Clinical trials: Therapy Effect
Knee Replacement Surgery
The Effect of a Prolonged Peripheral Nerve Block on the Level of Pain After a Knee Replacement
The aim of this study is to examine the effect of a prolonged peripheral nerve block (utilizing continuous adductor canal block) on the level of pain after a knee replacement surgery
- Trial name
- NCT06382285
- Testing
- Continues peripheral block
- Volunteers
- 50 people
- Sponsor
- Assaf-Harofeh Medical Center
Healthy Situation
The Effect of Deep Friction Massage on the Achilles Tendon Blood Flow
Background: There is a hypothesis in literature that the mechanical action of deep transverse friction massage (DTF) produces vasodilatation and increases blood flow.
- Trial name
- Friction (NCT01453543)
- Testing
- deep transverse friction massage
- Where
- Belgium
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University Ghent
Postoperative Pain
Effect of a Sciatic Block (SNB) Combined With a Continuous Femoral Block (CFNB) on Pain Scores After Knee Arthroplasty
The purpose of this study is to determine if the addition of a sciatic nerve block (SNB) to a continuous femoral nerve block (CFNB) improves post-operative analgesia after knee arthroplasty.
- Trial name
- NCT01337115
- Testing
- SNB plus CFNB, CFNB
- Where
- Portugal
- Volunteers
- 50 people
- Sponsor
- Centro Hospitalar do Porto
Diabetes Mellitus
Effect of Exenatide on Abdominal Fat Distribution in Patients With Type 2 Diabetes Pretreated With Metformin
A multicenter, randomized, double-blind, placebo-controlled trial will assess the effects of twice-daily subcutaneous injection with exenatide versus treatment with matching placebo injection on abdominal visceral fat content.
- Trial name
- NCT00701935
- Testing
- exenatide
- Where
- 17 sites in United States, Canada
- Volunteers
- 80 people
- Sponsor
- AstraZeneca
Primary IgA Nephropathy
The Effect of Nefecon® in Patients With Primary IgA Nephropathy at Risk of Developing End-stage Renal Disease
The objective of the study is to evaluate efficacy and safety of two different doses of NEFECON in the treatment of patients with primary IgA nephropathy (IgAN) at risk of developing end-stage renal disease, under rigorous blood…
- Trial name
- NEFIGAN (NCT01738035)
- Testing
- NEFECON
- Where
- 58 sites in Belgium, Czechia and 8 more
- Volunteers
- 150 people
- Sponsor
- Calliditas Therapeutics AB
Hepatic Impairment
A Phase I Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of AZD4144
This Phase I, open-label, parallel group study will investigate the single oral dose PK, safety, and tolerability of AZD4144 to male and female participants with mild, moderate, and severe hepatic impairment compared to matched…
- Trial name
- NCT07783308
- Testing
- AZD4144
- Where
- 4 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Mechanical Low Back Pain, Chronic Pain
Comparison of the Effect of Spinal Manipulation by Gender
The purpose of the study was to compare and evaluate the effects of spinal manipulation in patients with chronic mechanical low back pain by gender.
- Conditions
- Mechanical Low Back Pain, Chronic Pain, Gender, Neuromuscular Subluxation of Joint
- Trial name
- CESMG (NCT06578208)
- Testing
- Spinal Manipulation
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- SEFA HAKTAN HATIK
Thin-gingiva
Effect Of Injectable PRF And Microneedling In Patient Undergoing Orthodontic Treatment
To evaluate the effect injectable platelet rich fibrin (i-PRF) along with microneedling on gingival thickness in patients with thin gingival phenotype undergoing non extraction fixed orthodontic treatment
- Trial name
- NCT05449925
- Testing
- Injectable PRF and Microneedling
- Where
- India
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Squamous Cell Lung Cancer
Phase II Study of Platinum (Cisplatin/Carboplatin)and Polymeric Micelles Paclitaxel(Pm-Pac) With Ivonescimab in First Line Metastatic Squamous NSCLC.
This is a prospective, single-arm, multi-center, phase Ⅱ trial to evaluate the efficacy and safety of Polymeric Micelles paclitaxel(pm-Pac), platinum (cisplatin/carboplatin) in combination with Ivonescimab as first-line treatment…
- Trial name
- NCT07009925
- Testing
- Ivonescimab 20mg/kg intravenous every 3 weeks
- Volunteers
- 38 people
- Sponsor
- Jiangsu Cancer Institute & Hospital
Urologic Diseases
Effect of Prewarming During Induction of General Anesthesia Combined With Warmed Intravenous Fluid on Core Temperature.
