Clinical trials: Therapy Strategies
Coronary Artery Disease, Myocardial Infarction
Personalization of Long-Term Antiplatelet Therapy - RAPID EXTEND
In patients after myocardial infarction (MI) (heart attacks) and treated with percutaneous coronary intervention (PCI), the current standard is dual antiplatelet therapy (DAPT), with aspirin and a P2Y12 receptor inhibitor, for 1…
- Trial name
- RAPID EXTEND (NCT03729401)
- Testing
- Active Comparator: Dual Antiplatelet Therapy (DAPT) - Aspirin 81 mg + Ticagrelor 60mg twice daily, Ticagrelor Monotherapy: Ticagrelor 60 mg twice daily, Personalized Therapy Arm: Aspirin 81 mg or Ticagrelor 60mg twice daily or Clopidogrel 75 mg once daily
- Where
- Canada
- Volunteers
- 39 people
- Sponsor
- Ottawa Heart Institute Research Corporation
High Risk Bleeding
Investigating a Personalized Approach to Anti-Platelet Therapy
RAPID PREVENT aims to identify if a personalized (targeted) anti-platelet strategy will reduce bleeding events when compared to the current standard anti-platelet therapy.
- Trial name
- RAPID PREVENT (NCT07602257)
- Testing
- Genotyping guided therapy for anti-platelet management
- Where
- Canada
- Volunteers
- 1,760 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Posttraumatic Stress Disorder
Telehealth 2.0: Evaluating Effectiveness and Engagement Strategies for CPT-Text for PTSD
There is a pressing need to increase capacity to treat PTSD related to or exacerbated by the COVID-19 pandemic. Texting-based therapy holds promise to increase capacity and reduce barriers to delivering evidence-based treatments…
- Trial name
- CPT-TEXT (NCT05037175)
- Testing
- CPT-Text, Culturally Informed Trauma Treatment (CITT), Retention Incentive
- Where
- 3 sites in United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Stanford University
Stage II, III, Nasopharyngeal Squamous Cell Carcinoma
Optimized Treatment Strategies for Early and Medium Stage Nasopharyngeal Carcinoma
The purpose of this study is to optimize treatment strategies for patients with stage II and III nasopharyngeal carcinoma, reduce the side effects related to treatment and improve the quality of life.
- Conditions
- Stage II, III, Nasopharyngeal Squamous Cell Carcinoma, Induction Chemotheray, Concurrent Chemoradiotherapy
- Trial name
- NCT03908372
- Testing
- Docetaxel, Cisplatin, IMRT
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences
Myelodysplastic Syndrome, Leukemia, Myelomonocytic, Chronic
Health Outcomes of Recently Diagnosed Myelodysplastic Syndrome (MDS)/Chronic Myelomonocytic Leukemia (CMML) Patients Depending on Treatment Strategy (Wait and See, Support, Active Treatment)
Post-authorisation observational study to assess the evolution in normal clinical practice of patients recently diagnosed with myelodysplastic syndrome (MDS) or chronic myelomonocytic leukaemia (CMML), depending on the moment…
- Trial name
- NCT02085798
- Testing
- Either Wait and See, or Supportive Treatment, or Active Treatment at physician discretion
- Where
- 50 sites in Spain
- Volunteers
- 503 people
- Sponsor
- Celgene
Congenital Mitral Insufficiency
Study of Innovative Drug Strategies in Improving Left Ventricular Function After Mitral Repair
The goal of this observational study is to compare the safety and effectiveness of a modified drug therapy with traditional drug therapy in pediatric patients after mitral repair.
- Trial name
- NCT06039592
- Testing
- Captopril Tablets, Metoprolol Oral Tablet, Spironolactone Tablets
- Where
- China
- Volunteers
- 164 people
- Sponsor
- China National Center for Cardiovascular Diseases
Description of an Effective Surgical Strategy to Treat Cancer Related Lymphedema, a High Incidence Pathology
COMBINATION OF LYMPHATICO-VENULAR ANASTOMOSIS AND LIPOSUCTION IN TREATING LYMPHEDEMA
cooperation of an International team with many years of experience in surgical management of lymphedema description of an effective surgical strategy to treat cancer-related lymphedema, a high incidence pathology the combination…
- Trial name
- NCT04536064
- Testing
- LVA and liposuction
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- University of Siena
Hemorrhage
Retrospective Study on Characteristics and Outcomes in Hospitalised Patients Treated With Ondexxya
This is an observational retrospective database study of hospitalized patients treated with andexanet alfa in approximately 10 Dutch hospitals.
- Trial name
- NCT05898412
- Testing
- Andexanet alfa
- Where
- Netherlands
- Volunteers
- 217 people
- Sponsor
- AstraZeneca
MPA, PAN or EGPA With FFS=0
Association Corticosteroid/Azathioprine in Microscopic Polyangiitis/ Polyarteritis Nodosa or Eosinophilic Granulomatosis With Polyangiitis (Churg Strauss Syndrome)
To determine whether a combination of corticosteroids and azathioprine can achieve a higher remission rate and a lower subsequent relapse rate in patients with newly-diagnosed microscopic polyangiitis, polyarteritis nodosa or…
- Conditions
- MPA, PAN or EGPA With FFS=0, At Diagnosis or Within the First 15 Days Following Initiation of Corticosteroids
- Trial name
- CHUSPAN2 (NCT00647166)
- Testing
- corticosteroid and azathioprine
- Where
- France
- Volunteers
- 114 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Depression
Lactobacillus Helveticus in the Treatment of Major Depression
The main objective of the study is to evaluate whether the association of the probiotic Lactobacillus helveticus to standard antidepressant will contribute to the treatment of major depression.
