Clinical trials: Therapy Strategies
HIV
Phase I Study of HIV 1 Antigen Expanded Specific T Cell Therapy
This is a phase 1, single-site study is to evaluate the safety and immunologic and virologic efficacy of ex vivo expanded HIV-1 multi-antigen specific T-cell (HXTC) therapy in HIV-infected individuals with viral suppression on…
- Trial name
- HXTC (NCT02208167)
- Testing
- HXTC infusion
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of North Carolina, Chapel Hill
Trichomonas Vaginalis, Urethritis
Study to Improve Partner Services for STD Prevention
The goal of this study was to examine the efficacy of patient-delivered partner treatment (PDPT) compared to standard partner referral (PR) and booklet enhanced partner referral (BEPR).
- Trial name
- NCT00207467
- Testing
- Patient-delivered partner treatment, Booklet-enhanced partner referral
- Where
- 2 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- Centers for Disease Control and Prevention
Radiation Therapy, Chemoradiotherapy
Application of Intelligent Care Systems in Radiation Therapy: Enhancing Patient Safety and Reducing Anxiety Through System Optimization and Real-Time Blood Data Monitoring
This study aims to evaluate the impact of an intelligent care system on radiation therapy patients, focusing on real-time blood data monitoring, optimized patient education, and internal alert systems.
- Conditions
- Radiation Therapy, Chemoradiotherapy, Anxiety, Adherence
- Trial name
- ICS-RT (NCT06833801)
- Testing
- Real-Time Blood Data Monitoring System (Device/Software Integration), Enhanced Patient Education Materials (Behavioral/Educational Intervention), Internal Warning Signs and Alerts (Behavioral Intervention)
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Chung Shan Medical University
Rotator Cuff Tears of the Shoulder, Shoulder Adhesive Capsulitis
Partial Rotator Cuff Injury Combined With Stiff Shoulder
A Randomized Controlled Trial Comparing Early Surgical Intervention Versus a Structured Rehabilitation Program with Delayed Surgery if Needed for Partial-Thickness Rotator Cuff Tears with Concomitant Shoulder Stiffness: The…
- Conditions
- Rotator Cuff Tears of the Shoulder, Shoulder Adhesive Capsulitis, Shoulder Arthroscopy
- Trial name
- NCT07192302
- Testing
- Arthroscopy, Drugs administration
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Hebei Medical University Third Hospital
Type 1 Diabetes
Closed-loop Control of Overnight Glucose Levels (Artificial Pancreas) in Children With Type 1 Diabetes in a Diabetes Camp
Closed-loop strategy is composed of three components: glucose sensor to read glucose levels, insulin pump to infuse insulin and a dosing mathematical algorithm to decide on the required insulin dosages based on the sensor's…
- Trial name
- NCT02189694
- Testing
- Single-hormone closed-loop strategy, Dual-hormone closed-loop strategy, Insulin pump therapy
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Mitral Valve Insufficiency, Mitral Valve Annuloplasty
Study on Surgical Treatment Strategies for Moderate Ischemic Mitral Regurgitation
This study aimed to compare the efficacy of isolated coronary artery bypass grafting and coronary artery bypass grafting + mitral valve repair in moderate ischemic mitral regurgitation patients through a cohort and explore the…
- Conditions
- Mitral Valve Insufficiency, Mitral Valve Annuloplasty, Coronary Artery Bypass
- Trial name
- NCT06408779
- Testing
- mitral valve repair
- Where
- China
- Volunteers
- 464 people
- Sponsor
- China National Center for Cardiovascular Diseases
Carotid Stenosis
Clopidogrel and Atorvastatin Treatment During Carotid Artery Stenting
The purpose of this study is to evaluate the efficacy and safety of two different loading doses of Clopidogrel and a reloading of Atorvastatin in the prevention of periprocedural ischemic brain damage in patients undergoing…
- Trial name
- ARMYDA-CARO (NCT01572623)
- Testing
- Clopidogrel, Atorvastatin
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Campus Bio-Medico University
Beta Thalassemia Major
Monitoring of Chimerism After Transplantation in Patients With β Thalassemia Major and the Treatment Strategies for the Reduction of Chimerism
Hematopoietic stem cell transplantation is currently the only way to cure thalassemia, one of its main obstacles is the rejection after transplantation, chimerism continued to decline, which eventually lead to transplant failure.
- Trial name
- NCT03101423
- Testing
- Interleukin-2, Donor Regulatory T-Lymphocytes
- Where
- China
- Volunteers
- 30 people
- Sponsor
- First Affiliated Hospital of Guangxi Medical University
HIV Infections
A Randomized Trial of the Efficacy and Safety of a Strategy of Starting With Nelfinavir Versus Ritonavir Added to Background Antiretroviral (AR) Nucleoside Therapy in HIV-Infected Individuals With CD4+ Cell Counts Less Than or Equal to 200/mm3
To compare nelfinavir (NFV) with ritonavir (RTV) for delaying disease progression or death in HIV-infected patients with CD4+ cell counts less than 100 cells/mm3 [AS PER AMENDMENT 3/11/98: less than or equal to 200 cells/mm3].
- Trial name
- NCT00000859
- Testing
- Indinavir sulfate, Ritonavir, Nelfinavir mesylate
- Where
- 44 sites in United States, Canada
- Volunteers
- 1,300 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Functional Gastrointestinal Disorders
Emotion Focused Therapy in Irritable Bowel Syndrome Patients
The study was quasi-experimental including patients in two intervention and control groups. Three measurements were done: pretest, post-test, and a two-months follow-up.
