Clinical trials: Tenecteplase
Acute Ischemic Stroke
Early Administration of Tirofiban in Patients Treated With Tenecteplase for Acute Ischemic Stroke
The purpose of this study is to assess the safety and efficacy of early administration of tirofiban in patients treated with tenecteplase for acute ischemic stroke.
- Trial name
- INSTANT (NCT05604638)
- Testing
- Tirofiban Hydrochloride
- Where
- 38 sites in China
- Volunteers
- 348 people
- Sponsor
- Second Affiliated Hospital of Guangxi Medical University
Ischemic Stroke, Medium Vessel Occlusion
Intra-arterial Tenecteplase for Acute Medium Vessel Occlusion Stroke
The ANGEL-MeVO-TNK is a multicentered, prospective, randomized, open label, blinded endpoint (PROBE) phase III trial. A total of 488 AIS patients (age ≥18 years) with acute MeVO-AIS (occlusion of the M2/M3, the A1/A2/A3, the…
- Conditions
- Ischemic Stroke, Medium Vessel Occlusion, Tenecteplase, Endovascular Treatment
- Trial name
- ANGEL-MeVO-TNK (NCT07357987)
- Testing
- Intra-arterial Tenecteplase, standard medical management
- Where
- China
- Volunteers
- 488 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke
Efficacy and Safety of Tenecteplase Intravenous Thrombolysis in Acute Posterior Circulation Ischemic Stroke Within 4.5-24 Hours After Onset
This study aims to evaluate the efficacy and safety of tenecteplase (TNK) intravenous thrombolysis within the extended time window (4.5 to 24 hours) in patients with acute posterior circulation ischemic stroke.
- Trial name
- NCT07094763
- Testing
- TNK plus standard medical treatment, standard medical management
- Where
- China
- Volunteers
- 406 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Acute Ischemic Stroke, Large Vessel Occlusion
Tenecteplase or Reteplase as Bridging Thrombolysis Before Thrombectomy in Acute Ischemic Cerebrovascular Events
Acute ischemic stroke caused by large vessel occlusion (LVO) is a major cause of disability, and mechanical thrombectomy (MT) has become the standard treatment for eligible patients.
- Conditions
- Acute Ischemic Stroke, Large Vessel Occlusion, Anterior Circulation Brain Infarction
- Trial name
- TRACE- BRIDGE (NCT07748039)
- Testing
- rhTNK-tPA (0.25mg/kg), Reteplase 10 Units (U) plus a second dose of reteplase 10 U, No thrombolysis (thrombectomy alone)
- Where
- 5 sites in China
- Volunteers
- 1,440 people
- Sponsor
- Yongjun Wang
Myocardial Infarction
Trial to Compare the Efficacy and Safety of a Single Bolus of TNK-tPA (Tenecteplase, Metalyse®) With Accelerated Infusion of Rt-PA (Alteplase, Actilyse®) in Asian Patients With Acute Myocardial Infarction
The objective of this trial was to compare the efficacy and safety of a single bolus of TNK-tPA (tenecteplase, Metalyse®) compared with rt-PA (alteplase, Actilyse®) in Asian patients.
- Trial name
- NCT00148460
- Testing
- TNK-tPA, rt-PA
- Where
- 18 sites in China, Hong Kong and 1 more
- Volunteers
- 270 people
- Sponsor
- Boehringer Ingelheim
Acute Ischemic Stroke
Tenecteplase Compared to Alteplase for Patients With Large Vesel Oclusion Suspicion Before Thrombectomy
Background: The TNKCAT trial represents an innovative approach to optimize timely reperfusion in the Mothership and Drip-and-Ship scenarios.
- Trial name
- NCT05626972
- Testing
- Tenecteplase
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Acute Ischemic Stroke
Efficacy and Safety of Intra-arterial Tenecteplase in Acute Ischemic Stroke Patients With Medium Vessel Occlusion Stroke (DATE-MeVO)
DATE-MeVO is an investigator-initiated, multicenter, prospective, randomized controlled, open-label, blinded endpoint (PROBE) clinical trial aiming at evaluating the efficacy and safety of tenecteplase combined with standard…
- Trial name
- NCT07469293
- Testing
- Intra-arterial thrombolysis, Standard medical treatment
- Where
- 45 sites in China
- Volunteers
- 488 people
- Sponsor
- Southwest Hospital, China
Ischemic Stroke
TNK-tPA Evaluation for Minor Ischemic Stroke With Proven Occlusion
This trial will enroll patients that have been diagnosed with a transient ischemic attack (TIA) or minor stroke that has occurred within the past 12 hours.
- Trial name
- TEMPO-1 (NCT01654445)
- Testing
- Tenecteplase
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Calgary
Ischemic Stroke
Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis
The principle research question is: in patients with acute ischaemic stroke eligible for intravenous (IV) thrombolysis, is tenecteplase superior in efficacy to alteplase, based on functional outcome as assessed by modified Rankin…
- Trial name
- ATTEST2 (NCT02814409)
- Testing
- Intravenous recombinant tissue plasminogen activator (rtPA) Alteplase, Intravenous Tenecteplase
- Where
- United Kingdom
- Volunteers
- 1,858 people
- Sponsor
- NHS Greater Glasgow and Clyde
Acute Myocardial Infarction
An Observational Study of TNKase in Patients Enrolled in the National Registry of Myocardial Infarction 4 and 5 (POST)
The POST study comprised patients whose data were entered into the NRMI 4 and 5 databases. NRMI is a prospective, observational study of patients presenting with AMI in the United States.
