Clinical trials: Temporal Lobe
Epilepsy
Evaluation of Memory and Forgetting in Patients With Epilepsy
Drug-resistant focal epilepsy (DRFE) is frequently associated with complications of varying severity that impair patient's quality of life.
- Trial name
- EPIMNESIE (NCT04924933)
- Testing
- Computerised associative memory task using abstract words and landscape photographs
- Where
- France
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Epilepsy, Epilepsy, Temporal Lobe
Brain Network Activation Analysis in Epilepsy
This is a prospective study investigating the utility of Brain Network Activation (BNA) analysis in patients with epilepsy.
- Trial name
- NCT03265925
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- ElMindA Ltd
Amnesia, Memory Disorder
How do Patients With Amnesia Acquire New Knowledge?
THE STUDY AIMS to constitute the largest group of patients with major memory impairment resulting from various etiology and specific lesions of the medial temporal lobe (MTL) and use a combined psychometric and neuroimaging…
- Trial name
- ASSAM (NCT07191197)
- Testing
- MRI, Psychometric
- Where
- 2 sites in France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders
Integrating Metabolism, Connectivity, and Mesoscale Imaging at Ultra-high Field to Decipher Mechanisms of Resilience and Neurodegeneration in Neurological Diseases and Healthy Aging
The MESO7 study is a prospective observational research project designed to investigate the mechanisms of resilience and neurodegeneration in neurological diseases and healthy aging.
- Conditions
- Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders, Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD), Alzheimer Disease
- Trial name
- MESO7 (NCT07202494)
- Testing
- Imaging Techniques (MRI 3T & 7T, Functional, Structural, and Metabolic Imaging)
- Where
- France
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Epilepsies, Partial
MRI in Autosomal Dominant Partial Epilepsy With Auditory Features
This study will examine the possible structural and functional abnormalities in patients with an inherited form of epilepsy. It will use magnetic resonance imaging (MRI).
- Trial name
- NCT00072813
- Where
- 2 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Neural Bases of Speech Perception
Left and Right Hemisphere Contributions to Speech Perception
Left and right temporal brain areas are thought to contribute to speech perception, but the division of labor between left and right hemisphere regions is still unclear.
- Trial name
- NCT04989309
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Alzheimer's Disease
Memory Imaging of Normal Aging
The purpose of this study is to develop imaging techniques that can distinguish functional brain changes in people at high risk for dementia years prior to onset of clinical memory problems from those with normal changes of aging.
- Trial name
- NCT00315575
- Testing
- BOLD and Perfusion brain MRI
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Epilepsy, Epilepsy, Temporal Lobe
Language Mapping in Patients With Epilepsy
This study will examine how certain language skills, such as naming objects, understanding spoken language and reading are organized in the brain and how they are affected by seizures.
- Conditions
- Epilepsy, Epilepsy, Temporal Lobe, Partial Epilepsy
- Trial name
- NCT00706160
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Epilepsy
Evaluation of Stress Sensitivity and Hyperemotivity in Epilepsy Compared to and a Group of Healthy Volunteers
Recently, a possible subtype of temporal lobe epilepsy (TLE) has been proposed: this subtype presents ipsilateral amygdala enlargement (AE) without any other lesion.
- Trial name
- STELLA (NCT03464370)
- Testing
- Measure of emotional stressors
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Brain Diseases, Memory Disorders
Low Intensity Focused Ultrasound for Learning and Memory and Emotion Regulation
The goal of this clinical trial is to investigate the impact of low intensity focused ultrasound pulsation (LIFUP) to two different brain regions, the amygdala and entorhinal cortex, in older adults.
- Conditions
- Brain Diseases, Memory Disorders, Learning Disabilities, Cognitive Impairment
- Trial name
- LIFUPMEMEMOT (NCT03717922)
- Testing
- Low Intensity Focused Ultrasound Pulsation to Amygdala, Low Intensity Focused Ultrasound Pulsation to Entorhinal Cortex
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Epilepsy, Temporal Lobe
Study of [11C]DPA-713 for Temporal Lobe Epilepsy
Background: Some people with epilepsy have an epileptic focus, a small part of the brain that is the starting point of the seizure. This focus is like an irritant or an inflammation, and helps cause the seizure.
