Clinical trials: Therapeutic Drug Monitoring
Pharmacogenetics, HIV
Individualized Antiretroviral Therapy
The efficacy and safety of antiretroviral therapy and the damage caused by chronic inflammation in the presence of the virus has recently lead to the consideration of initiating antiretroviral therapy earlier than what is…
- Conditions
- Pharmacogenetics, HIV, Drug Monitoring
- Trial name
- IAT (NCT03385473)
- Testing
- Pharmacogenomic index, Therapeutic drug monitoring
- Where
- Argentina
- Volunteers
- 190 people
- Sponsor
- Hospital Italiano de Buenos Aires
Crohn Disease, Drug Monitoring
TDM Guided Early Optimization of ADAL in Crohn's Disease
To investigate the influence of early therapeutic drug monitoring and dose optimization on disease outcome in Crohn's patients treated with Adalimumab.
- Conditions
- Crohn Disease, Drug Monitoring, Inflammatory Bowel Diseases
- Trial name
- NCT03261102
- Testing
- Adalimumab
- Where
- 6 sites in Canada
- Volunteers
- 200 people
- Sponsor
- waqqas.afif
Methicillin-resistant Staphylococcus Aureus Septicemia
The Most Appropriate Parameter Correlates With Clinical Effectiveness of Vancomycin: Trough Drug Concentration or Area Under Curve (AUC)/Minimum Inhibitory Concentration (MIC)?
The purpose of this study is to evaluate which is the most appropriate parameter correlates with clinical effectiveness of vancomycin: trough drug level or AUC/MIC.
- Trial name
- NCT01995760
- Where
- Taiwan
- Volunteers
- 123 people
- Sponsor
- National Taiwan University Hospital
Diabetes Mellitus, Type 1, Hypoglycemia
Telemedicine Monitoring of Nocturnal Incidents
Reducing hypoglycemia is an important aspect of management of type 1 diabetes (T1D) in older adults, many of whom have hypoglycemic unawareness, cognitive impairment, or both.
- Trial name
- TELE-MONITOR (NCT04328896)
- Testing
- CGM-Tele-monitoring
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Southern California
Hypertension
Efficacy and Safety of Azilsartan Medoxomil, Once Daily (QD), Co-Administered With Amlodipine in Participants With Essential Hypertension
The purpose of this study is to evaluate the efficacy and safety of azilsartan medoxomil, once daily (QD), co-administered with amlodipine in treating individuals with essential hypertension, compared to treatment with amlodipine…
- Trial name
- NCT00591266
- Testing
- Azilsartan Medoxomil and amlodipine, Amlodipine
- Where
- 50 sites in United States
- Volunteers
- 566 people
- Sponsor
- Takeda
Carcinoid Syndrome, Metastatic Nonfunctional Well Differentiated Neuroendocrine Neoplasm
AMT-PET in Monitoring Telotristat Etiprate Treatment in Participants With MetastaticNeuroendocrine Neoplasm
This pilot trial studies how well telotristat etiprate works in treating participants with well differentiated neuroendocrine neoplasm that has spread to other places in the body and monitored by carbon C 11…
- Trial name
- NCT03453489
- Testing
- Carbon C 11 Alpha-methyltryptophan, Laboratory Biomarker Analysis, Positron Emission Tomography
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Healthy
Therapeutic Drug Monitoring and Pharmacokinetic Compartmental Analysis of Sulpiride After Oral Administration to Healthy Volunteers
The present study was adopted to evaluate the pharmacokinetics of sulpiride after oral administration.
- Trial name
- SUL (NCT01777685)
- Testing
- Sulpiride
- Where
- Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Damanhour University
Diabetes Mellitus
Trial of Steroid Avoidance and Low-dose CNI by ATG-induction in Renal Transplantation
Balancing immunosuppressive treatment in organ transplantation in order to achieve effective prevention of rejection on one side and avoidance of negative side effects on the other side is a major challenge, leading to developing…
- Trial name
- SAILOR (NCT02083991)
- Testing
- Steroid-free low TAC-arm: Thymoglobulin Standard low-TAC arm: Simulect, prednisolon
- Where
- Sweden
- Volunteers
- 224 people
- Sponsor
- Vastra Gotaland Region
Endocarditis, Prosthetic Material Related Infection
Individualized Diagnosis of Endocarditis and Its Therapy With a Focus on Infected Prosthetic materiAL
Infective endocarditis (IE) is a frequent and serious complication of implanted intracardiac prosthetic material, with a high morbidity and mortality.
- Trial name
- IDENTICAL (NCT02759978)
- Testing
- diagnostic workup
- Where
- Netherlands
- Volunteers
- 300 people
- Sponsor
- University Medical Center Groningen
Intensive Care Unit Syndrome
Bedside Therapeutic Monitoring of β-Lactam Levels in Newborns, Children and Adolescents Admitted to Intensive Care.
This study evaluate the capacity of the MON4STRAT device for drug monitoring of β- lactam antibiotic concentrations in newborns, children, and adolescents admitted in intensive care units with a health care-associated infection.
