Clinical trials: Teeth; Lesion
Gingival Recession, Localized
Effect of Restoration Margin Level in the Treatment of Gingival Recession Associated With Non-carious Cervical Lesion
The aim of this randomized, parallel-group clinical trial was to compare the 1-year periodontal, root coverage, esthetic, and patient-centered outcomes of the partial restoration placement with different apical margin levels…
- Trial name
- NCT05682274
- Testing
- Partial restoration approach combined with CAF+CTG
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Gazi University
Dental Caries, Microbial Colonization
Er:YAG Laser Effects on Microbial Population in Conservative Dentistry
The aim of this study is to verify the quantitative and qualitative effect of Erbium dental laser therapy on microbial populations in carious lesions and to compare the laser therapy with traditional conservative therapies.
- Trial name
- NCT04769882
- Testing
- Er:YAG Laser
- Where
- Italy
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University Of Perugia
Pulp Necroses, Periapical Lesion
Magnetic Resonance Imaging (MRI) of Pulp Regeneration
The present study was conducted to test whether pulp-like tissue can be regenerated in mature teeth with closed apex? And whether the size of the apical diameter affects the success of REPs? And whether Magnetic resonance imaging…
- Conditions
- Pulp Necroses, Periapical Lesion, Regeneration
- Trial name
- NCT03804450
- Testing
- Regenerative endodontic procedures (REPs)
- Where
- Egypt
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Gingival Recession, Tooth Abrasion
Mucoderm® Versus CTG in the Treatment of Multiple Gingival Recessions Associated With Non-carious Cervical Lesion.
The aim of the present study is to compare two different multidisciplinary protocols using two types of grafts, porcine acellular dermal matrix (Mucoderm®) versus connective tissue graft, both associated with modified coronally…
- Trial name
- NCT03594513
- Testing
- MCAF, PR, CTG
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Demineralisation, White Spot Lesions
A Trial of Tooth Mousse to Remineralise Post-orthodontic Treatment White Spot Lesions
Fixed dental braces are associated with the risk of developing White Spot Lesions (WSLs), which appear as white chalky marks on the teeth.
- Conditions
- Demineralisation, White Spot Lesions, Orthodontic Treatment
- Trial name
- NCT01344473
- Testing
- Tooth Mousse creme (Casein Phosphopeptide)(RECALDENT)
- Where
- 2 sites in United Kingdom
- Volunteers
- 90 people
- Sponsor
- University of Dundee
Carious Teeth
Evaluation of Survival of Mature Second Premolar Treated With Regenerative Techniques
This study aims to compare the ability of different regenerative protocols in the treatment of mature necrotic
- Trial name
- NCT02915419
- Testing
- PRP, PRF
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries
Remineralizing Efficacy of Grape Seed Extract in Management of White Spot Lesion in Post Orthodontic Treated Patients.
This clinical trial will be conducted to compare the efficacy of grape seed extract oil versus sodium fluoride mouth wash in the management of remineralization in adult patients with white spot lesion over six months.
- Trial name
- NCT04357093
- Testing
- Grape seed extract mouthwash, Sodium fluoride mouthwash
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Asymptomatic Apical Periodontitis
Antimicrobial Effect of Calcium Silicate and Pectin as Intracanal Medications in Necrotic Teeth With Periapical Lesions
It is tackling antimicrobial resistance in endodontics, specifically comparing different intracanal medications used in root canal treatment.
- Trial name
- NCT07423663
- Testing
- Calcium Hydroxide Intracanal medication, Calcium silicate based intracanal medication, Pectin
- Where
- Egypt
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
Immature Teeth, Periapical Lesion
Three Techniques in Bioceramic Apexification for Necrotic Immature Incisors
The goal of this randomized clinical trial is to find the most effective Bioceramic-based apexification procedures in children with immature necrotic maxillary incisors.
- Trial name
- NCT06119477
- Testing
- Bioceramic Putty Apical Plugs, Single Cone Gutta-percha with Bioceramic Sealer, Combination of Bioceramic Putty and Sealer
- Where
- Syria
- Volunteers
- 45 people
- Sponsor
- Damascus University
White Spot Lesions, Caries
Randomized Trial on Resin Infiltration in Deciduous Teeth
It was hypothesized that resin infiltration in conjunction with fluoride varnish treatment of smooth-surface caries lesions in deciduous teeth reduce considerably the progression of treated caries lesions, compared to fluoride…
- Trial name
- infiltration (NCT01881100)
- Testing
- resin infiltration, fluoride varnish
- Where
- Poland
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
White Spot Lesion of Tooth
Efficacy of Different Agents in Treatment of Initial Caries on Smooth Surfaces in Permanent Teeth in Children
White spot lesions (WSL) are characterized by an apparently intact outer surface and a demineralized subsurface, and are considered the first clinical sign of dental caries.
