Clinical trials: Therapy Strategies
Schizophrenia and Related Disorders, Immune Suppression
The Norwegian Prednisolone in Early Psychosis Study
Objective: The primary objective of this trial is to investigate whether prednisolone improves symptom severity as compared to placebo when given in addition to antipsychotic medication to patients with early-stage psychotic…
- Conditions
- Schizophrenia and Related Disorders, Immune Suppression, Psychosis, Cognitive Change
- Trial name
- NorPEPS (NCT03340909)
- Testing
- Prednisolone
- Where
- 3 sites in Norway
- Volunteers
- 12 people
- Sponsor
- Haukeland University Hospital
Postoperative Infection, Lactate
Preventive Therapy of Postoperative Intra-abdominal Infection Based on Serum Lactate Changes
Intra-abdominal infection is one of the most serious complications after pancreatic resection. The preventive use of antibiotics intraoperatively could reduce the incidence rate of postoperative intra-abdominal infection.
- Conditions
- Postoperative Infection, Lactate, Antibiotics
- Trial name
- NCT05052619
- Testing
- Preventive use of advanced antibiotics, Routine
- Where
- China
- Volunteers
- 297 people
- Sponsor
- Peking Union Medical College Hospital
Anxiety Depression
Development of the Neuroimaging Biomarker-based Prediction Model of Anxiety-related Disorders: Effect of Mindfulness-based Cognitive Therapy Using Neuroscience on the Brain
The purpose of this study designed a randomized clinical trial is to determine the efficacy of an 8-week mindfulness-based cognitive therapy using neuroscience (NMBCT) to reduce anxiety or depressive symptoms among adult…
- Trial name
- NCT05911412
- Testing
- Mindfulness-based cognitive therapy using neuroscience (NMBCT)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- CHA University
Embryo Transfer, Irregular Menstruation
Letrozole-stimulated Cycle Strategy Versus Artificial Cycle Strategy (LETSACT)
The goal of this randomized clinical trial is to evaluate the effectiveness of the letrozole-stimulated cycle strategy versus the artificial cycle strategy for endometrial preparation in women with irregular menstrual cycles…
- Conditions
- Embryo Transfer, Irregular Menstruation, Letrozole, Hormone Replacement Therapy
- Trial name
- NCT06372119
- Testing
- Letrozole-stimulated cycle strategy, Artificial cycle strategy
- Where
- 2 sites in Vietnam
- Volunteers
- 790 people, healthy volunteers welcome
- Sponsor
- Mỹ Đức Hospital
Obesity, Atherosclerosis
Observational Study of Early Metabolic and Vascular Changes in Obesity
To work against the increasing burden of obesity, the STYJOBS / EDECTA (STYrian Juvenile OBesity Study / Early DetECtion of Atherosclerosis) project was started at the Medical University of Graz in 2003.
- Conditions
- Obesity, Atherosclerosis, Inflammation, Adiponectin Deficiency
- Trial name
- STYJOBS (NCT00482924)
- Testing
- Lifestyle intervention
- Where
- Austria
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Tooth Sensitivity
Non-carious Cervical Lesions and Treatments
This study will compare clinically the efficacy, time to action and duration of different treatments for patients with non-carious cervical lesions (NCCLs) that caused dentin hypersensitivity (DH).
- Trial name
- NCCL (NCT03403088)
- Testing
- Experimental: • Group LA, Experimental: • Group DE, Experimental: • Group RGI
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Diverticulitis
Hospitalization or Ambulatory Treatment of Acute Diverticulitis
The purpose of 01DIVER is to evaluate efficacy and safety of a home treatment protocol for non complicated diverticulitis compared with management in the hospital.
- Trial name
- 01DIVER (NCT01081054)
- Testing
- Ambulatory versus hospitalisation
- Where
- 5 sites in Spain
- Volunteers
- 132 people
- Sponsor
- Hospital Universitari de Bellvitge
Breast Cancer, Breast Reconstruction
Immediate Autologous Tissue Breast Reconstruction and Radiotherapy Strategy After Breast Cancer Surgery
This is a prospective, open-label, controlled clinical trial aiming to investigate the optimal sequencing strategy between immediate autologous tissue breast reconstruction and radiotherapy in breast cancer patients.
- Conditions
- Breast Cancer, Breast Reconstruction, Radiotherapy
- Trial name
- NCT07798466
- Testing
- Immediate DIEP flap breast reconstruction, Hypofractionated radiotherapy
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Fudan University
Coronary Artery Disease
A New Strategy Regarding Discontinuation of Dual Antiplatelet
Drug-eluting stents (DES), markedly reducing the neointimal hyperplasia after stent implantation compared with bare-metal stents (BMS), have improved angiographic and clinical outcomes in the complex lesions and patients with…
- Trial name
- NCT01145079
- Testing
- Zotarolimus-eluting stent, Zotarolimus-eluting stent for ACS and DM, Everolimus-eluting stent for long lesion
- Where
- South Korea
- Volunteers
- 982 people
- Sponsor
- Yonsei University
Primary Immune Thrombocytopenia (ITP)
rhTPO Dose Escalation vs Eltrombopag Switch in ITP
This study is a prospective, multicenter, randomized controlled study, planning to enroll 110 ITP patients who failed to respond to conventional-dose rhTPO (300 IU/kg/d) after 14 days of treatment (PLT < 30×10⁹/L).
