Clinical trials: Therapy Strategies
Non-allergic Rhinitis
Elaboration of Patient-friendly Treatment Strategy With Capsaicin Nasal Spray in Patients With Idiopathic Rhinitis
Chronic rhinitis is affecting more than 200 million people worldwide. Its prevalence is estimated to be as high as 30% of the Western population.
- Trial name
- NCT02288156
- Testing
- Capsaicin
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Invasive Pneumococcal Infection
Innovative Anti-pneumococcal Vaccine Strategies in Patients With ANCA-associated Vasculitis Receiving Rituximab Therapy
The study hypothesis is that a "reinforced" pneumococcal combined vaccine strategy in patients with ANCA-associated vasculitides treated with rituximab will induce a better immune response than the current standard regimen, with…
- Trial name
- PNEUMOVAS (NCT03069703)
- Testing
- PCV13, PPV23, Rituximab
- Where
- France
- Volunteers
- 96 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cervical Artery Dissection
Antithrombotic Treatment Strategies in Cervical Artery Dissection
The goal of this clinical randomised controlled trial is to compare two treatment strategies - antiplatelet treatment strategy versus anticoagulation treatment strategy - in patients with acute, ischemic Cervical Artery…
- Trial name
- TREAT-CAD 2 (NCT07639892)
- Testing
- Antiplatelet Treatment Strategy, Anticoagulation Treatment Strategy
- Volunteers
- 1,100 people
- Sponsor
- University Department of Geriatric Medicine FELIX PLATTER
Patients With Uncomplicated Long-term Central Venous Catheter-related Biofilm-related Infection
Conservative Treatment of Catheter - Related Injections With Gentamicine/EDTA
Catheter-related infections are frequent. Treatment without catheter removal is difficult because of the presence of biofilm. The association of gentamicin and EDTA is active in vitro and in vivo against biofilms formed by Gram…
- Trial name
- CATH-GE (NCT04789928)
- Testing
- Gentamicins-EDTA
- Where
- 6 sites in France
- Volunteers
- 8 people
- Sponsor
- Institut Pasteur
Postoperative Complications, Rehabilitation
Pulmonary Expansion Device in Tracheostomized Patients Therapies in Tracheostomized Patients
The goal of this clinical trial is to evaluate the safety and efficacy of using PED (Pulmonary Expansion Device) in tracheostomized patients requiring lung reexpansion therapy within a single institution.
- Conditions
- Postoperative Complications, Rehabilitation, Postoperative Care
- Trial name
- PEDTRAQ (NCT06075381)
- Testing
- Pulmonary Expansion Device (PED), Conventional management
- Volunteers
- 50 people
- Sponsor
- Fundacion Clinica Valle del Lili
Obesity, Overweight
Reset: Enhancing Weight Loss in a Digital Intervention
The goal of the Reset trial is to learn about the optimal combination of dietary behavior strategies in a fully digital weight loss intervention. The intervention is designed for adults with overweight or obesity.
- Conditions
- Obesity, Overweight, Weight Loss, Health Behavior
- Trial name
- NCT07032571
- Testing
- Core Behavioral Weight Loss Intervention, Limit Red Zone Foods, Limit Eating Window
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- Stanford University
Leukemia, Lymphocytic, Chronic, B-Cell
Phase II Trial GA101 Inbrutinib B CLL
Phase II study testing chemo-free induction therapy with Ibrutinib + Obinutuzumab nine months / Study Part 1: All patients will receive 8 courses of GA101 + ibrutinib 420mg PO every 28 days Study Part 2: After evaluation at D1 of…
- Trial name
- ICLL07GAI (NCT02666898)
- Testing
- GA101, Ibrutinib, Cyclophosphamide
- Where
- France
- Volunteers
- 135 people
- Sponsor
- French Innovative Leukemia Organisation
Fluid Overload
Bio Electrical Impedance Analysis to Monitor Fluid Status During Deresuscitation Strategy in Continuous Renal Replacement Therapy
Fluid overload is a poor prognostic factor in patients undergoing continuous renal replacement therapy in critical care. A strategy of active fluid removal by net ultrafiltration (UFnet) is one of the means to correct it.
- Trial name
- UF BIA (NCT05160467)
- Testing
- Segmental multi-frequency bio electrical impedance analysis
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Hospices Civils de Lyon
Antifungal Agents, Invasive Fungal Infections
Anti-fungal Strategies in Acute-on-Chronic Liver Failure Patients
Early treatment of invasive fungal infections (IFI) may prevent undue mortality in acute on chronic liver failure (ACLF) patients.
- Conditions
- Antifungal Agents, Invasive Fungal Infections, Mycoses, Acute-On-Chronic Liver Failure
- Trial name
- NCT04157465
- Testing
- Treatment strategy trial
- Where
- India
- Volunteers
- 216 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
HIV Infections
Study to Identify and Determine Best Implementation Practices for Injectable Cabotegravir+Rilpivirine in the United States (US)
Chronic human immunodeficiency virus (HIV) infection in adults continues to be characterized by increased development of resistant virus, increased transmission of resistant virus and issues associated with the long-term toxicity…
- Trial name
- NCT04001803
- Testing
- CAB LA+RPV LA
- Where
- 9 sites in United States
- Volunteers
- 115 people
- Sponsor
- ViiV Healthcare
Healthy Volunteers Pharmacokinetic Study
Dose-escalation Study to Assess Selumetinib Safety, Tolerability and PK
The purpose of the study is to assess the safety, tolerability and PK of selumetinib (AZD6244; ARRY-142886) (Hyd-Sulfate) in healthy male Japanese and non-Japanese Asian volunteers following administration of a single dose.
