Clinical trials: Therapy Strategies
Multiple Myeloma
The Role of Ixazomib in Autologous Stem Cell Transplant in Relapsed Myeloma - Myeloma XII (ACCoRd)
Study design: Randomised, controlled, multi-centre, open-label, phase III trial (with a single intervention registration phase).
- Trial name
- NCT03562169
- Testing
- Ixazomib, thalidomide, & dexamethasone (ITD) re-induction, Conventional autologous stem cell transplant (ASCT-con), Augmented autologous stem cell transplant (ASCT-aug)
- Where
- 91 sites in United Kingdom
- Volunteers
- 406 people
- Sponsor
- University of Leeds
Advanced Colorectal Cancer, Circulating Tumor DNA
Circulating Tumor DNA Guided Therapeutic Strategies for CRC Patients With Small Pulmonary Nodules
The clinical diagnosis and treatment of small pulmonary nodules (suspected to be lung metastases) in advanced colorectal cancer patients remain controversy.
- Trial name
- NCT05495672
- Testing
- Local treatment
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Junjie Peng
Acute Kidney Injury, Fluid Overload
Early Deresuscitation Strategy Driven by Tissue Perfusion in Renal Replacement Therapy in Patients With Acute Renal Failure
In Intensive Care Unit (ICU) patients with acute kidney injury (AKI) and treated with renal replacement therapy (RRT) often present a fluid overload which is associated with morbidity (mechanical ventilation duration increase…
- Trial name
- EarlyDry (NCT05817539)
- Testing
- Fluid balance negativation, Body weight Stabilization
- Where
- 14 sites in France
- Volunteers
- 250 people
- Sponsor
- Hospices Civils de Lyon
Ovarian Cancer
Study of the Impact on Survival of a Paradigm Shift in the Therapeutic Strategy of Patients With Advanced Ovarian Cancer
Ovarian cancer is the 8th leading cause of cancer-related death in women. Its prognosis is poor, with diagnosis often made at an advanced stage.
- Trial name
- PACO (NCT06907771)
- Where
- France
- Volunteers
- 130 people
- Sponsor
- University Hospital, Strasbourg, France
Lyme Disease, Borrelia Infection
Persistent Lyme Empiric Antibiotic Study Europe
The purpose of the study is to establish whether prolonged antibiotic treatment of patients diagnosed with proven or presumed PLD (as endorsed by the international ILADS guidelines) leads to better patient outcome than short-term…
- Trial name
- PLEASE (NCT01207739)
- Testing
- Doxycycline, Clarithromycin and hydroxychloroquine
- Where
- 2 sites in Netherlands
- Volunteers
- 280 people
- Sponsor
- Radboud University Medical Center
Low Back Pain, Recurrent
Treatment of Veterans With Chronic Low Back Pain
The purpose of this study is to assess the effectiveness of hypnosis in the treatment of chronic low back pain.
- Trial name
- CLBP (NCT00361270)
- Testing
- Hyp-8, Hyp-2 w recordings, Hyp-8 w recordings
- Where
- United States
- Volunteers
- 161 people
- Sponsor
- VA Office of Research and Development
Multiple Myeloma
Minimal Residual Disease-based Strategy With T-Cell Redirector After Treatment With Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone (D-VRd) in Newly Diagnosed Multiple Myeloma
This is a Phase 2 study, open-label, 2-cohort, multicenter, national, interventional in patients with newly diagnosed multiple myeloma.
- Trial name
- IFm2022-01 (NCT06353022)
- Testing
- Teclistamab, Talquetamab, Lenalidomide
- Where
- 19 sites in France
- Volunteers
- 103 people
- Sponsor
- Nantes University Hospital
Dementia, Cognitive Impairment
Effective Strategies for Dementia Care
The purpose of this study is to determine whether the interventions of Snoezelen, structured reminiscence therapy and 10-minutes activation are effective to reduce apathy in long term care residents with dementia.
- Trial name
- WISDE (NCT00653731)
- Testing
- Snoezelen ©, structured reminiscence therapy, 10-minutes activation
- Where
- Germany
- Volunteers
- 327 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Oral Cancer
The Optimal Neck Treatments Strategy of Early Oral Cancer Based on Adverse Pathological Factor
Cervical nodal metastasis is the most certain prognostic factor in oral cancer. Appropriate management of the neck is therefore of paramount importance in the treatment of oral cancer.
- Trial name
- NCT03017053
- Testing
- Radiotherapy, Elective neck dissection
- Where
- China
- Volunteers
- 270 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
COVID-19
Treatment of COVID-19 Cases and Chemoprophylaxis of Contacts as Prevention
This study is a research project to evaluate the efficacy of hydroxychloroquine for post-exposure prophylaxis and early treatment of Covid-19.
