Clinical trials: Therapy Strategies
COPD
A Translational Study for Prediction of Biomarkers and Identification of Phenotype and Endotype of COPD and Pre-COPD Outcomes in Chinese Population
This is an observational study into more comprehensive understanding, including the trajectories of lung function decline, inflammatory/immunological mechanisms on pre-COPD or PRISm, clinical outcomes and relevant endotypes on…
- Trial name
- NCT06724848
- Where
- 14 sites in China
- Volunteers
- 850 people
- Sponsor
- AstraZeneca
Nonalcoholic Fatty Liver Disease, Type 2 Diabetes Mellitus
Adding Exenatide to Insulin Therapy for Patients With Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease
The primary aim of the study is to determine the impact on hepatic steatosis of replacing premeal rapid-acting insulin for exenatide (Byetta) while maintaining bedtime long-acting detemir (Levemir) insulin in well-controlled…
- Trial name
- NCT01006889
- Testing
- Exenatide
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Florida
CLOPIDOGREL, POOR METABOLISM of (Disorder)
Genotyping Guided Individualized Treatment of Clopidogrel and Ticagrelor in ACS
Clopidogrel, in addition to aspirin, is the cornerstone of therapy in patients suffering from Acute coronary syndrome. However, the platelet inhibitory response to clopidogrel varies substantially among individuals.
- Trial name
- GI-CT (NCT02048228)
- Testing
- genotyping guided therapy Ticagrelor, Clopidogrel, standard therapy clopidogrel
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chinese PLA General Hospital
Coronary Artery Disease
CHoice of Optimal Anti-Thrombotic Strategy in Patients Undergoing Implantation of Coronary Drug-Eluting Stents 4
This study is multi-center, open label, two-by-two factorial, randomized, noninferiority trial to compare the efficacy and safety of polymer-free cobalt-chromium thin drug-coated stents (BioFreedom Ultra) with biodegradable…
- Trial name
- SMART-CHOICE4 (NCT05066789)
- Testing
- Type of stent, Duration of DAPT
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Samsung Medical Center
Traffic Accident, Whiplash Syndrome
Evaluation of Effectiveness and Safety of Korean Herbal Medicine for Post-accident Syndromes After Acute Phase
This study is a single blind, randomized controlled trail. condition/disease: Post-accident syndromes after acute phase treatment/intervention: herbal medicine treatment strategy
- Trial name
- NCT05494008
- Testing
- Korean herbal medicine treatment, Non-Korean herbal medicine treatment
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Jaseng Medical Foundation
HIV Infections
Induction and Expansion of T Cell Repertoire Using Growth Hormone and Vaccination in HIV-1 Infected Patients
Concomitant administration of recombinant human growth hormone (rhGH) may boost the expansion of immune reconstitution and broaden specific T cell responses not achievable by vaccination alone.
- Trial name
- NCT00287677
- Testing
- recombinant human Growth Hormone, Vaccination, HAART
- Where
- 2 sites in Spain
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Germans Trias i Pujol Hospital
Coronary Artery Disease
CArdiac cT in the Treatment of Acute CHest Pain 2 - Myocardial CT Perfusion
The aim of this study is to assess whether the clinical management of patients with recent acute-onset chest pain without acute coronary syndrome may be optimized by a combined coronary CT angiography (CTA) + CT myocardial…
- Trial name
- CATCH2 (NCT02014311)
- Testing
- CTA+CTP guided treatment strategy, CTA guided treatment strategy
- Where
- 7 sites in Denmark
- Volunteers
- 600 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Acute Stroke, Blood Pressure
Blood Pressure Target in Acute Stroke to Reduce hemorrhaGe After Endovascular Therapy
A randomized, multicenter study comparing two strategies: 1 / standard management of systolic blood pressure according to international recommendations (systolic blood pressure <185 mm Hg) versus 2 / intensive blood pressure…
- Conditions
- Acute Stroke, Blood Pressure, Cerebral Hemorrhage
- Trial name
- BP-TARGET (NCT03160677)
- Testing
- Systolic blood pressure target < 130 mm Hg, Systolic blood pressure target < 185 mm Hg
- Where
- 7 sites in France
- Volunteers
- 320 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Asthma
Symbicort Usage in Asthma Treatment and Impact of a New Therapeutic Strategy on Compliance and Asthma Control in France
Descriptive pharmacoepidemiological study on the use of Symbicort Turbuhaler in the treatment of asthma in France and impact of a new therapeutic strategy on the compliance and control of asthma
- Trial name
- SYMBIOSE (NCT00812357)
- Where
- 168 sites in France
- Volunteers
- 579 people
- Sponsor
- AstraZeneca
Heart Failure
A Strategy of Home Telehealth for Management of Congestive Heart Failure(STARTEL)
To demonstrate the safety, feasibility, quality of life, primary caregiver satisfaction, and cost effectiveness of integrated Home Telehealth care versus standard care in a heart failure clinic.
- Trial name
- NCT00247000
- Testing
- Routine Care in a HF clinic vs Home Telehealth Care for HF
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Nova Scotia Health Authority
Inflammatory Bowel Diseases, Ulcerative Colitis
Preemptive HLA Genotyping for the Safe Use of Infliximab-combination Therapy in Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is a common disease in Canada, leading to significant morbidity as a result of remitting and relapsing intestinal inflammation.
