Clinical trials: Therapy Strategies
Alcohol Use Disorder
Leveraging Virtual Care Strategies to Improve Access and Treatment for Individuals With Alcohol Use Disorders
The purpose of this research study is to test new technology-driven programs to see if they might help people manage their health and health behaviors related to alcohol use and well-being.
- Trial name
- NCT05594238
- Testing
- Telephone Engagement, Portal Engagement, MI-CBT
- Where
- United States
- Volunteers
- 362 people
- Sponsor
- University of Michigan
Heart Failure
Strategy to Recognize and Initiate Treatment of Chronic Heart Failure
The purpose of this study is to determine whether a structured diagnostic-therapeutic strategy to detect and treat previously unrecognized (or unestablished) heart failure in primary care will improve the functional capacity…
- Trial name
- STRETCH (NCT01202006)
- Testing
- Training of general practitioners in an uptitration protocol.
- Where
- Netherlands
- Volunteers
- 585 people
- Sponsor
- UMC Utrecht
Coronary Artery Disease
Comparative Clinical Study of Drug-coating Balloon Strategy and Drug-eluting Stent Strategy
The trial aims to evaluate the long-term clinical outcome of the DCB-only technique is non-inferior to the provisional T stenting with DES in the patients who have 'true' bifurcation lesions.
- Trial name
- Kissing-DCB (NCT04842838)
- Testing
- paclitaxel DCB, DES
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Peking University Third Hospital
Depression
Personalized Antidepressant Adherence Strategies For Depressed Elders
The study is a randomized controlled trial to test the usefulness of a brief intervention to improve adherence to antidepressant medication prescribed to older adults in a primary care setting.
- Trial name
- TIP (NCT01301859)
- Testing
- TIP
- Where
- 2 sites in United States
- Volunteers
- 231 people
- Sponsor
- Weill Medical College of Cornell University
Chronic Pancreatitis
Pirfenidone as Treatment of Chronic Pancreatitis
The proposed project is focused towards evaluation of Pirfenidone as a novel therapeutic strategy in patients with chronic pancreatitis (CP).
- Trial name
- PATCH (NCT07755813)
- Testing
- Pirfenidone 267 mg Oral Tablet, PROMIS-Global Health, Comprehensive Pain Assessment Tool
- Volunteers
- 60 people
- Sponsor
- Vikas Dudeja
Bipolar Disorder
Optimal Length of Treatment Continuation With Olanzapine After Remission of Manic or Mixed Episode
This is a randomized, parallel, open-label study of patients who have responded to treatment in the acute phase of their manic or mixed episode, with or without psychotic symptoms, with olanzapine in mono or co-therapy, and who…
- Trial name
- NCT00191997
- Testing
- Olanzapine
- Where
- 11 sites in Spain
- Volunteers
- 180 people
- Sponsor
- Eli Lilly and Company
Human Immunodeficiency Virus
Prevention and Treatment Continuum for Youth at HIV Risk, Acutely Infected and With Established HIV Infection
This is a strategic prospective cohort study which will measure the effects of early intensive antiretroviral therapy (ART) on the establishment and persistence of HIV-1 reservoirs and HIV-1-specific immunity in acutely /recently…
- Trial name
- NCT03205696
- Testing
- Antiretrovirals
- Where
- 3 sites in United States
- Volunteers
- 101 people
- Sponsor
- University of California, Los Angeles
Preeclampsia
Blood Collection to Validated New Therapeutics Strategies Against Preeclampsia
The aim of the study is to setup a collection of maternal plasma and serum from patients with preeclampsia and normal pregnancy for in vitro validation of new therapeutics based on extra-corporal removal of sFlt-1
- Trial name
- APHERESE (NCT03188900)
- Testing
- A collection of maternal plasma and serum
- Where
- France
- Volunteers
- 236 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Tuberculosis, Multidrug-Resistant, Tuberculosis
Linezolid Dosing Strategies in Drug-Resistant TB
The purpose of the study was to evaluate the efficacy (how well the medicines work) and tolerability (whether participants stop treatment because of side effects from a drug) of an anti-TB treatment regimen that compared two…
- Conditions
- Tuberculosis, Multidrug-Resistant, Tuberculosis, Tuberculosis, Pulmonary
- Trial name
- NCT05007821
- Testing
- Linezolid 600 mg, Linezolid 1200 mg (QD), Linezolid 1200 mg (TIW)
- Where
- 13 sites in Botswana, Brazil and 5 more
- Volunteers
- 138 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Advanced Non-small Cell Lung Cancer (NSCLC), EGFR Exon 19 Deletion Mutation
Befotertinib Plus Chemotherapy With an MRD-guided Adaptive Strategy for Treatment Escalation and Response Optimization in EGFR-mutated NSCLC Patients
This is a multicenter, phase II exploratory clinical trial in untreated patients with EGFR-mutant non-small cell lung cancer (stages IIIB-IV) .All participants will receive oral befotertinib monotherapy for 3 weeks first, then…
- Conditions
- Advanced Non-small Cell Lung Cancer (NSCLC), EGFR Exon 19 Deletion Mutation, EGFR Exon 21 Mutation, EGFR Exon 21 L858R Mutation
- Trial name
- BE-MASTER (NCT07709585)
- Testing
- Befotinib, Pemetrexed + Cisplatin /Carboplatin
- Where
- 2 sites in China
- Volunteers
- 124 people
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
Critical Limb Ischemia
Registry of First-line Treatments in Patients With Critical Limb Ischemia
The principal research question is which treatment modality between open surgical, endovascular and conservative therapy is the most effective in terms of limb salvage, survival and reinterventions in patients with critical limb…
- Trial name
- CRITISCH (NCT01877252)
- Testing
- Surgical revascularization, Endovascular revascularization, No vascular intervention
- Where
- Germany
- Volunteers
- 1,200 people
- Sponsor
- St. Franziskus Hospital
Multiple Myeloma
MLN9708 and Dexamethasone for High-Risk Smoldering Multiple Myeloma
Background: Smoldering multiple myeloma (SMM) is a condition that can lead to multiple myeloma, a type of blood cancer. In many high-risk cases, SMM can develop into multiple myeloma in less than 2 years.