- Trial name
- NCT05206539
- Testing
- Self-assembling peptide (P11-4), CPP-ACFP, Resin infiltration
- Where
- Bulgaria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Plovdiv Medical University
Dentin Sensitivity, Hypersensitivity
A Clinical Trial to Compare Lasotronix Alone or in Combination With CPP-ACP to Treat DH
Dentin hypersensitivity (DH) is defined as sharp pain of a shorter duration arise from exposed dentin in response to several chemicals and thermal or tactile stimuli that cannot be ascribed to other dental defects".
- Conditions
- Dentin Sensitivity, Hypersensitivity, Cervical Lesion
- Trial name
- NCT06463938
- Testing
- Active comparator, Experimental group, Combination of laser and paste
- Where
- Pakistan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Dental Caries, Secondary Dental Caries
Clinical Criteria for the Evaluation of Caries Lesions Around Restorations in Primary Teeth (CARDEC-03)
There is still great divergence in the aspects related to caries lesions around restorations. The methods and the systems used for the detection of secondary caries lesions have presented low validity.
- Trial name
- CARDEC-03 (NCT03520309)
- Testing
- Dental treatment
- Where
- Brazil
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Polycystic Ovary Syndrome, Dental Caries
Oxidative Stress in Polycystic Ovary Syndrome With Periodontal Disease and Dental Caries Lesions
This study evaluates the oxidative stress parameters in females with polycystic ovary syndrome (PCOS) and clinically healthy. Because of the fact that both oral disease included periodontitis and dental caries, and metabolic…
- Trial name
- NCT03594968
- Testing
- polycystic ovary syndrome
- Where
- Turkey (Türkiye)
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Tooth Sensitivity
Non-carious Cervical Lesions and Treatments
This study will compare clinically the efficacy, time to action and duration of different treatments for patients with non-carious cervical lesions (NCCLs) that caused dentin hypersensitivity (DH).
- Trial name
- NCCL (NCT03403088)
- Testing
- Experimental: • Group LA, Experimental: • Group DE, Experimental: • Group RGI
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Noncarious Cervical Lesions
Noncarious Cervical Lesion Treatment Outcomes
The overall objective of this three-armed randomized clinical trial (RCT) is to determine the comparative efficacy of three treatments for hypersensitive noncarious cervical lesions (NCLs): chemoactive dentifrice use, dentin…
- Trial name
- NCT00867997
- Testing
- Chemoactive (remineralizing, neuroactive) dentifrice treatment, Clearfil S3 Bond; Clearfil Liner Bond 2 Protect Liner F, Clearfil S3 Bond; Premise Flowable resin-based composite
- Where
- 17 sites in United States
- Volunteers
- 304 people
- Sponsor
- Pearl Network
White Spot Lesion of Tooth, Long Term Adverse Effects
Comparison of Efficacy Of Probiotic Toothpaste and Chlorhexidine Mouthwash To Reduce S.Mutans
Orthodontic appliance causes increase in plaque accumulation, especially around brackets, wires and attachments. Advances in orthodontics in recent time have led to improved quality of appliance and treatment procedures…
- Conditions
- White Spot Lesion of Tooth, Long Term Adverse Effects, Caries, Dental, Orthodontic Appliance Complication
- Trial name
- NCT03004196
- Testing
- Probiotic Toothpaste, Dr. Reddy's Clohex, Control Group
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Peoples University, Bhanpur, Bhopal
Dental Caries, Dental Restoration Failure
Clinical Performance of Posterior Composite Tooth Fillings in Adults
The purpose of this study is to determine whether a new tooth-colored composite material is effective for load-bearing dental fillings.
- Trial name
- NCT03175627
- Testing
- Filtek One, Filtek Z250
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
White Spot Lesion
Self-assembling Peptide With Sodium Fluoride in Treating White Spot Lesionss in Primary Teeth
Regenerative medicine-based approaches for caries treatment focus on biomimetic remineralization of initial carious lesions as a minimally invasive therapy using Self-Assembling Peptide P11-4 (CURODONTTM REPAIR) which enhances…
- Trial name
- NCT05721586
- Testing
- Self Assembling Peptide P11-4 (CURODONTTM REPAIR) + Fluoride varnish (DURAFLOR, Fluoride varnish (DURAFLOR
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Hams Hamed Abdelrahman
Caries; Initial, Occlusal Caries
Early Treatments for Preventing Occlusal Caries Lesions
Sealants effectively arrest non-cavitated caries lesions on the fully erupted occlusal surface of permanent teeth. However, the clinical effectiveness of sealants is uncertain in preventing occlusal caries lesions in partially…
- Conditions
- Caries; Initial, Occlusal Caries, Caries,Dental
- Trial name
- NCT05969756
- Testing
- Fluoride varnish, Conventional etch and rinse sealant, Self-etch sealant
- Where
- 2 sites in Vietnam
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Hue University of Medicine and Pharmacy