Clinical trials: Teeth; Lesion
Dental Caries in Children
Efficacy of a Chemically Activated Composite Resin Alkasite in Atypical Caries Lesions of Deciduous Teeth
Atypical cavities, which involve more than two surfaces being one of them vestibular or lingual/palatine, are a challenge for restorative dentistry, since the risk of failure of the restorations are related to the number of…
- Trial name
- NCT04195386
- Testing
- Dental Restoration with Chemically activated Composite resin Alkasite, Dental Restoration with Resin-Modified Glass ionomer Cement
- Where
- Brazil
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Faculty Sao Leopoldo Mandic Campinas
White Spot Lesion of Tooth
Effect of Low-viscosity Resin Infiltration on Color Change of Enamel White Spot Lesions
this study aimed to assess the effect of the application of the low-viscosity Icon resin infiltrate on the color change of the diagnosed white spot enamel lesions (WSLs) over 3-, 6-, and 12-m follow-up periods.
- Trial name
- NCT05757440
- Testing
- Icon resin application
- Where
- Egypt
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- National Research Centre, Egypt
Molar Incisor Hypomineralization
Effect of Enamel Cleaning on a Remineralizing Paste for Hypomineralizated Lesions
Molar-incisor hypomineralization (MIH) is a qualitative defect of dental enamel, in which low mineral content and high protein content compromise the effectiveness of remineralizing treatments.
- Trial name
- ECLIPSE (NCT07653373)
- Testing
- Sodium hypochlorite 5.25%, CPP-ACPF
- Where
- Brazil
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universidade Ceuma
Endodontically Treated Teeth
Evaluation of The Effect of 980nm Diode Laser Intracanal Irradiation on Levels of Interleukin-8 Expression
This clinical trial will be conducted to evaluate the amount of Il-8 expression before and after the application of intracanal irradiation with diode laser 980 nm versus placebo in failed endodontic cases with periapical lesions.
- Trial name
- NCT05603988
- Testing
- Intracanal Diode laser irradiation
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
White Spot Lesions [Initial Caries] on Smooth Surface of Tooth, Moringa Oleifera
Remineralization Efficacy of Moringa Oleifera Varnish Vs MI Varnish in Initial Carious Lesions Over 6 Months Follow Up: a Randomized Controlled Clinical Trial
This randomized clinical trial aimed to test the remineralization effect of laboratory prepared Moringa Oleifera based varnish compared to MI varnish (CPP-ACP) on incipient carious lesions.
- Trial name
- NCT06905379
- Testing
- Moringa Oleifera, Varnish
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
White Spot Lesion of Tooth
Efficacy of Different Agents in Treatment of Initial Caries on Smooth Surfaces in Permanent Teeth in Children
White spot lesions (WSL) are characterized by an apparently intact outer surface and a demineralized subsurface, and are considered the first clinical sign of dental caries.
- Trial name
- NCT05206539
- Testing
- Self-assembling peptide (P11-4), CPP-ACFP, Resin infiltration
- Where
- Bulgaria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Plovdiv Medical University
Dental Caries, Patient Compliance
A Study to Compare Caries Detection in the Pediatric Population Between the iTero Element 5D System and Bitewing Radiographs
This is a non-significant risk, single site, prospective clinical study. The study will be conducted in the department of pediatric dentistry of the faculty of dental medicine of the Hebrew university, Israel
- Trial name
- NCT05792631
- Testing
- Near infra red imaging
- Where
- Israel
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
White Spot Lesions, White Spot Lesions [Initial Caries] on Smooth Surface of Tooth
Assessing the Effects of Resin Infiltration and Resin Modified Glass Ionomer on the Color Changes of White Spot Lesions in a Clinical and Laboratory Setting
The goal of this clinical trial is to assess the efficacy of "Icon® resin infiltration" and "VanishTM XT varnish" in restoring the appearance of white spot lesions WSLs in healthy children affected with anterior white spot…
- Conditions
- White Spot Lesions, White Spot Lesions [Initial Caries] on Smooth Surface of Tooth, Enamel Hypomineralization
- Trial name
- RI (NCT06696105)
- Testing
- Resin infiltration, Vanish XT varnish (resin modified glass ionomer restoration)
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Dental Caries in Children, Pit and Fissure Sealant
Progression of Active Microcavitated Carious Lesions on Primary Molar Occlusal Surfaces
Objective: To verify the progression of active microcavitated carious lesions on occlusal surfaces of primary molars after the orientation of the brushing technique associated with fluoride dentifrice compared to resin sealant…
- Conditions
- Dental Caries in Children, Pit and Fissure Sealant, Toothbrushing
- Trial name
- NCT04127357
- Testing
- 1450 ppm fluoride toothpaste brushing x Resin sealing (FluroShield, Dentsply, Brazil).
