Clinical trials: Tear Film Deficiency
Health Behaviors, Artificial Intelligence (AI)
AI Chatbot-Based Learning on Dry Eye and Eye Strain Knowledge
The aim of this project is to evaluate the effectiveness of using chatbots for patient education about dry eye disease. The study will examine how the chatbot affects patients' levels of information, managing symptoms, and…
- Conditions
- Health Behaviors, Artificial Intelligence (AI), Chatbot, Dry Eye
- Trial name
- NCT06785155
- Testing
- Chatbot group, website assisted
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Gaziantep Islam Science and Technology University
Dry Eye
Keratometric Tear Breakup Time and Fluorescein Tear Breakup Time
The purpose of the research is to determine if putting fluorescein onto the eye (most common test done for dry eye syndrome) is an accurate way to measure dry eye symptoms.
- Trial name
- NCT00854906
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Myopic LASIK Candidates With Spherical Equivalent up to - 10 Diopters
Thin-Flap Laser in Situ Keratomileusis Associated Dry Eye
Laser in situ keratomileusis (LASIK) eye surgery continues to be the most common refractive procedure used to correct different forms of ametropia.
- Trial name
- NCT04831177
- Testing
- Laser in situ keratomileusis
- Where
- Egypt
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Assiut University
Dry Eye Syndrome, Sjogren's Syndrome
Exosome-miRNA and Transcriptome Profiling of Dry Eye Syndrome and Sjogren's Syndrome
This study combines data from two trials testing acupuncture (ACUDES) and a Chinese herbal tea bag TBDESJS for Dry Eye Syndrome and Sjögren's syndrome. Both treatments improved tear production.
- Conditions
- Dry Eye Syndrome, Sjogren's Syndrome, Xerophthalmia
- Trial name
- NCT06475027
- Testing
- TBDESJS, Acupuncture
- Where
- Taiwan
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Dry Eye Syndromes
ACCURATE Study for Subjects With Dry Eyes
To determine treatment and imaging outcomes in bilateral ocular surface disease management with an intracanalicular dexamethasone (0.4 mg) insert compared to standard topical over-the-counter artificial tears lubrication…
- Trial name
- ACCURATE (NCT04237012)
- Testing
- Dextenza 0.4Mg Intracanalicular Insert, Over the counter Artificial tears
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Eye Centers of Racine and Kenosha
Dry Eye Syndrome
Efficacy and Safety Study of HU00701/HU007 Eye Drops in Patients With Dry Eye Syndrome
A multicenter, Placebo controlled, Restasis® referenced, Randomized, Double blind, Phase II Study to Evaluate the Efficacy and Safety of HU00701/HU007 Eye Drops in Adult Patients with Dry Eye Syndrome
- Trial name
- NCT02917512
- Testing
- HU00701, HU007, Restasis
- Where
- South Korea
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Huons Co., Ltd.
Dry Eye, MGD-Meibomian Gland Dysfunction
Study on Prevention and Treatment of Dry Eye in Patients Using Glaucoma Drops
A multicenter randomized controlled trial on prevention and treatment of ocular surface injury and meibomian gland dysfunction in patients using anti-glaucoma eye drops.
- Trial name
- NCT03515187
- Testing
- 0.3% sodium hyaluronate ophthalmic solution, 0.1% sodium bromide solution, Meibomian gland massage
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Shenzhen Hospital of Southern Medical University
Dry Eye, Neurotrophic Keratitis
DOMPE -MT Neurotrophic Keratitis
TITLE: Toyos Clinic / A Phase 4 Study to Assess Longer Duration of Treatment with Cenegermin in Moderate to Severe Dry Eye-Associated Neurotrophic Keratitis
- Trial name
- NCT06947850
- Testing
- Cenegermin Ophthalmic Solution [Oxervate]
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Toyos Clinic
Dry Eye
Bilateral, Masked Comparison of PEG-400 Based Artificial Tear and Systane for the Treatment of Dry Eye Signs, Symptoms and Visual Quality
To evaluate and compare the effects of PEG-400 based artificial tear and Systane tears in mild-moderate dry eye patients. TBUT, Visual impact and subjective evaluations will be assessed in this month long trial.
