Clinical trials: Therapy Strategies
Myeloproliferative Neoplasm, Secondary Leukemia
MultiOmic characteriZation of Acute Myeloid Leukemia Evolving From myelopRoliferative Neoplasm to Identify New Targeted Therapeutic Strategies
Myeloproliferative neoplasms (MPN) are chronic myeloid malignancies characterized by a risk of evolution to acute myeloid leukemia (AML).
- Trial name
- MOZART (NCT06022341)
- Testing
- Multiomic characterization, In vitro drug screening
- Volunteers
- 120 people
- Sponsor
- University Hospital, Angers
Major Depressive Disorder (MDD)
A Duloxetine Dosing Strategy Study in Korean Patients With Major Depressive Disorder
The purpose of this study is to assess nausea severity in response to four different drug dosing strategies of Duloxetine (30 mg with food, 60 mg with food, 30 mg without food, and 60 mg without food) in Korean patients with…
- Trial name
- NCT00960986
- Testing
- Duloxetine hydrochloride
- Where
- 7 sites in South Korea
- Volunteers
- 249 people
- Sponsor
- Eli Lilly and Company
Lung Cancer, Medication Adherence
Implementation Strategies for Monitoring Adherence in Real Time
The objective of this project is to identify effective strategies to help patients with lung cancer manage side effects and achieve optimal adherence to oral targeted therapies.
- Conditions
- Lung Cancer, Medication Adherence, Symptoms and Signs
- Trial name
- iSMART (NCT04347161)
- Testing
- Conversational Agent/Chatbot, Usual Care
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Rheumatoid Arthritis
RICE: Remission by Intra-articular Injection Plus CErtolizumab
Tight control of an adaptive concomitant treatment strategy after initiation of CZP will lead to an improved outcome of RA patients with an active disease despite DMARD treatment.
- Trial name
- RICE (NCT02293590)
- Testing
- Certolizumab Pegol
- Where
- Switzerland
- Volunteers
- 43 people
- Sponsor
- Rüdiger B. Müller
Non Small Cell Lung Cancer, EGFR Gene Mutation
Treatment Strategies and Survival Outcome for Non-small Cell Lung Cancer With Oncogenic Mutation
The purpose of this study is to assess the Treatment Strategies and Survival Outcome for Non-small Cell Lung Cancer With Oncogenic Mutation.
- Conditions
- Non Small Cell Lung Cancer, EGFR Gene Mutation, ALK Gene Mutation, ROS1 Gene Mutation
- Trial name
- PIKACHU (NCT04322890)
- Testing
- Osimertinib, Alectinib 150 MG, Crizotinib 250 MG
- Where
- China
- Volunteers
- 6,000 people
- Sponsor
- Hunan Province Tumor Hospital
Small Cell Lung Cancer Extensive Stage, Brain Metastases
Personalized Radiotherapy for Individualized Treatment Strategies and Monitoring (PRISM)
To characterize feasibility, safety, and/or preliminary efficacy of personalized strategies to adapt standard radiotherapy treatments to individual patient responses.
- Conditions
- Small Cell Lung Cancer Extensive Stage, Brain Metastases, Solid Tumor, Adult, Thoracic Cancer
- Trial name
- PRISM (NCT07139990)
- Testing
- Cohort A: Extensive Stage Small Cell Lung Cancer (ES-SCLC) Thoracic Tumor PULSAR (Personalized ultrahypofractionated stereotactic ablative radiotherapy), Cohort B: Brain metastasis PULSAR (Personalized ultrahypofractionated stereotactic ablative radiotherapy), Cohort C: Sarcoma Pre-Operative PULSAR
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- University of Texas Southwestern Medical Center
Renal Colic
Acupuncture Versus IV Morphine in the Treatment of Acute Pain in ED
Renal colics are a common cause af acute intense pain in medical emergency settings requiring often the use of high level antalgics (opioid) to relief the patient.
- Trial name
- AcuMoPE (NCT02152410)
- Testing
- acupuncture, Morphine
- Where
- 2 sites in Tunisia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Monastir
Type 2 Diabetes
Skin Samples of Diabetic Patients and Healthy Volunteers Collection
The main objective of this study is the Obtention of skin micro-samples collected from healthy volunteers and diabetic patients (type 2 and MODY), intended to be used afterwards to obtain stem cell lines, in the framework of new…
- Trial name
- NCT01349374
- Testing
- skin biopsy
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Cervical Precancer, Cervical Intraepithelial Neoplasia
Point of Care - Triage and Treatment for Cervical Pre-cancer
This study evaluates a modified two-probe thermal ablation protocol using the IRIS™ device and retrospectively assesses an AI-based Automated Visual Evaluation (AVE) triage algorithm among HPV-positive women in El Salvador.
- Conditions
- Cervical Precancer, Cervical Intraepithelial Neoplasia, Human Papillomavirus Infection
- Trial name
- POC (NCT07461818)
- Testing
- IRIS™ Thermal Ablation Device
- Where
- El Salvador
- Volunteers
- 5,000 people
- Sponsor
- Basic Health International, Inc.
Ischemic Stroke
Functional Prognosis in Patients With Ischemic Stroke According to the Therapeutic Strategy Used
The current management of ischemic stroke is based on different strategies that may be combined: intravenous thrombolysis in a stroke ICU, intravenous thrombolysis in a telemedicine procedure, endovascular thrombectomy.
