Clinical trials: Therapy Strategies
Early-stage Breast Cancer
Adopting the MRD Strategy to Optimize Post-operation Adjuvant Therapies for Early Stage Breast Cancer
This study is a prospective, multi-center, open-label cohort study, with 3 years disease free survival(DFS) as the primary endpoint.
- Trial name
- AMENDER (NCT05345860)
- Testing
- The MRD strategy for high risk or MRD+ TNBC patients, The MRD strategy for high risk or MRD+ HER2+ patients, The MRD strategy for high risk or MRD+ ER+ patients
- Where
- 3 sites in China
- Volunteers
- 300 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Chronic Obstructive Respiratory Diseases
Development of Predictive Biomarkers for the Diagnosis and Treatment of Asthma and COPD in Vietnam.
According to World Health Organization (WHO), non-communicable diseases account for 70% of global mortality. Chronic Respiratory Disease (CRD) affects more than one billion people and is the third leading cause of annual death of…
- Trial name
- NCT04232579
- Testing
- Therapeutic strategy
- Where
- 2 sites in Belgium, Vietnam
- Volunteers
- 600 people
- Sponsor
- Olivier Michel
Asthma, Lung Diseases
Comparison of Two Medication Adherence Strategies to Improve Asthma Treatment Adherence
This is a randomized, controlled study that will compare two medication adherence strategies in adults with moderate or severe persistent asthma as a method for improving or maintaining treatment adherence.
- Trial name
- NCT00115323
- Testing
- Problem Solving, Attention Control
- Where
- United States
- Volunteers
- 397 people
- Sponsor
- University of Pennsylvania
Peripheral Artery Disease
Clinical Outcomes of Three Different Percutaneous Revascularization Strategies for the Treatment of Lifestyle Limiting Claudication: A Retrospective Analysis
To determine the effect of three different percutaneous revascularization strategies (Balloon Cryoplasty vs. Stent Placement vs. Atherectomy) in the treatment of lifestyle limiting lower extremity claudication
- Trial name
- FIX-IT Retro (NCT00512720)
- Where
- United States
- Volunteers
- 355 people
- Sponsor
- Corewell Health West
Myocardial Infarction
STREAM-Strategic Reperfusion (With Tenecteplase and Antithrombotic Treatment) Early After Myocardial Infarction
This study aims at evaluating, in a proof of concept approach, the outcome of patients presenting with acute ST-elevation myocardial infarction within 3 hours of symptom onset in either a pre-hospital setting or community…
- Trial name
- NCT00623623
- Testing
- primary PCI, enoxaparin, catheterisation
- Where
- 201 sites in Austria, Belgium and 14 more
- Volunteers
- 1,899 people
- Sponsor
- Boehringer Ingelheim
Non-left Bundle Branch Block, Ischemic or Non-ischemic Cardiomyopathy
CRT Implant Strategy Using the Longest Electrical Delay for Non-left Bundle Branch Block Patients
The purpose of this study is to analyze the effect of left ventricular lead pacing location in the non-left bundle branch block (non-LBBB) heart failure patient population.
- Trial name
- ENHANCE CRT (NCT01983293)
- Testing
- QLV based implant strategy, Standard of care implant strategy
- Where
- 32 sites in United States
- Volunteers
- 248 people
- Sponsor
- Abbott Medical Devices
PARKINSON DISEASE (Disorder)
Multicontext Approach for Cognitive Function in Parkinson Disease
Mild cognitive decline is common in early Parkinson disease (PD) and is associated with disability, reduced quality of life (QOL), and increased risk for dementia.
- Trial name
- MC4PD R01 (NCT07190404)
- Testing
- A metacognitive strategy for cognitive rehabilitation called the Multicontext Approach., Cognitive (Process) Training, MC Approach Booster Session
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Washington University School of Medicine
Traffic Accident, Whiplash Syndrome
Evaluation of Effectiveness and Safety of Korean Herbal Medicine for Post-accident Syndromes After Acute Phase
This study is a single blind, randomized controlled trail. condition/disease: Post-accident syndromes after acute phase treatment/intervention: herbal medicine treatment strategy
- Trial name
- NCT05494008
- Testing
- Korean herbal medicine treatment, Non-Korean herbal medicine treatment
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Jaseng Medical Foundation
Kidney Disease, Chronic, Peritoneal Dialysis
Continuous Glucose Monitoring in Patients With Diabetes on Peritoneal Dialysis
Background: Patients with chronic kidney disease (CKD) caused by diabetes mellitus (DM) experience metabolic alterations characterized by elevated blood glucose levels and associated cardiovascular complications, which increase…
- Conditions
- Kidney Disease, Chronic, Peritoneal Dialysis, Diabetes Mellitus Type 2
- Trial name
- NCT06069518
- Where
- 2 sites in Mexico
- Volunteers
- 110 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Infertility, Female, Ovarian Stimulation
Double Ovarian Stimulation as Accumulation Strategy for Older Infertile Patients With Suboptimal Ovarian Response
Patients with infertility of the older age group of 37-42 years - a large cohort of patients of reproductive medicine. Two possible causes reduce their probability of pregnancy - an increasing age and a decrease of the ovarian…
- Conditions
- Infertility, Female, Ovarian Stimulation, In Vitro Fertilisation
- Trial name
- NCT03400722
- Testing
- Pergoveris, Clomiphene
- Where
- Russia
- Volunteers
- 120 people
- Sponsor
- Nova Clinic, Russia
Acute Ischemic Stroke
Brazilian Intervention to Increase Evidence Usage in Practice - Stroke (BRIDGE-Stroke)
Phase 1: An observational study ( registry) will be conducted with the objective of documenting the practice of stroke treatment in brazilian and latin american hospitals.
