Clinical trials: Temporal Summation
Cervical Proprioceptive Error in Healthy Young Individuals
Proprioceptive Puzzle: Effects on Quantitative Sensory Tests and Body Awareness
Background: Cervical proprioception, referring to the awareness of the head's position in space, plays a crucial role in maintaining postural control and preventing musculoskeletal injuries.
- Trial name
- NCT06559397
- Testing
- Assessment of cervical proprioception
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nagihan Acet
Healthy
Effects of Trancutaneous Auriculotemporal Nerve Stimulation
Neuromodulation works by either actively stimulating nerves, causing the alteration or modulation of nerve activity by delivering electrical agents directly to a target area.
- Trial name
- NCT07184190
- Testing
- Trancutaneous Auriculotemporal Nerve Stimulation
- Where
- Argentina
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Gran Rosario
Dyspareunia
What is the Nature of Pelvic Floor Muscle Involvement in Dyspareunia?
Dyspareunia, or pain experienced by women during penetrative sexual activities, affects the psychological and sexual health of more than one in five Canadian women [1], yet its pathophysiology is poorly understood [2-4] and…
- Trial name
- NCT04234555
- Testing
- Corticomotor excitability to the pelvic floor muscles, Pelvic floor muscle response to pressure applied at the vulvar vestibule, Pressure pain threshold (PPS)
- Where
- Canada
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Pain, Low Back Pain
Role of Thoracolumbar Fascia Stretching on Pain Parameters With Non-Specific Chronic Low Back Pain
Role of Thoracolumbar Fascia Stretching on Pain Parameters with Non-Specific Chronic Low Back Pain
- Trial name
- NCT06310096
- Testing
- TLF fascial stretching exercise, conventional physiotherapy program.
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Atılım University
Hysterectomy, Chronic Pain
Evaluation of Central Sensitization, Fear-Avoidance, and Pain-Pressure Threshold With Chronic Pain After Hysterectomy
Phase 1 (started in July 2019): Central Sensitization Inventory (CSI), Fear-Avoidance Components Scale (FACS), pain-pressure threshold are factors associated with chronic post-hysterectomy pain (CPHP), but a complete…
- Conditions
- Hysterectomy, Chronic Pain, Central Sensitisation, Anxiety Depression
- Trial name
- EPOCH (NCT04014829)
- Testing
- Pain-Pressure Threshold, Mechanical Temporal Summation, Hospital Anxiety and Depression Scale
- Where
- Singapore
- Volunteers
- 436 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Pain, Transcranial Direct Current Stimulation
Transcranial Versus Suboccipital Direct Current Stimulation
Randomized controlled trial, in parallel with cross-control design. Two groups of healthy subjects will be randomly selected to transcranial stimulation group or suboccipital stimulation group.
- Trial name
- NCT04117256
- Testing
- Direct Current Stimulation
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Back Pain, Back Pain With Radiation
Changes in Radicular Pain and Pain Modulation
The objectives of this study are: 1)To investigate the difference in pain modulatory mechanisms using quantitative sensory testing (QST) between healthy controls and patients with radicular leg pain due to nerve root compression.
- Trial name
- NCT04193969
- Testing
- Pressure pain assessment using computer controlled cuff algometry, Temporal summation (TS), Conditioned pain modulation (CPM)
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Spine Centre of Southern Denmark
Sensitivity
Effects of Acute Intermittent Hypoxia on Sensory Function in Healthy Adults
Exposure to acute intermittent hypoxia (AIH) can facilitate of motor output but no studies of sensory effects has been reported.
- Trial name
- SensoryFLO (NCT03283072)
- Testing
- Intervention 1, Intervention 2, Intervention 3
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Florida
Neck Pain
Sensory Characteristics and Psychosocial Factors Related With Non-specific Neck Musculoskeletal Pain Chronification
Chronic pain is commonly defined as any pain which lasts more than 12 weeks. Chronic non-specific neck pain (CNSNP) has no specific underlying disease causing the pain.
- Trial name
- CNSNP (NCT04330573)
- Testing
- No intervention. Observational study
- Where
- Spain
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Universidad San Jorge
Pain Intensity
The Effect of Transauricular Electrical Vagal Nerve Stimulation on Temporal Summation of Pain in Patients With Back Pain
The effect of transauricular electrical vagal nerve stimulation (taVNS) will be studied on temporal summation of heat pain (TSP) in 30 patients with chronic low-back pain and in 30 heathy volunteers.
