Clinical trials: Testosterone, open to volunteers
Spinal Cord Injury
Testosterone and Neural Function in Men With Spinal Cord Injury
Spinal cord injury (SCI) disrupts the nerves controlling movement, along with those that regulate functions like heart rate and blood pressure (known as the autonomic nervous system, or ANS).
- Trial name
- NCT06130449
- Testing
- Natesto testosterone intranasal gel, Ayr Saline Nasal Gel
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Castration Levels of Testosterone, Metastatic Prostatic Adenocarcinoma
Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer
This phase III trial studies how well standard systemic therapy with or without definitive treatment (prostate removal surgery or radiation therapy) works in treating participants with prostate cancer that has spread to other…
- Conditions
- Castration Levels of Testosterone, Metastatic Prostatic Adenocarcinoma, Stage IV Prostate Cancer AJCC v8, Stage IVA Prostate Cancer AJCC v8
- Trial name
- NCT03678025
- Testing
- Abiraterone, Bicalutamide, Degarelix
- Where
- 338 sites in United States, Chile and 3 more
- Volunteers
- 1,273 people
- Sponsor
- SWOG Cancer Research Network
Metastatic Castration-resistant Prostate Cancer
The COSMYC Trial (COmbined Suppression of MYC)
This research is being done to determine if receiving the combination of testosterone and ZEN-3694 followed by the combination of enzalutamide plus ZEN-3694 will decrease the size of tumors in patients with prostate cancer that…
- Trial name
- NCT06922318
- Testing
- ZEN-3694, Testosterone cypionate, Enzalutamide
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Hypogonadism, Male, Kidney Disease, Chronic
Testosterone Treatment in Men With Chronic Kidney Disease
This study in being conducted in men who have low testosterone and chronic kidney disease. The investigators will evaluate the effects of an oral testosterone preparation, JATENZO, on testosterone levels and hemoglobin (red blood…
- Trial name
- NCT05249634
- Testing
- Jatenzo Pill
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- St. Louis University
Transgenderism
Transgender Men, Non-binary Persons and Testosterone Treatment BODY IDENTITY CLINIC
The aim of this study is to investigate transgender men and non-binary persons before and during testosterone treatment. The study will focus on: Cardiovascular status Muscle strenght and power Aggression and quality of life…
- Trial name
- NCT04254354
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Marianne Andersen
Prostate Cancer
[18F]-Fluoro-2-Deoxy-D-Glucose and -[18F] Dihydro-Testosterone Pet Imaging in Patients With Progressive Prostate or Salivary Gland Cancer
This study will use PET scans, which is a type of x-ray test that uses a radiotracer, to see whether these scans may be better able to find places in the body where your prostate cancer may have spread.
- Trial name
- NCT00588185
- Testing
- [18F]-Fluoro-2-Deoxy-D-Glucose and -[18F] Dihydro-Testosterone
- Where
- 7 sites in United States
- Volunteers
- 300 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Prostate Cancer
Difluoromethylornithine and High Dose Testosterone With Enzalutamide in Metastatic Castration-Resistant Prostate Cancer
Asymptomatic patients with metastatic castrate resistant prostate cancer (mCRPC) without pain due to prostate cancer will be treated on an open label study to evaluate effectiveness of sequential treatment with the combination of…
- Trial name
- NCT06059118
- Testing
- DFMO, testosterone cypionate, Luteinizing hormone-releasing hormone (LHRH) analogue
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Psychological Experience in Fertility Treatment, Hypogonadism
Male Experiences With Intra Cytoplasmic Sperm Injection (ICSI) and Reduced Sperm Quality
Several international studies indicate that men with reduced semen quality often feel overlooked in the context of fertility treatment.
- Conditions
- Psychological Experience in Fertility Treatment, Hypogonadism, Testosteron Levels, Quality of Life
- Trial name
- NCT07546435
- Where
- Denmark
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Peter Humaidan
Transsexualism, Transgenderism
Effects of Cross-sex Hormone Therapy on Eating Behavior, Metabolism, Energy Balance and Cardiovascular System
Current study aims to characterize five highly interconnected physiological systems in patients undergoing cross-sex hormone therapy - namely glucose and lipid metabolism, energy balance, eating behavior, functional brain…
- Conditions
- Transsexualism, Transgenderism, Adiposity, Eating Behavior
- Trial name
- HHS (NCT04838249)
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Spinal Cord Injury, Spinal Cord Injuries
Testosterone Therapy With or Without Finasteride After Spinal Cord Injury: TRT-SCI Trial
Spinal cord injury (SCI) results in lower limb muscle loss, bone loss, and high fat mass that impede the recovery of physical function, increase bone fracture risk, and worsen health and quality of life.
