Clinical trials: Therapy Effect
Postoperative Ileus, Anastomotic Leak
SANICS II Trial: Stimulation of the Autonomic Nervous System in Colorectal Surgery by Perioperative Nutrition
The main objective is to investigate the effects of perioperative nutrition on postoperative ileus and anastomotic leakage in patients undergoing colorectal surgery.
- Trial name
- SANICSII (NCT02175979)
- Testing
- enriched enteral nutrition, standard
- Where
- 5 sites in Denmark, Netherlands
- Volunteers
- 280 people
- Sponsor
- Misha D.P. Luyer
Pain
Analgesic Effect of Ketamine in Patients Undergoing Hysteroscopic Endometrial Thermal Ablation Surgery
Hypothesis: The intraoperative administration of ketamine will result in a 30% reduction in opiate requirement following endometrial ablation surgery and the intraoperative administration of ketamine will result in a decreased…
- Trial name
- NCT01106846
- Testing
- Group A: Saline Group, Group B: 1% Ketamine group
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Northwestern University
Obesity, Insulin Resistance
Vitamin D Supplementation to Obese Chinese Males
Hypothesis: Oral Supplementation of Vitamin D can Reduce Hypersecretion of Parathyroid Hormone and Insulin Resistance in Obese Chinese Males.
- Trial name
- NCT01781169
- Testing
- Oral supplementation of vitamin D
- Where
- China
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Shenzhen Center for Chronic Disease Control
Nephrolithiasis, Urolithiasis
Vitamin D Repletion in Stone Formers With Hypercalciuria
Vitamin D plays a critical role in maintaining bone health, as well as preventing cardiovascular disease, cancer, and various autoimmune diseases, such as diabetes.
- Conditions
- Nephrolithiasis, Urolithiasis, Idiopathic Hypercalciuria, Vitamin D Deficiency
- Trial name
- NCT01295879
- Testing
- Ergocalciferol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- New York Presbyterian Hospital
Infection, Human Immunodeficiency Virus, HIV Infections
Safety and Efficacy Study of GSK2838232 in Human Immunodeficiency Virus (HIV)-1 Infected Adults
GSK2838232 is a novel HIV-1 maturation inhibitor (MI) that is being developed for the treatment of HIV-1 infection in combination with other antiretroviral therapy (ART).
- Trial name
- NCT03045861
- Testing
- GSK2838232, Cobicistat
- Where
- 14 sites in United States, Canada
- Volunteers
- 33 people
- Sponsor
- GlaxoSmithKline
Healthy
A Relative Bioavailability Study Evaluating Two New Encorafenib Formulations
Relative bioavailability study to evaluate the pharmacokinetics of two new encorafenib formulations
- Trial name
- ERBA (NCT05446142)
- Testing
- Encorafenib capsule formulation (CAP), Encorafenib first formulation, Encorafenib second formulation
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pfizer
Osteoporosis
Safety/Efficacy of Zoledronic Acid and Alendronate on Bone Metabolism in Postmenopausal Women With Osteoporosis
The aim of this study was to examine the effect of zoledronic acid and alendronate on bone metabolism as measured by biomarkers in postmenopausal women with osteoporosis.
- Trial name
- ROSE (NCT00404820)
- Testing
- Zoledronic acid 5 mg solution, Alendronate 70 mg tablets, Calcium/Vitamin D
- Where
- Germany
- Volunteers
- 604 people
- Sponsor
- Novartis
Scleral Buckling
The Effect of Glaucoma Drops on of the Duration of a Pure Intraocular Gas Bubble
A controlled clinical study comparing the effect of topical aqueous suppressants on intraocular gas duration.
- Trial name
- NCT01843920
- Testing
- Timolol-dorzolamide (Glaucoma drops), standard post-operative topical drops
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Jason Hsu, MD
Childhood Cancer, Insomnia
eHealth Insomnia Intervention for Adult Survivors of Childhood Cancer
There is evidence that survivors of childhood cancer have a high prevalence of poor sleep, including symptoms of insomnia. Insomnia is highly comorbid and has been associated with impaired cognitive performance, a range of…
- Conditions
- Childhood Cancer, Insomnia, Neurocognitive Impairment, Survivorship
- Trial name
- NCT04317742
- Testing
- Sleep Healthy Using the Internet (SHUTi) Intervention Group, Online Patient Education (PE) Control Group
- Where
- United States
- Volunteers
- 1,554 people
- Sponsor
- St. Jude Children's Research Hospital
ASCVD, Elevated Cholesterol
Inclisiran for Participants With Atherosclerotic Cardiovascular Disease and Elevated Low-density Lipoprotein Cholesterol
This is a Phase III, placebo-controlled, double-blind, randomized study in participants with ASCVD and elevated LDL-C despite maximum tolerated dose of LDL-C lowering therapies to evaluate the efficacy, safety, and tolerability…
- Trial name
- ORION-10 (NCT03399370)
- Testing
- Inclisiran Sodium
- Where
- 145 sites in United States
- Volunteers
- 1,561 people
- Sponsor
- The Medicines Company
Asthma
Assess Bronchodilator Effect and Safety of Two Doses of QVM149 Compared to a Fixed Dose Combination of Salmeterol/Fluticasone in Patients With Asthma.
