Clinical trials: Therapy Strategies
Invasive Aspergillosis, Antifungal Therapy
Treatment Duration of IPA
The goal of this observational study is to identify the duration of posaconazole-initiated antifungal treatment for IPA in patients with hematological malignancies and to explore the value of monitoring immune factors and cells…
- Trial name
- NCT06583512
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Peking University People's Hospital
Lung Cancer, Non Small Cell Lung Carcinoma
Residual Hypermethylation in Early Stage Non-Small Cell Lung Cancer (NSCLC) As Part of Adjuvant Therapy and Preventive Strategy
The trial investigates the feasibility and efficacy of targeting Non-Small Cell Lung Cancer (NSCLC) "driven" by epigenetic changes.
- Conditions
- Lung Cancer, Non Small Cell Lung Carcinoma, Hypermethylation
- Trial name
- NCT01209520
- Testing
- Cisplatin, Carboplatin, Paclitaxel
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Miami
Ischemic Stroke
Different Treatment Strategies on Prognosis of Acute Ischemic Stroke(AISDTS)
AISDTS is a prospective registry study, in which clinical information, examination and imaging data of patients with acute ischemic stroke receiving different treatment strategies were collected, grouped and statistically…
- Trial name
- NCT05410457
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Glycogen Storage Disease Type I
Dietary Treatment Strategies and Metabolic Control in Glycogen Storage Disease Type I
The present project will specifically assess metabolic effects of dietary interventions with controlled intake of fructose and fructose/galactose in GSDI, with the aim to provide evidence whether relaxed dietary restrictions of…
- Trial name
- GSD-DIET (NCT06852612)
- Testing
- Fructose, Fructose and galactose
- Where
- 2 sites in Switzerland
- Volunteers
- 20 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Organ Transplantation From Brain-dead Donors
Cooling to Optimize Organ Life in Donor Study
The purpose of this study is to assess the feasibility and safety of mild-to-moderate hypothermia as an in-vivo organ preservation strategy compared to normothermia in 60 brain-dead organ donors.
- Trial name
- COOLDonor (NCT01544530)
- Testing
- Cold isotonic fluid and central venous hypothermia catheter
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Pittsburgh
Overweight and Obesity
Familial Overweight: Comparing Use of Strategies
The purpose of this study is to compare the efficacy of two different approaches (prescribed \& self-directed) to the treatment of childhood obesity and their relative impact on child weight status, physical activity, and diet.
- Trial name
- FOCUS (NCT00746629)
- Testing
- FOCUS
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Non-small Cell Lung Cancer Metastatic, Non-small Cell Lung Cancer
Therapeutic Strategies in Patients With Non-squamous Non-small Cell Lung Cancer With Brain Metastases
The patients carrying a complicated primary lung cancer brain metastases die in less than 3 months of delay disease in the absence of treatment.
- Conditions
- Non-small Cell Lung Cancer Metastatic, Non-small Cell Lung Cancer, Adenocarcinoma of Lung Metastatic to Brain, Cerebral Metastases
- Trial name
- METAL2 (NCT02162537)
- Testing
- Cisplatin, Pemetrexed, Bevacizumab
- Where
- 41 sites in France
- Volunteers
- 95 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
New Strategies, GINA 2006
Opinion of Patients Under Treatment That Meets the Criteria of New Treatment Strategy According to GINA 2006
Cross-sectional, one visit study. All the data will be collected through questionnaires. Descriptives statistics will be applied to the data. 832 patients will participate to the study and 104 physicians.
- Conditions
- New Strategies, GINA 2006, Patient Opinion
- Trial name
- EPAGGELIA (NCT00695357)
- Where
- 31 sites in Greece
- Volunteers
- 832 people
- Sponsor
- AstraZeneca
Ovarian Cancer Stage IV, Ovarian Cancer Stage III
A Combination Therapy Strategy to Prevent Anti-PD-1 Therapy Resistance in Metastatic Ovarian Cancer Patients
This is an open label, non-randomized, 2-stage phase II, single arm study to determine the efficacy of New York esophageal squamous cell carcinoma 1 (NY-ESO-1) peptide vaccine as a priming mechanism to prevent anti-PD1 resistance…
- Conditions
- Ovarian Cancer Stage IV, Ovarian Cancer Stage III, Ovarian Cancer Stage 3
- Trial name
- NCT05479045
- Testing
- NY-ESO-1 Peptide vaccine, Toripalimab-tpzi
- Sponsor
- Georgetown University
Dementia, Cognitive Impairment
Effective Strategies for Dementia Care
The purpose of this study is to determine whether the interventions of Snoezelen, structured reminiscence therapy and 10-minutes activation are effective to reduce apathy in long term care residents with dementia.