- Trial name
- NCT02657668
- Testing
- Emotion Focused Therapy
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Najafabad Branch
Idiopathic Pulmonary Fibrosis
CleanUP IPF for the Pulmonary Trials Cooperative
The purpose of this study is to compare the effect of standard care, versus standard of care plus antimicrobial therapy (co-trimoxazole or doxycycline), on clinical outcomes in patients diagnosed with idiopathic pulmonary…
- Trial name
- CleanUp-IPF (NCT02759120)
- Testing
- Antimicrobial therapy: Co-trimoxazole or Doxycycline, No Intervention: Standard of Care
- Where
- 31 sites in United States
- Volunteers
- 513 people
- Sponsor
- Weill Medical College of Cornell University
Emotional Instability
Effectiveness Study of a Dialectical Behavioral Treatment for Adolescents With Emotional Instability and Their Families
Emotional instability disorder (IE) is appreciable since adolescence, and crises (suicidal ideation, self-harm, impulsive acts and brief psychotic episodes) carry a high use of health resources, coupled with the suffering of…
- Trial name
- NCT02991586
- Testing
- Dialectical Behaviour Therapy
- Where
- Spain
- Volunteers
- 96 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Coronary Artery Disease, Ischemic Heart Disease
Evaluation of Treatment Strategies for Severe CaLcIfic Coronary Arteries: Orbital Atherectomy vs. Conventional Angioplasty Technique Prior to Implantation of Drug-Eluting StEnts: The ECLIPSE Trial
This trial will evaluate Orbital Atherectomy compared to conventional balloon angioplasty technique for the treatment of severely calcified lesions prior to implantation of drug-eluting stents (DES).
- Conditions
- Coronary Artery Disease, Ischemic Heart Disease, Non ST Segment Elevation Myocardial Infarction
- Trial name
- ECLIPSE (NCT03108456)
- Testing
- Orbital Atherectomy, Balloon
- Where
- 104 sites in United States
- Volunteers
- 2,005 people
- Sponsor
- Abbott Medical Devices
Transplantation, Renal, Immunosuppression
MPA PK Monitoring Strategy With MMF/FK Based Immunosuppression
Individuals absorb Cellcept (MMF/Mycophenolate Mofetil) at different rates and it is difficult to determine an individuals level of Mycophenolate Mofetil (MMF, trade name Cellcept)from a single measurement.
- Trial name
- NCT00187941
- Testing
- Mycophenolate Mofetil
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Florida
HIV-1-infection, Antiretroviral Therapy
Evaluation of a Simplified Strategy for the Long-term Management of HIV Infection (Simpl'HIV)
The purpose of this study is to evaluate whether maintenance antiretroviral therapy could be simplified to DTG + FTC dual therapy and/or patient-centered monitoring once virological suppression is achieved.
- Conditions
- HIV-1-infection, Antiretroviral Therapy, Maintenance Therapy
- Trial name
- Simpl'HIV (NCT03160105)
- Testing
- Switch to DTG + FTC, Patient-centered monitoring
- Where
- 7 sites in Switzerland
- Volunteers
- 186 people
- Sponsor
- Calmy Alexandra
Venous Thromboembolic Disease, Kidney Failure, Chronic
Anticoagulation Strategies for Acute Venous Thromboembolism in Patients With End-Stage Renal Disease Using USRDS Data
Patients with end stage renal disease (ESRD) are at significantly increased risk of thrombosis and bleeding relative to those with normal renal function which makes anticoagulation particularly challenging.
- Trial name
- NCT04818151
- Testing
- Warfarin, Apixaban
- Where
- United States
- Volunteers
- 14,914 people
- Sponsor
- Johns Hopkins University
Aging, Arterial Stiffness
Empagliflozin Reversal of Arterial StiffnEss in Aging
Randomized placebo-controlled clinical trial in a cohort of males (n=40) and females (n=40), 60-80 years of age, with the hypothesis that SGLT2 inhibition with empagliflozin (10mg/day for 12 weeks) reduces aging-related arterial…
- Trial name
- ERASE-Aging (NCT06506422)
- Testing
- Empagliflozin 10 MG
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Locally Advanced Vulvar Carcinoma, Squamous Cell Carcinoma of the Vulva
Primary Chemoradiation VS. Neoadjuvant Chemotherapy Followed By Surgery As Treatment Strategy For LAVC
A phase 2 randomised controlled trial will be performed in which the efficacy and safety of standard treatment (primary chemoradiation; consisting of 64.5 Gy in 30 fractions of external beam radiotherapy with weekly cisplatin for…
- Trial name
- VULCANIZE-II (NCT05905315)
- Testing
- Paclitaxel and Carboplatin, Chemoradiation
- Where
- 2 sites in Netherlands
- Volunteers
- 98 people
- Sponsor
- The Netherlands Cancer Institute
Smoking Cessation, Smoking Cessation Intervention
Unraveling the Genetic Basis of Nicotine Addiction for Novel Therapeutic Strategies
This case-control study aims to investigate the genetic and molecular bases of nicotine addiction to identify potential therapeutic targets.
- Conditions
- Smoking Cessation, Smoking Cessation Intervention, Nicotine Addiction, Epigenetics
- Trial name
- NicoGen (NCT06471387)
- Testing
- Flexiquit Smoking Cessation Intervention
- Where
- Cyprus
- Volunteers
- 200 people
- Sponsor
- University of Cyprus
Tension-type Headache
Assessing the Effectiveness of Two Treatment Strategies for Tension-type Headache
The primary aim of the pilot data proposal is to compare usual care (medications) versus multi-disciplinary treatment in temporomandibular disorder (TMD) patients.
- Trial name
- NCT01347684
- Testing
- Behavioral therapy, splint therapy and physical therapy, Standard care using current drugs
- Where
- 2 sites in United States
- Sponsor
- University of Minnesota
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.