Clinical trials: Targeted Therapy
Allergic Contact Dermatitis
The Role of Interleukin-1 Beta Targeted Therapy for Patients Suffering From Allergic Contact Dermatitis
The study will investigate if Anakinra can ameliorate allergic contact dermatitis in participants with known nickel allergy
- Trial name
- NCT05498467
- Testing
- Anakinra, Sodium Chloride 9mg/ml Injection
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Herlev and Gentofte Hospital
Internal Radiation, Advanced Hepatocellular Carcinoma
Targeted Internal Radiation Therapy in Advanced HCC Patients.
The aim of this study is to evaluate the 131I-chTNT-1/B treatment effect and safety of individual therapy using randomized controlled study, in order to acquire the evidence of evidence-based medicine and create a new program of…
- Trial name
- NCT02724267
- Testing
- 131I-chTNT-1/B
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Eastern Hepatobiliary Surgery Hospital
B-Cell Neoplasm
Vaccine Responsiveness After CAR-T Cell Therapy
This phase I trial will use the inactivated rabies virus vaccine to assess immune function in patients who previously underwent B cell targeted chimeric antigen receptor-modified T cell immunotherapy (CARTx).
- Trial name
- NCT04410900
- Testing
- Wistar Rabies Virus Strain PM-1503-3M Vaccine, Biospecimen Collection
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Myocardial Infarction Type 2
Targeting Investigation and Treatment in Patients With Type 2 Myocardial Infarction
Type 2 myocardial infarction (MI) is common and associated with poor clinical outcomes, with as many as one in ten experiencing recurrent MI within one year, and only one in three alive at five years.
- Trial name
- TARGET-Type 2 (NCT05419583)
- Testing
- Coronary computed tomography angiography, Invasive coronary angiography, Transthoracic echocardiography
- Where
- 2 sites in United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Advanced Lung Cancer, Sarcopenia
Differences in Rate of Decline in CT-defined Skeletal Muscle Mass and Physical Performance in Patients With Advanced Non-small Cell Lung Cancer Receiving Chemotherapy and Targeted Therapy/Immunotherapy, Before and After Treatment.
Lung cancer is a common disease leading to 18 % of cancer deaths worldwide. Despite various improvement in treatment, there still remains low 5-year survival rate of 10-20 % in advanced lung cancer patients.
- Trial name
- NCT06326086
- Testing
- Chemotherapy drug, Targeted Agent, Immunotherapy
- Where
- Thailand
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Prince of Songkla University
COPD
Mechanisms and Impact of Bacterial Colonisation in COPD
COPD is a leading cause of lung disease and a common cause of hospitalisation, time off work and death. Smoking is the major factor associated with development of COPD.
- Trial name
- NCT03161561
- Testing
- capacity of primary phagocytes
- Where
- United Kingdom
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Autism Spectrum Disorder
Measuring Brain Inflammation in Autism
Autism spectrum disorders (ASD) are highly disabling, persistent neurodevelopmental disorders. There are no available treatments for core symptoms of ASD or biologically-based clinical biomarkers.
- Trial name
- NCT03117530
- Testing
- Minocycline
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Malaria, Anaemia
IMPACT2: Monitoring Interventions to Improve Artemisinin-based Combination Therapy (ACT) Access and Targeting
It is generally agreed that artemisinin-based combination therapy (ACT) is the malaria therapy of choice but there is much less agreement about the best ACT-deployment strategies.
- Trial name
- IMPACT2 (NCT01130155)
- Where
- Tanzania
- Volunteers
- 33,900 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Posttraumatic Stress Disorder, Sexual Assault
RCT for Innovating Stress-related eHealth
The Randomized Control Trial for Innovating Stress-related eHealth (RISE) Study tests the hypotheses that a highly promising digital therapeutic (RISE Guide) targeting anxiety sensitivity (AS) will be acceptable to women sexual…
- Conditions
- Posttraumatic Stress Disorder, Sexual Assault, Pain
- Trial name
- RISE (NCT05305235)
- Testing
- RISE Guide, Relaxation Control
- Where
- 2 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Myelodysplastic Syndromes
Interplay Between Immune and Metabolic Programs in Myelodysplastic Syndromes
Myelodysplastic syndromes (MDS) are a pre-leukemic condition with an extremely poor prognosis despite current treatments that justify new therapeutic approaches.