- Trial name
- WISDE (NCT00653731)
- Testing
- Snoezelen ©, structured reminiscence therapy, 10-minutes activation
- Where
- Germany
- Volunteers
- 327 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Acute Myeloid Leukemia, Relapsed/Refractory Acute Myeloid Leukemia
Salvage Haploidentical HSCT With DLI and Targeted Therapy for R/R AML
This is a prospective, single-center, observational study to evaluate the efficacy and safety of salvage haploidentical allogeneic hematopoietic stem cell transplantation (haplo-HSCT) combined with post-transplant relapse…
- Conditions
- Acute Myeloid Leukemia, Relapsed/Refractory Acute Myeloid Leukemia, AML, Relapsed/Refractory
- Trial name
- NCT07572695
- Testing
- Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation (haplo-HSCT), Post-transplant Maintenance Therapy
- Volunteers
- 40 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Stroke, Inpatients
A Novel Approach to Enhance True Recovery After Stroke
The purpose of this study is to elucidate pathophysiological mechanisms behind gait disturbances during the early recovery phase after hemiparetic stroke to identify targets for new treatment strategies.
- Conditions
- Stroke, Inpatients, Recovery of Function, Observational Study
- Trial name
- NCT05359367
- Testing
- Observational
- Where
- Sweden
- Volunteers
- 6 people
- Sponsor
- Danderyd Hospital
Literacy
Occupational Therapy-based Literacy Intervention and Classroom Based Literacy Intervention
The purpose of this study is to determine the impact of a literacy focused occupational therapy intervention program versus standard classroom-based reading intervention on reading engagement and reading achievement in elementary…
- Trial name
- NCT03975972
- Testing
- Occupational Therapy Based Literacy Intervention
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Helminthiasis, Nematode Infection
Impact of Alternative Treatment Strategies and Delivery Systems for Soil-transmitted Helminths in Kenya
The mainstay of control of soil-transmitted helminths (STH) is school-based deworming but recent modelling has highlights that in all but low very transmission settings, the treatment of school-aged children is unlikely to…
- Conditions
- Helminthiasis, Nematode Infection, Disease Transmission, Infectious
- Trial name
- TUMIKIA (NCT02397772)
- Testing
- albendazole
- Where
- Kenya
- Volunteers
- 21,761 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Immune Thrombocytopenia
Post IVIG Medication in Children With Immune Thrombocytopenia
This study is a single hospital system, single-arm year-long pilot to evaluate the feasibility of enrolling children with ITP who are receiving IVIG for treatment of disease to a scheduled post-infusion medication for 72 hours…
- Trial name
- NCT04741139
- Testing
- Acetaminophen and Diphenhydramine Only Product
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Baylor College of Medicine
Esophageal Cancer, Radiation Therapy
Toripalimab Plus Radiotherapy for Elderly Esophageal Cancer Patients Treated With Non-chemotherapy Strategy
The goal of this clinical trial is to explore the therapeutic efficacy of immune checkpoint inhibitors combined with radical radiotherapy in elderly patients with esophageal cancer.
- Conditions
- Esophageal Cancer, Radiation Therapy, Immunotherapy, Chemotherapy
- Trial name
- NCT05817201
- Testing
- Toripalimab, Tegafur, IMRT
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Taizhou Hospital
Open Angle Glaucoma
Comparative Effectiveness of Treatment Strategies for Primary Open-Angle Glaucoma
The primary objectives of the study are: 1. To compare the proportion of patients who achieve a successful response to treatment (reduction in Intraocular Pressure (IOP) of >15%) between patients treated with laser surgery…
- Trial name
- RiGOR (NCT01645319)
- Where
- United States
- Volunteers
- 2,597 people
- Sponsor
- Agency for Healthcare Research and Quality (AHRQ)
Amikacin Treatment
Prescription Strategies of Amikacin in Intensive Care Patients on Renal Replacement Therapy: an Observational Prospective Multicenter Study
Amikacin is the aminoglycoside of choice for treatment of severe infections in intensive care. An achievement of its objectives in pharmacokinetics and pharmacodynamics is difficult in intensive care patients because of…
- Trial name
- AMIDIAL-ICU (NCT04322019)
- Testing
- Data record
- Where
- France
- Volunteers
- 112 people
- Sponsor
- CHU de Reims
Esophageal Squamous Cell Carcinoma
Biomarker Based Neoadjuvant Strategies for Locally Advanced Resectable ESCC
This study aims to evaluate the impact of the neoadjuvant treatment strategy based on CPS score on the pathological complete response (pCR) rate in patients with resectable locally advanced esophageal cancer.
- Trial name
- ESCC (NCT06601309)
- Testing
- Serplulimab, Paclitaxel+Cisplatin (Neoadjuvant Chemotherapy), Paclitaxel+Cisplatin(Concurrent Chemoradiotherapy)
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Fujian Medical University Union Hospital
Chronic Pain
Strategies to Improve Pain and Enjoy Life
In the Strategies to Improve Pain and Enjoy Life (STRIPE) study, the effectiveness of a multicomponent intervention will be tested, compared with usual care, on opioid dose and pain outcomes among patients on high dose (≥ 40 mg…
- Trial name
- STRIPE (NCT03743402)
- Testing
- Pain self-management training, video education, motivational interviewing, voluntary self-paced opioid taper
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- University of Washington
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.