- Trial name
- NCT01660997
- Testing
- MLN9708, Dexamethasone
- Sponsor
- National Cancer Institute (NCI)
Psoriasis
A Study to Evaluate Further Therapeutic Strategies With Guselkumab in Participants With Moderate-to-Severe Plaque-Type Psoriasis
The purpose of this study is to demonstrate that Super-Responders (SRe; defined as psoriasis participants who receive on-label guselkumab treatment until week 20 and respond with a Psoriasis Area and Severity Index score (PASI) =…
- Trial name
- GUIDE (NCT03818035)
- Testing
- Guselkumab
- Where
- 90 sites in France, Germany
- Volunteers
- 880 people
- Sponsor
- Janssen-Cilag International NV
Spinal Deformity
CLIF Correction VS. Conventional Correction Strategy for ASD
The present study intends to: 1）establish a multi-center large-sample randomized controlled trial to explore the technical advantages and surgical indications of the novel surgical technique of CLIF correction for ASD compared…
- Trial name
- NCT05982808
- Testing
- CLIF correction, conventional correction strategy
- Where
- China
- Volunteers
- 420 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Gastrointestinal Motility Disorders in Children, Hirschsprung Disease
Improvement of Understanding of Pediatric Sacral Neuromodulation: Therapeutic Strategies and Outcome Variables
The goal of this study is to learn about the effects of sacral neuromodulation in pediatric patients with gastrointestinal motility disorders.
- Conditions
- Gastrointestinal Motility Disorders in Children, Hirschsprung Disease, Constipation - Functional
- Trial name
- SMART-GUT (NCT07519915)
- Testing
- SNM/MRI/EMG
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Friedrich-Alexander-Universität Erlangen-Nürnberg
Hepatitis C, Hepatitis
Strategies for Hepatitis C Testing and Treatment in Aboriginal Communities That Lead to Elimination
A community-based "test and treat" intervention integrating point-of-care HCV RNA testing, non-invasive liver disease assessment and linkage to care will lead to a reduction in HCV prevalence among people attending Aboriginal…
- Conditions
- Hepatitis C, Hepatitis, Liver Diseases, Hepatitis, Viral, Human
- Trial name
- SCALE-C (NCT03776760)
- Testing
- Fingerstick GeneXpert HCV RNA quantitative assay, sofosbuvir/velpatesvir, glecaprevir/pibrentasvir
- Where
- 4 sites in Australia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Kirby Institute
Substance Use
Substance Abuse Treatment to HIV Care (SAT2HIV): The Implementation & Sustainment Facilitation Experiment
A cluster randomized experiment focused on testing the extent to which the organization-focused Implementation \& Sustainment Facilitation (ISF) strategy is an effective adjunct to the staff-focused Addiction Technology Transfer…
- Trial name
- NCT03120598
- Testing
- ATTC strategy, ISF strategy
- Where
- 39 sites in United States
- Volunteers
- 190 people
- Sponsor
- RTI International
Rheumatoid Arthritis
Active Conventional Therapy Compared to Three Different Biologic Treatments in Early Rheumatoid Arthritis With Subsequent Dose Reduction
This is an international (Sweden, Finland, Norway, Denmark, Iceland and the Netherlands) trial designed to compare the safety and efficacy of active conventional therapy (ACT) and three biologic treatments in subjects with early…
- Trial name
- NCT01491815
- Testing
- Non-biological DMARD's, Cimzia, Orencia
- Where
- 30 sites in Denmark, Finland and 4 more
- Volunteers
- 812 people
- Sponsor
- Karolinska Institutet
Anal Fistula
Effectiveness of Silver Nitrate Solution in the Treatment of Anal Fistula
Effectiveness of silver nitrate solution in treatment of anal fistula is is aimed to be investigated.
- Trial name
- NCT01929525
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Marmara University
Heart Failure, Beta-blocker Treatment
Telephone Administered Psychotherapy for the Treatment of Depression for Veterans in Rural Areas
The purpose of this study is to examine the efficacy of telephone-administered cognitive-behavioral therapy (T-CBT) in treating major depression among veterans served by community-based outpatient clinics (CBOCs) in the Veteran�s…
- Trial name
- NCT00012974
- Testing
- GTelephone-administered Cognitive-Behavioral Therapy (T-CBT), Provider education, computer reminders, nurse case management
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- US Department of Veterans Affairs
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