- Trial name
- NCT04333277
- Testing
- Probiotic, Maltodextrin
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of Minas Gerais
Upper Urinary Tract Urothelial Carcinoma
Translational Cancer Observational Protocol
Observational study on relapse occurrence and on the quality of life in patients who underwent nephroureterectomy surgery
- Trial name
- NCT06169436
- Testing
- Nephroureterectomy
- Where
- Italy
- Volunteers
- 1,250 people
- Sponsor
- IRCCS San Raffaele
HR+/HER2- Early Breast Cancer
Efficacy and Safety of Culmerciclib Plus Aromatase Inhibitors in a Response-Adapted Neoadjuvant Strategy for Highly Proliferative ER-Positive/HER2-Negative Breast Cancer
This prospective, response-adapted phase II study evaluates the efficacy and safety of neoadjuvant culmerciclib in combination with aromatase inhibitors in patients with highly proliferative ER-positive/HER2-negative breast…
- Trial name
- TAYLOR-002 (NCT07616453)
- Testing
- Culmerciclib, Aromatase Inhibitors
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Atrial Fibrillation
Therapeutic Strategy with Direct Oral Anticoagulants and Antiaggregant Drugs in Ischemic Heart Disease
The study aims to depict the actual prescription patterns employed in clinical practice of patients affected by non-valvular atrial fibrillation undergoing percutaneous coronary intervention (i.e.
- Trial name
- PRODOAC (NCT06239402)
- Testing
- Observation
- Where
- Italy
- Volunteers
- 394 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Non - Tuberculosis Mycobacteria Lung Disease
NTM-LD Treatment Based on GenSeizer Characteristic Gene Capture Strategy
Treatment of non - tuberculosis mycobacteria lung disease is challenging. The current treatment used is from 2007 American Thoracic Society guidelines recommended antibiotic combination therapy, which is lack of validation of…
- Trial name
- NCT03224065
- Testing
- Genotype detected through GenSeizer high-throughput gene capture technology
- Where
- China
- Volunteers
- 246 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Barrett's Esophagus, Overweight and Obesity
CAlorie and Protein REstriction PROgram in Barrett's Esophagus Patients (CARE-PRO).
The increasing incidence of Esophageal Adenocarcinoma (EAC) in several Western countries can be primarily ascribed to risk factors such as obesity, chronic gastroesophageal reflux, dietary habits and alcohol intake.
- Trial name
- CARE-PRO (NCT03813381)
- Testing
- Calorie and protein restriction diet
- Volunteers
- 160 people
- Sponsor
- Istituto Oncologico Veneto IRCCS
Schizophrenia, Bipolar Disorder
ADH.E.R.E.: Therapeutic ADHerence and Treatment Strategies: A Mental Health Registry
The purpose of this study is to find out how well new treatment plans are followed by outpatients with major mental illnesses (schizophrenia, bipolar disorder, depression, personality disorder) and to determine the relationship…
- Conditions
- Schizophrenia, Bipolar Disorder, Depression, Personality Disorder
- Trial name
- NCT00264069
- Testing
- antipsychotic, antidepressants
- Volunteers
- 2,622 people
- Sponsor
- Janssen-Cilag, S.A.
Helicobacter Pylori Infection
New Strategy for the Detection and Treatment of Helicobacter Pylori Infections in Primary Care Guided by a Non-invasive PCR in Stool
In France, every year 1 million people are explored for Helicobacter pylori infection and 200,000 receive eradication treatment.
- Trial name
- HEPYPRIM (NCT05495854)
- Testing
- PCR test in the stool, Hp serology and gastroscopy
- Where
- 13 sites in France
- Volunteers
- 245 people
- Sponsor
- Poitiers University Hospital
Atrial Fibrillation, Heart Failure
Cardiac Resynchronization in Atrial Fibrillation Trial - a Pilot Study
The purpose of this prospective randomized study is to determine whether patients on cardiac resynchronization therapy with concomitant long-standing persistent or permanent atrial fibrillation would benefit from a strategy to…
- Trial name
- Pilot-CRAfT (NCT01850277)
- Testing
- Amiodarone, External electrical cardioversion (EEC), Pharmacotherapy to slow and control ventricular rate
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Severe Health Anxiety, Somatic Symptom Disorder
Cognitive Behavior Therapy for Health Anxiety: A Comparison of Three Forms of Self-help
Background Severe health anxiety, Somatic symptom disorder or Illness anxiety disorder according to the Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-5), is associated with considerable personal distress…
- Conditions
- Severe Health Anxiety, Somatic Symptom Disorder, Illness Anxiety Disorder
- Trial name
- NCT01966705
- Testing
- Cognitive Behavior Therapy, exposure and response prevention (Internet, guided), Cognitive Behavior Therapy, exposure and response prevention (Internet, unguided), Cognitive Behavior Therapy, exposure and response prevention (Book, unguided)
- Where
- Sweden
- Volunteers
- 132 people
- Sponsor
- Karolinska Institutet
Crohn's Disease
Reduce Risk for Crohn's Disease Patients
The purpose of this study is to compare the effectiveness of weekly subcutaneously administered Methotrexate for maintaining relapse-free sustained steroid/Enteral Nutrition -free 1-year remission compared with: daily oral…
- Trial name
- RCT (NCT02852694)
- Testing
- Methotrexate, Adalimumab, Azathioprine / 6 Mercaptopurine
- Where
- France
- Volunteers
- 192 people
- Sponsor
- PIBD-Net
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