Clinical trials: Termination of Pregnancy
Infertility, Intellectual Disability
Prospective Study to Assess Medical Performance of Optical Mapping and Long Read Sequencing in Detecting Numerical and Structural Chromosome Abnormalities
Chromosomal aberrations are major causes of developmental disorders (Intellectual disability (ID), multiple congenital anomalies (MCA), autism spectrum disorders (ASD)) as well as reproductive disorders (RD) in particular…
- Conditions
- Infertility, Intellectual Disability, Malformation, Miscarriage
- Trial name
- CHROMAPS (NCT05290051)
- Testing
- Optical Genome Mapping (Bionano®), Longread sequencing (Nanopore®)
- Where
- France
- Volunteers
- 350 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Pregnancy Loss, Early, Major Depression
Effect of Participating in a Study of Causes of Pregnancy Loss on Mental Health Outcomes: A Target Trial Emulation Using the COPL Cohort and Danish National Registries
Pregnancy loss is the most common severe pregnancy complication and is associated with significant mental health sequelae, including depression and anxiety.
- Conditions
- Pregnancy Loss, Early, Major Depression, Anxiety, Stress (Psychology)
- Trial name
- NCT07684677
- Testing
- COPL participation
- Where
- Denmark
- Volunteers
- 30,000 people
- Sponsor
- Amager Hospital
Hemorrhage, Obstetric, Uterine Abnormality
Evaluation of the Non-inferiority of Resorbable Gelatin Embolization Compared to Embolization Combined With Endometrial Aspiration for the Management of Hemorrhagic Uterine Vascular Abnormalities Following Premature Termination of Pregnancy
The goal of this clinical trial is to determine the best treatment for patients who experience vaginal bleeding following a premature termination of pregnancy.
- Conditions
- Hemorrhage, Obstetric, Uterine Abnormality, Uterine Artery Embolization, Vaginal Bleeding During Pregnancy
- Trial name
- NIEMBUT (NCT07206342)
- Testing
- embolization therapy, embolization followed by aspiration
- Where
- 4 sites in France
- Volunteers
- 110 people
- Sponsor
- University Hospital, Grenoble
Cervical Insufficiency
Azithromycin for Cerclage Prophylaxis
The primary goal is to assess the effectiveness in pregnancy prolongation utilizing azithromycin at the time of transvaginal cervical cerclage placement.
- Trial name
- NCT07608562
- Testing
- Azithromycin Prophylaxis, Cefazolin, Progesterone
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Wake Forest University Health Sciences
Infertility, Miscarriage
A Trial of Sperm Injection (PICSI) on Miscarriage Rates in Assisted Conception
Physiological intracytoplasmic sperm injection (PICSI) is a technique used to select healthy, mature sperm for use in infertility treatment based on their physiological ability to bind to hyaluronan (HA), a natural compound found…
- Trial name
- PICSI (NCT05762770)
- Testing
- PICSI
- Where
- United Kingdom
- Volunteers
- 140 people
- Sponsor
- Shrewsbury and Telford Hospitals NHS Trust
Subfertility
Does Hormonal Luteal Support After Intra-uterine Insemination (IUI) Increase the Pregnancy Rate?
A randomized study to investigate if hormonal luteal support after intra-uterine insemination (IUI) in ovulation induction cycles with human menopausal gonadotropin increases the pregnancy rate
- Trial name
- NCT00700492
- Testing
- progesterone
- Where
- Belgium
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gasthuisberg
Abortion Early, Abortion in First Trimester
Delivery of Audiovisual Information on Early Medical Abortion
The majority of abortions in the United Kingdom (UK) are performed before 9 weeks (63 days) gestation using a method known as Early Medical Abortion (EMA).
- Trial name
- EMAVID (NCT03417362)
- Testing
- Animation
- Where
- 3 sites in France, Sweden and 1 more
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- NHS Lothian
Missed Abortion
Comparison of Efficacy and Safety of Oral Versus Vaginal Misoprostol in Missed Abortion in First Trimester of Pregnancy
Incomplete abortion has an eminent clinical diagnosis and is characterized by transvaginal bleeding associated with an open uterine cervix upon physical examination when the products of conception have not been wholly discharged.
- Trial name
- NCT07526064
- Testing
- Oral misoprostol, Misoprostol (given vaginally)
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Hamna Khaliq
Pain Management, Anti-Inflammatory Agents, Non-Steroidal
Effectiveness of Anti-Inflammatory Drugs for Preventing Pain Versus Treating Pain During Medical Abortion From 13 to 22 Weeks at Hung Vuong Hospital
The goal of this clinical trial is to assess the effectiveness of non-steroidal anti-inflammatory drugs (NSAIDs) for prophylactic pain relief compared to on-demand pain relief during medical abortion for pregnancies between 13…
- Conditions
- Pain Management, Anti-Inflammatory Agents, Non-Steroidal, Abortion, Spontaneous
- Trial name
- NCT06696573
- Testing
- Prophylactic NSAID Administration, On-Demand NSAID Administration
- Where
- Vietnam
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Le Thi Kieu Trang
Abortion Early
Transabdominal and Transvaginal Sonography in Medical Abortion
The investigator will perform a multicenter, randomized controlled trial in practices that routinely use transvaginal sonography (TVS) to compare how often clinicians order additional testing prior to medical abortion after the…
- Trial name
- TASvTVS (NCT03047551)
- Testing
- Transabdominal sonography, Transvaginal sonography
- Where
- 2 sites in United States
- Volunteers
- 634 people, healthy volunteers welcome
- Sponsor
- Columbia University
Abortion-Related Disorders
Pain Assessment in MToP Up to 7 WA (during 5h After Misoprostol Intake)
In 2016, medical termination of pregnancy represent 64% of total abortions in France. Thus, it is a frequent act involving a large majority of women and a health-care public subject.
- Trial name
- DoMy (NCT03659045)
- Testing
- scale of pain
- Where
- 8 sites in France
- Volunteers
- 320 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Vaginal Infections, Bacterial Vaginosis
Va-Sense - Bacterial Vaginosis Once A Week Screening And Treatment To Reduce Infective Complications, Abortion And Preterm Delivery In Pregnant Women With Previous Preterm Delivery
The purpose of this study is to determine whether screening of pregnant women with history of previous preterm delivery, once a week, for bacterial vaginosis using VA-SENSE, and treatment of positive women will reduce the risk of…
- Conditions
- Vaginal Infections, Bacterial Vaginosis, Late Miscarriage, Preterm Birth
- Trial name
- NCT01152528
- Testing
- VA-SENSE
- Where
- Israel
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- Common Sense
Pregnancy Termination, Catheter
Foley Catheter vs Double-balloon Catheter
The efficiency of double-balloon and Foley catheters in the second trimester medical termination of pregnancies will be compared.
- Trial name
- NCT03521674
- Testing
- pregnancy termination
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Abortion Rate
Post Abortion IUD & Recurrent Abortion 2001-2004
It has been shown that the immediate insertion of intrauterine devices (IUDs) post-abortion prevents repeat abortions. The researchers hypothesize that providing free IUDs post-abortion will be associated with a lower rate of…
- Trial name
- NCT00965770
- Testing
- Intrauterine device (IUD)
- Where
- Canada
- Volunteers
- 1,101 people, healthy volunteers welcome
- Sponsor
- University of British Columbia