- Trial name
- TVNS_TSP_LBP (NCT04503889)
- Testing
- Transauricular electrical vagal nerve stimulation
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Pain, Pregnancy
The Effect of Pregnancy on Temporal Summation and Venipuncture Pain Perception
Recent studies have shown that women are more likely to experience pain in many medical situations. During pregnancy, women may experience an increase in pain threshold.
- Trial name
- NCT01017861
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Diabetes Mellitus (DM)
Central Sensitization in Painful and Painless Diabetic Peripheral Neuropathy
This research is structured as a cross-sectional observational study. The primary objective is to compare central sensitization across painful and painless phenotypes of diabetic peripheral neuropathy.
- Trial name
- NCT07316322
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Inonu University
Gynecological Disorder
Timing of Rocuronium After Induction With Propofol on Temporal Summation of Pain
Temporal summation of pain, which is defined as the perception of increasingly greater pain evoked by repetitive painful stimuli, is highly variable between individuals.
- Trial name
- NCT04547608
- Testing
- The difference of the timing of rocuronium administration after propofol injection
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wonkwang University Hospital
Chronic Low Back Pain (CLBP), Chronic Insomnia
Studying the Neurobiological Mechanisms of Non-specific Chronic Low Back Pain and Chronic Insomnia: a Four-group Cross-sectional Study
This study is a part of a larger project aiming to evaluate the neurobiological mechanisms underlying the relationship between sleep and pain in people with non-specific chronic low back pain.
- Conditions
- Chronic Low Back Pain (CLBP), Chronic Insomnia, Neuroinflammation
- Trial name
- SY-NAPS-CS (NCT06973837)
- Testing
- Real-life monitoring, experimental pain testing, brain imaging, blood and stool sampling.
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Central Sensitisation, Elbow Pain
Relation Between Temporal Summation and Fatigue
Central sensitization (CS) is a common feature in chronic musculoskeletal pain conditions including rheumatoid arthritis, chronic whiplash syndrome, fibromyalgia, temporomandibular joint disorders, low back pain and lateral elbow…
- Conditions
- Central Sensitisation, Elbow Pain, Fatigue
- Trial name
- NCT05146960
- Testing
- Temporal summation
- Where
- Belgium
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University Ghent
Histamine, Cowhage
Itch Sensation Induced by Multiple Applications of Pruritogens (temporal Summation)
In This experiment, the investigators would like to design a new itch model based on the temporal summation of pruritic stimuli.
- Trial name
- NCT06328543
- Testing
- Histamine, Cowhage
- Where
- Denmark
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Low Back Pain, Compare Pain Modulation Assessments in Pain-free Cohorts
Pain Modulation - Experimental Assessments Using Different Modalities
The goal of this study is to investigate how different painful stimuli are processed and modulated in the nervous system. In various pain conditions, including low back pain, often no specific source can be identified as the…
- Trial name
- NCT04323293
- Testing
- Cold Water Bath, Neutral Water Bath
- Where
- Switzerland
- Volunteers
- 705 people, healthy volunteers welcome
- Sponsor
- Schweinhardt Petra
Hyperalgesia, Pain Perception
Session-Order Sensitivity of TS and OA in a Capsaicin Crossover Model
Temporal summation (TS) and offset analgesia (OA) are widely used psychophysical endpoints in pain research that index different components of central nociceptive processing.
- Conditions
- Hyperalgesia, Pain Perception, Central Nervous System Sensitization, Pain Threshold
- Trial name
- TS-OA-Cap (NCT07625475)
- Testing
- Topical 0.075% capsaicin cream (Zostrix), Topical vehicle lotion (Lubriderm)
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Healthy
The Effect of the Nature And Frequency of a Stimulation on the Amplitude of the Temporal Summation of Pain
Temporal summation is a mechanism that enhances pain perception. It is a natural mechanism present in most individuals. Generally, temporal summation is measured by the application of a moderately painful stimulation for several…
- Trial name
- NCT05006066
- Testing
- Temporal Summation
- Where
- Canada
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke