Clinical trials: The Metabolic Syndrome
Carcinomas, Amyloidosis
B-Receptor Signaling in Cardiomyopathy
We hope to determine the importance of different genes (including B receptors) in anthracycline-induced cardiomyopathy. This has important benefits to patients exposed to anthracyclines, as this could help determine whether…
- Conditions
- Carcinomas, Amyloidosis, Anal Cancer, Anemia
- Trial name
- NCT01135849
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Daniel Bernstein
Hypercholesterolemia, Myocardial Infarction
IMPROVE-IT: Examining Outcomes in Subjects With Acute Coronary Syndrome: Vytorin (Ezetimibe/Simvastatin) vs Simvastatin (P04103)
This is a randomized, active-control, double-blind study of subjects with stabilized high-risk acute coronary syndrome (ACS). The primary objective is to evaluate the clinical benefit of Ezetimibe/Simvastatin Combination 10/40…
- Trial name
- NCT00202878
- Testing
- ezetimibe/simvastatin, simvastatin
- Volunteers
- 18,144 people
- Sponsor
- Organon and Co
T-Cell Immune Deficiency Diseases, Severe Combined Immunodeficiency
IMM 0212: Busulfan With Fludarabine and Antithymocyte Globulin as Preparative Therapy for Hematopoietic Stem Cell Transplant for the Treatment of Severe Congenital T-Cell Immunodeficiency
This is a multi-institution, single arm, non-randomized pilot study coordinated by the Pediatric Blood and Marrow Transplant Consortium.
- Trial name
- NCT00228852
- Testing
- Busulfan, Fludarabine and ATG
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Emory University
Gut Microbiota, Metabolic Syndrome
Effect of Non-nutritive Sweeteners of High Sugar Sweetened Beverages on Metabolic Health and Gut Microbiome
Increasing evidence suggest that artificial sweeteners such as saccharin, aspartame and sucralose may not be as metabolically safe as they first appeared, and it has been proposed that their consumption may be linked to important…
- Trial name
- NCT03259685
- Testing
- 710 ml of regular soft drinks, taken daily for 10 weeks, 710 ml of diet soft drinks, taken daily for 10 weeks, 710 ml of stevia-sweetened soft drinks, taken daily for 10 weeks
- Where
- Canada
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Laval University
Overweight and Obesity, Inflammation
Clinical Trials of Five Different Food Supplements With Restriction Diet in Adults
In recent years, dietary supplement are of great interest for the improvement of human health. This study is designed as a parallel, randomized, double blind study exploring the efficacy of two months daily oral dosing of five…
- Conditions
- Overweight and Obesity, Inflammation, Hypercholesterolemia, Hypertension
- Trial name
- FOODSU (NCT05333315)
- Testing
- IP1, IP2, IP3
- Where
- Slovenia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Primorska
MPS I
Ascending Dose Study of Genome Editing by the Zinc Finger Nuclease (ZFN) Therapeutic SB-318 in Subjects With MPS I
The purpose of the study is to evaluate the safety, tolerability of ascending doses of SB-318. SB-318 is an intravenously delivered Zinc Finger Nuclease (ZFN) Therapeutic for genome editing.
- Trial name
- NCT02702115
- Testing
- SB-318
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Sangamo Therapeutics
Metabolic Syndrome
The Effect of Pioglitazone and Rosiglitazone on Atherosclerotic and Inflammatory Markers in Patients With Metabolic Syndrome
Pioglitazone and rosiglitazone are used in the treatment of diabetic patients. Thiazolidinediones increase insulin sensitivity and show favorable effect blood glucose levels and lipid profiles.
- Trial name
- NCT00314561
- Testing
- Pioglitazone, Rosiglitazone
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Korea University Anam Hospital
Obesity, Type 2 Diabetes
The Effects of Weight Loss on Neuroadrenergic Function
Elevated subconscious nervous system activity is a characteristic of the obese state and contributes importantly to the risk of heart disease and diabetes.
- Conditions
- Obesity, Type 2 Diabetes, Metabolic Syndrome
- Trial name
- NCT01771042
- Testing
- Dietary weight loss at 25% energy deficit
- Where
- Australia
- Volunteers
- 120 people
- Sponsor
- Baker Heart Research Institute
Heart Failure, Congestive, Metabolic Syndrome X
The Effect of Diet and Exercise in Heart Failure
A growing number of people in this country are overweight or obese. This is concerning as increasing weight has been shown to increase the risk of developing heart failure.
