Clinical trials: Tear
Rotator Cuff Tears, Central Sensitisation
Effect of Pregabalin on Shoulder Pain in Patients With Central Sensitization After Arthroscopic Rotator Cuff Repair
This study aims to investigate the effects of Pregabalin intake on shoulder pain management in patients with central sensitization undergoing arthroscopic rotator cuff repair.
- Conditions
- Rotator Cuff Tears, Central Sensitisation, Neuropathic Pain
- Trial name
- NCT06367998
- Testing
- Pregabalin
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
ACL - Anterior Cruciate Ligament Rupture
Prospective Evaluation of Osseous Integration in ACL Reconstruction Comparing Tightrope vs Interference Screw Fixation
The purpose of our study was to compare osseous integration of the bone block in Achilles tendon allograft ACL reconstruction using a cortical button versus biocomposite interference screw fixation.
- Trial name
- NCT03841500
- Testing
- Biocomposite intereference screw femoral tunnel fixation, Endobutton (Tightrope) femoral tunnel fixation
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Kelsey-Seybold Clinic
Rotator Cuff Tear
A Selective COX-2 Inhibitor Provides Pain Control But Hinders Healing Following Arthroscopic Rotator Cuff Repair
Selective cyclooxygenase (COX)-2 inhibitors are commonly used analgesics that provide similar analgesia but reduced adverse effects compared to other analgesics.
- Trial name
- NCT02850211
- Testing
- Celecoxib, Ibuprofen, Tramadol
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Full-thickness Rotator Cuff Tear
Why Does my Shoulder Hurt? Understanding the Presence of Pain in Individuals With Full-thickness Rotator Cuff Tears
Full-thickness rotator cuff tears (FTRCT), defined as "through-and-through" tears of one of the shoulder tendons, affect up to 32% of the population (mostly individuals older than 50 years) and are one of the most painful and…
- Trial name
- NCT03857009
- Where
- Canada
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Laval University
Evaporative Dry Eye
Comparison of Tear Evaporation Rate With Systane Complete in Dry Eye and Non-Dry Eye
The objective of the study is to compare the rate of tear evaporation, measured with a novel evaporimeter, before and for one hour after an eye drop containing nano-sized oil droplets has been instilled.
- Trial name
- BULLDOG (NCT04091581)
- Testing
- Systane Complete
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Healthy Volunteers
Tear Collection in Adult Volunteers
This exploratory study will collect tear samples from adult volunteers for determining and quantifying tear composition profiles. No investigational drug will be administered in this study.
- Trial name
- NCT01969162
- Testing
- Tear Sample Collection
- Where
- Australia
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Allergan
Intracranial Aneurysm, Cerebral Aneurysm
PET-imaging of Unruptured Intracranial Aneurysm Inflammation
The main purpose of this study is to determine if PET-imaging can be used to evaluate inflammation level of intracranial aneurysms, thus helping to evaluate the rupture risk of intracranial aneurysm.
- Conditions
- Intracranial Aneurysm, Cerebral Aneurysm, Inflammation
- Trial name
- PET-IA (NCT04715503)
- Testing
- PET imaging, 18F-FDG, PET imaging, 68Ga-DOTANOC
- Where
- Finland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Age-related Cataract
Effects of Holy-Comod and Tears Naturale Forte in Patients After Phaco+IOL
The purpose of the study it to compare the effects of Holy-Comod and Tears Naturale Forte on ocular surface and tear inflammatory mediators in patients after Phaco+IOL.
- Trial name
- NCT02817191
- Testing
- Hylo-Comod eye drop, Tears Naturale Forte eye drop
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Meibomian Gland Dysfunction, Evaporative Dry Eye
Tear Film Innovations iLux Safety Study
The objective of this study was to measure the temperature of the cornea and surrounding eye tissue temperature immediately after heating the eyelids with the iLux device using the protocol treatment profile.
- Trial name
- NCT03055897
- Testing
- iLux 2020 System
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Tear Film Innovations, Inc.
Tear Film Hyperosmolarity
Tear Osmolarity Changes in Habitual Contact Lens Wearers
Tear osmolarity refers to the amount of osmotically active particles in tears and has been reported as one of the best diagnostic test for dry eye disease.