- Trial name
- PARADISE (NCT02856074)
- Testing
- prise de sang, quality of life questionnaire
- Where
- France
- Volunteers
- 821 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Breast Cancer, Invasive Breast Cancer
A Phase 2 Randomized, Double-blind Trial Evaluating the Effects of Chloroquine in Breast Cancer
Chloroquine (CQ) is a well known, well tolerated medication that has been used for many years traditionally for arthritis, lupus, and malaria.
- Trial name
- CUBiC (NCT02333890)
- Testing
- Chloroquine
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Ottawa Hospital Research Institute
Liver Neoplasms, Liver/Hepatobiliary Cancer
CE-IOUS Impact on Surgical Strategy of Liver Tumours and Liver Metastases
Contrast-enhanced intraoperative ultrasound (CE-IOUS) plays an increasingly important role in the surgical therapy planning of primary liver lesions as well as liver metastases.
- Conditions
- Liver Neoplasms, Liver/Hepatobiliary Cancer, Colorectal Cancer Metastatic, Metastases
- Trial name
- NCT05261113
- Testing
- CE-IOUS
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University of Regensburg
Chronic Obstructive Pulmonary Disease
Strategy to Improve Adherence of Roflumilast
Main adverse events of Roflumilast are weight loss, loss of appetite, insomnia, headache, diarrhea, vomiting, and nausea. Although the majority of these adverse reactions were mild or moderate.
- Trial name
- NCT02018432
- Testing
- Roflumilast escalation dosage, Roflumilast conventional dosage
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Asan Medical Center
Ovarian Cancer
Evolution of the Therapeutic Care in Ovarian Cancer From 2011
The ESME Ovarian Cancer database is a multi-center real life database using a retrospective data collection process in 18 French Comprehensive Cancer Center (FCCC) over 20 sites).
- Trial name
- ESME OC (NCT03275298)
- Where
- 20 sites in France
- Volunteers
- 13,331 people
- Sponsor
- UNICANCER
Renal Insufficiency, Chronic, Anxiety
AI-Guided Personalized Relaxation for Hemodialysis Patients
Patients undergoing maintenance hemodialysis frequently experience impaired health-related quality of life, anxiety, and difficulties in coping with the long-term demands of treatment.
- Conditions
- Renal Insufficiency, Chronic, Anxiety, Relaxation Therapy, Maintenance Hemodialysis
- Trial name
- NCT07522944
- Testing
- AI-Guided Relaxation Platform, Standard Hemodialysis Nursing Care
- Where
- Egypt
- Volunteers
- 128 people
- Sponsor
- Alexandria University
Brain Metastases, Growing Lesions After Radiosurgical Treatment
Non Invasive Methods for Differential Diagnosis Radionecrosis/Recurrence After Radiosurgery of Brain Metastases
The purpose of this multicenter study is to assess a diagnostic strategy concerning differential diagnosis between radiation necrosis and relapse in brain metastases treated with radiosurgery.
- Trial name
- CV-METANEC (NCT02636634)
- Testing
- imaging
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
HIV
A Multicentre Trial of Second-line Antiretroviral Treatment Strategies in African Adults Using Atazanavir or Lopinavir/Ritonavir
In the well recognized context of HIV infection chronicity, it is now crucial to identify and evaluate effective, well tolerated and affordable second line regimen in resources limited countries where patients often change…
- Trial name
- ALISA (NCT01255371)
- Testing
- Lopinavir, Atazanavir
- Where
- 2 sites in South Africa, Tanzania
- Sponsor
- ANRS, Emerging Infectious Diseases
Fluid Overload, Fluid Loss
Peroperative Fluid Management in Major Gynecological Cancer Surgeries
The aim of this study is to evaluate the effect of perioperative fluid management on postoperative kidney damage in gynecological cancer surgeries.
- Conditions
- Fluid Overload, Fluid Loss, Perioperative/Postoperative Complications, Acute Kidney Injury
- Trial name
- NCT06101498
- Testing
- Akut kidnet injury(AKI)
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Intellectual Disability, Intellectual Impairment
Perceptual-vision Training and Intellectual Disabilities
Physical activity for healthy ageing is an important feature and the possibility to detect practical solutions to solve the need for feasible health promotion interventions to reduce health disparities and wellbeing in…
- Conditions
- Intellectual Disability, Intellectual Impairment, Activity, Motor, Sports Physical Therapy
- Trial name
- NCT06628999
- Testing
- Visual Training, Control Group, Visual Training-detraining
- Volunteers
- healthy volunteers welcome
- Sponsor
- Università degli Studi dell'Insubria
Rheumatoid Arthritis, Osteoarthritis
Patient Education in Rheumatoid Arthritis and Osteoarthritis
This project will evaluate the effectiveness and general usefulness of two arthritis patient education programs. The first, the Arthritis Self-Management Program, is a 6-week, community-based program taught in small groups by…
- Trial name
- NCT00000414
- Testing
- Arthritis Self-Management Program, SMART Program
- Where
- 5 sites in United States, Canada
- Volunteers
- 1,200 people
- Sponsor
- Stanford University
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