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Faculty Sao Leopoldo Mandic Campinas
Demineralization, Tooth, White Spot Lesion of Tooth
Preventive Effects of Silver Diamine Fluoride on Early Enamel Caries
Fixed orthodontic patients are at risk of developing dental caries. Topical application of fluoride varnish (FV) around the orthodontic brackets and using fluoridated mouth rinses have been suggested to prevent the formation of…
- Conditions
- Demineralization, Tooth, White Spot Lesion of Tooth, Fixed Appliances, Early Caries Lesions
- Trial name
- NCT06797882
- Testing
- Silver diamine fluoride- potassium iodide, Fluoride varnish, 0.9 % saline
- Where
- Malaysia
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Root Canal Infection, Periapical Diseases
Microbial Load After Apical Enlargement in Asymptomatic Teeth With Periapical Lesion
The goal of this observational study is to define the role of apical shaping and irrigation activation on root canal cleanliness.
- Conditions
- Root Canal Infection, Periapical Diseases, Periapical; Infection, Endodontic Disease
- Trial name
- NCT06035185
- Testing
- apical shaping size
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Dental Caries, Microbial Colonization
Er:YAG Laser Effects on Microbial Population in Conservative Dentistry
The aim of this study is to verify the quantitative and qualitative effect of Erbium dental laser therapy on microbial populations in carious lesions and to compare the laser therapy with traditional conservative therapies.
- Trial name
- NCT04769882
- Testing
- Er:YAG Laser
- Where
- Italy
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University Of Perugia
Gingival Recession, Tooth Abrasion
Mucoderm® Versus CTG in the Treatment of Multiple Gingival Recessions Associated With Non-carious Cervical Lesion.
The aim of the present study is to compare two different multidisciplinary protocols using two types of grafts, porcine acellular dermal matrix (Mucoderm®) versus connective tissue graft, both associated with modified coronally…
- Trial name
- NCT03594513
- Testing
- MCAF, PR, CTG
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
White Spot Lesion of Tooth
Effect of Diode Laser With Dye and Remineralizing Agent on Surface Area of White Spot Lesions by Using Digital Subtraction Radiograph Techniques.
The current study was conducted to compare effect of diode laser and perio green dye with reminerlizing agent on surface area white spot lesions by using digital subtraction radiographic techniques.
- Trial name
- NCT07818655
- Testing
- remin pro
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Dental Caries, Dental Pulp Exposure
Stepwise and One Step Techniques In Deep Dentin Lesion
This double blind, randomized, controlled clinical trial aimed to observe the success of stepwise (SW) and one step (OneS) excavation techniques in the management of deep dentin caries.
- Trial name
- NCT04351048
- Testing
- Stepwise Excavation, One Step Excavation
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- TIJEN PAMIR
Attachment Loss, Tooth,Non Vital
Immediate Verses Delayed Surgical Periodontal Therapy After Endodontic Treatment in Endo Perio Lesion With Communication
The aim of the study is to conduct a prospective randomized clinical trial to evaluate the effect of immediate and delayed surgical periodontal therapy after non-surgical endodontic treatment on periodontal healing of the…
- Trial name
- NCT02630745
- Testing
- Immediate periodontal surgery, Delayed periodontal surgery
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Pulp Necroses, Periapical Lesion
Magnetic Resonance Imaging (MRI) of Pulp Regeneration
The present study was conducted to test whether pulp-like tissue can be regenerated in mature teeth with closed apex? And whether the size of the apical diameter affects the success of REPs? And whether Magnetic resonance imaging…
- Conditions
- Pulp Necroses, Periapical Lesion, Regeneration
- Trial name
- NCT03804450
- Testing
- Regenerative endodontic procedures (REPs)
- Where
- Egypt
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Pulp Disease, Dental
Effect of Cavity Disinfectants on Post Operative Pain & Success of Partial Caries Removal
To investigate The Effect of Sodium hypochlorite and Chlorhexidine as cavity Disinfectants on the post operative pain and Success of Partial Caries Removal in deep carious lesion with moderate pulpitis in permanent teeth
- Trial name
- NCT06836882
- Testing
- Selective caries removal, Selective caries removal with NaOCl, Selective caries removal with CHX
- Where
- India
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Dental Caries
Evaluation of Antimicrobial Photodynamic Therapy as an Adjunct Treatment of Deep Carious Lesions in Children
This project aims to evaluate the effect of antimicrobial photodynamic therapy (aPDT) in deep carious lesions. This study was approved by the Research Ethics Committee and was conducted on 53 patients between 3 and 12 years.
- Trial name
- NCT02908789
- Testing
- Antimicrobial photodynamic therapy (aPDT), Without Antimicrobial phothodynamic therapy
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Federal Fluminense
Root Caries
Silver Diamine Fluoride Treatment of Active Root Caries Lesions in Older Adults: A Case Series
The authors conducted a case series to determine the outcomes of treatment of root surface caries lesions when the teeth were treated topically with 38% silver diamine fluoride.
- Trial name
- NCT04370080
- Testing
- Silver Diamine Fluoride 38%
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Roseman University of Health Sciences