Clinical trials: Therapy Strategies
Dengue
Dengue Vaccine Hesitancy and Acceptance in Endemic Regions of Argentina: Impact of Communication Strategies
Among all arboviruses, Dengue (DEN) is the vector borne disease with the highest burden worldwide. Around 390 million infections per year are estimated, of which around 96 million are clinically apparent.
- Trial name
- NCT05213364
- Volunteers
- 1,500 people
- Sponsor
- Fundacion GESICA
Major Depressive Disorder
Antidepressant Incomplete Response Depression
Observational, non-interventional, longitudinal, prospective,multicenter, open label (No treatment is involved). 3 assessment will be carried out .
- Trial name
- DRIA (NCT00782964)
- Where
- 48 sites in Spain
- Volunteers
- 364 people
- Sponsor
- AstraZeneca
HIV-Associated Lipodystrophy Syndrome
Strategies of Interruption/Reinitiation of Antiretroviral Therapy in HIV-Infected Patients With Lipodystrophy
Aim: To assess the safety on the progression of HIV infection and the efficacy on the evolution of metabolic parameters and body fat of either viral load- or CD4 cell-driven strategies of intermittent treatment in chronically…
- Trial name
- NCT00646984
- Testing
- Standard continuous antiretroviral therapy, CD-4 guided therapy interruption, Viral load driven treatment interruption
- Where
- Spain
- Volunteers
- 147 people
- Sponsor
- Hospital Clinic of Barcelona
Coronary Artery Disease, Coronary Artery Disease Progression
Critical Treatment of Coronary Artery Disease
Identifying the critical lesion of coronary artery disease and determining the interventional plan are significant for reducing adverse cardiovascular adverse events.
- Trial name
- CTCAD (NCT03195621)
- Testing
- Stent implantation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Southeast University, China
Acute Coronary Syndrome
Timing of Coronary Artery Bypass Surgery Among Patients With Acute Coronary Syndromes Initially on Ticagrelor
Ticagrelor, a more potent P2Y12 inhibitor, has been shown to reduce major adverse cardiac events (MACE) in acute coronary syndromes (ACS). It is increasingly used as a first line therapy in ACS.
- Trial name
- RAPID CABG (NCT02668562)
- Testing
- Early CABG (Day 2-3 after ticagrelor discontinuation), Delayed CABG (Day 5-7 after ticagrelor discontinuation)
- Where
- 2 sites in Canada
- Volunteers
- 143 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Hematopoietic/Lymphoid Cancer, Accelerated Phase Chronic Myelogenous Leukemia
Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell Transplant
RATIONALE: Infection prophylaxis and management may help prevent cytomegalovirus (CMV) infection caused by a stem cell transplant.
- Conditions
- Hematopoietic/Lymphoid Cancer, Accelerated Phase Chronic Myelogenous Leukemia, Acute Undifferentiated Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
- Trial name
- NCT01199562
- Testing
- infection prophylaxis and management, laboratory biomarker analysis, flow cytometry
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- City of Hope Medical Center
Carotid Atherosclerosis, Stroke
Diagnosis and Therapy of Vulnerable Atherosclerotic Plaque
The aim of the present study is to examine the atherosclerotic plaque stability using in vivo and in vitro techniques and to investigate the influence of exercise, anti-diabetic, lipid-lowering and cannabinoids receptor…
- Conditions
- Carotid Atherosclerosis, Stroke, Type 2 Diabetes, Metabolic Syndrome
- Trial name
- NCT00636766
- Testing
- atorvastatin, rimonabant, rosiglitazone
- Where
- Greece
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Left Main Coronary Artery Stenosis
The OPTIMAL Randomized Controlled Trial
The OPTIMAL study is a randomized, controlled, multicentre, international study. A total of 800 patients will be randomized in a 1:1 fashion to Intravascular Ultrasound (IVUS)-guided PCI versus qualitative angio(QCA)-guided…
- Trial name
- OPTIMAL (NCT04111770)
- Testing
- IVUS guided Percutaneous Coronary Intervention, Qualitative or quantitative angiography will guide percutaneous coronary intervention
- Where
- 28 sites in Italy, Spain and 1 more
- Volunteers
- 806 people
- Sponsor
- ECRI bv
Lung Cancer
Piloting 'mPal,' a Multilevel Strategy for Palliative Care Implementation
The purpose of this study is to assess the feasibility and acceptability of mPal, a multilevel implementation strategy to improve palliative care use among advanced stage lung cancer patients receiving cancer treatment.
- Trial name
- NCT05270395
- Testing
- mPal
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Laurie McLouth
Evidence-Based Practices, CBT
A Hybrid Type 2 Trial of Trauma-Focused Cognitive Behavioral Therapy and a Pragmatic Individual-Level Implementation Strategy
This research project is a hybrid type 2 effectiveness-implementation trial that simultaneously examines (1) the effectiveness of a trauma-focused intervention for youth in the education sector and (2) the impact of a…
- Conditions
- Evidence-Based Practices, CBT, School Health Services, Trauma, Psychological
- Trial name
- NCT04451161
- Testing
- Beliefs and Attitudes for Successful Implementation in Schools (BASIS), Trauma-Focused Cognitive-Behavioral Therapy, Treatment as Usual
- Where
- United States
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- University of Washington
Cancer (Solid Tumors), Geriatric Oncology
TRTRM (ACTTOP) -Guided Dosing Strategy in Older Patients With Cancer
Older adults receiving systemic cancer treatments are at increased risk of developing severe treatment-related toxicities (TRT).