- Trial name
- HCQ4COV19 (NCT04304053)
- Testing
- Treatment and prophylaxis, Standard Public Health measures
- Where
- Spain
- Volunteers
- 2,300 people, healthy volunteers welcome
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
Diabetes
Leveraging Interventions for Needs and Knowledge in Diabetes
Unmet social needs and economic burden persist as key reasons why one-third of people with diabetes have poor disease control. The purpose of this study is to learn whether different tools and types of support may help people…
- Trial name
- LINKD (NCT07676188)
- Testing
- FindHelp, Peer Support, Social Work
- Where
- United States
- Volunteers
- 694 people
- Sponsor
- University of Michigan
Binge Eating Disorder Associated With Obesity, Binge Eating Disorder
Behavioral Therapy and GLP-1 Analogue Effects on Binge Eating, Weight, and Coping in Obesity
This study is a clinical, longitudinal, non-randomized, prospective observational study that seeks to compare the treatment effects and safety of using GLP-1 analogues versus not using appetite suppressants during a lifestyle…
- Conditions
- Binge Eating Disorder Associated With Obesity, Binge Eating Disorder, Eating Disorder Binge, Eating Disorders
- Trial name
- BETTER-GLP1 (NCT07042672)
- Testing
- GLP-1, CBTe Group Therapy
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Haukeland University Hospital
COVID-19, Immunodeficiency
OPtimisation of Antiviral Therapy in Immunocompromised COVID-19 Patients: a Randomized Factorial Controlled Strategy Trial
The overall purpose of the trial is to evaluate the efficacy and safety of possible combination antiviral therapy DAA (remdesivir + nirmatrelvir/r)∞ versus the reference monotherapy (nirmatrelvir/r alone) and to assess the…
- Trial name
- OPTICOV (NCT05587894)
- Testing
- Paxlovid 5 days, Paxlovid 10 days, Veklury
- Where
- 18 sites in France, Italy and 1 more
- Volunteers
- 256 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Postoperative Pain, Anxiety
The Effect of Coaching Strategy on Some Patient Outcomes After Total Knee Arthroplasty Surgery
Total knee arthroplasty (TKA); It is frequently applied to adults, especially those over the age of 55. Total knee arthroplasty surgery is among the surgeries with a high satisfaction rate for the patient, although complications…
- Conditions
- Postoperative Pain, Anxiety, Self Efficacy, Patient Satisfaction
- Trial name
- NCT04683588
- Testing
- Nursing Coaching
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Selcuk University
HIV (Human Immunodeficiency Virus), Substance Abuse Disorder
TechMPower: Advancing HIV/SUD Care and Service Delivery for People in Re-entry
The goal of this clinical study in one NY county is to pilot and refine implementation strategies aimed at improving delivery and uptake of evidence-based practices (EBPs) for HIV prevention/treatment and substance use disorder…
- Trial name
- TMP Project (NCT07088770)
- Testing
- Community Coalition CLS Workgroup/Network of Providers, Tech-mediated Training and Service Delivery, Multidisciplinary Implementation Team with Champion
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Columbia University
Cocaine Dependence
A PET Exploration of the Mechanism of Action of Dopamine Beta-hydroxylase Inhibition in Cocaine Addicts
This study represents a randomized, double blind placebo-controlled trial. Thirty cocaine dependant patients will be included in this study during their hospitalization for withdrawal.
- Trial name
- RAPID (NCT02134002)
- Testing
- Disulfiram
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Helicobacter Pylori Infection
Study of Levofloxacin-based Concomitant Therapy for H. Pylori Eradication in Diabetic Patients
The study aims to evaluate H. pylori eradication rate in diabetic patients by using novel 10-day levofloxacin-based concomitant therapy compared with conventional 10-day sequential therapy.
- Trial name
- NCT02466919
- Testing
- Pantoprazole, Amoxicillin, Metronidazole
- Volunteers
- 114 people
- Sponsor
- Chung-Tai Wu
Upper Gastrointestinal Bleeding
Anticoagulation With Enhanced Gastrointestinal Safety (AEGIS) Trial
This is a pragmatic, single center, feasibility pilot cluster randomized trial with embedded individual randomization to evaluate implementation strategies to increase the use of evidence-based practices to reduce upper…
- Trial name
- AEGIS (NCT05085405)
- Testing
- Clinician notification, Clinician Notification with Nurse Facilitation, Clinician Notification / Patient Activation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Michigan
Mild-to-moderate Ulcerative Colitis
Study to Assess Effectiveness of Therapy Timely Adjustment Based on Self-monitoring in Patients Suffering From Mild-to-moderate Ulcerative Colitis (OPTIMISE Study)
The purpose of this study is to provide evidence that a therapy of Ulcerative Colitis (UC) disease adjusted on tight monitoring of non-invasive parameters, such as clinical symptoms and faecal calprotectin (FC) (substance that is…
- Trial name
- OPTIMISE (NCT04340895)
- Testing
- Faecal Calprotectin Home Test, PRO-2 Scoring
- Where
- 42 sites in Czechia, Hungary and 4 more
- Volunteers
- 250 people
- Sponsor
- Ferring Pharmaceuticals
Hodgkin Lymphoma
CCCG-HD-2018 for Children and Adolescents With Newly Diagnosed Hodgkin Lymphoma
The incidence of Hodgkin's lymphoma (HL) in Chinese children and adolescents is only 1 / 10 of that in Europe and the United States, which is a "rare" childhood tumor.
- Trial name
- NCT04726501
- Testing
- Combined chemotherapy with or without involved-field radiotherapy
- Where
- 3 sites in China
- Volunteers
- 200 people
- Sponsor
- Children's Cancer Group, China
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