- Trial name
- NCT01793532
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Focal Epilepsy, Temporal Lobe Epilepsy
Spatial Scene Recognition Memory in Epilepsy Surgery
This study investigates the anatomical and physiological basis of spatial scene recognition memory in patients with temporal lobe epilepsy and temporal lobe lesions.
- Conditions
- Focal Epilepsy, Temporal Lobe Epilepsy, Medically Refractory Epilepsy, Memory Disorders
- Trial name
- NCT07580183
- Testing
- Virtual Tour Recognition Memory Task, Intracranial EEG Recording with Research Electrodes (Aim III only), MRI Neuroimaging and Neuropsychological Assessment (Aim I)
- Where
- 2 sites in United States
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Epilepsy, Temporal Lobe, Temporal Lobe
Light Scattering Spectroscopy to Determine Brain Tumors
This study will use light scattering spectroscopy (LSS) to analyze brain tissue removed from patients during brain surgery to determine if this new technology can be used to differentiate between normal and cancerous cells.
- Trial name
- NCT00067418
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Healthy
Magnetic Resonance Imaging of the Brain in Emotional Processing
This study will use magnetic resonance imaging (MRI) to identify brain regions involved in performing certain tasks, especially those involving emotions.
- Trial name
- NCT00061204
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Mild Cognitive Impairment
Linking Tau PET to Medial Temporal Lobe Subregions With High Resolution MRI
The investigators will conduct a tau PET scan in cognitively normal older adults and patients with Mild Cognitive Impairment (MCI), enrolled in the National Alzheimer's Coordinating Center (NACC) study at the University of…
- Trial name
- NCT04251130
- Testing
- 2-(2-([18F]fluoro)pyridin-4-yl)-9H-pyrrolo[2,3-b:4,5-c']dipyridine
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Temporal Lobe Epilepsy (TLE)
MRI Volumetry and Diffusion Tensor Imaging in Temporal Lobe Epilepsy
This works aims at evaluating the diagnostic performance of combined MRI Volumetry, Diffusion tensor imaging and Conventional MRI in lateralizing the epileptogenic focus in patients with temporal lobe epilepsy and correlate these…
- Trial name
- NCT07384351
- Testing
- MRI
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Assiut University
Not Applicable - Healthy Participants, Focus is the Memory System
MEMRI: Memory Emergence Using MRI
Episodic memory is our ability to remember personal experiences, such as a birthday party or a visit to the park. This study aims to understand how this type of memory develops during the first two years of a baby's life.
- Conditions
- Not Applicable - Healthy Participants, Focus is the Memory System, Paediatric
- Trial name
- MEMRI (NCT07849075)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Paediatric Neuroimaging Research Group
Healthy, Schizophrenia
Electrophysiology and Blood Flow in Patients With Schizophrenia and Their Siblings
This study will explore how the brain works during memory testing in an effort to understand why some patients with schizophrenia have memory difficulties.
- Trial name
- NCT00001921
- Where
- United States
- Volunteers
- 1,386 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Epilepsy, Temporal Lobe
Language and Emotional Function in Patients With Temporal Lobe Epilepsy
This study uses functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) to examine how the brain processes tasks involving language and emotion in normal volunteers and in patients with epilepsy.
- Trial name
- NCT00081432
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Effect of Deep Transcranial Magnetic Stimulation on Memory
Facilitating Associative Memory Via Deep Transcranial Magnetic Stimulation to the Medial Temporal Lobe
The goal of the proposed research is to map the effects-in particular facilitation-of Transcranial Magnetic Stimulation (TMS) of the Medial Temporal Lobes (MTL) onto the processing of associative memory.
- Trial name
- NCT01599208
- Testing
- TMS
- Volunteers
- healthy volunteers welcome
- Sponsor
- Brainsway