Clinical trials: Target Controlled Infusion
Children Under General Anesthesia
Target-controlled Infusion of Propofol for Induction of Pediatric Anesthesia
The purpose of this study is to determine a effect-site concentration of propofol in children 3 to 11 years effective to make a induction of general anesthesia.
- Trial name
- NCT01411020
- Testing
- endotracheal intubation
- Where
- Chile
- Volunteers
- 60 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Propofol, Target Controlled Infusion
Propofol TCI Administered by Gastroenterologists During Endoscopy: a Randomized Double Blind Controlled Study
Many studies address safety and effectiveness of non-anesthesiologist propofol sedation (NAPS) for GI endoscopy. Target Controlled Infusion (TCI) is a sophisticated tool for providing optimal sedation regimen and avoiding under…
- Conditions
- Propofol, Target Controlled Infusion, Moderate Sedation, Gastrointestinal Endoscopy
- Trial name
- PropTCI/2012 (NCT01941888)
- Testing
- Propofol, Midazolam, Target Controlled Infusion
- Where
- 2 sites in Italy
- Volunteers
- 140 people
- Sponsor
- Ospedale San Raffaele
Anesthetics, Intravenous, Pharmacology
Minto Model in Effect Site Mode for Target-Controlled Infusion of Remifentanil During Cardiopulmonary Bypass
Target controlled infusion with remifentanil is widely used during cardiac surgery, wich is performed using the Minto model. It was derived from patients undergoing general surgery.
- Conditions
- Anesthetics, Intravenous, Pharmacology, Anesthetics, Cardiopulmonary Bypass
- Trial name
- NCT02566733
- Testing
- Remiva, Ultiva
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Seoul National University Hospital
Hepatocellular Carcinoma, Chemotherapy Effect
Concurrently vs Sequentially Combined HAIC With Targeted and Immunotherapy in Potentially Resectable HCC
The goal of this clinical trial is to compare HAIC concurrently with sequentially combined with targeted and immunotherapies in terms of efficacy and safety in patients with potentially resectable intermediate and advanced HCC…
- Conditions
- Hepatocellular Carcinoma, Chemotherapy Effect, Chemotherapeutic Toxicity
- Trial name
- HAIC (NCT06041477)
- Testing
- Oxaliplatin,calcium folinic acid, levofolinic acid, 5-FU, Concurrent Lenvatinib, Concurrent PD-1 antibody
- Where
- China
- Volunteers
- 540 people
- Sponsor
- Sun Yat-sen University
Hypoxemia, Conscious Sedation
Impact of Nasal Mask Versus Nasal Cannula Oxygenation on Hypoxemia in Gastrointestinal Endoscopy: A Brain Function Monitoring (SedLine)-Guided Randomized Controlled Trial (NAMSHIC)
This randomized controlled trial compared the efficacy of a nasal mask versus a standard nasal cannula for oxygen delivery during gastrointestinal endoscopic procedures performed under target controlled propofol infusion…
- Trial name
- NAMSHIC (NCT07500779)
- Testing
- Nasal Mask Oxygenation, Nasal Cannula Oxygenation
- Where
- Turkey (Türkiye)
- Volunteers
- 600 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Target Controlled Infusion of Propofol
Validation Study of Covariates Model (VaSCoM) for Propofol
Anaesthesia for surgical procedures can be provided using a continuous infusion of intravenous drug. The most commonly used drug for this technique is propofol.
- Trial name
- VaSCoM (NCT01492712)
- Testing
- Propofol
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Golden Jubilee National Hospital
Emergence Delirium, Post-Operative Cognitive Dysfunction
Post Operative Cognitive Dysfunction and Delirium After Spinal Surgery
Aim of this trial is to define if Post-Operative Cognitive Dysfunction and Delirium, detected analyzing changes between pre-operative and post-operative Neurocognitive Test, relate to concentration of effector's site…
- Trial name
- NCT03950557
- Volunteers
- 200 people
- Sponsor
- University of Padova
Target Controlled Infusion, Intracranial Neoplasm
Comparison of Opioid Consumption During TCI Guided by NOL Index or Standard Care Undergoing Intracranial Tumor Surgery
In this prospective, randomized controlled study, we hypothesized that nociception level index monitoring reduced opioid administration during surgery.
- Conditions
- Target Controlled Infusion, Intracranial Neoplasm, Opioid, Nociceptive Pain
- Trial name
- NOLopioid (NCT05732896)
- Testing
- Nociception Leve Indeks
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Turkish Society of Anesthesiology and Reanimation
Propofol, Anesthesia Brain Monitoring
Effects of Aminophylline Bolus on TCI (Target Controlled Infusion) Concentrations at Return of Responsiveness
Aminophylline is an intravenous drug commonly utilized for asthma. However, some preclinical studies and few case reports and case series have described its utility in decrease the timing of return of consciousness after Propofol…
- Trial name
- TCI (NCT06098196)
- Testing
- Aminophyllin
- Where
- 2 sites in Italy
- Volunteers
- 48 people
- Sponsor
- University of Padova
Anesthesia
The Effect on the Older's Cognition of Dual-loop Target Controlled Infusion Guided by Narcotrend Index
To investigate the effect on older's cognition of the application of closed target-controlled infusion(TCI) of propofol and remifentanil guided by Narcotrend index .