- Trial name
- NCT07484932
- Testing
- TRTRM-guided risk-stratified treatment strategy
- Where
- Hong Kong
- Volunteers
- 400 people
- Sponsor
- The University of Hong Kong
Suicide
TEEM-GIFTS: A Gamified mHealth to Reduce Post-Discharge Suicide Risk
Patients with mental disorders are at significantly higher risk of suicide after discharge compared to the general population and patients with other diseases.
- Trial name
- NCT06358339
- Testing
- TEEM
- Where
- China
- Volunteers
- 640 people
- Sponsor
- Shenzhen Kangning Hospital
Pneumonia
Efficiency of the Imaging Strategy for the Management of Pneumonia
For patients with suspected pneumonia presenting to the emergency room, the imaging strategy most often involves a frontal and lateral chest x-ray despite poor diagnostic input.
- Trial name
- EFFI-PNEUMO (NCT05140408)
- Where
- France
- Volunteers
- 2,240 people
- Sponsor
- University Hospital, Strasbourg, France
Osteo Arthritis Knee
Effectiveness of Five Intraarticular Strategies on Knee Osteoarthritis
BACKGROUND: Current medical treatment strategies for knee osteoarthritis (OA) are aimed at pain reduction and symptom control. The Non-Arthroscopic Joint Lavage (NAJL) is included inside the therapeutic algorithm of knee OA when…
- Trial name
- NCT03783455
- Testing
- Non arthroscopic joint lavage, Non arthroscopic joint lavage plus corticosteroid, Non arthroscopic joint lavage plus hyaluronic acid
- Volunteers
- 150 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Metastatic Castration-resistant Prostate Cancer
3TMPO (Triple-Tracer Strategy Against Metastatic Prostate Cancer
Prostate cancer (PCa) is the most common solid organ cancer in North American men. Patients becoming refractory to loco-regional therapy receive androgen deprivation therapy, but their disease will inevitably progress to…
- Trial name
- NCT04000776
- Testing
- FDG Positron emission tomography (PET) scan, PSMA Positron emission tomography (PET) scan, OCTREOTATE Positron emission tomography (PET) scan
- Where
- 5 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Université de Sherbrooke
Osteoarthritis, Meniscus Lesion
A Study on Different Treatments for Knee Osteoarthritis Caused by Damaged Roots of the Medial Meniscus.
Medial meniscus posterior root tears (MMPRT) account for 20% or more of all meniscus tears, but the diagnosis and treatment of this condition continues to plague the general population due to the complexity of the diagnosis and…
- Trial name
- NCT06707948
- Testing
- Arthroscopic meniscus surgery
- Volunteers
- 69 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Hemophilia A With Inhibitor
Basic Study of Combination Therapy Based on APCC-induced FVllI Activation in Hemophilia A Patients With Inhibitors
Using whole blood samples and plasma samples obtained from some hemophilia A patients with inhibitors, the investigators will perform the coagulation assessment in the co-presence of aPCC and factor VIII by comprehensive…
- Trial name
- NCT02554526
- Where
- Japan
- Volunteers
- 10 people
- Sponsor
- Nara Medical University
Male Sterility Due to Y-chromosome Deletions
Aneuploidies in Embryos and Spermatozoa From Patients With Y-chromosome Microdeletions
In this study, investigators assess, using Fluorescence in situ Hybridization (FISH) and Comparative Genomic Hybridization (CGH) arrays for Preimplantation Genetic Screening (PGS), the incidence of aneuploidies in spermatozoa and…
- Trial name
- NCT02527954
- Where
- 3 sites in Spain
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI Alicante
Acute Respiratory Infection
Expanded Diagnostic Strategy in Older Adults Hospitalized With Community-Acquired Acute Respiratory Infection
This study will evaluate whether an expanded diagnostic strategy can reduce antibiotic use in patients aged 65 years or older who are hospitalized with community-acquired acute respiratory infection, without negatively affecting…
- Trial name
- NeuBluMul (NCT07883902)
- Testing
- Expanded Diagnostic Strategy, Conventional Diagnostic Strategy
- Where
- Spain
- Volunteers
- 406 people
- Sponsor
- Santiago Lopez Gil
Idiopathic Granulomatous Mastitis, Granulomatous Mastitis
GRAnulomatous MAstitis REGistry Study
Idiopathic granulomatous mastitis (IGM) is a rare benign inflammatory breast condition with unknown cause, affecting approximately 2.4 per 100,000 women aged 20-40 years.
- Trial name
- GRAMAREG (NCT07422870)
- Where
- 2 sites in Germany
- Volunteers
- 1,000 people
- Sponsor
- European Breast Cancer Research Association of Surgical Trialists
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