- Conditions
- Spinal Cord Injury, Spinal Cord Injuries, Injuries, Spinal Cord, Spinal Cord Contusion
- Trial name
- TRT-SCI (NCT07742553)
- Testing
- testosterone cypionate, finasteride
- Where
- 4 sites in United States
- Volunteers
- 300 people
- Sponsor
- VA Office of Research and Development
Metastatic Castration-resistant Prostate Cancer
Supraphysiologic Testosterone Priming Induces Darolutamide Extended Response
The objective of this study is to determine the safety and clinical effects of alternating pharmacologic (i.e. supraphysiologic) testosterone therapy with darolutamide in men with metastatic prostate cancer as first line hormonal…
- Trial name
- NCT07142551
- Testing
- Testosterone cypionate, Luteinizing hormone-releasing hormone (LHRH) analogue, Darolutamide
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Hypoactive Sexual Desire Disorder
An Open-Label Study of 50 Mg Oral Testosterone Undecanoate (Kyztrex) in Menopausal Women with Low Testosterone and HSDD
This is an unblinded study to be conducted at a single research center, San Diego Sexual Medicine. Eligible subjects will receive 50 mg capsules of Kyzatrax® to be taken orally daily over a 3-month period.
- Trial name
- NCT06082817
- Testing
- Oral Testosterone Undecanoate
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- San Diego Sexual Medicine
Cerebral Blood Flow, Cerebral Blood Flow Regulation
The Role of Estrogen and Testosterone in Determining Brain Blood Flow and Metabolic Regulation in Humans
Due to historical exclusion of females from research, there are gaps in the understanding of female physiology, how it differs from males, and how sex-specific hormones contribute.
- Conditions
- Cerebral Blood Flow, Cerebral Blood Flow Regulation, Sex Differences, Exercise
- Trial name
- NCT07212712
- Testing
- GnRH antagonist, Estradiol (E2), Testosterone
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Skeletal Muscle Physiology
Testosterone-induced Muscle Memory and Underlying Mechanisms
The purpose of this project is to investigate underlying mechanisms of testosterone- and resistance training-induced muscle hypertrophy and muscle memory in humans.
- Trial name
- NCT06188767
- Testing
- Testosterone Undecanoate
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Morten Hostrup, PhD
Adolescent Depression
Adolescent Mood During Puberty and Testosterone
Starting at puberty, female adolescents are nearly three-times more likely to develop internalizing disorders, like depression, while male adolescents are two-times more likely to develop externalizing disorders, like attention…
- Trial name
- AMPT (NCT06072677)
- Testing
- Healthy Minds Program
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Fertility Disorders
TRAP Study: Testosterone for Androgen Receptor Polymorphism
To determine whether pretreatment with transdermal testosterone increases the number of cumulus-oocyte complexes (COCs) obtained after ovarian stimulation by more than 1.5 in patients with low ovarian reserve and androgen…
- Trial name
- TRAP (NCT06195163)
- Testing
- Transdermal Gel in Sachet Dosage Form, No pretreatment
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Instituto Bernabeu
Adult Healthy Volunteers
Effect of RhizomK on Testosterone Levels, the Anabolic Response to Exercise and Overall Quality of Life in Physically Active Healthy Males
Given that testosterone is a key modulator of muscle protein synthesis and overall anabolic response to resistance training, any natural intervention that boosts testosterone levels could logically contribute to improved exercise…
- Trial name
- NCT07143474
- Testing
- RhizomK, Plcebo
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Klinefelter Syndrome, Thyroiditis, Autoimmune
Thyroid Function and Structure in Klinefelter Syndrome
This is a longitudinal retrospective study for the evaluation of thyroid function and structure in patients with Klinefelter syndrome compared to healthy controls and patients affected by chronic lymphocytic thyroiditis.
- Conditions
- Klinefelter Syndrome, Thyroiditis, Autoimmune, Hypothyroidism
- Trial name
- THINKS (NCT05581147)
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- University of Roma La Sapienza
Critical Illness
Effects of Early Testosterone Gel Administration on Physical Performance in the Critically Ill
Critically ill patients experience major insults that lead to increased protein catabolism. Hypermetabolism occurs early and rapidly during the first week of critical illness to provide amino acids for the production of energy…
- Trial name
- TestICUs (NCT05825092)
- Testing
- Androgel Topical Product, Physical performance, Muscle strength
- Where
- 5 sites in France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Clermont-Ferrand
Castration-resistant Prostate Cancer, Homologous Recombination Deficiency
Bipolar Androgen Therapy + Carboplatin in mCRPC
The purpose of this study is to determine the efficacy of BAT and carboplatin in men with metastatic castrate-resistant prostate cancer (mCRPC).
- Trial name
- HiTeCH (NCT03522064)
- Testing
- Testosterone Enanthate 100 MG/ML Injectable Solution, Testosterone Enanthate 100 MG/ML Injectable Solution / Carboplatin AUC 5
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- St Vincent's Hospital, Sydney