- Trial name
- BRIDGEStroke (NCT02223273)
- Testing
- Multifaceted Strategy
- Where
- Brazil
- Volunteers
- 1,624 people
- Sponsor
- Hospital do Coracao
Insomnia, CBT
Study on the Remote Diagnosis and Treatment Strategy of New-onset Insomnia Under the COVID-19 Epidemic
Insomnia is a disorder characterized by both nocturnal and daytime symptoms. The main symptoms are unsatisfactory sleep quality or duration, accompanied by difficulty falling asleep before bedtime, frequent or prolonged…
- Conditions
- Insomnia, CBT, Depression, Anxiety
- Trial name
- NCT05926531
- Testing
- CBTI online programe
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Nanfang Hospital, Southern Medical University
HIV Infections
An Observational Study of Induction Therapy With Fuzeon (Enfuvirtide) in Combination With Antiretroviral Drugs in Patients With HIV-1 Infection
This multicenter, retrospective, observational study will evaluate the therapeutic effectiveness of a strategy of induction with Fuzeon (enfuvirtide) within an optimized regimen of antiretroviral drugs in patients with HIV-1…
- Trial name
- NCT01902615
- Where
- Spain
- Volunteers
- 58 people
- Sponsor
- Hoffmann-La Roche
Helicobacter Pylori Infection, Antimicrobial Susceptibility Testing
Antimicrobial Susceptibility Testing Guided Antibiotic Selection Strategies in Salvage Helicobacter Pylori Treatment
Helicobacter pylori (H. pylori), which infects about 50% of the global population, has been recognized as a main risk factor of multiple gastric pathologies, especially non-cardiac gastric cancer.
- Trial name
- NCT02988089
- Testing
- Clarithromycin susceptibility dependant strategy, 2 susceptible antibiotics (amoxicillin, clarithromycin, metronidazole, tinidazole,levofloxacin, furazolidone and tetracycline ), proton pump inhibitor (PPI) and Colloidal Bismuth Pectin
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Shandong University
Alzheimer Disease, Cholinesterase Inhibitors
Comparison of Therapeutic Strategies With Cholinesterase Inhibitors (SOS TRIAL)
Cholinesterase inhibitors (CI) remain the only drugs with a recognized efficacy in mild to moderate Alzheimer's disease (AD) in spite of enormous research efforts.
- Trial name
- NCT03454646
- Testing
- cholinesterase inhibitors (CI) (donepezil, galantamine or rivastigmine)
- Where
- 31 sites in France
- Volunteers
- 1,205 people
- Sponsor
- University Hospital, Bordeaux
Community Aquired Pneumonia
Study to Evaluate Two Diagnostic Strategies for the Treatment of Severe Community Acquired Pneumonia (SCAP)
Main hypothesis: microbiological diagnossis off severe community acquired pneumonia can be performed by non invasive or semi invasive microbiological tools, semi invasive tools including protected distal bronchial samplings by…
- Trial name
- NCT00308659
- Testing
- FOB protected distal microbiological samplings
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hepatitis C, Drug Use
HCV Seek, Test and Rapid Treatment for Young PWID
The purpose of this randomized study is to determine whether a community-based test and treat model of hepatitis C (HCV) care delivery will be superior to the usual care practice of referral to specialist clinics for the outcomes…
- Trial name
- HCV ST&RT (NCT03627546)
- Testing
- Rapid Treatment strategy, Usual Care (facilitated referral)
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Weill Medical College of Cornell University
Atrial Fibrillation
Stepwise Strategy for Treatment of Atrial Fibrillation Substrate Extended Study
This is an observational, bidirectional cohort study, aiming to establish a long-term registry of adult patients with Persistent atrial fibrillation (ps-AF) in Southwest China to characterize patient profiles and evaluate…
- Trial name
- SAFE-extended (NCT07380620)
- Testing
- other
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Yuehui Yin
Cytomegalovirus Infection
CMV Antiviral Prevention Strategies in D+R-Liver Transplants ("CAPSIL")
This is a trial of preemptive therapy vs. prophylaxis for prevention of Cytomegalovirus (CMV) disease in R-D+ liver transplant patients.
- Trial name
- NCT01552369
- Testing
- Valganciclovir
- Where
- 6 sites in United States
- Volunteers
- 205 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Autoimmune Diseases
Treatment Strategies in IgG4-RD Patients With Re-elevation of Serum IgG4 Level During Maintenance Remission Period
This study has been designed as a 52-week, randomized double blind placebo controlled multicenter clinical trial. The study aims to compare the efficacy and safety of two treatment strategies in IgG4-RD patients with re-elevation…
- Trial name
- NCT05974683
- Testing
- mycophenolate mofetil
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Peking Union Medical College Hospital
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