- Trial name
- IMET-MDS (NCT04803721)
- Where
- France
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Trigeminal Neuropathic Pain
Brain as a Therapeutic and Research Target in Trigeminal Neuropathic Pain
The main goal of this study to integrate techniques producing images of the brain (also called neuroimaging techniques) with non-invasive brain stimulation to investigate factors that may be associated with chronic pain in…
- Trial name
- NCT03003715
- Testing
- PET Scans, transcranial direct current stimulation (tDCS), MRI
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Pediatric Obesity
Pediatric Obesity Observational Prospective Trial
Using an observational case-control cohort design, the investigator aims to define the mechanisms underlying microbiome regulation of metabolism in adolescence before and after medically indicated therapies for obesity.
- Trial name
- NCT03139877
- Where
- United States
- Volunteers
- 295 people, healthy volunteers welcome
- Sponsor
- Duke University
Primary Myelofibrosis (PMF), Healthy Subjects
Role of Myeloid-derived Suppressor Cells In Primary Myelofibrosis
The goals of this observational study are to investigate the role of myeloid-derived suppressor cells (MDSCs) in fueling chronic inflammation that is a relevant pathogenetic mechanism in patients with primary myelofibrosis (PMF)…
- Trial name
- NCT07319026
- Where
- Italy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Diabetes Mellitus
Role of Red Blood Cells in Cardiovascular Disease
The risk of myocardial infarction is dependent on cardiovascular risk factors including type 2 diabetes (T2D) but underlying mechanisms are poorly understood.
- Trial name
- NCT07151222
- Where
- Sweden
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Diabetes Mellitus, Type 2
Contraction (Exercise) Mediated Glucose Uptake as a Therapeutic Target in Type 2 Diabetes
The purpose of this project is to determine whether glucose metabolism can be improved by administering a substance (nitric oxide donor) normally released by muscles during exercise.
- Trial name
- NCT00168519
- Testing
- nitroprusside, pentalong, imdur, AICAR, isoptin
- Where
- Australia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Baker Heart Research Institute
Cardio Vascular Disease
Platelets and Plasma Lipids Relationship as a Biomarker and Potential Therapeutic Target of Thrombogenesis
The objective of this clinical trial is to compare the effect of two different lipid emulsion formulations versus no emulsion on platelet aggregation in individuals without a history of ischemic disease.
- Trial name
- NCT07774845
- Where
- Brazil
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Stroke
Robotic Pedaling Therapy for Targeted Neural Plasticity
The aim of this Pilot study is to determine whether robotically targeted lower-limb pedaling therapy can increase the extent of stroke recovery on behavioral measures and induce brain plasticity as measured by functional magnetic…
- Trial name
- NCT03300258
- Testing
- Robotic therapy, Aerobic therapy
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Breast Cancer, Breast Cancer Lymphedema
The Recovery of Reaching Movement in Breast Cancer Survivors: Two Different Rehabilitative Protocols in Comparison
This study emphasizes the importance of rehabilitation in breast cancer survivors after mastectomy, even during the course of radiotherapy and chemotherapy, both for good efficacy in reducing pain and for functional recovery of…
- Conditions
- Breast Cancer, Breast Cancer Lymphedema, Pain, Pain, Postoperative
- Trial name
- NCT04166279
- Testing
- Single rehabilitative treatment, Group rehabilitative treatment
- Where
- Italy
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Heart Transplant Rejection
Biomarkers for Diagnosis, Prognosis, and Targeted Therapy After Heart Transplantation
The objective of this prospective observational single center study is to investigate donor-derived cell-free DNA (ddcfDNA), peripheral blood platelet mRNA, peripheral blood extracellular vesicle mRNA, and peripheral blood…
- Trial name
- EMBIO (NCT06064123)
- Testing
- Cell-free DNA
- Where
- Finland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital