Clinical trials: Therapeutic Endoscopy
Obesity, Mild
EGPSS for Weight Management in an in Vivo Human Model
ndoscopic bariatric and metabolic therapies (EBMTs) have introduced more convenient, minimally invasive, and safe approaches to weight management.
- Trial name
- NCT07186959
- Testing
- endoscopic gastric purse-string suturing
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Liu Yan
Neoplasms,Colorectal
Self-expandable Metal Stent (SEMS) Endoscopic Placement for Malignant Colonic Obstruction Therapy
Compare the effectiveness of Self-expandable metal stent (SEMS) and diverting stoma formation for the bowel preparation as a bridge to surgical treatment of patients with MCO.
- Trial name
- PATENCY (NCT05643989)
- Testing
- Stoma formation, Endoscopic self-expandable metal stent placement
- Where
- Russia
- Volunteers
- 56 people
- Sponsor
- Russian Society of Colorectal Surgeons
Allergic Fungal Rhinosinusitis (AFRS), Chronic Rhinosinusitis (CRS)
Study of Dupilumab 300 mg Every Other Week After Endoscopic Sinus Surgery in Patients With Allergic Fungal Rhinosinusitis (AFRS) on a Background Therapy With Intranasal Corticosteroid Spray
Background: Allergic fungal rhinosinusitis (AFRS) is a severe type of sinus infection. People with AFRS develop heavy mucus and growths called polyps that apply pressure to the sinuses and block their breathing.
- Conditions
- Allergic Fungal Rhinosinusitis (AFRS), Chronic Rhinosinusitis (CRS), Asthma, Nasal Polyps
- Trial name
- NCT06461949
- Testing
- Dupilumab
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Achalasia, Dysphagia
Efficacy & Safety of Submucosal Endoscopic Myotomy With Mucosal Flap (SEMF) in the Treatment of Patients With Achalasia
The purpose of this study is to learn about the safety and usefulness of a procedure called endoscopic submucosal myotomy, which is a new technique in the treatment of achalasia.
- Trial name
- NCT01438398
- Testing
- Submucosal endoscopic myotomy with mucosal flap technique, Submucosal Endoscopic Mucosal Flap (SEMF) technique
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Winthrop University Hospital
Anastomotic Leak Esophagus
Endoscopic Negative Pressure Therapy After Oncological Gastrectomies
Background and study aims: Management of esophago-jejunal anastomotic leackages (EJAL) after gastric resections is challenging. Endoscopic negative pressure therapy (ENPT) is an emerging effective tool for treatment of…
- Trial name
- NCT04362605
- Testing
- Endoscopic Negative Pressure Therapy
- Where
- Germany
- Volunteers
- 8 people
- Sponsor
- University Hospital Tuebingen
Endoscopic Hemostasis, Sedation
Endoscopic Hemostatic and Sedative Treatment of Esophageal and Gastric Variceal Bleeding
Remazolam besylate was used for sedation during endoscopic hemostasis in patients with esophageal and gastric varices rupture and bleeding in liver cirrhosis.
- Trial name
- NCT05554965
- Testing
- Propofol, Remimazolam besylate
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Renmin Hospital of Wuhan University
Esophageal Varices, Non-alcoholic Fatty Liver
Non-invasive Prediction of Esophageal Varices in Patients With Non-Alcoholic Fatty Liver Disease With Advanced Fibrosis
Non-alcoholic fatty liver disease (NAFLD) is defined as accumulation of fat in the liver which is not related to either alcohol excess or other causes such viral infection, immune-mediated, or medication related which can lead to…
- Conditions
- Esophageal Varices, Non-alcoholic Fatty Liver, Compensated Cirrhosis
- Trial name
- NCT05485714
- Testing
- Reviewing records retrospectively of patients undergoing screening endoscopy
- Where
- United Arab Emirates
- Volunteers
- 73 people
- Sponsor
- United Arab Emirates University
Inflammatory Bowel Diseases
Treatment Outcomes of Advanced Neoplasia in IBD
In this study, we aimed to (1) compare cumulative incidences of synchronous and metachronous colorectal neoplasia as well as mortality following AN in CD and UC patients who underwent proctocolectomy, (sub)total colectomy…
- Trial name
- NCT05674773
- Testing
- Endoscopic or surgical resection
- Where
- Netherlands
- Volunteers
- 189 people
- Sponsor
- Radboud University Medical Center
Intraventricular Hemorrhage, Endoscopic Intraventricular Evacuation Surgery, Extraventricular Drainage
Endoscopic Intraventricular Hematoma Evacuation Surgery Versus EVD for IVH
Intraventricular hemorrhage (IVH) accounts for about 20% of intracerebral hemorrhage, but its mortality rate is as high as 50%-80%.
- Trial name
- NCT04037267
- Testing
- endoscopic intraventricular evacuation surgery
- Where
- China
- Volunteers
- 956 people
- Sponsor
- Nanjing PLA General Hospital
Esophageal and/or Gastric Varices
Efficacy and Safety of Endoscopic Injection of Fibrin Sealant Versus Endoscopic Ligature for Bleeding Esophageal Varices
The purpose of this study was to assess whether endoscopic sclerotherapy with Fibrin Sealant was superior to ligature, with or without Polidocanol, in achieving hemostasis in bleeding esophageal varices and preventing rebleeding.
- Trial name
- NCT00161915
- Testing
- Fibrin Sealant
- Where
- 12 sites in Germany
- Sponsor
- Baxter Healthcare Corporation
Liver Cirrhosis and Hepatoma., Gastric Variceal Bleeding
Endoscopic Cyanoacrylate Obliteration vs. Nadolol Treatment in the Prevention of Gastric Variceal Rebleeding
Gastric variceal bleeding has a very high rebleeding rate even after endoscopic variceal injection of cyanoacrylate (GVO) which is considered the first choice of endoscopic treatment.
- Trial name
- GVO-nadolol (NCT00567216)
- Testing
- Nadolol
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Nasopharyngeal Carcinoma, Postradiation, Necrosis, Endoscopy Surgery, Conservative Treatment
A Randomized Controlled Clinical Trial of Surgery Versus Conservative Treatment for Mild and Moderate-grade Nasopharyngeal Necrosis
Post radiation nasopharyngeal necrosis is a relatively special radiotherapy sequelae after radiotherapy for nasopharyngeal carcinoma.
- Trial name
- NCT05228093
- Testing
- Curative-intent endoscopic necrectomy followed by reconstruction using the posterior pedicle nasal septum and floor mucoperiosteum flap, Conservative treatment
- Where
- 4 sites in China
- Volunteers
- 216 people
- Sponsor
- Sun Yat-sen University
Diabetes Mellitus, Type 2
A Trial to Evaluate Safety, Feasibility and Efficacy of Endoscopic Duodenal PEF Therapy
The objective of this study is to evaluate the safety, feasibility and efficacy of pulsed electric field induced duodenal mucosal regeneration (with the Endogenex System en Gen 2 Device) combined with a GLP-1 receptor agonist…
- Trial name
- EMINENT-2 (NCT05984238)
- Testing
- PEF therapy using the Endogenex Device, Semaglutide, 1.0 mg/mL
- Where
- Netherlands
- Volunteers
- 33 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Peptic Ulcer Bleeding
Comparing Two Doses of IV Esomeprazole After Successful Endoscopic Therapy
The investigators used two different doses of esomeprazole (40 mg IV q.d. and 40 mg IV q6h for three days followed by esomeprazole 40 mg q.d.
- Trial name
- lowdosePPI (NCT04407832)
- Testing
- heat probe or hemoclip
- Where
- Taiwan
- Sponsor
- Changhua Christian Hospital
Advanced Hepatocellular Carcinoma, Variceal Bleeding
Early Transjugular Intrahepatic Portosystemic Shunt for Advanced Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) with main trunk portal vein tumor thrombus (PVTT) has poor prognosis. The main lethiferous factor is the upper gastrointestinal hemorrhage by PVTT-related portal hypertension.
- Trial name
- NCT06624098
- Testing
- Early TIPS
- Where
- 2 sites in China
- Volunteers
- 22 people
- Sponsor
- Sun Yat-sen University
Jaw Cysts
Treatment of Mandibular Bone Cyst by Navigation and Endoscopy
In this study, with the assistance of endoscopic technology and intraoperative navigation technology, the removal and curettage of large odontogenic jaw cyst occurred in the mandible were performed to reduce the rate of…
- Trial name
- NCT06567535
- Testing
- Navigation and endoscopy
- Where
- China
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Intracerebral Haemorrhage
Early Minimally Invasive Image Guided Endoscopic Evacuation of Intracerebral Haemorrhage (EMINENT-ICH)
This is an open-labelled, single centre randomised controlled trial evaluating the efficacy of early minimally invasive image-guided hematoma evacuation in combination with the current best medical treatment compared to best…
- Trial name
- EMINENT-ICH (NCT05681988)
- Testing
- Early minimally invasive image guided endoscopic hematoma evacuation, Best medical treatment (BMT)
- Where
- 10 sites in Switzerland
- Volunteers
- 200 people
- Sponsor
- University Hospital, Basel, Switzerland
Patient Satisfaction and Efficacy of Bowel-preparation
Patient Satisfaction and Efficacy of Different PEG-based Bowel Preparations- an Observational Study
An multi-center, observational study where we compare the current standard, PEG-based bowel-prep to a (in Sweden) recently approved and introduced low volume (1 litre) PEG-based bowel-prep (Plenvu) in a clinical routine…
- Trial name
- NCT05192551
- Testing
- Bowel-prep (Plenvu as experimental arm)
- Where
- 5 sites in Sweden
- Volunteers
- 1,000 people
- Sponsor
- Karolinska Institutet
GAVE - Gastric Antral Vascular Ectasia, Bleeding
Cryotherapy for GAVE
Gastric antral vascular ectasia (GAVE) is a condition that can lead to blood loss in the gastrointestinal tract and low blood counts or anemia.
- Conditions
- GAVE - Gastric Antral Vascular Ectasia, Bleeding, Bleeding Gastric
- Trial name
- GAVE Cryo (NCT04760873)
- Testing
- cryotherapy
- Where
- 5 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Gastroesophageal Reflux Disease (GERD)
A Study to Determine the Effectiveness of Endoscopic Full-Thickness Plication for the Treatment of GERD
The aim of this study was to determine the effectiveness of endoscopic full-thickness plication (Plicator; NDO Surgical, Inc., Mansfield, MA) for the treatment of GERD in comparison to a sham procedure.
- Trial name
- NCT00575822
- Testing
- NDO Full-thickness Plicator
- Where
- 15 sites in United States, Belgium and 1 more
- Volunteers
- 159 people
- Sponsor
- NDO Surgical, Inc.