- Trial name
- MON4STRAT (NCT03404089)
- Testing
- pharmacokinetic device
- Where
- France
- Volunteers
- 13 people
- Sponsor
- University Hospital, Lille
Beta-lactam, Continuous Renal Replacement Therapy
Beta-Lactams Dosing In Pneumonia in ICU in Patients Treated by Continuous Renal Replacement Therapy: the BLIPIC Study
Pneumonia are the most frequent infections in ICU. Little is known about beta-lactam doses necessary for this infection for patients treated with continuous veino-veinous hemodialysis.
- Conditions
- Beta-lactam, Continuous Renal Replacement Therapy, Pneumonia, Antibiotic
- Trial name
- BLIPIC (NCT03897582)
- Where
- France
- Volunteers
- 65 people
- Sponsor
- Centre Hospitalier de Valenciennes
Neurofibromatosis 1, Neurofibroma, Plexiform
Medication Adherence in Children, Adolescents and Adults With Neurofibromatosis Type 1(NF1) on Clinical Treatment Trials
Background: Neurofibromatosis type 1 (NF1) is a genetic disorder. It has a broad variety of effects on the body. Up to half of people with NF1 get plexiform neurofibromas (PNs). These are benign tumors.
- Trial name
- NCT03531814
- Testing
- Medication Event Monitoring System (MEMS^TM), Questionnaires
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Cancer Institute (NCI)
Hypertension
Antihypertensive Efficacy of Fixed Combination Drug
Treatment and control of hypertension is still insufficient. About 50% of the patients remain uncontrolled. Lack of compliance with discontinuation of drug treatment is an important reason for not achieving blood pressure.
- Trial name
- NCT01211314
- Testing
- Lercanidipine/enalapril fixed combination
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Meir Medical Center
Stroke
Using Artificial Intelligence to Measure and Optimize Adherence in Patients on Anticoagulation Therapy.
AiCure uses artificial intelligence and visual recognition technology to confirm medication ingestion. The software is available as an app and downloaded onto a smart phone.
- Trial name
- NCT02599259
- Testing
- Monitored (M+)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- AiCure
Inflammatory Bowel Disease (IBD), Medication Compliance
Telehealth Monitoring in Inflammatory Bowel Disease: Effects on Medication Compliance, Self-Efficacy, and Quality of Life
This randomized controlled trial aims to evaluate the effect of nurse-led telehealth monitoring on medication adherence, self-efficacy, and quality of life in individuals with inflammatory bowel disease (IBD).
- Conditions
- Inflammatory Bowel Disease (IBD), Medication Compliance, Quality of Life, Telehealth Monitoring
- Trial name
- NCT06971627
- Testing
- Nurse-led Telehealth Monitoring Program, No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Istanbul University - Cerrahpasa
ECMO Treatment, ARDS
Hemodynamic Monitoring and Fluid Responsiveness in Venovenous Extracorporeal Membrane Oxygenation (VV ECMO) - "HemodynamECMOnitoring-VV Study"
In extracorporeal membrane oxygenation (ECMO), blood is drawn out of the body via tubes, oxygenated in an artificial lung; and then pumped back into the blood vessels.
- Conditions
- ECMO Treatment, ARDS, Pneumonia, Intensive Care
- Trial name
- NCT06593717
- Testing
- Transthoracic Echocardiography, Uncalibrated Pulse Contour Analysis, Transpulmonary Thermodilution/Calibrated Pulse Contour Analysis
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Crohn's Disease
Observational Study Evaluating the Effectiveness of Drug Concentration to Predict the Recapture of Response in Crohn's Disease Patients With Loss of Response ( PRADA )
This is a multi-center study that explores the relationship between recapture of response with escalation to weekly adalimumab and trough adalimumab concentration before escalation in patients experiencing lack of response (LOR).
- Trial name
- PRADA (NCT02896985)
- Where
- 24 sites in Canada
- Volunteers
- 98 people
- Sponsor
- AbbVie
Kidney Transplantation
Prediction of Medication Compliance Following Renal Transplantation
The purpose of this study is to quantitate pre-transplant medication compliance, dialysis compliance, and related psychological variables, and then examine their validity as predictors of post-transplant noncompliant behaviors…
- Trial name
- NCT00148187
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Bacterial Infections
Therapeutic Drug Monitoring of Teicoplanin in Children
In this study, the therapeutic drug monitoring of teicoplanin is carried out among children to obtain the drug concentration, clinical efficacy and safety data of children patients in different gender and age groups.
- Trial name
- NCT03933748
- Testing
- Teicoplanin-PMMA
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Shandong University
Hypertension
WIreless Monitoring and Financial Incentives for Uncontrolled HYpertension (WIFHY) Study
Hypertension is a major risk factor for cardiovascular morbidity and mortality. Despite the risks of hypertension and availability of effective treatment, a substantial number of patients have uncontrolled Blood Pressure (BP).
- Trial name
- WIFHY (NCT03368417)
- Testing
- Usual Care, Wireless HBPM System, BP Monitoring Incentives
- Where
- 2 sites in Singapore
- Volunteers
- 42 people
- Sponsor
- Duke-NUS Graduate Medical School