Clinical trials: Tear Film
Dry Eye Disease
Diurnal Variation in Tear Osmolarity
The purpose of this study is to measure the change in Tear Osmolarity during the course of the day to support clinical diagnosis of aqueous deficiency or meibomian gland disease and differentiate between the two forms of dry eye.
- Trial name
- NCT01321424
- Where
- 6 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ophthalmic Consultants of Long Island
Dry Eye Disease
Evaluation of Tear Film Quality and Stability in Subjects With Dry Eye Disease Using OC-01 (Varenicline Solution) Nasal Spray 0.03 mg as Compared to Vehicle Control Nasal Spray
A randomized, controlled, double-masked, investigator-initiated trial to evaluate tear film quality and stability in subjects with dry eye disease using OC-01 (varenicline solution) nasal spray 0.03 mg as compared to vehicle…
- Trial name
- TSUNAMI (NCT05514041)
- Testing
- Varenicline solution
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stephenson Eye Associates
Dry Eye Syndromes, Sjogren's Syndrome
Effects of Sustained Reading on the Ocular Surface
This research is being done to to see if changes in visual reading function correlate with changes in optical and retinal image quality.
- Trial name
- NCT02031172
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Dry Eye Syndrome
Efficacy and Safety of the Ophthalmic Solution PRO-087 Versus Systane ® Ultra and Ultra Preservative Free (087LATAMFIV)
Efficacy and Safety of the Ophthalmic Solution PRO-087 versus Systane ® Ultra and Systane ® Ultra Preservative Free on the Tear Film Dysfunction Syndrome from Mild to Moderate Clinical trial To evaluate the effectiveness of…
- Trial name
- 087LATAMFIV (NCT03223909)
- Testing
- PRO-087, Systane Ultra, Systane Ultra Preservative Free
- Where
- Mexico
- Volunteers
- 326 people
- Sponsor
- Laboratorios Sophia S.A de C.V.
Dry Eye
Detection of Acetylsalicylic Acid and Omega-3 Fatty Acids in Schirmers' Test Strips Using Mass Spectrometry
Evaluation of tear fluid production using Schirmers' tests is a well-known and frequently used examination method in ophthalmology.
- Trial name
- NCT05775536
- Testing
- Aspirin 500Mg Tab, Dr. Böhm® Omega 3 complex 870 mg
- Where
- Austria
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Dry Eye
20-20-20 Rule Plus Artificial Tears for Dry Eye
This study is for anyone struggling with dry, tired, or uncomfortable eyes, especially from long hours on screens. We all know that feeling after staring at a laptop or phone too long.
- Trial name
- NCT07896395
- Testing
- Artificial Tears (AT), 20/20/20 rule
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Zagazig University
Thyroid Eye Disease
AS-OCT of the Cornea in Thyroid Diseases
use the anterior segment optical coherence tomography (AS-OCT) to evaluate the tear meniscus parameters, total corneal thickness (CT), and epithelial thickness in active and inactive thyroid eye diseases (TED) patients and…
- Trial name
- NCT05241626
- Testing
- AS-OCT
- Where
- 2 sites in Egypt
- Volunteers
- 70 people
- Sponsor
- Minia University
Dry Eye Syndrome, Lipid Deficiency
Evaluation of SYSTANE® BALANCE in Dry Eye Subjects With Lipid Deficiency
The purpose of this study is to evaluate the repeated use of SYSTANE® BALANCE on stabilizing the tear film of dry eye patients with an unstable tear film.
- Trial name
- NCT01688726
- Testing
- SYSTANE® BALANCE eyedrops, Minims® Saline 0.9% eyedrops
- Volunteers
- 91 people
- Sponsor
- Alcon Research
Dry Eye
Efficacy of Quantum Molecular Resonance Combined With Intense Pulsed Light in Mixed Dry Eye
This study examines the effectiveness of combining Quantum Molecular Resonance (QMR) and Intense Pulsed Light (IPL) treatments for Mixed Dry Eye, a condition where both tear production and tear quality are compromised.