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Disease
- Trial name
- INHERIT (NCT04109300)
- Testing
- HLADQA1*05A>G screening, Standard of Care
- Where
- Canada
- Volunteers
- 162 people
- Sponsor
- Western University, Canada
Assess Fidelity to Cognitive-behavioral Therapy for Youth
Project FACTS (Fidelity Accuracy: Comparing Three Strategies)
The objective is to compare the accuracy, costs, and cost-effectiveness of three fidelity measurement methods to assess fidelity to cognitive-behavioral therapy for youth.
- Trial name
- NCT02820623
- Testing
- Self-report, Chart-Stimulated Recall, Behavioral Rehearsal
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Chronic Hepatitis C
Use or Non-use of Epoetin Beta in Patients Infected by Chronic Hepatitis C
The purpose is to demonstrate a correction of anemia in hepatitis C virus treatment with peginterferon plus ribavirin.
- Trial name
- NCT00262379
- Testing
- epoetin beta (NeoRecormon®)
- Where
- 37 sites in France
- Volunteers
- 229 people
- Sponsor
- University Hospital, Angers
Obesity, Cardiovascular Disease
Effectiveness of Four Popular Diet Strategies for Weight Loss and Cardiac Risk Reduction
A single-center randomized trial at an academic medical center in Boston, Mass, of overweight or obese adults with known hypertension, dyslipidemia, or fasting hyperglycemia.
- Conditions
- Obesity, Cardiovascular Disease, Metabolic Syndrome
- Trial name
- NCT02454127
- Testing
- Atkins Diet, Zone Diet, Weight Watchers Diet
- Volunteers
- 160 people
- Sponsor
- Tufts Medical Center
Therapy Adverse Effect
Preoperative Goal-directed Fluid Therapy and Physiological Changes Following One-lung Ventilation
Intraoperative goal-directed fluid therapy (GDFT) is proposed to improve the outcomes of patients undergoing major surgery. In the GDFT algorithm, the employment of fluid bolus plays a crucial role.
- Trial name
- NCT03064880
- Testing
- SV maximization
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Gestational Diabetes, Type 2 Diabetes
Medical Nutrition Therapy Program for Pregnant Women With Diabetes
No dietary strategies have been designed and proved for Mexican pregnant women with diabetes. This is a randomized clinical trial of pregnant women with pregestational type 2 diabetes and gestational diabetes that were followed…
- Trial name
- NCT00860613
- Testing
- medical nutrition therapy program
- Where
- Mexico
- Volunteers
- 162 people
- Sponsor
- Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes
Tubal Pregnancy
Evaluation of Therapeutic Strategies for Treatment of Ectopic Pregnancies (EP) and Evaluation of Subsequent Fertility
Three protocols are used to treat ectopic pregnancies: medical treatment by methotrexate, conservative surgery or radical surgery. There are no data about subsequent fertility except in a cohort study.
- Trial name
- NCT00137982
- Testing
- Treatment of ectopic pregnancy
- Where
- 18 sites in France
- Volunteers
- 600 people
- Sponsor
- Hopital Antoine Beclere
Ulcerative Colitis, Unspecified
Impact of Anti-cytomegalovirus Treatment in the Management of Relapsing Ulcerative Colitis Requiring Vedolizumab Therapy
Ulcerative Colitis (UC) is an inflammatory bowel disease that can require the use of anti-TNF alpha therapy. When anti-TNF alpha failed to obtain a clinical response, the use of a new anti-integrin therapy, vedolizumab, can be…
- Trial name
- CYTOVEDO (NCT04064697)
- Testing
- Valganciclovir
- Where
- 8 sites in France
- Volunteers
- 6 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Asthma
Airway Hyper-responsiveness Study In Asthma Using Salmeterol/Fluticasone Propionate Combination Product
This double-blind, stratified, parallel group study is to determine whether aiming for 'Total control' results in better airway hyper-responsiveness than maintaining the treatment level at which 'Well-controlled' asthma was…
- Trial name
- NCT00291382
- Testing
- Salmeterol/fluticasone propionate combination
- Where
- 35 sites in Belgium, Estonia and 8 more
- Volunteers
- 150 people
- Sponsor
- GlaxoSmithKline
Factor V Leiden Heterozygous Mutation, Factor II Heterozygous Mutation
Evaluation of a Preventive Therapeutic Strategy for Postpartum Venous Thromboembolism in Women With Genetic Risk Factor
Background : pregnancy and postpartum period are times of increased risk for deep vein thrombosis (DVT). The incidence of venous thromboembolic disease (VTE) during pregnancy is estimated at 1-2 per 1,000, and this risk increases…
- Conditions
- Factor V Leiden Heterozygous Mutation, Factor II Heterozygous Mutation, Pregnancy, Postpartum
- Trial name
- POSTPART AS5-2 (NCT07342127)
- Testing
- Retrospective collection of health data, Phone call to every participant
- Where
- 2 sites in France
- Volunteers
- 86 people
- Sponsor
- Hospices Civils de Lyon
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