- Trial name
- NCT07476846
- Testing
- Recombinant Human Thrombopoietin（rhTPO）, Eltrombopag PfOS
- Volunteers
- 112 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Postoperative Pain, Pain Assessment
Establishment and Validation of Early-warning Model of Perioperative Pain for the Elders
This study will collect perioperative pain-related data of elderly patients in multi-centers. Analyzing these collected data to find the high-risk factors of postoperative pain in elderly patients and to establish an…
- Conditions
- Postoperative Pain, Pain Assessment, Elderly, Model
- Trial name
- NCT04228705
- Where
- China
- Volunteers
- 6,000 people
- Sponsor
- Peking University People's Hospital
Autism
The Feasibility of a Remote Problem-Solving Intervention for Autistic Adolescents or Young Adults and a Caregiver
This project seeks to evaluate the feasibility and acceptability of a remote metacognitive strategy training intervention in transition-age autistic adolescents and young adults and a primary caregiver.
- Trial name
- NCT07216196
- Testing
- Pathways and Resources for Engagement and Participation (PREP)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Missouri-Columbia
ST-elevation Myocardial Infarction
The Short- and Long Term Outcomes of Early Routine PCI With the Standard Treatment in Low-intermediate Risk ST-elevation Myocardial Infarction Patients Who Successfully Fibrinolysis.
1. Objective: To evaluate short- and long-term in the STEMI patients who successfully thrombolysis with early routine and delay percutaneous coronary intervention in low-intermediate risk patients. 2.
- Trial name
- NCT02131103
- Testing
- Percutaneous coronary intervention
- Where
- Thailand
- Volunteers
- 130 people
- Sponsor
- Chiang Mai University
Developmental Delay Disorders, Chromosome Deletion
Treatment Strategies for Children With Smith-Magenis Syndrome
This study will examine the effect of bright light or melatonin treatment on sleep in children with Smith-Magenis syndrome (SMS), a genetic disorder characterized by certain physical, behavioral and developmental features.
- Conditions
- Developmental Delay Disorders, Chromosome Deletion, Mental Retardation, Sleep Disorders, Circadian Rhythm
- Trial name
- NCT00506259
- Testing
- dTR Melatonin (NIH CC PDS), Phototherapy (Bright Light), Melatonin CR
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Advanced Breast Cancer
Timing of ctDNA Testing in Advanced Breast Cancer
This multicenter, prospective observational cohort study aims to investigate the impact of circulating tumor DNA (ctDNA) level and key actionable gene mutation status on prognosis and treatment response in patients with advanced…
- Trial name
- TIMING (NCT07681323)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Geneplus-Beijing Co. Ltd.
Malaria
Seasonal Intermittent Preventive Treatment With Sulfadoxine-Pyrimethamine in Children in Mali
Recent, randomized controlled trials conducted in areas of perennial malaria transmission have shown that intermittent preventive treatment (IPT) given at the time of vaccination reduced the incidence of the first episode of…
- Trial name
- NCT00623155
- Testing
- Seasonal IPT in children - Sulfadoxine-pyrimethamine
- Where
- Mali
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- University of Bamako
Seminoma
Therapeutic Strategy Guided by PET-TDM for Patients With Seminoma
The purpose of the study is to evaluate the ration of patients getting an lighten therapeutic strategy after 18F-fluoro-désoxyglucose positron emission tomography (PET-TDM) in grade I (cohort 1) or metastatic (cohort 2) seminoma
- Trial name
- SEMITEP (NCT01887340)
- Testing
- Carboplatin, Etoposide, Cisplatin
- Where
- France
- Volunteers
- 271 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Stroke, Ischemic, Intravascular Thrombosis
Intra-arterial Neuroprotective Strategy for Ischemic STroke Patients With Endovascular Therapy (INSIST-ET)
To explore the safety and feasibility of intra-arterial neuroprotective strategy in acute ischemic stroke patients who received recanalization operation.
- Conditions
- Stroke, Ischemic, Intravascular Thrombosis, Mechanical Thrombectomy
- Trial name
- NCT04664933
- Testing
- Intra-arterial administration of neuroprotective agents
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Hui-Sheng Chen
Recurrent Acute Pancreatitis
Evaluation of Pirfenidone as a Novel Therapeutic Strategy Against Recurrent Acute Pancreatitis.
This clinical will evaluate the safety, tolerability and early efficacy of pirenidone in patients with recurrent acute pancreatitis.
- Trial name
- PirfenidoneRAP (NCT06253117)
- Testing
- Pirfenidone
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Alabama at Birmingham
Gestational Diabetes, Type 2 Diabetes
Medical Nutrition Therapy Program for Pregnant Women With Diabetes
No dietary strategies have been designed and proved for Mexican pregnant women with diabetes. This is a randomized clinical trial of pregnant women with pregestational type 2 diabetes and gestational diabetes that were followed…
- Trial name
- NCT00860613
- Testing
- medical nutrition therapy program
- Where
- Mexico
- Volunteers
- 162 people
- Sponsor
- Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes
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