- Trial name
- NCT06576245
- Testing
- Quantum Molecular Resonance (QMR) Therapy, Intense Pulsed Light (IPL) Therapy, Tear Substitute Treatment (Supportive Therapy)
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- University of Seville
Environmental Exposure
Controlled Adverse Environment: A Pilot Study to Evaluate Tear Film Stability and Tear Evaporation
Dry eye and ocular surface disease account for a lot of morbidity and socio-economic burden in Asia and the rest of the world. This is a small pilot study to evaluate tear function under different conditions of humidity and…
- Trial name
- NCT01448356
- Testing
- temperature and humidity
- Where
- Singapore
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Singapore Eye Research Institute
Dry Eye
Evaluation of Extended Tear Film Break Up Time (TFBUT) With an Ocular Emulsion
The primary objective of this investigation will be to quantify the increase in tear film break-up time (TFBUT) associated with the instillation of a single eyedrop of an Ocular Emulsion in dry eye sufferers.
- Trial name
- NCT01368198
- Testing
- Systane Balance Lubricating Eye Drops, OPTIVE™
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Dry Eye Disease
Optical Coherence Tomography of Tear Film Dynamics In-Vivo
The purpose of this study is to evaluate a new instrument that takes digital images of tear film (a thin film that coats the eye that is made up of oil and water).
- Trial name
- NCT02554084
- Testing
- Optical Coherence Tomography
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Covid19, Eye Diseases
Tear Film SARS-nCoV-2 Detection in Symptomatic and Pauci-symptomatic Patients.
To investigate the presence of SARS-nCoV-2 in the tear film of symptomatic and pauci-symptomatic SARS-nCoV-2 positive patients.
- Trial name
- Eye-Covid (NCT04799704)
- Testing
- swabbing of conjunctiva
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dry Eye Syndrome
Evaluation of the Effect of Repeated Usage on the Tear Film Characteristics of an Investigational Eye Drop in Dry Eye Sufferers
The main objectives of the investigation will be to assess the effect of the repeated usage of an investigational eye drop on the tear film characteristics of dry eye sufferers and demonstrate the benefit of this eye drops for…
- Trial name
- NCT01339936
- Testing
- Carboxymethylcellulose sodium, glycerin and polysorbate 80
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Optometric Technology Group Ltd
Keratoconus
Changes in the Tear Film With Scleral Contact Lens Wear for Keratoconic Eyes
The purpose of this study is to investigate changes in the level of inflammatory mediators in the tear film of scleral contact lens wearers in a keratoconic population.
- Trial name
- NCT02806921
- Testing
- ZenLens
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Meibomian Gland Dysfunction
Efficacy of 0.05 % Cyclosporine Ophthalmic Emulsion Compare With Tear in Meibomian Gland Dysfunction
To evaluate the efficacy of 0.05% cyclosporine ophthalmic emulsion (Restasis® , Allergan) versus an artificial tears alone in patients with meibomian gland dysfunction that have abnormal tear quality and quantity by subjective…
- Trial name
- NCT00705510
- Testing
- 0.05% cyclosporin eye drop
- Where
- Thailand
- Volunteers
- 70 people
- Sponsor
- Mahidol University
Dry Eye
Effect of Intense Pulse Light (IPL) Treatment on Tear Film Osmolarity
Evaluate changes in tear film osmolarity and other DED signs/symptoms following treatment with IPL.
- Trial name
- NCT02992535
- Testing
- Intense Pulse Light Energy delivery (IPL)
- Volunteers
- 60 people
- Sponsor
- Carones Ophthalmology Center
Dry Eye Disease (DED)
Effects of NOV03 on the Tear Film
Determine the effect of a single instillation of NOV03 on the thickness and evaporation rate of the mucus-aqueous layer of the tear film
- Trial name
- NCT05723770
- Testing
- instillation of NOV03
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Bausch & Lomb Incorporated
Dry Eye Disease
Tear Film Stability After Instillation of Over-the-Counter (OTC) Artificial Drops
The goal of this research is to evaluate and compare the effectiveness of Systane® versus Optive™ on aqueous tear film stability in patients with a diagnosis of Dry Eye Syndrome and to determine the possible application for this…
- Trial name
- NCT00610480
- Testing
- 1st visit Optive, then 2nd visit Systane, 1st visit Systane, then 2nd visit Optive
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center