Clinical trials: Therapeutic Endoscopy
Rhinocerebral Mucormycosis
Endoscopic Surgical Treatment of Rhino-Sinusal Mucormycosis
Radical endoscopic transnasal surgery associated with medical treatment with liposomal amphotericine B may increase the local control of Rhino-Sinusal Mucormycosis and the survival rate.
- Trial name
- MICCA (NCT02226705)
- Testing
- Multiple transnasal endoscopic surgeries
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Gastric Varices
Angiography for Evaluation of the Feeder Vessel in EUS-guided Coils and Cyanoacrylate Therapy for Gastric Varices
INTRODUCTION: Bleeding from gastric varices (GV) is associated with a high mortality rate. Injection of cyanoacrylate (CYA) using standard gastroscope has demonstrated to achieve higher hemostasis and lower rebleeding rates…
- Trial name
- NCT03277937
- Testing
- angiography in EUS-injection of coils + CYA
- Where
- Ecuador
- Volunteers
- 30 people
- Sponsor
- Instituto Ecuatoriano de Enfermedades Digestivas
Shigellosis
Therapeutic Induction of Endogenous Antibiotics
Shigellosis is one of the major causes of morbidity and mortality in many developing countries. The continued emergence of antibiotic resistant strains has complicated the treatment of shigellosis and has increased the cost of…
- Trial name
- NCT00800930
- Testing
- Sodium Butyrate, Saline
- Where
- 2 sites in Bangladesh
- Volunteers
- 80 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Lumbar Spinal Stenosis
Comparision of Endoscopic Discectomy and Microdiscectomy for the Treatment of Lumbar Spinal Stenosis
The purpose of this study is to conduct a multicenter comparison of the clinical efficacy of Endo-Surgi Plus endoscopic technique, UBE endoscopic technique, and microdiscectomy technique in the treatment of lumbar spinal…
- Trial name
- NCT06719037
- Testing
- Endo-Surgi Plus endoscopic surgery, Unilateral biportal endoscopic surgery, Microdiscectomy
- Where
- China
- Volunteers
- 324 people
- Sponsor
- Qilu Hospital of Shandong University
Upper Gastrointestinal Bleeding
A Double Blind Study Comparing Two Doses of IV Esomeprazole After Successful Endoscopic Therapy
A bleeding peptic ulcer remains a serious medical problem with significant morbidity and mortality. Endoscopic therapy significantly reduces further bleeding, surgery, and mortality in patients with bleeding peptic ulcers and is…
- Trial name
- NCT01275937
- Testing
- Esomeprazole
- Where
- Taiwan
- Volunteers
- 65 people
- Sponsor
- Taipei Medical University
Choledocholithiasis, Higher Risk Patients
Study Investigating the Best Method of Treatment of Bile Duct Stones in Higher Risk Patients
The aim of the trial is to compare two operations which are used to treat bile duct stones. The hypothesis of the study is that there is no difference between endoscopic sphincterotomy followed by laparoscopic cholecystectomy or…
- Trial name
- NCT00612846
- Testing
- Endoscopic sphincterotomy and subsequent laparoscopic cholecystectomy, Laparoscopic bile duct exploration during cholecystectomy
- Volunteers
- 91 people
- Sponsor
- North Bristol NHS Trust
Severe Ulcerative Colitis
Multi-centre Acute Severe Ulcerative Colitis Prospective Cohort Study (Elevate ASUC)
Up to one third of patients with Ulcerative Colitis (UC) will require hospitalisation for severe disease (ASUC - Acute Severe Ulcerative Colitis), often within the first 12 months of diagnosis.
- Trial name
- ELEVATE-ASUC (NCT03907631)
- Testing
- Standard of care
- Where
- United Kingdom
- Volunteers
- 189 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Chronic Pancreatitis
The PASTEC Study: Endoscopic Stenting Versus Surgery for the Treatment of Bile Duct Stricture in Chronic Pancreatitis
Biliary obstruction complicates the course of chronic pancreatitis in 3%-23% of patients and in these cases, endoscopy and surgery are the treatment modalities of choice.
- Trial name
- PASTEC (NCT02366988)
- Testing
- Endoscopic Biliary Stenting, Surgical treatment Bilio-enteric anastomosis
- Where
- 7 sites in France
- Volunteers
- 7 people
- Sponsor
- University Hospital, Lille
Chronic Rhinosinusitis (Diagnosis), Cystic Fibrosis
Impact of Sinus Surgery on Individuals With Cystic Fibrosis
This study will be a prospective, observational study of patients who undergo endoscopic sinus surgery for cystic fibrosis-related chronic rhinosinusitis (CRS).
