Clinical trials: Therapeutic Drug Monitoring
HIV Infections
Using Drug Levels in the Blood to Guide Therapy in HIV Infected Patients Taking a Protease Inhibitor
Drug resistance testing can be used to see which anti-HIV drugs are likely to suppress the growth of HIV and to select an anti-HIV regimen for HIV infected patients who have failed previous drug regimens.
- Trial name
- NCT00041769
- Testing
- Therapeutic Drug Monitoring (TDM)
- Where
- 47 sites in United States, Puerto Rico
- Volunteers
- 360 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Transplant, Kidney
Pilot Trial for Implementation of a MPA PK Monitoring Strategy
This study is a prospective interventional trial of de novo renal transplant recipients, aiming to validate a strategy which combines the use of early post transplant MPA AUC sampling, and subsequent MPA trough level monitoring…
- Trial name
- MPA (NCT00187915)
- Testing
- Mycophenolate mofetil + Tacrolimus, Mycophenolate mofetil + Cyclosporin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Florida
Patient Education as Topic, Surveys and Questionnaires
Development and Validation of a Self-administered QUestionnaire to Identify Levers of Adhesion Behavior to Patient's Medication in Order to Adapt the Educational Monitoring.
Medication non-adherence is an economic problem and a major public health challenge. Factors influencing medication adherence can be modelled according to five dimensions: disease, medication, patient and its close relatives…
- Conditions
- Patient Education as Topic, Surveys and Questionnaires, Medication Adherence, Pulmonary Disease, Chronic Obstructive
- Trial name
- QUILAM (NCT02865525)
- Where
- France
- Volunteers
- 282 people
- Sponsor
- University Hospital, Grenoble
Infectious Disease
Beta-lactams Therapeutic Drug Monitoring in Critically Ill Patients
The population of these monocentric and retrospective study includes patients hospitalized in one of the critical care services of Nîmes' community hospital.
- Trial name
- SPT BETALACT (NCT05352997)
- Where
- France
- Volunteers
- 156 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
HIV Infections
Ritonavir and Agenerase Treatment for Patients Who Have Failed Previous Anti-HIV Treatment
The purpose of this study is to determine if treatment with an anti-HIV drug containing ritonavir and Agenerase is safe and can lower the level of HIV in the blood in patients who have failed an anti-HIV drug treatment containing…
- Trial name
- NCT00006591
- Testing
- Ritonavir, Amprenavir
- Where
- United States
- Sponsor
- Gathe, Joseph, M.D.
Adherence, Medication, Risk Behavior
DOT Diary Optimization Pilot: A Pilot Study to Optimize the DOT Diary App to Measure PrEP Adherence
The researchers are working with a technology company, AiCure, to develop a smartphone app, DOT Diary, which combines two drug adherence strategies.
- Conditions
- Adherence, Medication, Risk Behavior, Pre-Exposure Prophylaxis, HIV Prevention
- Trial name
- NCT03387462
- Testing
- Emtricitabine / Tenofovir Disoproxil Oral Tablet, DOT Diary mobile app
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Public Health Foundation Enterprises, Inc.
Resistant Hypertension, Medication Adherence
Heart Rate Variability and Medication Adherence in Resistant Hypertension
This single-center, cross-sectional observational study examines the relationship between adherence to antihypertensive therapy - verified objectively by therapeutic drug monitoring (TDM) - and heart rate variability (HRV) in…
- Conditions
- Resistant Hypertension, Medication Adherence, Autonomic Nervous System
- Trial name
- HRV-HYP-1 (NCT07707583)
- Testing
- Heart rate variability recording (Polar H10) ·, Therapeutic drug monitoring (antihypertensive drug levels), Questionnaires (MARS-CZ, PHQ-9, SF-36, IPAQ)
- Where
- Czechia
- Volunteers
- 150 people
- Sponsor
- Nemocnice AGEL Trinec-Podlesi a.s.
Childhood Obesity, Treatment Adherence
The Evira Study: Additional Support During Obesity Treatment
The goal of this clinical trial is to evaluate the effect of adding a digi-physical treatment tool as a complement to the local treatment with obesity medication in adolescents with obesity.
- Trial name
- NCT06836284
- Testing
- Digi-physical treatment tool, Evira, Obesity medication with liraglutide or semaglutide
- Where
- 3 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska Institutet
Voriconazole, Fungal Infection
The Study of Voriconazole Trough Level in the First Two Weeks After Administration in King Chulalongkorn Memorial Hospital.
Invasive fungal infections are a significant cause of morbidity and mortality in immunocompromised host such as prolong neutropenic patients , post transplantation patients, malignancies or advanced AIDS .
- Trial name
- NCT03260634
- Testing
- Voriconazole
- Where
- Thailand
- Volunteers
- 92 people
- Sponsor
- Chulalongkorn University
Kidney Cancer, Renal Cell Carcinoma Metastatic
TDM for Optimized Outcome in Patients With mRCC.
The purpose of this observational study is to assess the role of plasma concentration monitoring of treatment drugs for patients with metastatic renal cell carcinoma (mRCC) in terms of efficacy and side effects.