Hypothermia occurs frequently during general anesthesia. This study is to evaluate the efficacy of 10 minutes of prewarming during induction of general anesthesia during urologic surgery.
- Trial name
- NCT05636189
- Testing
- warming during induction of anesthesia, Prewarmed intravenous fluid administration
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Inje University
Menstrual Pain
Effect of a Calisthenic Exercises on Premenstrual Symptoms
The aim of this study is to examine the effects of an eight-week calisthenic home exercise program on premenstrual symptoms, pain and sleep quality in young women.
- Trial name
- NCT06530368
- Testing
- Calisthenic home exercise programs
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Halic University
Autoimmune, Lupus Erythematosus, Systemic
Effect of Green Tea on Treatment of Lupus
This randomized double blind clinical trial performed on 68 patients (32 in intervention and 36 in control group) diagnosed with SLE.
- Trial name
- NCT02875691
- Testing
- green tea extract
- Where
- Iran
- Volunteers
- 68 people
- Sponsor
- Ahvaz Jundishapur University of Medical Sciences
Adult and Pediatric Chronic Cerebral Disorders
Oxygen Toxicity of HBOT in Chronic Brain Injury
Hypothesis: That HBOT can be toxic in the low-pressure range.
- Trial name
- NCT00592891
- Testing
- Hyperbaric oxygen therapy
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Paul G. Harch, M.D.
Advanced Solid Tumors
Study of MLN8237 in Participants With Advanced Solid Tumors
The purposes of this study were to estimate the relative (Rel) bioavailability (BA) of an oral solution (OS) formulation of alisertib in reference to a powder-in-capsule (PIC) formulation, to characterize the effect of food on…
- Trial name
- NCT00962091
- Testing
- Alisertib
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
Cesarean Scar Defect
Double Vers Single in Cesarean Incision
To assess the effect of single versus double layer closure of caesarean scar on the residual myometrium on the short \& intermediate term.
- Trial name
- NCT05276518
- Testing
- Closure of cesarean section incision
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Orthodontic Treatment
Effect of Laser Application in Pain Management Following the Use of Orthodontic Elastomeric Separators
The aim of this study is to evaluate the effect of low level laser therapy (LLLT) on pain management in people commencing orthodontic treatment. The study design is a randomized controlled trial.
- Trial name
- NCT02209818
- Testing
- Laser Irradiation One dose, Laser Irradiation Two doses
- Where
- Syria
- Volunteers
- 72 people
- Sponsor
- Damascus University
Endometriosis
A Study To Investigate How The Body Handles Multiple Doses Of PF-0243873 And To Investigate The Effect Of PF-02413873 On Sex Hormone Levels In Healthy Young Women
The study will investigate how well multiple doses of PF-02413873 are tolerated by healthy young women, how the body handles multiple doses of PF-02413873 and which effect PF-02413873 has on sex hormones in healthy young women
- Trial name
- NCT00800618
- Testing
- PF-02413873 100 mg QD, PF-02413873 1500 mg QD, PF-02413873 20 mg QD
- Where
- 4 sites in United States, Belgium
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Pfizer
Adenocarcinoma of the Prostate, Recurrent Prostate Cancer
Effect of Quercetin on Green Tea Polyphenol Uptake in Prostate Tissue From Patients With Prostate Cancer Undergoing Surgery
This randomized pilot phase I trial will evaluate if quercetin enhances the uptake of green tea polyphenols in the prostate tissue of men taking green tea extract and undergoing radical prostatectomy.
- Conditions
- Adenocarcinoma of the Prostate, Recurrent Prostate Cancer, Stage I Prostate Cancer, Stage IIA Prostate Cancer
- Trial name
- NCT01912820
- Testing
- green tea extract, quercetin, therapeutic conventional surgery
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Critical Illness, Sepsis
Sepsis Pathophysiological & Organisational Timing
This project proposes to measure delay to admission to Intensive Care (ICU). Delays in the United Kingdom NHS are widely reported possibly because there are fewer ICU beds than in many other developed health care systems.
- Trial name
- SPOT(Light) (NCT01099813)
- Where
- United Kingdom
- Volunteers
- 15,602 people
- Sponsor
- Intensive Care National Audit & Research Centre
Non Insulin Dependent Diabetes
Curcumin Supplementation and Patients With Type 2 Diabetes
Diabetes mellitus is the most common endocrine disorder, causes many complications such as micro- and macro-vascular diseases. Various kinds of antidiabetic drugs have been developed, but most of them have side effects.
- Trial name
- NCT02529982
- Testing
- Curcumin
- Where
- Iran
- Volunteers
- 44 people
- Sponsor
- National Nutrition and Food Technology Institute
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