- Trial name
- NCT01960374
- Testing
- Selumetinib
- Where
- United Kingdom
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
HIV Infections, Anus Neoplasms
A Study of Anal Cancer Development in HIV Infected People
The purpose of this study is to compare the development of abnormal cell growth or cancer in the anal region of individuals who are receiving one of two different anti-HIV treatment strategies.
- Trial name
- NCT00107679
- Where
- 13 sites in United States
- Volunteers
- 560 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hiv, Alcohol Use, Unspecified
Practice Facilitation as a Strategy to Improve Alcohol Treatment Adoption and Implementation in HIV Care
Despite availability of evidence-based alcohol reduction interventions (EBI), unhealthy alcohol use remains a barrier to HIV medication adherence, viral suppression and retention in HIV care and consequently HIV treatment as…
- Trial name
- NCT05241990
- Testing
- Practice Facilitation, Alcohol Stepped Care
- Where
- 3 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Chronic Obstructive Pulmonary Disease
Short Compared With Standard Duration of Antibiotic Treatment for AECOPD
Chronic obstructive pulmonary disease (COPD) is one of the most common diseases in the world. Acute exacerbation of COPD (AECOPD) refers to an exaggeration of the symptoms of the disease.
- Trial name
- AECOPD (NCT03698682)
- Testing
- Levofloxacin 500mg
- Where
- Tunisia
- Volunteers
- 310 people
- Sponsor
- University of Monastir
HIV-1 Infection
EFFICACY AND SAFETY OF A SIMPLIFICATION STRATEGY BASED ON DOLUTEGRAVIR AND DARUNAVIR / COBICISTAT VS OPTIMIZED TREATMENT IN SUPPRESSED HIV-1-INFECTED PATIENTS CARRYING ARCHIVED MULTIDRUG RESISTANCE MUTATIONS
The availability of antiretroviral therapy has led to a reduction in morbidity and mortality in patients with chronic HIV infection.
- Trial name
- NCT03683524
- Testing
- Dolutegravir (DTG) plus Darunavir/cobicistat (DRV/cobi)., Current ART
- Where
- Spain
- Volunteers
- 96 people
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
Enterobacteriaceae Infections
Efficacy of Piperacillin-tazobactam as Empirical Antimicrobial Therapy for VAP Among ESBL-E Carriers.
Antimicrobial resistance is a major threat worldwide and now concerns last-ressource antibiotics such as carbapenems. As the resistance to carbapenems is directly due to their use, their spare has become a public health…
- Trial name
- PROBATAZO (NCT04276480)
- Testing
- Piperacillin-tazobactam
- Where
- 2 sites in France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Bordeaux
Preeclampsia
New Therapeutic Strategy Against Preeclampsia
Preeclampsia is a hypertensive disorder of pregnancy associated with important maternal and perinatal mortality. It complicates 2 to 5% of pregnancies and causes more than 70 000 maternal deaths each year worldwide.
- Trial name
- APHERESE2 (NCT06464159)
- Testing
- Biological collection
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Community-acquired Pneumonia, Child, Only
Stopping Pneumonia Antibiotherapy Regimen Early
The hypothesis for this trial is that an antibiotic strategy for the management of non-severe community-acquired alveolar pneumonia in children aged 3 to 59 months, including amoxicillin 80-100 mg/kg/day for at least 3 days in…
- Trial name
- SPARE (NCT06291012)
- Testing
- Quick response: Amoxicillin for 3 days, Delayed response: Amoxicillin for 5 days, Quick response: Amoxicillin for 5 days
- Where
- France
- Volunteers
- 1,100 people
- Sponsor
- University Hospital, Montpellier
Hiv
LoViReT (Low Viral Reservoir Treated Patients)
The main purpose of this study is to unravel the mechanisms by which the "Low Viral Reservoir Treated" patients (LoViReT) maintain extremely low HIV-1 DNA levels despite having initiated cART during chronic HIV-1 infection.
- Trial name
- LoViReT (NCT02972931)
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- IrsiCaixa
Ovarian Cancer Stage IV, Ovarian Cancer Stage III
A Combination Therapy Strategy to Prevent Anti-PD-1 Therapy Resistance in Metastatic Ovarian Cancer Patients
This is an open label, non-randomized, 2-stage phase II, single arm study to determine the efficacy of New York esophageal squamous cell carcinoma 1 (NY-ESO-1) peptide vaccine as a priming mechanism to prevent anti-PD1 resistance…
- Conditions
- Ovarian Cancer Stage IV, Ovarian Cancer Stage III, Ovarian Cancer Stage 3
- Trial name
- NCT05479045
- Testing
- NY-ESO-1 Peptide vaccine, Toripalimab-tpzi
- Sponsor
- Georgetown University
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