- Conditions
- Heart Failure, Congestive, Metabolic Syndrome X, Obesity
- Trial name
- LIMIT-HF (NCT00297154)
- Testing
- Lifestyle Modification (diet, exercise, and behavior)
- Volunteers
- 20 people
- Sponsor
- Baylor College of Medicine
HIV Infections, Weight Gain
Optimising Metabolic Management for People With Human Immunodeficiency Virus (HIV) on Integrase Based Antiretroviral Therapy (ART)
People with HIV are at a higher risk of cardiovascular diseases (CVD) due to the effects of the virus and its treatment. Integrase strand transfer inhibitors (INSTIs), a common HIV treatment, are associated with increased CVD…
- Trial name
- OPTIMAR (NCT06317051)
- Testing
- Dapagliflozin 10mg Tab, Pitavastatin 4 Mg Oral Tablet, Rosuvastatin and Ezetimibe
- Where
- 10 sites in Argentina, Australia and 7 more
- Volunteers
- 300 people
- Sponsor
- Kirby Institute
Metabolic Syndrome
The Effect of Probiotics on Obesity. Metabolic Endotoxemia and Inflammation
In spite of the growing evidence for the beneficial effects of probiotics, their anti-obesity effects are not well examined. No previous studies were conducted in this research area in the UAE.
- Trial name
- NCT03883685
- Testing
- Probiotane
- Where
- United Arab Emirates
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Sharjah
Celiac Disease
Glutenfree, Gut Microbiota and Metabolic Regulation
High intake of dietary fiber provides health benefits and reduces the risk of developing cardio-metabolic diseases, such as type 2 diabetes (T2D) and cardiovascular disease (CVD).
- Trial name
- GRAIN (NCT05135923)
- Testing
- Randomized, controlled trial (RCT) with parallel arms and double blinded
- Where
- Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oslo Metropolitan University
Gluten Sensitivity
Influence of the Immunosystem in Non-celiac Glutensensitivity
Patients with non-celiac gluten sensitivity (NCGS) complain about gastrointestinal and extraintestinal symptoms while consuming gluten-containing cereals.
- Trial name
- NCGS (NCT03268720)
- Testing
- FODMAP low diet, gluten-free diet
- Where
- Germany
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Anemia, Leukemia
Darbepoetin Alfa Compared With Epoetin Alfa in Treating Anemia in Patients Receiving Chemotherapy for Cancer
RATIONALE: Darbepoetin alfa and epoetin alfa may stimulate red blood cell production and treat anemia in patients who are receiving chemotherapy.
- Conditions
- Anemia, Leukemia, Lymphoma, Lymphoproliferative Disorder
- Trial name
- NCT00070382
- Testing
- darbepoetin alfa, epoetin alfa
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Polycystic Ovary Syndrome
The Study of Polycystic Ovary Syndrome(PCOS) With Gene and Questionnaire
Polycystic ovary syndrome (PCOS) is an extremely common disorder in women of reproductive age. Diagnosis of PCOS is principally based on clinical and physical findings.
- Trial name
- NCT01114659
- Where
- Taiwan
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University WanFang Hospital
Arthritis, Psoriatic, Metabolic Syndrome
The DIET Trial - Dietetic Intervention in Psoriatic Arthritis
Psoriasis (Ps) and psoriatic arthritis (PsA) are associated with increased risk of metabolic syndrome (MetS), body fatness and cardiovascular risk.
- Trial name
- DIET (NCT03142503)
- Testing
- Diet + supplementation
- Volunteers
- 194 people
- Sponsor
- Federal University of São Paulo
Human Immunodeficiency Virus Infection
The Effect of an Enhanced Rice Bran Nutritional Supplement in HIV
The purpose of this study is to investigate the effects of the nutritional supplement rice bran arabinoxylan compound (RBAC) on metabolic syndrome variables in persons living with HIV.
- Trial name
- BRM4 (NCT02214173)
- Testing
- rice bran arabinoxylan compound (RBAC)
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- University of Miami
Obstructive Sleep Apnea, Pregnancy
Positive Airway Pressure, Sleep Apnea, and the Placenta (PAP-SAP)
This study is testing the hypothesis of whether continuous positive airway pressure (CPAP) therapy improves placental histopathology and secretory function.
- Conditions
- Obstructive Sleep Apnea, Pregnancy, Obesity, Preeclampsia
- Trial name
- PAP-SAP (NCT02412696)
- Testing
- Positive Airway Pressure, Nasal Dilator Strips
- Where
- United States
- Volunteers
- 262 people
- Sponsor
- The Miriam Hospital
Diabetes Mellitus Type 2, Mild Cognitive Impairment
The Early Warning System for the Diabetic Encephalopathy
Diabetes( mainly type II diabetes )lead to the central nervous system (CNS) function impairment, especially the mild cognitive impairment that increased the risk of progression to dementia.The primary objectives are defined…
- Conditions
- Diabetes Mellitus Type 2, Mild Cognitive Impairment, Metabolic Syndrome X
- Trial name
- NCT02420470
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Men, Life Style
Dietary Effects on Weight Loss and Lipid Profile in Sedentary Men
Negative-calorie diet is among the popular dieting guides for weight loss; however, there is still little knowledge about this method.
- Conditions
- Men, Life Style, Lipid Metabolism Disorders, Obesity
- Trial name
- NCT03082794
- Testing
- NCD, LCD
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- P.L.Shupik National Medical Academy of Post-Graduate Education