is a feasible approach in the treatment of anxiety symptoms and comorbid depressive symptoms in older adults.
- Trial name
- NCT02403557
- Testing
- Waitlist, Tailored Internet-delivered CBT
- Volunteers
- 66 people
- Sponsor
- Linkoeping University
Percutaneous Coronary Intervention, Platelet Aggregation Inhibitors
Algorithm-based Tailoring of Dual Antiplatelet Therapy to Improve Outcomes Following Percutaneous Coronary Interventions
The use of aspirin combined with a P2Y12 inhibitor (dual antiplatelet therapy, DAPT) represents the standard of care for patients undergoing percutaneous coronary intervention (PCI) with stent implantation.
- Conditions
- Percutaneous Coronary Intervention, Platelet Aggregation Inhibitors, Coronary Artery Disease
- Trial name
- TAILOR-DAPT (NCT05732701)
- Testing
- Algorithm-guided DAPT duration, Standard-of-care DAPT duration
- Where
- 4 sites in Bosnia and Herzegovina, Italy and 1 more
- Volunteers
- 2,788 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Obesity & Overweight, Vulnerable Families
Evaluation of a Multicomponent Early Intervention for Childhood Obesity Prevention in Vulnerable Families
Childhood obesity is a public health concern. Evidence-based, multicomponent, parenting interventions targeting early childhood and adapted to families' socioeconomic context are needed to prevent childhood obesity.
- Conditions
- Obesity & Overweight, Vulnerable Families, Children, Families With Infants
- Trial name
- Bambú (NCT07529704)
- Testing
- Bambú program
- Where
- 4 sites in Spain
- Volunteers
- 526 people, healthy volunteers welcome
- Sponsor
- Helena Vall Roqué
Leukemia, Myeloid
Phase 2 Study of Temozolomide to Treat Poor Risk / Refractory Acute Myeloid Leukemia
Open-label, non-randomized, parallel assignment, phase 2 trial assessing the safety and efficacy of distinct temozolomide treatment regimens for patients with AML and poor prognosis
- Trial name
- NCT00611247
- Testing
- Temozolomide
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Bruno C. Medeiros
Cancer
Individually Tailored Training Prescriptions in Cancer Patients: The TOP Study
The TOP Study is a two-stage study on individually tailored endurance and resistance training prescriptions for breast and prostate cancer patients after the end of primary therapy in order to optimize training effects.
- Trial name
- TOP (NCT02883699)
- Testing
- Standard endurance training, Polarized endurance training, Standard resistance training
- Where
- Germany
- Volunteers
- 132 people
- Sponsor
- University Hospital Heidelberg
Chronic Kidney Disease
Veteran Centered Meal Intervention in Chronic Kidney Disease
This study will study if medically tailored meals can improve health and well-being among Veterans with kidney disease. Participants will be randomly assigned to receive either medically tailored meals or usual care (wait-list…
- Trial name
- VETCKD (NCT07793591)
- Testing
- Medically tailored meals (MTMs)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- VA Office of Research and Development