- Trial name
- NCT04469439
- Where
- 9 sites in United States
- Volunteers
- 170 people
- Sponsor
- University of California, Los Angeles
Oesophageal Cancer, Oesophageal Disease
EndoVE endosCopic Treatment for Oesophageal and Gastric canceR
This project aims to establish the safety and efficacy of treating patients with inoperable oesophageal cancer or gastric cancer, using an endoscopic electroporation system (EndoVE) to facilitate direct chemotherapy tumour…
- Conditions
- Oesophageal Cancer, Oesophageal Disease, Gastric Cancer
- Trial name
- VECTOR (NCT04649372)
- Testing
- EndoVE
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Mirai Medical
Plantar Fasciitis
Plantar Fasciitis, Operation or Conservative Treatment
The purpose of this study is to compare in a randomized controlled trial the effect of endoscopic operation with the standard conservative treatmentprotocol with training supplemented with 1-3 injections of glucocorticoids in…
- Trial name
- NCT02448316
- Testing
- endoscopic surgery, methylprednisolon, lidokaine
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Bispebjerg Hospital
Pancreas Cancer
Perfusion Assessment With Contrast-Enhanced EUS in Locally Advanced and Metastatic Pancreatic Cancer
Patients with non-resectable pancreatic cancer have a poor prognosis.The analysis of prognostic factors before treatment may be helpful in selecting appropriate candidates for chemotherapy and determining treatment strategies.
- Trial name
- PEACE (NCT03513198)
- Testing
- Endoscopic ultrasound (including fine needle aspiration), Contrast-enhanced endoscopic ultrasound (CE-EUS), Endoscopic ultrasound elastography (EG-EUS)
- Volunteers
- 200 people
- Sponsor
- University of Medicine and Pharmacy Craiova
Crohn Disease
Comparing Endoscopic Strictureplasty vs. Balloon Dilation in Crohn's Disease Strictures
Crohn's disease (CD) is an inflammatory bowel disease characterized by chronic ulcers, strictures, and penetrating lesions in the intestinal tract.
- Trial name
- ES vs BD in CD (NCT06203782)
- Testing
- endoscopic stricturoplasty, endoscopic balloon dilation
- Where
- China
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Diabetes Mellitus, Type 2
Trial to Evaluate Efficacy+Safety of Revita DMR Treatment Paradigm 1 and Retreatment in Type 2 Diabetes Patients
The objective of this study is to evaluate feasibility, safety, and efficacy of endoscopic DMR Treatment Paradigm 1 (compared to sham) and to evaluate feasibility, safety, and efficacy of re-treatment with DMR at 24 weeks…
- Trial name
- REMIND (NCT06092476)
- Testing
- Revita® DMR Treatment
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Obstructive Sleep Apnea
Mechanisms of Upper Airway Obstruction
The current study is designed to examine underlying mechanisms of action of lingual muscles in the maintenance of airway patency during sleep.
- Trial name
- DISE-CAD (NCT04322097)
- Testing
- Hypoglossal Nerve Stimulation
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Chronic Rhinosinusitis With Nasal Polyps
Efficacy of Long-Term Low Dose Macrolide Therapy in Preventing Early Recurrence of Nasal Polyps After Endoscopic Sinus Surgery
This randomized controlled trial evaluated the effectiveness of long-term, low-dose clarithromycin (250 mg/day) in reducing symptoms, improving endoscopic and radiologic scores, and preventing early recurrence of nasal polyps…
- Trial name
- NCT07316959
- Testing
- clarithromycin 250 mg
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Fatima Jinnah Medical University
Achalasia Cardia
Endoscopic Versus Robotic Myotomy for Treatment of Achalasia
Achalasia is a primary esophageal motor disorder of unknown etiology characterized by degeneration of the myenteric plexus, resulting in impaired relaxation of the esophagogastric junction (EGJ), along with loss of peristalsis in…
- Trial name
- ERMA (NCT06290882)
- Testing
- Robotic Heller Myotomy, Peroral Endoscopic Myotomy
- Where
- Spain
- Volunteers
- 144 people
- Sponsor
- Germans Trias i Pujol Hospital
Gastroparesis With Diabetes Mellitus
Trial Investigating Efficacy of G-POEM
The goal of this randomized sham-controlled trial is to ivestigate efficacy and safety of G-POEM in treatment of diabetic gastroparesis and explore impact of G-POEM on glucose metabolism and incretine hormones.
- Trial name
- G-POEM (NCT05830994)
- Testing
- G-POEM
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Hvidovre University Hospital
Diabetes Mellitus, Type 2, Obesity
Holding vs. Continuing Incretin-based Therapies Before Upper Endoscopy
To assess whether holding incretin-based therapy before endoscopy reduces the likelihood of clinically relevant Residual Gastric Volume (RGV).
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Gastroparesis
- Trial name
- NCT06533527
- Testing
- GLP-1 medication
- Where
- 2 sites in United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Urologic Diseases
Aquablation in Benign Prostatic Hyperplasia in Canada
To document the clinical outcome of Aquablation therapy for BPH patient in Canadian cohort.
- Trial name
- NCT05169892
- Testing
- Aquablation
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Can-Am HIFU Inc.