Clinical trials: Therapy Strategies
Vasculitis, Wegener's Granulomatosis
Treatment of Necrotizing Vasculitides for Patients Older Than 65 Years
The aim of this trial is to lower the morbidity rate in elderly patients affected with systemic necrotizing vasculitides, by reducing mortality and improving global outcome.
- Conditions
- Vasculitis, Wegener's Granulomatosis, Microscopic Polyangiitis, Churg-Strauss Syndrome
- Trial name
- CORTAGE (NCT00307671)
- Testing
- prednisone, methylprednisolone,cyclophosphamides, Cyclophosphamide, Azathioprine,prednisone,methylprednisolone, Mycophenolate mofetil,methotrexate
- Where
- France
- Volunteers
- 108 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Tension-type Headache
Assessing the Effectiveness of Two Treatment Strategies for Tension-type Headache
The primary aim of the pilot data proposal is to compare usual care (medications) versus multi-disciplinary treatment in temporomandibular disorder (TMD) patients.
- Trial name
- NCT01347684
- Testing
- Behavioral therapy, splint therapy and physical therapy, Standard care using current drugs
- Where
- 2 sites in United States
- Sponsor
- University of Minnesota
Myocardial Infarction
A Trial Evaluating the Efficacy and Safety of Tenecteplase Together With Unfractionated Heparin Prior to Early Percutaneous Coronary Intervention (PCI) as Compared to Standard Primary PCI in Patients With Acute Myocardial Infarction (ASSENT 4 PCI)
To show whether addition of thrombolytic treatment by a single bolus injection of tenecteplase prior to early standard PCI (percutaneous coronary intervention) will improve the clinical outcome in patients with large acute…
- Trial name
- NCT00168792
- Testing
- Tenecteplase, PCI
- Where
- 176 sites in United States, Austria and 16 more
- Volunteers
- 1,671 people
- Sponsor
- Boehringer Ingelheim
Coronary Artery Disease, Percutaneous Coronary Intervention
Effect and Efficacy of Xpedition™/Alpine™, Everolimus-eluting Stent for Coronary Atherosclerosis
The objectives of this study are 1. To establish a prospective registry of the whole patients who received percutaneous coronary intervention with Xience Xpedition™/Alpine™ stent 2.
- Conditions
- Coronary Artery Disease, Percutaneous Coronary Intervention, Acute Coronary Syndrome, Angina Pectoris
- Trial name
- HOST-ALPINE (NCT02845804)
- Testing
- Alpine
- Where
- 20 sites in South Korea
- Volunteers
- 1,533 people
- Sponsor
- Seoul National University Hospital
Current Smoker, Tobacco Smoking
Strategies to Connect Patients at Federally Qualified Health Clinics With Evidence Based Tobacco Cessation Treatment
This trial aims to connect tobacco using patients of Community Health Centers (CHCs) and Federally Qualified Health Centers (FQHCs) with evidence-based treatment to help them quit.
- Conditions
- Current Smoker, Tobacco Smoking, Tobacco Use
- Trial name
- NCT03900767
- Testing
- Ask-Advise-Connect (AAC), Text Messaging (TM), Motivation And Problem-Solving (MAPS)
- Where
- United States
- Volunteers
- 12,009 people
- Sponsor
- University of Utah
HIV, Contraception
Pharmacologic Strategies to Use the Levonorgestrel Implant in HIV-infected Women
The purpose of this study is to determine whether increasing the dose of the levonorgestrel subdermal contraceptive implant will overcome a detrimental drug-drug interaction with efavirenz based antiretroviral therapy.
- Trial name
- NCT02722421
- Testing
- Levonorgestrel, Efavirenz
- Where
- Uganda
- Volunteers
- 28 people
- Sponsor
- University of Nebraska
Helicobacter Pylori, Drug Resistance, Multiple
14-day Susceptibility-guided Bismuth Quadruple Therapy for Multiple Drug Resistant H. Pylori Infection
The goal of this clinical trial is to learn if the 14-day susceptibility-guided bismuth quadruple therapy works to treat multiple drug resistant Helicobacter pylori (H. pylori) in adults.
- Trial name
- BSUS-2 (NCT06687499)
- Testing
- Bismuth-based susceptibility-guided treatment
- Where
- Taiwan
- Volunteers
- 46 people
- Sponsor
- National Cheng-Kung University Hospital
Chronic Kidney Disease, Acute Kidney Injuries
Dementia and Kidney Disease: Epidemiological Approaches to Risk Factors and Treatment Strategies
Kidney disease and dementia are both common in older adults, posing a significant burden on individuals and society. Growing evidence suggests that there may be links between the kidney and the brain.
- Conditions
- Chronic Kidney Disease, Acute Kidney Injuries, Real World Study, Dementia
- Trial name
- NCT07093684
- Testing
- Kidney disease
- Where
- Sweden
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Coronavirus Disease-2019
Sequential Oxygen Therapy Strategy for Patients With COVID-19
All patients with COVID-19 were divided into three groups according to their illness: mild patient who receive conventional oxygen therapy, severe patients who receive nasal high flow oxygen inhalation or non-invasive positive…
- Trial name
- SOTSPC (NCT04312100)
- Testing
- oxygen treatment
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Henan Provincial People's Hospital
Traumatic Brain Injury, Substance Use Disorder (SUD)
Implementation of TBI-RECOVER in Substance Use Treatment
The goal of this hybrid type 2 pilot trial is to understand the implementation and effectiveness of the TBI-RECOVER intervention model (e.g., brain injury screening, cognitive and behavioral challenges screening, and…
- Trial name
- TBI-RECOVER (NCT07215221)
- Testing
- TBI-RECOVER, Control
- Where
- United States
- Volunteers
- 900 people
- Sponsor
- Ohio State University
Esophageal Cancer TNM Staging Primary Tumor (T) T4
Establishing Best Treatment Strategy for T4 Esophageal Cancer
The goal of this clinical trial is to investigate the safety and efficacy of a new treatment approach for T4-stage esophageal cancer, which involves chemoradiotherapy after induction chemotherapy.