- Trial name
- POCD;TCI (NCT03010098)
- Testing
- Dual-Loop TCI, Open-Loop TCI
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Neurosurgery, Intervention
Pharmacokinetic and Pharmacodynamic Modelling of Norepinephrine in Patients Under Target Controlled Infusions (TCI) for Anaesthesia
Currently, administration of norepinephrine diluted at 5 µg/ml bolus or continuous infusion is common during sympatholysis hypotension of TCI following the elimination of hypovolemia or anesthetic overdosage.
- Trial name
- NOR-PHARM (NCT03454204)
- Testing
- Pharmacokinetic
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Postoperative Cognitive Dysfunction (POCD)
Intravenous Anesthesıa and Cognıtıve Functıon ın Spınal Surgery
The aim of this study is to investigate the effect of these two different intravenous infusion techniques [manuel controlled infusion (MCI) and Target controlled Infusion( TCI)] on POCD.
- Trial name
- NCT07701187
- Testing
- Manuel controlled infusion group
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Analgesia, Ketamine
Characterization of the Temporal Profile of the Anti-nociceptive Effect of Ketamine Bolus Measured With ANI
Ketamine, an intravenous anesthetic, and analgesic agent has experienced a resurgence in its clinical application, particularly in subanesthetic doses.
- Conditions
- Analgesia, Ketamine, Pharmacokinetic
- Trial name
- Keta-ANI (NCT06344858)
- Testing
- Ketamine
- Where
- Chile
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Adjuvants, Anesthesia
Effects of Dexmedetomidine Target Controlled Infusion on Patient State Index Values and Electroencephalographic Spectrum During Total Intravenous Anesthesia With Propofol
Dexmedetomidine Target Controlled infusion (TCI, Dyck model) effects on Neuromonitoring during Total Intravenous Anesthesia (TIVA) with Propofol and Remifentanil TCI (Eleveld model) has not been investigate yet.
- Trial name
- NCT07259460
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Padova
Scheduled Laparoscopic Surgery
Pupillary Reflex Measurement to Guide Intraoperative Analgesia During Laparoscopic Surgery
The purpose of this study is to determine whether analgesia guided by pupillary reflex during laparoscopic surgery is effective in opioid sparing (intraoperative remifentanil and postoperative morphine).This is a prospective…
- Trial name
- NCT02116868
- Testing
- Pupillometry guided analgesia (PP), Tailored remifentanil controlled infusion, Tailored antihypertensive drug administration
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- Central Hospital, Nancy, France
Anesthesia; Reaction
Study of Nerve Block Anesthesia for Surgery of Hip Fracture in the Elderly
The investigators aim to examine target-controlled propofol infusion as a technique of anesthesia for surgery of hip fracture under ultrasound guidance lumbar and sacral plexus block or lumbar, sacral and paravertebral nerve…
- Trial name
- NCT02104908
- Testing
- paravertebral nerve, lumbar and sacral plexus block
- Volunteers
- 80 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Obesity
Propofol Effect-Site Target Controlled Infusion in the Obese: Characterization of the Time Profile of Bispectral Index Response
The aim of this study is to characterize the Pharmacokinetic/Pharmacodynamic relationship of a single bolus dose of propofol in obese patients and to extract a time to peak effect (t-peak) from the estimated model parameters.
- Trial name
- NCT01665079
- Testing
- Propofol
- Where
- Chile
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Universidad del Desarrollo
Tumor of Ear, Nose and Throat
Conditions of Diagnostic Panendoscopy of the Upper Airway Under Propofol Remifentanil General Anesthesia
The most important considerations for the general anesthesia in diagnostic panendoscopy of the upper airway is the maintenance of a patient's airway for optimal surgical exposure, adequate ventilation and sufficient depth of…
- Trial name
- ENDOTANIL (NCT02093143)
- Testing
- Remifentanil
- Where
- 2 sites in France
- Volunteers
- 256 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Anesthesia
Optimal Remifentanil Concentration and Thyroidectomy
The study is aimed at determining the remifentanil effect site concentration suppressing the cough at extubation after surgical thyroidectomy, performed under remifentanil/desflurane based general anesthesia, expressed as median…
- Trial name
- ORCO (NCT03218124)
- Testing
- Remifentanil Effect site concentration
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Cagliari
Esketamine
Effect of Subanesthetic Dose Esketamine on Propofol-refentanil Closed-loop Targeted Controlled Infusion
The propofol-refentanil program-controlled closed-loop target-controlled infusion system based on NI guidance has been clinically verified.
- Trial name
- NCT05943028
- Testing
- Subanesthetic dose of esketamine
- Volunteers
- 48 people
- Sponsor
- bo xu