Clinical trials: Temporal Interference Stimulation (TIS)
Healthy Controls
Temporal Interference Stimulation for Social Cognition
The long-term goal of this project is to evaluate whether a procedure termed transcranial interference stimulation (tIS) may be useful in the future in the treatment of severe neuropsychiatric disorders such as schizophrenia.
- Trial name
- TISSC (NCT06607432)
- Testing
- Transcranial Interference Stimulation (tIS)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Columbia University
Temporal Interference Stimulation (TIS), Parkinson's Disease
Study on the Efficacy of Temporal Interference Stimulation (TIS) for Parkinson's Disease
The primary objective of this clinical study is to evaluate the therapeutic efficacy of Temporal Interference Stimulation (TIS), a non-invasive deep brain stimulation technique, in patients with Parkinson's disease, and to…
- Trial name
- NCT07312279
- Testing
- TIS
- Volunteers
- 24 people
- Sponsor
- Zhongnan Hospital
Temporal Interference Stimulation, Non Suicidal Self Injury
TIS for NSSI in Adolescent Depression
Temporal Interference Stimulation (TIS) has been successfully used to help patients with depression. However, its role in alleviating self injuries remained uncertain.
- Conditions
- Temporal Interference Stimulation, Non Suicidal Self Injury, Major Depressive Disorder
- Trial name
- NCT07554755
- Testing
- Active Temporal Interference Stimulation (TIS)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Second Hospital of Anhui Medical University
Parkinson Disease
Subthalamic Nucleus (STN)-Targeted Transcranial Temporal Interference Stimulation (TIS) for Parkinson's Disease: Efficacy and Safety From a Single-Center, Prospective, Double-Blind Randomized Controlled Trial
This is a single-center, prospective, double-blind, randomized controlled trial to evaluate the efficacy and safety of transcranial temporal interference stimulation targeting the subthalamic nucleus in patients with Parkinson's…
- Trial name
- TIS-STN-PD1 (NCT07361250)
- Testing
- NervioX-1000
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Tang Zhouping
Epilepsy
TIS for Drug Resistant TLE
Temporal interference (TI) stimulation is a new neuromodulation method. Compared with traditional neuromodulation therapy, TI has deep targeting and focusing, and it has been confirmed to modulate sleep, cognition, and movement…
- Trial name
- TITE-Effect (NCT07519018)
- Testing
- TI Stimulation
- Volunteers
- 30 people
- Sponsor
- Xijing Hospital
Cognitive Impairment Associated With Schizophrenia (CIAS)
TIS for Improving Cognitive Impairment Associated With Schizophrenia
This study aims to evaluate the efficacy and safety of TIS targeting the hippocampus in ameliorating cognitive impairment associated with schizophrenia (CIAS). Participants will receive TIS twice a day for 2 weeks.
- Trial name
- NCT07446478
- Testing
- temporal interference stimulation
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Central South University
Depressive Disorder, Temporal Interference Stimulation
Intervention Effect of Temporal Interference Stimulation (TIS) on Depressive Disorder
To investigate the effect of Temporal Interference Stimulation (TIS) on associative memory (AM) in patients with depressive disorder
- Trial name
- NCT07191392
- Testing
- Temporal Interference Stimulation (TIS)
- Where
- 2 sites in China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Second Hospital of Anhui Medical University
Schizophrenia Disorder, Cognitive Impairments
TIS for Improving Cognitive Impairment in Schizophrenia
This study aims to evaluate the efficacy, safety, and underlying neural mechanisms of TIS targeting the hippocampus in ameliorating cognitive impairment associated with schizophrenia (CIAS).
- Trial name
- NCT07647380
- Testing
- temporal interference stimulation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Central South University
Major Depressive Disorder
Amygdala MRI-TIS for Depression
The study utilizes a non-invasive deep brain stimulation (temporal interference, TI) technique primarily targeting the amygdala to preliminarily explore the clinical efficacy and potential mechanisms of MRI-compatible TI…
- Trial name
- NCT06461260
- Testing
- Nervio-X
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University
Mild Cognitive Impairment (MCI)
Hippocampal Temporal Interference Stimulation for Memory and Dual-Task Postural Control in Older Adults With Mild Cognitive Impairment
This trial aims to investigate whether a single session of 40 Hz hippocampal temporal interference stimulation can improve memory function and dual-task postural control among older adults with mild cognitive impairment (MCI).
- Trial name
- NCT07771036
- Testing
- Temporal Interference Stimulation
- Where
- China
- Volunteers
- 21 people
- Sponsor
- Shanghai University of Sport
Neuropathic Pain, tTIS
Effects and Mechanisms of Temporal Interference Stimulation (TIS) on Neuropathic Pain
This study employs temporal interference stimulation (tTIS) to investigate the analgesic effects of tTIS on neuropathic pain and monitor changes in neural plasticity, and explore the dynamic relationship between analgesic…
- Trial name
- TIS (NCT07735975)
- Testing
- Transcranial temporal interference stimulation
- Volunteers
- 60 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
PARKINSON DISEASE (Disorder)
TIS for Brain Network Modulation and Clinical Efficacy in Parkinson's Disease
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor dysfunction. While deep brain stimulation (DBS) is effective, its invasive nature limits its application in early-stage patients.
- Trial name
- PD TIS (NCT07480317)
- Testing
- Temporal Interference Stimulation (130 Hz), Temporal Interference Stimulation (40 Hz)
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Jiangsu Province Nanjing Brain Hospital
Major Depressive Disorder (MDD)
6 Weeks Right-Amygdala TIS for Depression
The current investigation employs a directed neuromodulation technique, specifically targeting the right amygdala, to ascertain its therapeutic efficacy in managing depressive episodes.
- Trial name
- NCT07059143
- Testing
- Nervio-X
- Where
- 3 sites in China
- Volunteers
- 38 people
- Sponsor
- Ruijin Hospital
Parkinson's Disease
Temporal Interference Stimulation on Motor Symptoms in Parkinson's Disease
The goal of this clinical trial is to learn whether a type of brain stimulation called transcranial temporal interference stimulation (TIS) of the internal globus pallidus (GPi) can help improve movement symptoms in people with…
- Trial name
- NCT07309198
- Testing
- Transcranial Temporal Interference Stimulation (TIS)
- Where
- China
- Volunteers
- 37 people
- Sponsor
- Shanghai University of Sport
Major Depressive Disorder
Amygdala TIS for Depression
The current investigation employs a directed neuromodulation technique, specifically targeting the right amygdala, to ascertain its therapeutic efficacy in managing depressive episodes.
- Trial name
- NCT06477276
- Testing
- Nervio-X
- Where
- 3 sites in China
- Volunteers
- 92 people
- Sponsor
- Ruijin Hospital
Major Depressive Disorder
Amygdala and dLPFC MRI-TIS for Depression in Adolescents
The study utilizes a non-invasive deep brain stimulation (temporal interference, TI) technique primarily targeting the amygdala to preliminarily explore the clinical efficacy and potential mechanisms of MRI-compatible TI…
- Trial name
- NCT06452849
- Testing
- Nervio-X
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University
PARKINSON DIS
Comparative Study of TIS Efficacy Across Different Targets
This prospective, randomized, participant- and outcome-assessor-blinded, parallel-group exploratory trial will compare the target-dependent clinical, neuroimaging, and electrophysiological effects of temporal interference…
- Trial name
- tTIS (NCT07745673)
- Testing
- TIS-STN, TIS-GP
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Zhongnan Hospital