- Trial name
- NCT06531434
- Testing
- "Docetaxel", "Cisplatin", "fluorouracil", "Radiation"
- Where
- Taiwan
- Volunteers
- 22 people
- Sponsor
- National Cheng-Kung University Hospital
HIV-1-infection, Antenatal Care
An Integrated Strategy to Support Antiretroviral Therapy and Pre-exposure Prophylaxis Adherence for HIV Prevention in Pregnant and Breastfeeding Women
This study is composed of two parallel, pilot randomized groups that will obtain preliminary data about the the acceptability, fidelity, and clinical outcomes associated with a multi-component adherence support strategy for HIV…
- Trial name
- NCT04330989
- Testing
- iNSC and Adherence supporter training
- Where
- Malawi
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
HIV, Tuberculosis
Evaluation of South Africa's National Adherence Strategy
NOTE THAT THE STUDY IS LED BY SOUTH AFRICA NATIONAL DEPARTMENT OF HEALTH AND WORLD BANK WITH SUPPORT FROM BOSTON UNIVERSITY. The South Africa National Department of Health (NDOH) intends to launch its newly developed National…
- Conditions
- HIV, Tuberculosis, Diabetes, Hypertension
- Trial name
- ENHANCE (NCT02536768)
- Testing
- Minimum package of interventions to improve ART adherence
- Where
- South Africa
- Volunteers
- 8,020 people, healthy volunteers welcome
- Sponsor
- Boston University
Breast Cancer, Complementary Therapies
Supportive Effects of Craniosacral Therapy for Women With Breast Cancer
Craniosacral Therapy (CST) is a non-manipulative, very gentle, manual treatment method that aims to release restrictions of the fasciae and regulate the arousal of the sympathetic nervous system, which is often increased in…
- Trial name
- CRANIO4US (NCT04319510)
- Testing
- Craniosacral therapy, Craniosacral self-help group training, Treatment as usal / wait list
- Where
- 3 sites in Germany
- Volunteers
- 102 people
- Sponsor
- Universität Duisburg-Essen
Severe Community-acquired Pneumonia
Diagnosis and Treatment Strategy Optimization of Severe Pneumonia Based on Multi-omics Data Integration
Severe community-acquired pneumonia still has a high incidence and mortality, but the molecular mechanism and prognostic biomarkers of severe community-acquired pneumonia caused by different pathogens are still unclear, and the…
- Trial name
- NCT06288074
- Testing
- Multi-omics tests
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
Unruptured Cerebral Aneurysm, Treatment Strategy
New Therapeutic System of Unruptured Intracranial Aneurysms Based on Big Data From Chinese Population
This is a prospective, multicenter, observational study, aiming at comparing the Safety and effectiveness among the different surgical treatment of unruptured intracranial aneurysms in China, so as to improve the diagnosis and…
- Trial name
- NATIONAL-1 (NCT03153865)
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Changhai Hospital
Diabetes Mellitus, Hypertension
Prevention of Diabetes and Hypertension
Background. Antihypertensive therapy with ß-blockers (ßBs) and diureticts (Ds) is accompanied by a higher incidence of diabetes mellitus (DM) than therapy with ACE-inhibitors (ACEIs) or angiotensin-receptor blockers (ARBs).
- Trial name
- PHIDIAS (NCT00456963)
- Testing
- Diet, Moderate exercise, enalapril tablets
- Where
- Italy
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
HIV Infections, ART
Evaluation of Secondary Distribution of HIV Self-screening Tests by Women With HIV
Many South African men do not visit clinics or get tested due to multiple real and perceived barriers. Nkangala District has significant gaps to identifying PLHIV who are not on ART, reaching their ART targets, especially in…
- Conditions
- HIV Infections, ART, HIV Seropositivity
- Trial name
- HIVSSSA (NCT05074251)
- Testing
- HIV self test, Counseling and referral for partner testing
- Where
- South Africa
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Suicide
TEEM-GIFTS: A Gamified mHealth to Reduce Post-Discharge Suicide Risk
Patients with mental disorders are at significantly higher risk of suicide after discharge compared to the general population and patients with other diseases.
- Trial name
- NCT06358339
- Testing
- TEEM
- Where
- China
- Volunteers
- 640 people
- Sponsor
- Shenzhen Kangning Hospital
Sickle Cell Anemia
Effectiveness of New Analgesic Strategy Compared to the Usal Antalgic Strategy
Quality of life of adult patients with sickle cell disease is deeply impaired by severe adverse medical events that inadvertently occur throughout their time life.
- Trial name
- DREPANOX (NCT00874172)
- Testing
- Rapid optimized analgesic strategy, current analgesic strategy
- Where
- France
- Volunteers
- 176 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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