- Trial name
- NCT03531346
- Testing
- Daily-disposable soft contact lens
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Healthy
Local Tolerability and Safety of Povidone K25 Eye Drops (Artificial Tears Containing Povidone) Versus Placebo in Healthy Volunteers
Instillation of artificial tears is standard treatment in dry eye syndrome and in patients experiencing dry eye symptoms when wearing contact lenses.
- Trial name
- NCT00135824
- Testing
- Povidone K25 eye drops (povidone)
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Novartis
Chorioamnionitis
Treatment of Chorioamnionitis After Delivery
Chorioamnionitis occurs in 1% to 5% of term pregnancies and may complicate up to 25% of cases of preterm labor. The traditional regimen used to treat intra-amniotic infection is intravenous ampicillin 2g every 6 hours and…
- Trial name
- NCT00814905
- Testing
- saline, ampicillin gentamicin, Ampicillin gentamicin clindamycin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, Portsmouth
Contact Lens Complication, Dry Eye
Correlation Study of Corneal Nerve Changes and Dry Eye in Contact Lens Wearers
This study aims to analyze the changes of corneal nerve morphology and function in contact lens-related dry eye(CLADE) patients and further discuss the role of corneal nerve in the genesis and development of CLADE.
- Trial name
- NCT04663529
- Testing
- contact lens
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Premature Rupture of Membranes
FOLCROM Trial: Foley Catheter in Rupture of Membranes
Multicenter randomized clinical trial comparing oxytocin versus oxytocin and foley catheter for induction in women who present with premature rupture of membranes who are not in labor.
- Trial name
- FOLCROM (NCT01973036)
- Testing
- Foley Catheter, Oxytocin
- Where
- 5 sites in United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Geisinger Clinic
Rotator Cuff Tears, Shoulder Surgery
Regeneten Patch vs Standard Care in Partial Thickness Rotator Cuff Repair
Shoulder pain is a common complaint with the most common reason being tendinopathy and/or tearing of the rotator cuff. While many rotator cuff tears are often considered normal, age-related degenerative disorders, with either…
- Trial name
- NCT04673344
- Testing
- Regeneten Collagen Patch
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Rotator Cuff Tears
Effect of Telerehabilitation on Quality of Life, Pain, and Function After Rotator Cuff Surgery
he purpose of this study was to find out whether telerehabilitation after rotator cuff surgery can help reduce pain, improve shoulder movement, increase muscle strength, enhance functional ability, and improve quality of life…
- Trial name
- TELERO-ROT (NCT07205094)
- Testing
- Telerehabilitation exercise program, Conventional physiotherapy program
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aysan Yaghoubi
Dry Eye Syndrome
Tears Substitutions and Their Effects on Higher Order Aberrometery
Hypothesis is that tear substitutions cause blur after they are instilled. The investigators will use aberrometry as a measurement over time after a tear formulation is used and try to determine if there are any measurable change…
- Trial name
- NCT00812721
- Testing
- Preservative Free Saline, Optive, Refresh Moderate/Severe
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Gina Rogers
Dry Eye Syndromes
Diagnostic Evaluation of the Tear Film
The objectives of this study are to assess for a difference between normal and dry eye subjects in tear film quality using a diagnostic interferometry device and to determine whether there are associations between tear film…
- Trial name
- NCT00761917
- Testing
- Tear Film Analyzer
- Where
- 8 sites in United States
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- TearScience, Inc.
Anterior Cruciate Ligament Tear, Medial Collateral Ligament
A Study to Evaluate the Incrediwear Products Immediately After ACL Repair
To assess the benefits of using the Incrediwear knee products after ACL or ACL+MCL arthroscopic surgery, on the postoperative pain, range of motion and effusion.
- Trial name
- NCT06668376
- Testing
- Leg Sleeve
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Texas Bone and Joint
Superior Capsular Reconstruction
Superior Capsular Reconstruction With InternalBrace Study
The aim of the study is to investigate the clinical and radiological outcomes after superior capsular reconstruction with InternalBrace (SCRIB) performed for irreparable rotator cuff tears.
- Trial name
- SCRIB (NCT05360654)
- Where
- United Kingdom
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Wrightington, Wigan and Leigh NHS Foundation Trust