- Conditions
- Kidney Cancer, Renal Cell Carcinoma Metastatic, Drug Toxicity, Drug Side Effect
- Trial name
- NCT04659343
- Testing
- Measurement of concentration of active metabolite in cancer treatment.
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Niels Fristrup
Multidrug-resistant Gram-negative Bacteria Infection
Clinical Usefulness of Therapeutic Drug Monitoring of Colistin in Patients Treated With Colistin.
Clinical usefulness of therapeutic drug monitoring of colistin in patients treated with colistin
- Trial name
- NCT03007290
- Testing
- Therapeutic drug monitoring
- Where
- South Korea
- Volunteers
- 15 people
- Sponsor
- Seoul National University Hospital
Melanoma (Skin)
Therapeutic Drug Monitoring of BRAF-mutated Advanced Melanoma
BRAF V600-mutant metastatic melanoma are commonly treated using a combination of anti-BRAF and anti-MEK tyrosine kinase inhibitors (TKIs).
- Trial name
- OPTIMEL (NCT03416933)
- Testing
- Blood sampling
- Where
- 4 sites in France
- Volunteers
- 35 people
- Sponsor
- Institut de Cancérologie de Lorraine
Osteoperosis, Femoral Neck Fractures
Monitoring Bleeding of Patients Using NOAC Anticoagulation Therapy in Proximal Femoral Fracture Internal Fixation Surgery Without Waiting. We Measure Bleeding in Surgery and the Levels of Noac Drug in Blood. We Will Try to Compare to Regular Pateints Later
until today we waited at least 24 hours before surgery of femoral neck fractures in patients who take anticouagolation . in our new reasearch we belive that patients who take NOAC can go under surgery earlier with minimal risk
- Conditions
- Osteoperosis, Femoral Neck Fractures, Anticoagulant Therapy
- Trial name
- NCT06644976
- Testing
- femoral neck CRIF
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Meir Hospital, Kfar Saba, Israel
HIV Infections
Alternative Dosing Strategy for Anti-HIV Drugs
Anti-HIV drugs are usually given to patients at fixed, standardized doses. This study will investigate alternative ways of dosing anti-HIV drugs to improve viral control.
- Trial name
- NCT00059384
- Testing
- Concentration-controlled therapy
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hyperlipidemia, Diabetes
Point-of-Care Testing (POCT) Detection and Management of Metabolic Syndrome in Patients With Mental Illness
The study was a 12-month, multi-centered, quasi-experimental design to assess point-of-care (POCT) screening/monitoring of subjects on antipsychotic agents for metabolic syndrome.
- Conditions
- Hyperlipidemia, Diabetes, Hypertension
- Trial name
- NCT02029989
- Testing
- Glucose and lipids, Glycosylated Hemoglobin A1c, Blood Pressure and Heart Rate
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Depression
Physiologic Monitoring of Antidepressant Treatment Response
Study Objectives: to identify neurophysiologic effects of venlafaxine treatment in normal controls using quantitative EEG (QEEG) cordance to examine the effects of venlafaxine on different rating scales measuring mood and anxiety…
- Trial name
- Ven Nls I (NCT00759317)
- Testing
- venlafaxine (Effexor)
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Multiple Myeloma, Bortezomib
Evaluation of Clinical Treatment of Multiple Myeloma Based on Multi-omics
With the emergence of new drugs, the short-term survival rate of multiple myeloma has been significantly increased. However, in clinical treatment, doctors found that different patients may present different clinical efficacy and…
- Trial name
- NCT04678089
- Testing
- Bortezomib
- Where
- China
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Beijing Chao Yang Hospital
HIV
Therapeutic Drug Monitoring (TDM) in Generic Tenofovir/Lamivudine/Efavirenz
The purpose of this study is to determine the mid levels of the tenofovir, lamivudine, and efavirenz, and 144 weeks safety and efficacy of the generic fixed dose combination of tenofovir /lamivudine/efavirenz tablets 300/300/600…
- Trial name
- NCT01160120
- Testing
- generic FDC of TDF/3TC/EFV
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- The HIV Netherlands Australia Thailand Research Collaboration
Crohn's Disease, Ulcerative Colitis
Predicting Response to Vedolizumab in Pediatric Inflammatory Bowel Diseases
Vedolizumab (VDZ) is a humanized immunoglobulin G1 monoclonal antibody acting against α4β7 integrin which modulates lymphocyte trafficking in the gut.
- Conditions
- Crohn's Disease, Ulcerative Colitis, Inflammatory Bowel Disease
- Trial name
- NCT02862132
- Testing
- Vedolizumab
- Where
- 15 sites in United States, Denmark and 4 more
- Volunteers
- 142 people
- Sponsor
- Shaare Zedek Medical Center
Pneumonia, Sepsis
Therapeutic Drug Monitoring - Targeting IMproved Effectiveness
Severe infections can be caused by various organisms, such as bacteria or viruses, and lead to otherwise healthy people getting very unwell, sometimes needing treatment in hospital or even intensive care.
- Conditions
- Pneumonia, Sepsis, Infection, Bacterial
- Trial name
- TDM-TIME (NCT05971979)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Manchester University NHS Foundation Trust