- Trial name
- NCT00622037
- Testing
- PEG-400 based artificial tear, Systane
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Bp Consulting, Inc
Dry Eyes Chronic
Clinical Efficacy of Amniotic Membrane Extract Eye Drops in Dry Eye Treatment
This prospective longitudinal study aims at evaluating the clinical efficacy of human amniotic fluid extract eye drops in the treatment of dry eye disease.
- Trial name
- NCT05169931
- Testing
- RegenerEyes
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Healthy Volunteers, Sjögren's Syndrome
A Study to Evaluate the Effects of ASP5502 in Healthy Adults and Adults With Primary Sjögren's Syndrome
Primary Sjögren's syndrome (pSS) is a condition when the body's immune system attacks glands that produce fluids, such as the tear and saliva glands. This leads to dry eyes and a dry mouth.
- Trial name
- NCT06544642
- Testing
- ASP5502
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Global Development, Inc.
Dry Eye Syndromes
A Usability Study of External Neuromodulation With iTEAR100 Generation 2
A Usability Study of External Neuromodulation With iTEAR100 Generation 2. A study which evaluates user ability to train and access the iTEAR100 device in a telehealth environment.
- Trial name
- NCT05304650
- Testing
- iTEAR100
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Olympic Ophthalmics, Inc.
Dry Eyes
Dry Eye Symptoms and Quality of Life
Dry eye syndrome is a very common condition with multiple etiologies that includes systemic and ocular disease that causes reduction in the production of tears, as well as increase in tears evaporation.
- Trial name
- NCT01988597
- Testing
- Dry eyes
- Where
- Singapore
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Singapore National Eye Centre
MGD-Meibomian Gland Dysfunction
Single Lipiflow Treatment to Reduce Pharmacologic Burden in DED
Purpose: To evaluate the efficacy of vectored thermal pulsation treatment in subjects with a history of dry eye disease currently using a topical immunomodulator medication.
- Trial name
- Reduce (NCT06542276)
- Testing
- Thermal Vectored Pulsation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dunes Eye Consultants
Dry Eye Disease
Ocular Microbiome and Immune System in Dry Eyes
The primary objectives of this study are the characterization of the ocular microbiome as well as of the local immune system in participants with and without dry eye disease.
- Trial name
- NCT04658238
- Testing
- Ocular microbiome, Ocular immune system
- Where
- Switzerland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Dry Eye
Effect of Re-esterified Triglyceride (rTG) Form Omega-3 Supplements on Dry Eye Following Cataract Surgery
To evaluate the clinical outcomes of the systemic re-esterified triglyceride (rTG) form of omega-3 fatty acids in patients with dry eye symptoms after cataract surgery
- Trial name
- NCT04411615
- Testing
- Omega 3
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Dry Eye Disease
Clinical Efficacy of H.P. Acthar Gel 80 U/ml to Improve the Signs and Symptoms in Subjects With Dry Eye Disease
Study Title: A Phase 4 Study to Assess the Clinical Efficacy of H.P. Acthar Gel 80 U/ml to Improve the Signs and Symptoms in Subjects with Dry Eye Disease
- Trial name
- NCT03287635
- Testing
- Corticotropin 80Unit/Ml Repository Injection
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Toyos Clinic
Dry Eye Syndromes, Sjogren's Syndrome
TrueTear in Sjogren's Disease Patients
The purpose of this study is to evaluate acute tear production produced by the intranasal tear neurostimulator in participants with Sjögrens syndrome and aqueous tear deficiency.
- Trial name
- NCT03719885
- Testing
- TrueTear Intranasal Tear Neurostimulator
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Dry Eye Disease, Dry Eye Sensation
Study to Evaluating PRO-240 Ophthalmic Solution Compared to Optive®
This is a phase I clinical study to evaluating safety and tolerability of PRO-240 ophthalmic solution through the incidence of unexpected adverse events, as well as through changes in Best Corrected Visual Acuity (BCVA), and the…
- Conditions
- Dry Eye Disease, Dry Eye Sensation, Ocular Surface Disease
- Trial name
- NCT06375343
- Testing
- PRO-240, Optive®
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Laboratorios Sophia S.A de C.V.
Dry Eye
Dry Eye Screening and Referral System
Dry eye is one of the most common ocular surface diseases. Its pathogenic factors are related to multiple etiology. Because of the complexity of the pathogenesis of dry eye, the diversity of related examinations, and the…
- Trial name
- NCT04413370
- Testing
- Dry eye diagnostic test
- Where
- China
- Volunteers
- 1,273 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University