- Trial name
- NCT00669045
- Volunteers
- 253,668 people
- Sponsor
- Genentech, Inc.
Acute Ischemic Stroke
Tenecteplase for Late-Window Stroke Guided by DWI-FLAIR Mismatch
The goal of this clinical trial is to evaluate the efficacy and safety of tenecteplase administered 4.5-9 hours after stroke onset (defined as the time the patient was first found with symptoms, including wake-up stroke and…
- Trial name
- TRUST-MISMATCH (NCT07540416)
- Testing
- TNK-tPA, Aspirin
- Where
- China
- Volunteers
- 564 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Basilar Artery Occlusion, Acute Cerebrovascular Accident
Intravenous Tenecteplase Plus EVT Versus EVT Alone on 4.5 to 24 Hours After Basilar Artery Occlusion
To assess the effect of intravenous tenecteplase plus endovascular thrombectomy (EVT) compared to EVT alone on 4.5 to 24 hours after stroke due to basilar artery occlusion.
- Conditions
- Basilar Artery Occlusion, Acute Cerebrovascular Accident, Stroke Due to Basilar Artery Occlusion
- Trial name
- NCT05701956
- Testing
- Tenecteplase, Endovascular thrombectomy
- Where
- China
- Volunteers
- 330 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Ischemic Stroke, Stroke, Acute
Tenecteplase in Wake-up Ischaemic Stroke Trial
Stroke is a leading causes of death and disability. At least 20% of strokes occur during sleep, so- called 'wake up stroke'. Thrombolysis with the clot-busting drug alteplase is effective for acute ischaemic stroke, provided that…
- Trial name
- TWIST (NCT03181360)
- Testing
- Tenecteplase, Control
- Where
- 83 sites in United States, Denmark and 9 more
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University Hospital of North Norway
Ischemic Stroke
Tenecteplase Versus Alteplase in Ischemic Stroke Management (TALISMAN)
This is a double-blind parallel arm randomized trial aimed to assess efficacy and safety of intravenous Tenecteplase compared to intravenous Alteplase in eligible patients who present with symptoms of acute ischemic stroke within…
- Trial name
- TALISMAN (NCT02180204)
- Testing
- Tenecteplase, Alteplase
- Where
- United States
- Sponsor
- Reza Behrouz, DO
Ischemic Stroke
Adjunctive Intra-arterial Tenecteplase Following Mechanical Thrombectomy Pilot Trial
Prospective, single center, non-randomized, pilot study to assess the feasibility of IA TNK following standard of care mechanical thrombectomy (MT) in patients with AIS.
- Trial name
- ALLY (NCT05172934)
- Testing
- intra-arterial tenecteplase
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- ProMedica Health System
Stroke, Ischemic
Tenecteplase REperfusion in Acute Ischemic sTroke Registry（TREAT）
The aim of the study was to establish tenecteplase thrombolysis database and to investigate the effectiveness and safety of rhTNK-tPA in acute ischemic stroke patients.
- Trial name
- NCT05724342
- Testing
- rhTNK-tPA Thrombolysis
- Where
- China
- Volunteers
- 1,600 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke Due to Medium-vessel-occlusion
Dual IntraVenous Thrombolysis Approach (DIVA) in Patients With Medium-vessel-occlusion Strokes: a Retrospective Study
The purpose of this study (Dual IV thrombolysis Approach (DIVA) study) is to assess a new medical strategy for Medium-vessel-occlusion (MeVO) strokes, based on a second IV thrombolysis with tenecteplase (TNK) for persistent…
- Trial name
- DIVArétro (NCT05809921)
- Testing
- alteplase, Alteplase + possible complementary IVT with tenecteplase
- Where
- France
- Volunteers
- 294 people
- Sponsor
- Centre Hospitalier Sud Francilien
THROMBOLYSIS
Tenecteplase in Stroke Patients Between 4.5 and 24 Hours
This study will evaluate the efficacy and safety of tenecteplase compared with placebo in participants with acute ischemic stroke (AIS).
- Trial name
- TIMELESS (NCT03785678)
- Testing
- Tenecteplase
- Where
- 97 sites in United States, Canada
- Volunteers
- 458 people
- Sponsor
- Genentech, Inc.
Acute Respiratory Distress Syndrome
Treatment of Acute Respiratory Distress Syndrome With Tenecteplase: A Dose Escalation Pilot Study
The pathogenesis of ARDS appears to be from damage to the alveolar-capillary barrier, which is composed of the microvascular endothelium and the alveolar epithelium. This damage may occur from direct or indirect lung injury.
- Trial name
- NCT00431379
- Testing
- Tenecteplase
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Intravenous, Thrombosis
Intravenous TNK vs TPA for AIS Treatment on MSU,a Prospective Multicenter RCT
Acute ischemic stroke is one of the devastating diseases that increase hospitalization, disabilities, and deaths worldwide. Current treatment with intravenous thrombolytic agent can help reduce disabilities and improve quality of…
- Conditions
- Intravenous, Thrombosis, Acute Ischemic Stroke
- Trial name
- NCT06498323
- Testing
- tenecteplase
- Where
- Thailand
- Volunteers
- 160 people
- Sponsor
- Mahidol University