The purpose of this study is to assess peak FEV1 of two doses of QVM149 compared to a fixed-dose combination of salmeterol/fluticasone (50/500μg b.i.d.) and to characterize the respective 24 hour bronchodilator effect profiles in…
- Trial name
- NCT03063086
- Testing
- QVM149 150/50/80 μg o.d., QVM149 150/50/160 μg o.d., salmeterol/fluticasone FDC 50/500 μg b.i.d.
- Where
- 12 sites in Bulgaria, China and 4 more
- Volunteers
- 116 people
- Sponsor
- Novartis Pharmaceuticals
Subdural Hematoma, Traumatic
To Study the Effect of Early Cooling in Acute Subdural Hematoma Patients
This randomized, prospective trial will study the effect of very early cooling in patients undergoing surgical evacuation of acute subdural hematomas (35°C prior to opening the dura followed by maintenance at 33°C for a minimum…
- Trial name
- HOPES (NCT02064959)
- Testing
- Temperature management Zoll Intravascular Temperature Management device
- Where
- 14 sites in United States, Japan
- Volunteers
- 32 people
- Sponsor
- The University of Texas Health Science Center, Houston
Allergic Rhinitis
Effect of Veramyst on the Nasal and Ocular Symptoms of the Early Reaction to Nasal Challenge With Allergen
The purpose of this study is to help us to a better understanding of how nose and eye symptoms are related in patients with allergies.
- Trial name
- NCT00791973
- Testing
- fluticasone furoate
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Insomnia, Major Depressive Disorder
The Exploratory Study to Investigate the Effect of Ramelteon for Insomnia Patients With Major Depressive Disorder by Using Actigraphy
The purpose of this study is to investigate exploratorily the effect of ramelteon 8 mg once daily for 8 weeks in the treatment of insomnia patients with depression by using actigraphy.
- Trial name
- NCT02669082
- Testing
- Ramelteon
- Where
- 7 sites in Japan
- Volunteers
- 26 people
- Sponsor
- Takeda
Primary Sclerosing Cholangitis
Primary Sclerosing Cholangitis With Oral Vancomycin by the Study of Its Antimicrobial and Immunomodulating Effects
Determine the benefit of oral vancomycin therapy for Primary Sclerosing Cholangitis.
- Trial name
- PSC (NCT01802073)
- Testing
- Oral Vancomycin
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Stanford University
Pain, Obesity
IV Lidocaine on Postoperative Pain and QOR on Morbid Obese Patients Undergoing Bypass Surgery
Can Intraoperative systemic lidocaine decrease postoperative opioid consumption and improve quality of recovery after laparoscopic gastric bypass surgery? The hypotheses:does the use of intraoperative systemic lidocaine decrease…
- Trial name
- NCT01180660
- Testing
- Lidocaine Infusion, Normal Saline
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Northwestern University
Filariasis
Relative Bioavailability Study of Emodepside IR-tablets and Solution
This study evaluates 2 new immediate release (IR)-tablet formulations of emodepside and they will be compared to the oral liquid service formulation (LSF) used in the FIH Single Ascending Dose study (DNDi-EMO-001 study) (CT.gov…
- Trial name
- NCT03383523
- Testing
- Emodepside (BAY 44-4400)
- Where
- United Kingdom
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Drugs for Neglected Diseases
Neovascular Age-Related Macular Degeneration
Study of Brolucizumab in Adult Patients With Suboptimal Anatomically Controlled Neovascular Age-related Macular Degeneration
Neovascular age-related macular degeneration is characterized by the presence of choroidal neovascularization (CNV), which consists of abnormal blood vessels originating from the choroid that can lead to hemorrhage, fluid…
- Trial name
- SWIFT (NCT04264819)
- Testing
- RTH258/Brolucizumab
- Where
- 51 sites in France
- Volunteers
- 295 people
- Sponsor
- Novartis Pharmaceuticals
Diarrhea Predominant Irritable Bowel Syndrome
Effects of a Very Low Carbohydrate Diet on Symptoms of Irritable Bowel Syndrome (IBS)
The purposes of this study are to prospectively determine the effect of a very low carbohydrate diet on quality of life and gastrointestinal symptoms in patients with diarrhea-predominant irritable bowel syndrome (IBS-D); and to…
- Trial name
- NCT00616200
- Testing
- Very low carbohydrate diet
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of North Carolina, Chapel Hill
Postoperative Pain
Patient Controlled Analgesia Pump Cues on Patient Satisfaction
To examine whether providing patients with a cue to the availability of pain medication affects patient satisfaction, patient anxiety, PCA efficacy, and safety.
- Trial name
- PCA Cues (NCT02456909)
- Testing
- Patient-Controlled Analgesia pump with Cues, Patient-Controlled Analgesia pump without Cues, Morphine
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Medical College of Wisconsin
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